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1. Full Text EphA2 Signaling Following Endocytosis: Role of Tiam1
by Boissier, Pomme and Chen, Jin and Huynh‐Do, Uyen
Traffic, ISSN 1398-9219, 12/2013, Volume 14, Issue 12, pp. 1255 - 1271
Eph receptors, a complex subfamily of receptor tyrosine kinases, are rapidly endocytosed following ligand‐mediated activation and traffic through endocytic... 
Tiam1 | endocytosis | recycling | signaling endosomes | EphA2 | Signaling endosomes | Endocytosis | Recycling | LIGAND-BINDING | C-CBL | NUCLEOTIDE EXCHANGE FACTORS | CELL BIOLOGY | PDGF BETA-RECEPTOR | TRANSFERRIN RECEPTOR | NEURITE OUTGROWTH | CELL-MIGRATION | EPIDERMAL-GROWTH-FACTOR | RHO-GTPASES | INTRACELLULAR TRAFFICKING | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Humans | Receptor, EphA2 - metabolism | Animals | Lysosomes - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Receptor, EphA2 - genetics | Cell Line, Tumor | Cell Membrane - metabolism | Mice | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | rac1 GTP-Binding Protein - metabolism | Cell adhesion & migration | signalling endosomes
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2. Full Text The TWEAK/Fn14 pathway is required for calcineurin inhibitor toxicity of the kidneys
by Claus, Meike and Herro, Rana and Wolf, Dennis and Buscher, Konrad and Rudloff, Stefan and Huynh‐Do, Uyen and Burkly, Linda and Croft, Michael and Sidler, Daniel
American Journal of Transplantation, ISSN 1600-6135, 07/2018, Volume 18, Issue 7, pp. 1636 - 1645
Calcineurin inhibitor toxicity (CNT) is a frequent occurrence in transplanted renal grafts and autochthone kidneys from patients undergoing long‐term treatment... 
interstitial fibrosis and tubular atrophy | animal models | immunosuppressant ‐ calcineurin inhibitor (CNI) | translational research/science | kidney transplantation/nephrology | pharmacology | kidney (allograft) function/dysfunction | fibrosis | basic (laboratory) research/science | immunosuppressant - calcineurin inhibitor (CNI) | SURGERY | basic (laboratory) research | kidney transplantation | INJURY | MECHANISMS | MATRIX PROTEINS | NEPHROPATHY | dysfunction | TRANSPLANTATION | nephrology | CHRONIC CYCLOSPORINE NEPHROTOXICITY | GROWTH-FACTOR-BETA | science | DISEASE | NEPHRITIS | kidney (allograft) function | translational research | MULTIFUNCTIONAL CYTOKINE | Analysis | Immunosuppressive agents | Kidneys | Toxicity | Epithelial cells | Pathogenesis | Calcineurin | Calcineurin inhibitors | Inflammation | Cyclosporin A | Metastases | Tacrolimus | Tumor necrosis factor | Tumor necrosis factor-TNF | Apoptosis | Kidney transplantation
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3. Full Text Fabry disease genotype, phenotype and migalastat amenability: insights from a national cohort
by Nowak, Albina and Uyen, Huynh-Do and Krayenbuehl, Pierre-Alexandre and Beuschlein, Felix and Schiffmann, Raphael and Barbey, Frédéric
Journal of inherited metabolic disease, ISSN 0141-8955, 08/2019
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by α-galactosidase A (α-Gal A) deficiency. The progressive accumulation of... 
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4. Full Text Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry
by Kummer, Mirjam and Šestáková, Nela and Theurillat, Regula and Huynh‐Do, Uyen and Endimiani, Andrea and Sendi, Parham and Thormann, Wolfgang
Journal of Separation Science, ISSN 1615-9306, 11/2018, Volume 41, Issue 21, pp. 4067 - 4074
Cefepime monitoring in urine by micellar electrokinetic capillary chromatography with UV detection and liquid chromatography coupled to mass spectrometry via... 
cefepime | micellar electrokinetic capillary chromatography | capillary electrophoresis | therapeutic drug monitoring | DIRECT SAMPLE INJECTION | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | HEALTHY-SUBJECTS | VALIDATION | CEREBROSPINAL-FLUID | HUMAN SERUM | INHIBITOR COMBINATIONS | IN-VITRO | PHARMACOKINETICS | BETA-LACTAM ANTIBIOTICS | Liquid chromatography | Precipitation (Meteorology) | Mass spectrometry | Analysis | Urine | Spectroscopy | Electrokinetics | Ions | Stability analysis | Chromatography | Proteins | Dilution | Ionization | Scientific imaging | Monitoring
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5. Full Text Reduced β-catenin expression affects patterning of bone primordia, but not bone maturation
by Pflug, Tobias and Huynh-Do, Uyen and Rudloff, Stefan
Biology Open, ISSN 2046-6390, 05/2017, Volume 6, Issue 5, pp. 582 - 588
Wnt/beta-catenin signaling is involved in patterning of bone primordia, but also plays an important role in the differentiation of chondrocytes and... 
