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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Artemisinins | Malaria | Half lives | Antimalarials | Peroxides | Parasites | Dosage | Ozonides | Blood | Blood plasma | 1,2,4-trioxolane | Antimalarial drug discovery | OZ277 | PHARMACODYNAMIC PROPERTIES | MULTIDISCIPLINARY SCIENCES | ARTEROLANE | TRIOXOLANE | 1-AMINOBENZOTRIAZOLE | antimalarial drug discovery | PEROXIDES | IN-VITRO ASSESSMENT | PLASMODIUM-FALCIPARUM | ANTIMALARIAL ACTIVITY | ARTEMISININ | Peroxides - administration & dosage | Plasmodium berghei - physiology | Male | Peroxides - therapeutic use | Peroxides - pharmacokinetics | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Heterocyclic Compounds - chemistry | Time Factors | Adamantane - therapeutic use | Adamantane - administration & dosage | Adamantane - pharmacokinetics | Artemisinins - chemistry | Adamantane - analogs & derivatives | Antimalarials - pharmacokinetics | Heterocyclic Compounds - administration & dosage | Drug Stability | Peroxides - chemistry | Rats | Treatment Outcome | Antimalarials - therapeutic use | Iron - metabolism | Rats, Sprague-Dawley | Animals | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Antimalarials - chemistry | Malaria - parasitology | Heterocyclic Compounds - pharmacokinetics | Mice | Adamantane - chemistry | Heterocyclic Compounds - therapeutic use | Malaria - drug therapy | Care and treatment | Composition | Health aspects | Malaria vaccine | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/1996, Volume 93, Issue 25, pp. 14367 - 14372
Lysophosphatidic acid (1-acyl-2-lyso-sn-glycero-3-phosphate, LPA) is a multifunctional lipid mediator found in a variety of organisms that span the... 
Proteins | Lysophosphatidic acid receptors | Receptors | Oligonucleotides | Amino acids | Antisense oligonucleotides | Lipids | Complementary RNA | Biochemistry | Oocytes | PHOSPHATIDYLINOSITOL | PHOSPHATIDIC-ACID | IDENTIFICATION | MESSENGER | MULTIDISCIPLINARY SCIENCES | Xenopus | Cell receptors | Genetic aspects | Antisense DNA | Research | Cloning
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2011, Volume 108, Issue 11, p. 4400
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Drugs | Malaria | Erythrocytes | Clinical trials | Parasitic protozoa | Blood
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 03/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Journal Article
AIDS Research and Human Retroviruses, ISSN 0889-2229, 1992, Volume 8, Issue 5, pp. 597 - 604
We have investigated the ability of pyridoxal-5'-phosphate to inhibit a recombinant deletion mutant of human immunodeficiency virus type 1 (HIV-1) reverse... 
RETROVIRUSES HTLV-III | INFECTIOUS DISEASES | MECHANISM | ESCHERICHIA-COLI | PYRIDOXAL 5'-PHOSPHATE INHIBITION | AIDS | DNA-POLYMERASE | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | IDENTIFICATION | EXPRESSION | BINDING
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 1997, Volume 4, Issue 7, pp. 608 - 616
Apoptosis, or programmed cell death, is an active metabolic response to physiological signals or exposure to cytotoxic agents, Recent evidence has shown that... 
Ceramide | Cardiomyocytes | Phospholipids | Reperfusion | Ischemia | Apoptosis | SIGNAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | apoptosis | phospholipids | ischemia | CELL-DEATH | CELL BIOLOGY | cardiomyocytes | ceramide | TUMOR-NECROSIS-FACTOR | LYSOPHOSPHATIDIC ACID | DNA FRAGMENTATION | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | K DR CELL BIOLOGY | XENOPUS OOCYTES | FLOW-CYTOMETRY | reperfusion
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/1996, Volume 93, Issue 25, pp. 14367 - 14372
Journal Article
Science, ISSN 0036-8075, 1/1987, Volume 235, Issue 4786, pp. 348 - 350
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/1996, Volume 93, Issue 25, p. 14367
  Lysophosphatidic acid (LPA) is a multifunctional lipid mediator found in a variety of organisms that span the phylogenetic tree from humans to plants. Guo et... 
Deoxyribonucleic acid | DNA | Lipids | Biochemistry
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 1992, Volume 50, Issue 2, pp. 325 - 333
Journal Article
Trends in Biotechnology, ISSN 0167-7799, 1992, Volume 10, Issue 11, pp. 388 - 391
Journal Article
Nutrition and Cancer, ISSN 0163-5581, 07/1999, Volume 34, Issue 2, pp. 199 - 205
Journal Article
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