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1. Full Text Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry
by Eisen, Alon and Bhatt, Deepak L and Steg, P. Gabriel and Eagle, Kim A and Goto, Shinya and Guo, Jianping and Smith, Sidney C and Ohman, E. Magnus and Scirica, Benjamin M and REACH Registry Investigators and the REACH Registry Investigators
Journal of the American Heart Association, ISSN 2047-9980, 10/2016, Volume 5, Issue 10, p. n/a
Background The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated. Methods... 
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
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2. Full Text The genome of Tetranychus urticae reveals herbivorous pest adaptations
by Grbić, Miodrag and Van Leeuwen, Thomas and Clark, Richard M and Rombauts, Stephane and Rouzé, Pierre and Grbić, Vojislava and Osborne, Edward J and Dermauw, Wannes and Ngoc, Phuong Cao Thi and Ortego, Félix and Hernández-Crespo, Pedro and Diaz, Isabel and Martinez, Manuel and Navajas, Maria and Sucena, Élio and Magalhães, Sara and Nagy, Lisa and Pace, Ryan M and Djuranović, Sergej and Smagghe, Guy and Iga, Masatoshi and Christiaens, Olivier and Veenstra, Jan A and Ewer, John and Villalobos, Rodrigo Mancilla and Hutter, Jeffrey L and Hudson, Stephen D and Velez, Marisela and Yi, Soojin V and Zeng, Jia and Pires-Da Silva, Andre and Roch, Fernando and Cazaux, Marc and Navarro, Marie and Zhurov, Vladimir and Acevedo, Gustavo and Bjelica, Anica and Fawcett, Jeffrey A and Bonnet, Eric and Martens, Cindy and Baele, Guy and Wissler, Lothar and Sanchez-Rodriguez, Aminael and Tirry, Luc and Blais, Catherine and Demeestere, Kristof and Henz, Stefan R and Gregory, T. Ryan and Mathieu, Johannes and Verdon, Lou and Farinelli, Laurent and Schmutz, Jeremy and Lindquist, Erika and Feyereisen, René and Van De Peer, Yves and Joint Genome Institute (JGI)
Nature, ISSN 0028-0836, 11/2011, Volume 479, Issue 7374, pp. 487 - 492
The spider mite Tetranychus urticae is a cosmopolitan agricultural pest with an extensive host plant range and an extreme record of pesticide resistance. Here... 
MITE | HOX GENES | MODEL | MULTIDISCIPLINARY SCIENCES | SPIDER | Multigene Family - genetics | Tetranychidae - genetics | Herbivory - physiology | Plants - parasitology | Genomics | Gene Expression Regulation | Genome - genetics | Molting - genetics | Adaptation, Physiological - physiology | Fibroins - genetics | Molecular Sequence Data | Transcriptome - genetics | Genes, Homeobox - genetics | Tetranychidae - physiology | Ecdysterone - analogs & derivatives | Ecdysterone - genetics | Silk - biosynthesis | Animals | Herbivory - genetics | Adaptation, Physiological - genetics | Nanostructures - chemistry | Gene Transfer, Horizontal - genetics | Silk - chemistry | Evolution, Molecular | Tetranychidae | Genetic aspects | Genomes | Models | Food and nutrition | Agricultural pests | Natural history | Biomedical materials | Pesticides | DNA methylation | Genetics | Chromosomes
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3. Full Text Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
by Kempers, Marlies JE, MD and Kuiper, Roland P, PhD and Ockeloen, Charlotte W, MD and Chappuis, Pierre O, MD and Hutter, Pierre, PhD and Rahner, Nils, MD and Schackert, Hans K, Prof and Steinke, Verena, MD and Holinski-Feder, Elke, Prof and Morak, Monika, PhD and Kloor, Matthias, MD and Büttner, Reinhard, MD and Verwiel, Eugene TP, BSc and van Krieken, J Han, Prof and Nagtegaal, Iris D, MD and Goossens, Monique, BSc and van der Post, Rachel S, MD and Niessen, Renée C, PhD and Sijmons, Rolf H, MD and Kluijt, Irma, MD and Hogervorst, Frans BL, PhD and Leter, Edward M, MD and Gille, Johan JP, PhD and Aalfs, Cora M, MD