Limb patterning | β-catenin dosage | Bone development | Canonical wnt signaling | ENDOCHONDRAL OSSIFICATION | OSTEOBLAST DIFFERENTIATION | APICAL ECTODERMAL RIDGE | beta-catenin dosage | MOUSE EMBRYO | CHONDROCYTE DIFFERENTIATION | CARTILAGE | LIMB DEVELOPMENT | SIGNALING PATHWAY | Canonical Wnt signaling | BIOLOGY | GENE-EXPRESSION | MICE | Transcription factors | Wnt protein | Bone diseases | Dosage | Osteoblasts | Cartilage | Osteoporosis | β-catenin | Biomedical materials | Mineralization | Extracellular matrix | Biocompatibility | Primordia | Chondrogenesis | Maturation | Abnormalities | Medical treatment | Embryos | Signaling | Skeletogenesis | Bone mass | Osteoblastogenesis | Chondrocytes | Calcification | Bone | Differentiation
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6. Full Text SuO019REDUCED β-CATENIN LEVELS DURING KIDNEY DEVELOPMENT DISTURB RENAL MORPHOLOGY AND KIDNEY FUNCTION IN THE ADULT
by Rudloff, Stefan and Karolin, Andrea and Lambert, Delphine and Huynh-Do, Uyen
Nephrology Dialysis Transplantation, ISSN 0931-0509, 05/2018, Volume 33, Issue suppl_1, pp. i623 - i623
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7. Full Text Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury
by Rodriguez, Stéphane and Rudloff, Stefan and Koenig, Katrin Franziska and Karthik, Swapna and Hoogewijs, David and Huynh-Do, Uyen
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 8/2016, Volume 468, Issue 8, pp. 1433 - 1448
Acute kidney injury (AKI) is common in hospitalized patients and has a poor prognosis, the severity of AKI being linked to progression to chronic kidney... 
EphrinA1 | Biomedicine | Bidirectional | Human Physiology | Kidney repair | EPO | EphA2 | VITRO | ACUTE KIDNEY INJURY | INDUCIBLE FACTOR | ACTIVATION | PHYSIOLOGY | MESENCHYMAL STEM-CELLS | ISCHEMIA-REPERFUSION INJURY | GENE | IN-VIVO | ENDOTHELIAL-CELLS | RECEPTORS | Ephrin-A1 - metabolism | Humans | Cells, Cultured | Receptor, EphA2 - metabolism | Rats | Male | Coculture Techniques - methods | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Hypoxia - metabolism | Animals | Up-Regulation - physiology | Cell Line, Tumor | Signal Transduction - physiology | Erythropoietin - metabolism | Laminin - metabolism | Acute Kidney Injury - metabolism | Physiological aspects | Laminin | Kidney diseases | Erythropoietin | RNA | Analysis | Life Sciences | Cancer
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8. Full Text Fabry disease genotype, phenotype and amenability: A full country overview
by Nowak, Albina and Krayenbuehl, Pierre-Alexandre and Huynh-Do, Uyen and Barbey, Frederic
Molecular Genetics and Metabolism, ISSN 1096-7192, 02/2019, Volume 126, Issue 2, pp. S110 - S111
Enzymes | Genetic aspects | Kidney diseases | Gangliosides
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9. Full Text Employment 12 months after kidney transplantation
: An in-depth bio-psycho-social analysis of the Swiss Transplant Cohort
by Danuser, Brigitta and Simcox, Amira and Studer, Regina and Koller, Michael and Wild, Pascal and Psychosocial Interest Grp and Swiss Transplant Cohort Study and Psychosocial Interest Group, Swiss Transplant Cohort Study and for the Psychosocial Interest Group, Swiss Transplant Cohort Study
PLoS one, ISSN 1932-6203, 2017, Volume 12, Issue 4, Art. e0175161, pp. 17 - 12:4, Art. e0175161<17
Background Return to work with or after a chronic disease is a dynamic process influenced by a variety of interactions between personal, work, societal and... 
