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humans (61) 61
index medicus (61) 61
female (54) 54
physics (49) 49
systemic sclerosis (48) 48
dermatology (47) 47
measuring (45) 45
scleroderma (45) 45
testing (45) 45
measurement of nuclear or x-radiation (44) 44
middle aged (43) 43
male (41) 41
systemic scleroderma (37) 37
aged (34) 34
electricity (27) 27
basic electric elements (26) 26
animals (23) 23
mice (23) 23
rheumatology (23) 23
adult (21) 21
scleroderma, systemic - blood (21) 21
fibrosis (20) 20
skin - pathology (18) 18
digital ulcers (16) 16
case-control studies (15) 15
electric solid state devices not otherwise provided for (15) 15
semiconductor devices (15) 15
skin (15) 15
care and treatment (14) 14
fibroblasts - metabolism (13) 13
fli1 (13) 13
interstitial lung disease (13) 13
medicine & public health (13) 13
proto-oncogene protein c-fli-1 - genetics (13) 13
gamma ray or x-ray microscopes (12) 12
irradiation devices (12) 12
nuclear engineering (12) 12
nuclear physics (12) 12
scleroderma, systemic - complications (12) 12
surgery (12) 12
techniques for handling particles or ionising radiation nototherwise provided for (12) 12
angiogenesis (11) 11
diagnosis (11) 11
down-regulation (11) 11
fibroblasts (11) 11
scleroderma, systemic - pathology (11) 11
cells, cultured (10) 10
mice, knockout (10) 10
scleroderma, systemic - metabolism (10) 10
disease models, animal (9) 9
enzyme-linked immunosorbent assay (9) 9
human necessities (9) 9
hygiene (9) 9
identification (9) 9
immunohistochemistry (9) 9
medical or veterinary science (9) 9
proto-oncogene protein c-fli-1 - deficiency (9) 9
scleroderma, diffuse - blood (9) 9
scleroderma, systemic - physiopathology (9) 9
skin - metabolism (9) 9
abridged index medicus (8) 8
association (8) 8
biomarkers - blood (8) 8
cells (8) 8
disease (8) 8
endothelial cells (8) 8
expression (8) 8
gene silencing (8) 8
genetic engineering (8) 8
inflammation (8) 8
lung diseases (8) 8
proto-oncogene protein c-fli-1 - metabolism (8) 8
scleroderma fibroblasts (8) 8
treatment outcome (8) 8
vasculopathy (8) 8
autoimmunity (7) 7
cyclophosphamide (7) 7
cyclophosphamide - administration & dosage (7) 7
growth-factor-beta (7) 7
integumentary system (7) 7
medical colleges (7) 7
medical research (7) 7
mice, inbred c57bl (7) 7
pathogenesis (7) 7
pulmonary arterial hypertension (7) 7
rodents (7) 7
scleroderma, systemic - drug therapy (7) 7
scleroderma, systemic - genetics (7) 7
analysis (6) 6
apoptosis (6) 6
biopsy (6) 6
dermal fibroblasts (6) 6
endothelium (6) 6
fibroblasts - pathology (6) 6
flow-mediated dilation (6) 6
general tagging of cross-sectional technologies spanning over several sections of the ipc (6) 6
general tagging of new technological developments (6) 6
lung diseases, interstitial - blood (6) 6
lung diseases, interstitial - drug therapy (6) 6
lung diseases, interstitial - etiology (6) 6
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1. Full Text Fibrosis, Vascular Activation, and Immune Abnormalities Resembling Systemic Sclerosis in Bleomycin‐Treated Fli‐1–Haploinsufficient Mice
by Taniguchi, Takashi and Asano, Yoshihide and Akamata, Kaname and Noda, Shinji and Takahashi, Takehiro and Ichimura, Yohei and Toyama, Tetsuo and Trojanowska, Maria and Sato, Shinichi
Arthritis & Rheumatology, ISSN 2326-5191, 02/2015, Volume 67, Issue 2, pp. 517 - 526
Objective Fli‐1, a potential predisposing factor for systemic sclerosis (SSc), is constitutively down‐regulated in the lesional skin of patients with SSc by an... 