and Redeker, Egbert JW, PhD and Hes, Frederik J, MD and Tops, Carli MJ, PhD and van Nesselrooij, Bernadette PM, MD and van Gijn, Marielle E, PhD and García, Encarna B Gómez, MD and Eccles, Diana M, Prof and Bunyan, David J, PhD and Syngal, Sapna, MD and Stoffel, Elena M, MD and Culver, Julie O, MSc and Palomares, Melanie R, MD and Graham, Tracy, MSc and Velsher, Lea, MD and Papp, Janos, PhD and Oláh, Edith, Prof and Chan, Tsun L, PhD and Leung, Suet Y, Prof and van Kessel, Ad Geurts, Prof and Kiemeney, Lambertus ALM, Prof and Hoogerbrugge, Nicoline, Prof and Ligtenberg, Marjolijn JL, Dr
Lancet Oncology, The, ISSN 1470-2045, 2011, Volume 12, Issue 1, pp. 49 - 55
Summary Background Lynch syndrome is caused by germline mutations in MSH2, MLH1, MSH6 , and PMS2 mismatch-repair genes and leads to a high risk of colorectal... 
Hematology, Oncology and Palliative Medicine | STEM-CELLS | METHYLATION | HYPERMETHYLATION | MANAGEMENT | MSH2 | ONCOLOGY | REPAIR GENE HMSH2 | MUTATION CARRIERS | FAMILIES | SURVEILLANCE | TACSTD1 | Antigens, Neoplasm - genetics | Promoter Regions, Genetic | Sequence Deletion | Cell Adhesion Molecules - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Endometrial Neoplasms - etiology | Male | Risk | MutS Homolog 2 Protein - genetics | Epithelial Cell Adhesion Molecule | Colorectal Neoplasms - etiology | Endometrial Neoplasms - genetics | Gene Deletion | Adolescent | Adult | Female | Aged | Cohort Studies | Prevention | Molecular genetics | Endometrial cancer | Gene mutations | Oncology, Experimental | Research | Universities and colleges | Biometry | Cancer
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4. Full Text The Immune Landscape of Cancer
by Thorsson, Vesteinn and Thorsson, Vésteinn and Gibbs, Richard A and Gibbs, David L and Brown, Scott D and Wolf, Gregory and Wolf, Denise and Bortone, Dante S and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Gao, Jianjiong and Plaisier, Christopher L and Eddy, James A and Ziv, Elad and Culhane, Aedin C and Paull, Evan O and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Wenbin and Liu, Jianfang and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Rader, Janet and Dhankani, Varsha and Reynolds, Sheila and Reynolds, Sheila M and Bowlby, Reanne and Califano, Andrea and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Newman, Aaron M and Rao, Arvind and Chen, Amy and Chen, Chu and Chen, Ken and Krasnitz, Alexander and Hu, Jianhong and Hu, Hai and Malta, Tathiane M and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Ojesina, Akinyemi I and Lamb, Andrew and Zhou, Wanding and Shen, Hui and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Saltz, Joel and Holt, Robert and Holt, Robert A and Rabkin, Charles S and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Jioajiao and Wang, Min and Wang, Linghua and Wang, Zhining and Wang, Timothy and Wang, Jing and Yang, Ju Dong and Yang, Hannah and Yang, Liming and Yang, Ian and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Zhang, Jiexin and Zhang, Lizhi and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Yichao and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
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5. Full Text A new bioinformatics tool to help assess the significance of BRCA1 variants
by Cusin, Isabelle and Teixeira, Daniel and Zahn-Zabal, Monique and De Laval, Valentine Rech and Gleizes, Anne and Viassolo, Valeria and Chappuis, Pierre O and Hutter, Pierre and Bairoch, Amos and Gaudet, Pascale
Human Genomics, ISSN 1473-9542, 01/2018, Volume 12, Issue 1, pp. 36 - 11
Background: Germline pathogenic variants in the breast cancer type 1 susceptibility gene BRCA1 are associated with a 60% lifetime risk for breast and ovarian... 
