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chemistry, multidisciplinary (17) 17
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chemistry, medicinal (12) 12
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biochemistry & molecular biology (7) 7
chemistry (7) 7
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design (6) 6
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pharmacology, medicinal chemistry, vaccines, serums (6) 6
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organic chemistry, review (5) 5
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human cancer (4) 4
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urease inhibition (4) 4
acetylcholinesterase - metabolism (3) 3
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alkaline phosphatase (3) 3
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1,3,4-thiadiazole (2) 2
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European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of N-heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Inhibitors | Synthetic methods | Cross-coupling reactions
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of -heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Synthetic methods | Inhibitors | Cross-coupling reactions | CHEMISTRY, MEDICINAL | ONE-POT SYNTHESIS | CRYSTAL-STRUCTURE | EFFICIENT SYNTHESIS | CELL LINES | NATIONAL-CANCER-INSTITUTE | C-H BONDS | ACRIDONE ALKALOIDS | ANTIINFLAMMATORY AGENTS | BIOLOGICAL EVALUATION | PROTEIN-KINASE INHIBITORS | Phosphotransferases - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Glucuronidase - metabolism | Phosphotransferases - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Anticonvulsants - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Angiogenesis Inhibitors - chemical synthesis | Quinazolinones - pharmacology | Anticonvulsants - chemical synthesis | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Anti-Bacterial Agents - chemical synthesis | Quinazolinones - chemical synthesis | Anticonvulsants - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Quinazolines - pharmacology | Angiogenesis Inhibitors - chemistry
Journal Article
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 95, pp. 93016 - 93047
Oxazole, a central structural motif of numerous complex natural products and pharmaceuticals, is closely associated with the development of contemporary drug... 
Journal Article
CrystEngComm, ISSN 1466-8033, 2017, Volume 19, Issue 25, pp. 3485 - 3498
Journal Article
Journal Article
RSC Advances, ISSN 2046-2069, 10/2015, Volume 5, Issue 109, pp. 89919 - 89931
In the design of new drugs, the hybridization approach might allow obtaining molecules with improved biological activity with respect to the corresponding lead... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2014, Volume 78, pp. 167 - 177
Nitrogen-containing heterocycles are of particular interest and significant importance for the discovery of potent bioactive agents in pharmaceutical industry.... 
Heterocycles | Cyclocondensation | Lung carcinoma | Leishmanias | Alkaline phosphatase inhibition | CHEMISTRY, MEDICINAL | ALKALINE-PHOSPHATASE | ANTIBACTERIAL | UREASE INHIBITION | 1,2,4-TRIAZOLE | 1,3,4-THIADIAZOLE DERIVATIVES | ACETYLCHOLINESTERASE | TRIAZOLOTHIADIAZOLES | PHARMACOLOGICAL-ACTIVITIES | SCAFFOLDS | CELL-LINE | Parasitic Sensitivity Tests | Antineoplastic Agents - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Crystallography, X-Ray | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Dose-Response Relationship, Drug | Thiadiazines - chemistry | Butyrylcholinesterase - metabolism | Thiadiazoles - chemistry | Antiprotozoal Agents - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Thiadiazoles - pharmacology | Cell Line | Thiadiazines - chemical synthesis | Leishmania major - drug effects | Models, Molecular | Antiprotozoal Agents - chemistry | Antineoplastic Agents - chemistry | Antiprotozoal Agents - pharmacology | Thiadiazoles - chemical synthesis | Cholinesterase Inhibitors - pharmacology | Fibroblasts - drug effects | Cell Proliferation - drug effects | Thiadiazines - pharmacology | Acetylcholinesterase - metabolism | Thiols | Triazoles | Lung cancer | Analysis | Resveratrol | Crystals | Nuclear magnetic resonance spectroscopy | Structure | Phosphatases
Journal Article