GROWTH-FACTOR-BETA | SCLERODERMA FIBROBLASTS | INCREASED EXPRESSION | COLLAGEN FIBRILLOGENESIS | DERMAL FIBROBLASTS | ANIMAL-MODEL | PROTEIN-ASSOCIATED FACTOR | RHEUMATOLOGY | MESENCHYMAL TRANSITION | TRANSCRIPTION FACTOR FLI1 | INTEGRIN ALPHA-V-BETA-5 | Skin - metabolism | Epithelial-Mesenchymal Transition - physiology | Scleroderma, Systemic - pathology | Integrins - metabolism | Cell Movement - physiology | Mice, Mutant Strains | Scleroderma, Systemic - physiopathology | Female | Proto-Oncogene Protein c-fli-1 - deficiency | Skin - pathology | Disease Models, Animal | Haploinsufficiency - genetics | Cytokines - metabolism | Macrophages - pathology | Proto-Oncogene Protein c-fli-1 - genetics | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Proto-Oncogene Protein c-fli-1 - physiology | Immune System - pathology | Bleomycin - adverse effects | Scleroderma, Systemic - chemically induced | Animals | Immune System - physiopathology | Mast Cells - pathology | Fibrosis | Endothelium, Vascular - pathology | Mice | Transforming Growth Factor beta - metabolism | Medical research | Rodents | Cell adhesion & migration
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2. Full Text Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
by Noda, Shinji and Asano, Yoshihide and Nishimura, Satoshi and Taniguchi, Takashi and Fujiu, Katsuhito and Manabe, Ichiro and Nakamura, Kouki and Yamashita, Takashi and Saigusa, Ryosuke and Akamata, Kaname and Takahashi, Takehiro and Ichimura, Yohei and Toyama, Tetsuo and Tsuruta, Daisuke and Trojanowska, Maria and Nagai, Ryozo and Sato, Shinichi
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5797
Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation. So far, a unifying hypothesis underpinning these pathological events... 
GROWTH-FACTOR-BETA | DNA-BINDING | PULMONARY ARTERIAL-HYPERTENSION | MULTIDISCIPLINARY SCIENCES | COLLAGEN FIBRILLOGENESIS | TISSUE FIBROSIS | GENE-EXPRESSION | PROTEIN-ASSOCIATED FACTOR | DISEASE SCLERODERMA | TRANSCRIPTION FACTOR FLI1 | AUTOIMMUNE-DISEASE | Autoimmunity | RNA, Small Interfering - genetics | Skin - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Connective Tissue Growth Factor - immunology | Epigenesis, Genetic | Humans | Scleroderma, Systemic - pathology | Autoantibodies - biosynthesis | Case-Control Studies | Blood Vessels - immunology | Collagen - genetics | Lung - metabolism | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Skin - pathology | Disease Models, Animal | Fibroblasts - metabolism | Skin - immunology | Lung - pathology | Proto-Oncogene Protein c-fli-1 - genetics | Signal Transduction | Lymphocyte Activation | Collagen - immunology | Scleroderma, Systemic - metabolism | Scleroderma, Systemic - genetics | Mice, Transgenic | Connective Tissue Growth Factor - agonists | Scleroderma, Systemic - immunology | Fibroblasts - pathology | Proto-Oncogene Protein c-fli-1 - antagonists & inhibitors | Animals | B-Lymphocytes - immunology | Fibrosis | Fibroblasts - immunology | Collagen - agonists | Connective Tissue Growth Factor - genetics | Mice | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | Lung - immunology | Proto-Oncogene Protein c-fli-1 - immunology | RNA, Small Interfering - metabolism
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3. Full Text Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma
by Takahashi, Takehiro and Asano, Yoshihide and Sugawara, Koji and Yamashita, Takashi and Nakamura, Kouki and Saigusa, Ryosuke and Ichimura, Yohei and Toyama, Tetsuo and Taniguchi, Takashi and Akamata, Kaname and Noda, Shinji and Yoshizaki, Ayumi and Tsuruta, Daisuke and Trojanowska, Maria and Sato, Shinichi
Journal of Experimental Medicine, ISSN 0022-1007, 04/2017, Volume 214, Issue 4, pp. 1129 - 1151
Systemic sclerosis (SSc), or scleroderma, is a multisystem autoimmune disorder characterized by vasculopathy and fibrosis in the skin and internal organs, most... 