Qualifikation | Rehabilitand | Dialyse | Erwerbsquote | Medizin | Medizinische Rehabilitation | Erwerbsbeteiligung | Schweiz | Berufliche Reintegration | Depression (Psy) | Psychosozialer Faktor | Gesundheitszustand | Chronische Krankheit | DEPRESSION | DONOR RENAL-TRANSPLANTATION | MULTIDISCIPLINARY SCIENCES | WORK | LIVER-TRANSPLANT | QUALITY-OF-LIFE | HEALTH | RECIPIENTS | ACCESS | PARTICIPATION | UNEMPLOYMENT | Employment - statistics & numerical data | Humans | Middle Aged | Male | Kidney Transplantation - statistics & numerical data | Models, Statistical | Switzerland | Social Class | Young Adult | Kidney Transplantation - psychology | Adolescent | Adult | Female | Aged | Employment - psychology | Cohort Studies | Psychological aspects | Care and treatment | Kidneys | Chronic kidney failure | Patient outcomes | Organ transplant recipients | Transplantation | Research | End-stage renal disease | Transplants & implants | Liver | Mental health | Social factors | Mental depression | Demographics | Employment | Education | Surgery | Population | Occupational health | Age | Chronic illnesses | Diabetes mellitus | Patients | Quality of life | Studies | Anxieties | Social analysis | Dialysis | Diabetes | Society | Kidney diseases | Kidney transplantation | Life Sciences | Human health and pathology | Santé publique et épidémiologie | Urology and Nephrology
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10. Full Text The role of PTEN in tumor angiogenesis
by Rodriguez, Stéphane and Huynh-Do, Uyen
Journal of Oncology, ISSN 1687-8450, 2012, Volume 2012, pp. 1 - 11
During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is... 
Review
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11. In Process Citation
by Huynh-Do, Uyen
Therapeutische Umschau. Revue therapeutique, ISSN 0040-5930, 03/2015, Volume 72, Issue 3, p. 139
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12. Full Text TRPC1 is regulated by caveolin‐1 and is involved in oxidized LDL‐induced apoptosis of vascular smooth muscle cells
by Ingueneau, Cécile and Huynh‐Do, Uyen and Marcheix, Bertrand and Athias, Anne and Gambert, Philippe and Nègre‐Salvayre, Anne and Salvayre, Robert and Vindis, Cécile
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 08/2009, Volume 13, Issue 8b, pp. 1620 - 1631
Oxidized low‐density lipoprotein (oxLDL) induced‐apoptosis of vascular cells may participate in plaque instability and rupture. We have previously shown that... 
apoptosis | oxidized low‐density lipoprotein | vascular smooth muscle cell | caveolin‐1 | TRPC1 | Caveolin-1 | Vascular smooth muscle cell | Oxidized low-density lipoprotein | Apoptosis | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | LOCALIZATION | ACTIVATION | INSERTION | OPERATED CA2+ INFLUX | RECEPTOR POTENTIAL CHANNEL-1 | PLASMA-MEMBRANE | CELL BIOLOGY | caveolin-1 | CALCIUM-ENTRY | ENDOTHELIAL-CELLS | LIPID RAFTS | oxidized low-density lipoprotein | Base Sequence | Humans | Cells, Cultured | Gene Expression Regulation - physiology | Lipoproteins, LDL - physiology | RNA, Small Interfering | Apoptosis - physiology | Muscle, Smooth, Vascular - cytology | TRPC Cation Channels - genetics | Caveolin 1 - physiology | Lipoproteins (low density) | Cell culture | Membranes | Regulators | Deregulation | Toxicity | Trafficking | Homeostasis | Smooth muscle | Lipids | Kinases | Cell surface | Calcium influx | Proteins | Transient receptor potential proteins | Cell growth | Actin | Atherosclerosis | Calcium homeostasis | Translocation | Fractionation | Biotinylation | Caveolin | Muscles | Cholesterol | Arteriosclerosis | Cytoskeleton | Membrane trafficking | Calcium ions | Caveolin 1 | Muscle, Smooth, Vascular | TRPC Cation Channels | Gene Expression Regulation | Lipoproteins, LDL
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13. Full Text Prevalence, persistence and clinical correlations of classic and novel antiphospholipid antibodies in systemic lupus erythematosus
by Marchetti, Tess and Ribi, Camillo and Perneger, Thomas and Trendelenburg, Marten and Huynh-Do, Uyen and de Moerloose, Philippe and Chizzolini, Carlo
Rheumatology, ISSN 1462-0324, 08/2018, Volume 57, Issue 8, pp. 1350 - 1357
Abstract Objectives aPL are frequently present in SLE. In a well characterized SLE cohort we aimed at investigating the prevalence of aPL and assessing their... 
