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1. Full Text Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
by Zuchero, Y. Joy Yu and Chen, Xiaocheng and Bien-Ly, Nga and Bumbaca, Daniela and Tong, Raymond K and Gao, Xiaoying and Zhang, Shuo and Hoyte, Kwame and Luk, Wilman and Huntley, Melanie A and Phu, Lilian and Tan, Christine and Kallop, Dara and Weimer, Robby M and Lu, Yanmei and Kirkpatrick, Donald S and Ernst, James A and Chih, Ben and Dennis, Mark S and Watts, Ryan J
Neuron (Cambridge, Mass.), ISSN 0896-6273, 01/2016, Volume 89, Issue 1, pp. 70 - 82
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain - metabolism | Fusion Regulatory Protein 1, Heavy Chain - immunology | Antibodies - therapeutic use | Animals | Transcytosis - physiology | Endothelial Cells - metabolism | Antibodies - immunology | Biological Transport - physiology | Mice | Proteomics - methods | Receptors, Transferrin - metabolism | Blood-Brain Barrier - metabolism | Proteins | Viral antibodies | Nervous system diseases | Antibodies | Health aspects | Biopharmaceutics | Brain | Antigens | Immunoglobulins | Blood-brain barrier | Rodents | Proteomics | Scientific imaging | Gene expression | Experiments | Mass spectrometry | Index Medicus
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2. Full Text Recurrent R-spondin fusions in colon cancer
by Seshagiri, Somasekar and Stawiski, Eric W and Durinck, Steffen and Modrusan, Zora and Storm, Elaine E and Conboy, Caitlin B and Chaudhuri, Subhra and Guan, Yinghui and Janakiraman, Vasantharajan and Jaiswal, Bijay S and Guillory, Joseph and Ha, Connie and Dijkgraaf, Gerrit J. P and Stinson, Jeremy and Gnad, Florian and Huntley, Melanie A and Degenhardt, Jeremiah D and Haverty, Peter M and Bourgon, Richard and Wang, Weiru and Koeppen, Hartmut and Gentleman, Robert and Starr, Timothy K and Zhang, Zemin and Largaespada, David A and Wu, Thomas D and De Sauvage, Frederic J
Nature (London), ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 660 - 664
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Colonic Neoplasms - genetics | Thrombospondins - genetics | Humans | Molecular Sequence Data | Gene Expression Profiling | Wnt Proteins - metabolism | Colonic Neoplasms - metabolism | Genes, APC | Insulin-Like Growth Factor II - genetics | Base Sequence | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Genes, Neoplasm - genetics | Gene Expression Regulation, Neoplastic - genetics | Transcription Factor 7-Like 2 Protein - genetics | Intercellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | Receptor, ErbB-3 - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Gene Fusion - genetics | Exome - genetics | Dioxygenases - genetics | Sequence Analysis, RNA | Colonic Neoplasms - pathology | Polymorphism, Single Nucleotide - genetics | Care and treatment | Colon cancer | Gene mutations | Genomics | Patient outcomes | Genetic aspects | Research | Proteins | Mutation | Colon | Genes | Index Medicus
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3. Full Text Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
by Friedman, Brad A and Srinivasan, Karpagam and Ayalon, Gai and Meilandt, William J and Lin, Han and Huntley, Melanie A and Cao, Yi and Lee, Seung-Hye and Haddick, Patrick C.G and Ngu, Hai and Modrusan, Zora and Larson, Jessica L and Kaminker, Joshua S and van der Brug, Marcel P and Hansen, David V
Cell reports (Cambridge), ISSN 2211-1247, 01/2018, Volume 22, Issue 3, pp. 832 - 847
microgliosis | tauopathy | myeloid | RNA-seq | Alzheimer’s disease | neuroinflammation | neurodegeneration | FACS | microglia | gene expression | Alzheimer's disease | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Brain - metabolism | Microglia - metabolism | Animals | Humans | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Disease Models, Animal | Index Medicus
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4. Full Text Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
by Dejanovic, Borislav and Huntley, Melanie A and De Mazière, Ann and Meilandt, William J and Wu, Tiffany and Srinivasan, Karpagam and Jiang, Zhiyu and Gandham, Vineela and Friedman, Brad A and Ngu, Hai and Foreman, Oded and Carano, Richard A.D and Chih, Ben and Klumperman, Judith and Bakalarski, Corey and Hanson, Jesse E and Sheng, Morgan
Neuron (Cambridge, Mass.), ISSN 0896-6273, 12/2018, Volume 100, Issue 6, pp. 1322 - 1336.e7
