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Science, ISSN 0036-8075, 2019, Volume 363, Issue 6432, pp. 1148 - 1149
Approximately 2.6 billion years ago, during the Proterozoic period, the evolution of photosynthesis in cyanobacteria led to the introduction of the by-product... 
DEMETHYLASES | CANCER | MULTIDISCIPLINARY SCIENCES | Chromatin | Oxygen | Histones - genetics | Histone Demethylases | Hypoxia-inducible factors | Physiological effects | Homeostasis | Metabolism | Embryonic growth stage | Embryogenesis | Lysine | Stem cells | Cyanobacteria | Oxygen probes | Evolution | Hypoxia | Physiology | Sensors | Cardiovascular diseases | Oxygen tension | Photosynthesis | Cancer | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 460 - 462
The presence of internal tandem duplications (ITD) in the receptor tyrosine kinase gene have long been known to confer a poor prognosis in patients with acute... 
Journal Article
Science, ISSN 0036-8075, 03/2019, Volume 363, Issue 6432, p. 1148
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2018, Volume 34, Issue 4, pp. 533 - 535
In this issue of , de Boer et al. refine a set of acute myeloid leukemia (AML)-enriched plasma membrane markers that can be used to identify, prospectively... 
ONCOLOGY | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | Prospective Studies | Mutation | Leukemia, Myeloid, Acute | Humans | Cells, Cultured | Cloning | Leukemia | Stem cells | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 04/2018, Volume 131, Issue 15, pp. 1639 - 1653
FLT3 internal tandem duplication (FLT3 ) mutations are common in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new-generation... 
Journal Article
Cancer discovery, ISSN 2159-8274, 06/2019, Volume 9, Issue 6, pp. 699 - 701
Mutations in isoforms of isocitrate dehydrogenase (IDH) enzymes are described in multiple cancers and both mutant and wild-type IDH are important for the... 
Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7370, pp. 529 - 533
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 4, pp. 387 - 397
Journal Article
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7724, pp. 473 - 478
Journal Article
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 708 - 709
A new study provides the first insights into epigenetic heterogeneity in AML. The study highlights a striking independence of genetic and epigenetic variation,... 
MEDICINE, RESEARCH & EXPERIMENTAL | EVOLUTION | ACUTE MYELOID-LEUKEMIA | CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Epigenetic inheritance | Genotype | Properties | Health aspects | Studies | Epigenetics | Genetics | Kinetics | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 09/2014, Volume 32, Issue 9, pp. 2324 - 2337
Chronic myeloid leukemia (CML) is initiated and maintained by the tyrosine kinase BCR‐ABL which activates a number of signal transduction pathways, including... 
FOXO transcription factors | progenitor cells | Chronic myeloid leukemia | BCR‐ABL | CD34 | Tyrosine kinase inhibitors | Quiescence | BCR-ABL | SURVIVAL | APOPTOSIS | STEM-CELLS | CML | PERSISTENCE | CD34(+) progenitor cells | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MAINTENANCE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMATINIB | RESISTANCE | QUIESCENT | HEMATOLOGY | REMISSION | Forkhead Transcription Factors - biosynthesis | Phosphorylation | Signal Transduction | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Gene Expression Profiling | G1 Phase - drug effects | Forkhead Transcription Factors - genetics | Dasatinib - pharmacology | Animals | Transfection | Cell Cycle Checkpoints - drug effects | Forkhead Transcription Factors - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | K562 Cells | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Neoplastic Stem Cells - pathology | Mice | Protein Kinase Inhibitors - pharmacology | Cellular signal transduction | Genetic engineering | DNA binding proteins | Analysis | Stem cells | Transcription factors | Kinases | Leukemia | Rodents | Apoptosis | Index Medicus | CD34+ progenitor cells | Cancer Stem Cells
Journal Article