Functional defect assessment | BRCA1 | Biological database | Genetic variants | Molecular phenotypes | Cancer | MISSENSE VARIANTS | PROTEIN | DNA-DAMAGE RESPONSE | HEREDITARY BREAST | SEQUENCE VARIANTS | GENETICS & HEREDITY | FUNCTIONAL-ANALYSIS | OVARIAN | HOMOLOGOUS RECOMBINATION | INTERACT IN-VIVO | Genetic Predisposition to Disease | Humans | Middle Aged | Computational Biology | Ovarian Neoplasms - pathology | Germ-Line Mutation - genetics | Genetic Variation | Ovarian Neoplasms - genetics | BRCA1 Protein - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Adult | Female | Protein Conformation | Aged | BRCA1 Protein - chemistry | Genetic variance | BRCA1 protein | Genomics | Benign | Poly(ADP-ribose) polymerase | Breast cancer | Mutation | Health risk assessment | Bioinformatics | Ovarian cancer
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6. Full Text Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
by Eeles, R.A and Kote Jarai, Z and Al Olama, A.A and Giles, G.G and Guy, M and Severi, G and Muir, K and Hopper, J.L and Henderson, B.E and Haiman, C.A and Schleutker, J and Hamdy, F.C and Neal, D.E and Donovan, J.L and Stanford, J.L and Ostrander, E.A and Ingles, S.A and John, E.M and Thibodeau, S.N and Schaid, D and Park, J.Y and Spurdle, A and Clements, J and Dickinson, J.L and Maier, C and Vogel, W and Dork, T and Rebbeck, T.R and Cooney, K.A and Cannon Albright, L and Chappuis, P.O and Hutter, P and Zeegers, M and Kaneva, R and Zhang, H.W and Lu, Y.J and Foulkes, WD and English, D.R and Leongamornlert, D.A and Tymrakiewicz, M and Morrison, J and Ardern Jones, A.T and Hall, A.L and O'Brien, L.T and Wilkinson, R.A and Saunders, E.J and Page, E.C and Sawyer, E.J and Edwards, S.M and Dearnaley, D.P and Horwich, A and Huddart, R.A and Khoo, V.S and Parker, C.C and Van As, N and Woodhouse, C.J and Thompson, A and Christmas, T and Ogden, C and Cooper, C.S and Southey, M.C and Lophatananon, A and Liu, J.F and Kolonel, L.N and Le Marchand, L and Wahlfors, T and Tammela, T.L and Auvinen, A and Lewis, S.J and Cox, A and FitzGerald, L.M and Koopmeiners, J.S and Karyadi, D.M and Kwon, E.M and Stern, M.C and Corral, R and Joshi, A.D and Shahabi, A and McDonnell, S.K and Sellers, T.A and Pow Sang, J and Chambers, S and Aitken, J and Gardiner, R.A and Batra, J and Kedda, M.A and Lose, F and Polanowski, A and Patterson, B and Serth, J and Meyer, A and Luedeke, M and Stefflova, K and Ray, A.M and Lange, E.M and Farnham, J and Khan, H and Slavov, C and Mitkova, A and British Assoc Urological Surg and PRACTICAL Consortium and UK ProtecT Study Collaborators and UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology and The PRACTICAL Consortium and The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators
Nature Genetics, ISSN 1061-4036, 01/2009, Volume 41, Issue 10, pp. 1116 - 21
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously... 
RISK | AUSTRALIAN CASE-CONTROL | VARIANTS | MULTIPLE | GENETICS & HEREDITY | ANTIGEN | Genome-Wide Association Study | Disease Susceptibility | Prostatic Neoplasms - genetics | Humans | Genotype | Male | Chromosomes, Human | Polymorphism, Single Nucleotide | Genome, Human | Disease susceptibility | Genetic aspects | Research | Diagnosis | Single nucleotide polymorphisms | Health aspects | Prostate cancer | Risk factors | Studies | Medical research | Inflation | Regression analysis | Chromosomes
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