Antiphospholipid | Beta 2-glycoprotein 1 | Domain 1 | Systemic lupus erythematosus | Phos-phatidylserine/prothrombin complex | Lupus anticoagulant | DIAGNOSIS | ASSAY | domain 1 | phosphatidylserine/prothrombin complex | RISK | CLASSIFICATION | lupus anticoagulant | RHEUMATOLOGY | antiphospholipid | ANTIPHOSPHATIDYLSERINE/PROTHROMBIN | PATHOGENESIS | systemic lupus erythematosus | beta 2-glycoprotein 1 | ANTICARDIOLIPIN | REVISED CRITERIA | I ANTIBODIES | Immunoglobulin M | Antiphospholipid antibodies | Thrombosis | Immunoglobulin G
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14. Editorial
by Huynh-Do, Uyen
Therapeutische Umschau, ISSN 0040-5930, 2015, Volume 72, Issue 3, p. 139
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15. Full Text Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway
by Hlushchuk, Ruslan and Styp-Rekowska, Beata and Dzambazi, Jehona and Wnuk, Monika and Huynh-Do, Uyen and Makanya, Andrew and Djonov, Valentin
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182813
Angiogenesis is a highly coordinated, extremely complex process orchestrated by multiple signaling molecules and blood flow conditions. While sprouting mode of... 
CROSS-TALK | RECOVERY | CELLS | RECRUITMENT | GROWTH-FACTOR-BETA | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | NOTCH | PTK787/ZK222584 | PROMOTER | EXPRESSION | Blood Vessels - growth & development | Blood Vessels - metabolism | Humans | Glomerulonephritis - genetics | Rats | Receptors, Notch - genetics | Smad Proteins - genetics | Signal Transduction - genetics | Glomerulonephritis - metabolism | Chick Embryo | Intussusception - genetics | Neovascularization, Pathologic - pathology | Cell Differentiation - genetics | Animals | COUP Transcription Factor II - genetics | Gene Expression Regulation, Developmental | Glomerulonephritis - pathology | Endoglin - genetics | Intussusception - pathology | Protein Binding | Neovascularization, Pathologic - genetics | Endoglin - antagonists & inhibitors | Physiological aspects | Transcription factors | Glycoproteins | Neovascularization | Research | Glomerulonephritis | Ovalbumin | Phosphorylation | Intravenous administration | Pathogenesis | Intussusception | Pillars | Metastasis | Kinases | Blood flow | Studies | Angiogenesis | Endoglin | Signal transduction | Molecular modelling | Rodents | Microvasculature | Inhibition | Differentiation | Prostate cancer | Growth factors | CD105 antigen | Veins & arteries
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16. Full Text Low‐Dose Irinotecan Improves Advanced Lupus Nephritis in Mice Potentially by Changing DNA Relaxation and Anti–Double‐Stranded DNA Binding
by Frese‐Schaper, Manuela and Keil, Andreas and Steiner, Selina K and Gugger, Mathias and Körner, Meike and Kocher, Gregor J and Schiffer, Lena and Anders, Hans‐Joachim and Huynh‐Do, Uyen and Schmid, Ralph A and Frese, Steffen
Arthritis & Rheumatology, ISSN 2326-5191, 08/2014, Volume 66, Issue 8, pp. 2259 - 2269
Objective Despite clear advances in the treatment of systemic lupus erythematosus (SLE), many patients still present with refractory lupus nephritis, requiring... 
TOPOISOMERASE-I INHIBITOR | ANTIBODIES | MORTALITY | CELLS | EFFICACY | HYBRID MICE | CAMPTOTHECIN | SENSITIVITY | RHEUMATOLOGY | ANTITUMOR-ACTIVITY | ERYTHEMATOSUS | Topoisomerase I Inhibitors - pharmacology | Animals | Topoisomerase I Inhibitors - administration & dosage | Camptothecin - administration & dosage | Female | Lupus Nephritis - drug therapy | Mice | Mice, Inbred NZB | Camptothecin - pharmacology | Disease Progression | Camptothecin - analogs & derivatives | DNA - drug effects | Lupus | Autoimmune diseases | Rodents | Deoxyribonucleic acid--DNA
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