MEDICINE, RESEARCH & EXPERIMENTAL | DIGITAL ULCERS | AIRE | GENE-EXPRESSION PATTERNS | DOWN-REGULATION | CD4(+) T-CELLS | DISEASE SCLERODERMA | SKIN | IMMUNOLOGY | TRANSCRIPTION FACTOR | SCLEROSIS PATIENTS | DERMAL FIBROSIS | Autoimmunity | Th17 Cells - physiology | Transcription Factors - physiology | Th2 Cells - physiology | Humans | Transcriptome | Keratin-14 - analysis | Proto-Oncogene Protein c-fli-1 - physiology | Transcription Factors - genetics | Epithelial Cells - physiology | Esophagus - pathology | Animals | Scleroderma, Systemic - etiology | Keratinocytes - metabolism | Fibrosis | Mice | Homeodomain Proteins - physiology | Skin - pathology | Disease Models, Animal | Transcription factors | Pathogenesis | Epithelial cells | Leukemia | Viruses | Mimicry | Thymus | Keratin | Vascular diseases | Rodents | Fibroblasts | Scleroderma | Immune system | Lung diseases | Organs | Keratinocytes | Esophagus | Gene silencing | Lungs | Systemic sclerosis | Skin | AIRE protein | Autoimmune diseases | Auditory defects | 300
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4. Full Text Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells
by Inada, M and Shindo, M and Kobayashi, K and Sato, A and Yamamoto, Y and Akasaki, Y and Ichimura, K and Tanuma, SI
PLOS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, p. e0216358
The interaction between high-mobility group box 1 protein (HMGB1) and receptor for advanced glycation end products (RAGE) is important for tumor cell growth.... 
MALIGNANT GLIOMA | MULTIDISCIPLINARY SCIENCES | GROWTH | CYCLE ARREST | HMGB1 | BLOOD-BRAIN-BARRIER | DISCOVERY | Antimitotic agents | Product development | Antineoplastic agents | Drug therapy | Papaverine | Glioblastoma multiforme | Cell proliferation | Cell culture | Brain cancer | Xenotransplantation | Glioblastoma | Smooth muscle | Oncology | Biochemistry | Neurosurgery | Drug development | HMGB1 protein | Cancer therapies | Hemorrhage | Cell adhesion & migration | Anticancer properties | Biological effects | Cell growth | Xenografts | Cell cycle | DNA methylation | Supplementation | Pharmaceutical sciences | Deoxyribonucleic acid--DNA | Medical research | Advanced glycosylation end products | Muscle relaxants | Narcotics | Muscles | Breast cancer | Glycosylation | Radiation therapy | Medicine | Chemotherapy | Brain research | Inhibitors | In vivo methods and tests | Glioblastoma cells | Temozolomide | Cell migration | Tumors | Apoptosis | Deoxyribonucleic acid | DNA
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5. Full Text Amelioration of Tissue Fibrosis by Toll‐like Receptor 4 Knockout in Murine Models of Systemic Sclerosis
by Takahashi, Takehiro and Asano, Yoshihide and Ichimura, Yohei and Toyama, Tetsuo and Taniguchi, Takashi and Noda, Shinji and Akamata, Kaname and Tada, Yayoi and Sugaya, Makoto and Kadono, Takafumi and Sato, Shinichi
Arthritis & Rheumatology, ISSN 2326-5191, 01/2015, Volume 67, Issue 1, pp. 254 - 265
Objective Bleomycin‐induced fibrosis and the tight skin (TSK/+) mouse are well‐established experimental murine models of human systemic sclerosis (SSc).... 