postsynaptic density | C1q | Alzheimer’s disease | proteomics | neurodegeneration | Tau | mass spectrometry | synapse | complement | GTPase | Neuroscience(all) | Alzheimer's disease | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain | Ontology | Genes | Blocking antibodies | Complement | Synaptic density | Experiments | Proteins | Dendritic spines | Neurodegeneration | Actin | Transgenic animals | Age | Statistical analysis | Neurodegenerative diseases | Therapeutic applications | Transgenic mice | Guanosine triphosphatases | Microglia | Complement component C1q | Pathology | Tau protein | Cytoskeleton | Proteomes | Evacuations & rescues | Regulatory proteins
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5. Full Text Complex regulation of ADAR-mediated RNA-editing across tissues
by Huntley, Melanie A and Lou, Melanie and Goldstein, Leonard D and Lawrence, Michael and Dijkgraaf, Gerrit J.P and Kaminker, Joshua S and Gentleman, Robert
BMC genomics, ISSN 1471-2164, 01/2016, Volume 17, Issue 1, pp. 61 - 61
RNA-DNA difference | ADAR | RNA-editing | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | RNA-Binding Proteins - genetics | Introns - genetics | Adenosine Deaminase - genetics | RNA Editing - genetics | Humans | Gene Expression Regulation | Adenosine Deaminase - biosynthesis | Brain - growth & development | Brain - metabolism | Organ Specificity - genetics | RNA-Binding Proteins - biosynthesis | Animals | Transcription, Genetic | Mice | Protein Isoforms - genetics | Physiological aspects | Research | Genetic regulation | RNA processing | Index Medicus
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6. Full Text Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes
by Huntley, Melanie A and Srinivasan, Karpagam and Friedman, Brad A and Wang, Tzu-Ming and Yee, Ada X and Wang, Yuanyuan and Kaminker, Josh S and Sheng, Morgan and Hansen, David V and Hanson, Jesse E
The Journal of neuroscience, ISSN 0270-6474, 01/2020, Volume 40, Issue 5, pp. 958 - 973
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cerebral cortex | Interneurons | Target recognition | Splicing | Neurons | Identification methods | Circuits | Internet resources | Genomes | Gene expression | Parvalbumin | Functional plasticity | Specialization | Intestine | Vasoactive agents | Neural networks | Data sets | Vasoactive intestinal peptide | Synaptic plasticity | Presynaptic plasticity | Somatostatin | Internet | Index Medicus | psychiatric | interneuron | splicing | VIP | SST
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7. Full Text Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
by Wu, Tiffany and Dejanovic, Borislav and Gandham, Vineela D and Gogineni, Alvin and Edmonds, Rose and Schauer, Stephen and Srinivasan, Karpagam and Huntley, Melanie A and Wang, Yuanyuan and Wang, Tzu-Ming and Hedehus, Maj and Barck, Kai H and Stark, Maya and Ngu, Hai and Foreman, Oded and Meilandt, William J and Elstrott, Justin and Chang, Michael C and Hansen, David V and Carano, Richard A.D and Sheng, Morgan and Hanson, Jesse E
Cell reports (Cambridge), ISSN 2211-1247, 08/2019, Volume 28, Issue 8, pp. 2111 - 2123.e6
tauopathy | amyloidosis | Alzheimer’s disease | neuroinflammation | neurodegeneration | synapse | complement | astrocyte | microglia | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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8. Full Text Evolutionary Analysis of Amino Acid Repeats across the Genomes of 12 Drosophila Species
by Huntley, Melanie A and Clark, Andrew G
Molecular biology and evolution, ISSN 0737-4038, 12/2007, Volume 24, Issue 12, pp. 2598 - 2609
Homopeptides | Protein repeats | Simple sequence | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Evolutionary Biology | Science & Technology | Amino Acid Sequence | Species Specificity | Genome, Insect - genetics | Selection, Genetic | Molecular Sequence Data | Drosophila - classification | Phylogeny | Chi-Square Distribution | Trinucleotide Repeats - genetics | Repetitive Sequences, Amino Acid | Sequence Alignment | Animals | Base Sequence | Insect Proteins - chemistry | Drosophila - genetics | Evolution, Molecular | Proteins | Amino acids | Evolutionary biology | Insects | Molecular biology | Genomics | Index Medicus
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9. Full Text Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
by Srinivasan, Karpagam and Friedman, Brad A and Etxeberria, Ainhoa and Huntley, Melanie A and van der Brug, Marcel P and Foreman, Oded and Paw, Jonathan S and Modrusan, Zora and Beach, Thomas G and Serrano, Geidy E and Hansen, David V
Cell reports (Cambridge), ISSN 2211-1247, 06/2020, Volume 31, Issue 13, pp. 107843 - 107843
transcriptomics | neurodegenerative diseases | aging | Alzheimer’s disease | neuroinflammation | microglia | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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