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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 8, pp. 3041 - 3046
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the... 
ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | MUTATION | KERATOACANTHOMAS | SENSITIVITY | SENESCENCE | SORAFENIB | HUMAN CANCER | PROGRESSION | BRAF(V600E) | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7574, pp. 583 - 586
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2015, Volume 373, Issue 5, pp. 428 - 437
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 03/2013, Volume 102, Issue 3, pp. 967 - 981
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 14, pp. 5689 - 5694
Inflammation and cancer, two therapeutic areas historically addressed by separate drug discovery efforts, are now coupled in treatment approaches by a growing... 
Receptors | Kidneys | Bones | Osteoclasts | Mast cells | Arthritis | Macrophages | Inhibitory concentration 50 | Tumors | Cancer | CSF1R | Cancer bone metastasis | Rheumatoid arthritis | Scaffold-based drug design | CHRONIC MYELOGENOUS LEUKEMIA | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | scaffold-based drug design | COLONY-STIMULATING FACTOR | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | rheumatoid arthritis | PROTOONCOGENE C-KIT | cancer bone metastasis | GASTROINTESTINAL STROMAL TUMORS | OSTEOCLAST DIFFERENTIATION | IMATINIB MESYLATE | Human Umbilical Vein Endothelial Cells | Escherichia coli | Humans | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Mutation, Missense - genetics | Spodoptera | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Sf9 Cells | Neoplasm Metastasis - drug therapy | Inflammation - drug therapy | Proto-Oncogene Proteins c-kit - genetics | Molecular Structure | Indoles | Cell Survival - drug effects | Oncogene Protein gp140(v-fms) - genetics | Protein Kinase Inhibitors - chemical synthesis | Oncogene Protein gp140(v-fms) - antagonists & inhibitors | Crystallization | Models, Molecular | Mast Cells - drug effects | Aminopyridines - chemical synthesis | Pyrroles - pharmacology | Animals | Chromatography, Affinity | Pyrroles - chemical synthesis | Aminopyridines - pharmacology | Pyrroles - chemistry | Macrophages - drug effects | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Oncogene Protein gp140(v-fms) - chemistry | Proto-Oncogene Proteins c-kit - chemistry | Osteoclasts - drug effects | Cell receptors | Care and treatment | Pharmacology, Experimental | Cancer cells | Physiological aspects | Research | Properties | Oncogenes | Immune system | Inhibitor drugs | Research & development--R&D | Medical treatment | Pharmacology | Kinases | Inflammatory diseases | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2009, Volume 106, Issue 1, pp. 262 - 267
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2015, Volume 5, Issue 6, pp. 668 - 679
Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKIs) used to treat cancer, including the... 
Resistance | Gatekeeper Mutations | Quizartinib | FLT3
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 06/2015, Volume 5, Issue 6, pp. 668 - 679
Journal Article