LUNG FIBROSIS | TIGHT-SKIN | IMMUNE-RESPONSES | SERUM-LEVELS | REGULATES SKIN | RHEUMATOLOGY | AUTOIMMUNE-DISEASE | BLEOMYCIN-INDUCED SCLERODERMA | PULMONARY-FIBROSIS | CLINICAL-SIGNIFICANCE | INNATE IMMUNITY | Cytokines - metabolism | Mice, Inbred C57BL | Toll-Like Receptor 4 - genetics | Bleomycin - adverse effects | Mice, Knockout | Scleroderma, Systemic - chemically induced | Toll-Like Receptor 4 - physiology | Animals | Toll-Like Receptor 4 - deficiency | Scleroderma, Systemic - physiopathology | Female | Neovascularization, Pathologic - physiopathology | Signal Transduction - physiology | Mice | Fibrosis - pathology | Fibrosis - prevention & control | Scleroderma, Systemic - prevention & control | Skin - pathology | Disease Models, Animal | Medical research | Rodents | Immune system
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6. Full Text Endothelin Receptor Blockade Ameliorates Vascular Fragility in Endothelial Cell–Specific Fli‐1–Knockout Mice by Increasing Fli‐1 DNA Binding Ability
by Akamata, Kaname and Asano, Yoshihide and Yamashita, Takashi and Noda, Shinji and Taniguchi, Takashi and Takahashi, Takehiro and Ichimura, Yohei and Toyama, Tetsuo and Trojanowska, Maria and Sato, Shinichi
Arthritis & Rheumatology, ISSN 2326-5191, 05/2015, Volume 67, Issue 5, pp. 1335 - 1344
Objective It is generally accepted that blockade of endothelin receptors has potentially beneficial effects on vasculopathy associated with systemic sclerosis... 
GROWTH-FACTOR-BETA | SCLERODERMA FIBROBLASTS | DIGITAL ULCERS | DEFICIENCY CONTRIBUTES | DERMAL FIBROBLASTS | PROTEIN-ASSOCIATED FACTOR | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | TRANSCRIPTION FACTOR FLI1 | EXPRESSION | BOSENTAN REVERSES | Immunohistochemistry | Phosphorylation | Capillary Permeability | Humans | Actins - metabolism | Immunoblotting | RNA, Messenger - metabolism | Chromatin Immunoprecipitation | Proto-Oncogene Protein c-fli-1 - metabolism | Vascular Diseases | Microvessels - cytology | Cell Line | Promoter Regions, Genetic | Gene Expression | Proto-Oncogene Protein c-fli-1 - genetics | Endothelial Cells - metabolism | Endothelin-1 - metabolism | Scleroderma, Systemic - metabolism | Cells, Cultured | Receptors, Endothelin - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Mice, Knockout | Protein Kinase C-delta - metabolism | Endothelin Receptor Antagonists - pharmacology | Animals | Proto-Oncogene Proteins c-abl - metabolism | Mice | Proteins | Kinases | Rodents | Deoxyribonucleic acid--DNA
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7. Full Text Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis
by Ryosuke Saigusa and Yoshihide Asano and Takashi Taniguchi and Takashi Yamashita and Yohei Ichimura and Takehiro Takahashi and Tetsuo Toyama and Ayumi Yoshizaki and Koji Sugawara and Daisuke Tsuruta and Tadatsugu Taniguchi and Shinichi Sato
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 49, pp. 15136 - 15141
Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations resulting from tissue fibrosis and extensive vasculopathy. A... 
