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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 570 - 575
Journal Article
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2017, Volume 27, Issue 1, pp. 1 - 5
Journal Article
Science, ISSN 0036-8075, 12/2014, Volume 346, Issue 6216, pp. 1480 - 1486
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here, we describe a pharmacogenomic... 
CELL LUNG-CANCER | ALK | KINASE INHIBITION | GEFITINIB | ACTIVATION | CERITINIB | MULTIDISCIPLINARY SCIENCES | CRIZOTINIB | MUTATIONS | CHEMOTHERAPY | BYPASS MECHANISMS | Lung Neoplasms - drug therapy | Sulfones - therapeutic use | Humans | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | MAP Kinase Kinase 1 - genetics | DNA Mutational Analysis | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Cells, Cultured | Molecular Targeted Therapy - methods | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Patient-Specific Modeling | Drug Resistance, Neoplasm - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | Enzyme Activation - genetics | Drug Screening Assays, Antitumor | Antimitotic agents | Cancer patients | Care and treatment | Lung cancer | Dosage and administration | Genetic aspects | Antineoplastic agents | Drug therapy | Drug resistance | Methods | Cancer | Cell culture | Oncology | Pharmaceutical sciences | Drugs | Mutations | Therapy | Genetics | Kinases | Patients | Tumors
Journal Article
Journal Article
International Journal of Oncology, ISSN 1019-6439, 1/2013, Volume 42, Issue 1, pp. 44 - 54
In contrast to mitochondria in healthy cells, which utilize oxidative phosphorylation, malignant cells undergo elevated glycolysis for energy production using... 
pyruvate dehydrogenase | gastric neoplasm | chemotherapy | prognosis | Pyruvate dehydrogenase | Chemotherapy | Prognosis | Gastric neoplasm | CELLS | TUMOR | CHEMORADIOTHERAPY | OVARIAN-CANCER | HYPOXIA | IN-VITRO | METABOLISM | REDUCTION | ONCOLOGY | ADAPTATION | Tissue Array Analysis | Humans | Middle Aged | Glucose Transporter Type 1 - metabolism | Male | Immunoenzyme Techniques | Adenocarcinoma, Mucinous - enzymology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antimetabolites, Antineoplastic - pharmacology | Female | Tumor Cells, Cultured | Adenocarcinoma, Mucinous - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Signet Ring Cell - drug therapy | Stomach Neoplasms - enzymology | Cell Survival - drug effects | Neoplasm Invasiveness | Lactic Acid - metabolism | Adenocarcinoma - enzymology | Survival Rate | Carcinoma, Signet Ring Cell - enzymology | Lymphatic Metastasis | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Blotting, Western | Adenocarcinoma, Mucinous - mortality | Carcinoma, Signet Ring Cell - mortality | Dichloroacetic Acid - pharmacology | Glucose - metabolism | Glycolysis | Aged | Fluorouracil - pharmacology | Hexokinase - metabolism | Stomach Neoplasms - mortality | Adenocarcinoma - mortality | Medical research | Phosphorylation | Dehydrogenases | Glucose | Metabolism | Kinases | Cancer therapies | Stomach cancer | Studies | Proteins | Medical prognosis | Tomography | Hypoxia | Tumors | Apoptosis
Journal Article