Vasculopathy | Interferon regulatory factor 5 | Systemic sclerosis | Fibrosis | Toll-like receptor 4 | FUNCTIONAL POLYMORPHISM | MULTIDISCIPLINARY SCIENCES | interferon regulatory factor 5 | RECEPTOR 4 | FLI1 | SCLERODERMA | systemic sclerosis | INFLAMMATION | DISEASE | fibrosis | vasculopathy | ASSOCIATION | CLINICAL-SIGNIFICANCE | Toll-Like Receptor 4 - physiology | Animals | B-Lymphocytes - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Scleroderma, Systemic - physiopathology | Interferon Regulatory Factors - genetics | Interferon Regulatory Factors - physiology | Female | Mice | Mice, Knockout | Care and treatment | Transcription factors | Systemic scleroderma | Patient outcomes | Scleroderma (Disease) | Development and progression | Research | Risk factors | Biological Sciences
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8. Full Text Contribution of Soluble Forms of Programmed Death 1 and Programmed Death Ligand 2 to Disease Severity and Progression in Systemic Sclerosis
by Fukasawa, Takemichi and Yoshizaki, Ayumi and Ebata, Satoshi and Nakamura, Kouki and Saigusa, Ryosuke and Miura, Syunsuke and Yamashita, Takashi and Hirabayashi, Megumi and Ichimura, Yohei and Taniguchi, Takashi and Asano, Yoshihide and Shimizu, Hisashi and Kazoe, Yutaka and Mawatari, Kazuma and Kitamori, Takehiko and Sato, Shinichi
Arthritis & Rheumatology, ISSN 2326-5191, 09/2017, Volume 69, Issue 9, pp. 1879 - 1890
Objective To determine the function and serum levels of soluble forms of programmed death 1 (sPD‐1) and one of its ligands, soluble PD ligand 2 (sPD‐L2), in... 
LUNG FIBROSIS | SCLERODERMA | B-CELL | AUTOIMMUNITY | T-CELL-ACTIVATION | RECEPTOR | SKIN | RHEUMATOLOGY | PD-1 | ASSOCIATION | EXPRESSION | Severity of Illness Index | Scleroderma, Systemic - blood | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | DNA Topoisomerases, Type I | Scleroderma, Systemic - pathology | Male | Programmed Cell Death 1 Ligand 2 Protein - blood | Programmed Cell Death 1 Receptor - blood | Disease Progression | Macrophages - metabolism | Animals | Flow Cytometry | Scleroderma, Systemic - etiology | T-Lymphocytes - metabolism | Adult | Female | Mice | B-Lymphocytes - metabolism | Lymphocyte receptors | Flow cytometry | PD-1 protein | Interleukin | Lymphocytes T | Macrophages | Lymphocytes | Rodents | Enzyme-linked immunosorbent assay | Recombinant | Cytokines | Abnormalities | Mortality | DNA topoisomerase | Cultures | Patients | Serum levels | Cytometry | Lymphocytes B | Systemic sclerosis | Interleukin 10 | Fibrosis | Ligands | Death | Apoptosis
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9. Full Text Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells
by Saigusa, Ryosuke and Asano, Yoshihide and Taniguchi, Takashi and Hirabayashi, Megumi and Nakamura, Kouki and Miura, Shunsuke and Yamashita, Takashi and Takahashi, Takehiro and Ichimura, Yohei and Toyama, Tetsuo and Yoshizaki, Ayumi and Trojanowska, Maria and Sato, Shinichi
Arthritis Research and Therapy, ISSN 1478-6354, 02/2018, Volume 20, Issue 1, pp. 23 - 11
Background: Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various... 
Fibroblasts | Regulatory T cells | IL-33 | Systemic sclerosis | Fli1 | DNA-BINDING | TGF-BETA | DOWN-REGULATION | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | BLEOMYCIN-INDUCED SCLERODERMA | ANIMAL-MODEL | MICE | EXPRESSION | FLI1 DEFICIENCY CONTRIBUTES | TH17 CELLS | T-Lymphocytes, Regulatory - metabolism | Dermis - metabolism | Proto-Oncogene Protein c-fli-1 - genetics | Skin - metabolism | Coculture Techniques | Mice, Inbred C57BL | Scleroderma, Systemic - metabolism | Cells, Cultured | Scleroderma, Systemic - genetics | Cell Transdifferentiation - genetics | Th2 Cells - metabolism | Haploinsufficiency | Mice, Knockout | Animals | Proto-Oncogene Protein c-fli-1 - metabolism | Cell Transdifferentiation - drug effects | Cell Communication - drug effects | Interleukin-33 - metabolism | Bleomycin - pharmacology | Female | Fibroblasts - metabolism | Phenotype | Care and treatment | Systemic scleroderma | Scleroderma (Disease) | Development and progression | Genetic aspects | Health aspects
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10. Full Text Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth
by INADA, MANA and SATO, AKIRA and SHINDO, MIKA and YAMAMOTO, YOHEI and AKASAKI, YASUHARU and ICHIMURA, KOICHI and TANUMA, SEI-ICHI
Anticancer Research, ISSN 0250-7005, 12/2019, Volume 39, Issue 12, pp. 6743 - 6750
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11. Full Text Possible pro‐inflammatory role of heparin‐binding epidermal growth factor‐like growth factor in the active phase of systemic sclerosis
by Hirabayashi, Megumi and Asano, Yoshihide and Yamashita, Takashi and Miura, Shunsuke and Nakamura, Kouki and Taniguchi, Takashi and Saigusa, Ryosuke and Takahashi, Takehiro and Ichimura, Yohei and Miyagawa, Takuya and Yoshizaki, Ayumi and Miyagaki, Tomomitsu and Sugaya, Makoto and Sato, Shinichi
The Journal of Dermatology, ISSN 0385-2407, 02/2018, Volume 45, Issue 2, pp. 182 - 188
Heparin‐binding epidermal growth factor (EGF)‐like growth factor (HB‐EGF) is a member of the EGF family growth factors, which affects multiple aspects of the... 
wound healing | heparin‐binding epidermal growth factor‐like growth factor | systemic sclerosis | inflammation | interstitial lung disease | heparin-binding epidermal growth factor-like growth factor | SCLERODERMA | CLASSIFICATION | PULMONARY-FIBROSIS | FLI1 | CLINICAL-SIGNIFICANCE | DERMATOLOGY | Heparin-binding EGF-like Growth Factor - genetics | Scleroderma, Systemic - blood | Skin - cytology | Humans | Middle Aged | Scleroderma, Systemic - pathology | Male | Pulmonary Fibrosis - blood | Lung - diagnostic imaging | RNA, Messenger - metabolism | Pulmonary Fibrosis - diagnostic imaging | Heparin-binding EGF-like Growth Factor - blood | Fibroblasts | Adult | Female | Skin - pathology | Scleroderma, Systemic - diagnostic imaging | Lung - pathology | Cells, Cultured | Pulmonary Fibrosis - pathology | Heparin-binding EGF-like Growth Factor - metabolism | Biopsy | Fibrosis | Mucin-1 - blood | Aged | Respiratory Function Tests | Transforming Growth Factor beta - metabolism | Respiratory tract diseases | Anticoagulants (Medicine) | Epidermal growth factor | Systemic scleroderma | Scleroderma (Disease) | Wound healing | Transforming growth factor-b | Lung diseases | mRNA | Inflammation | Small intestine | Contraction | Angiogenesis | Heparin-binding epidermal growth factor-like growth factor | Systemic sclerosis | Skin diseases | Heparin | Growth factors
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12. Full Text Progranulin Overproduction Due to Fli‐1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor in Systemic Sclerosis
by Ichimura, Yohei and Asano, Yoshihide and Akamata, Kaname and Noda, Shinji and Taniguchi, Takashi and Takahashi, Takehiro and Toyama, Tetsuo and Tada, Yayoi and Sugaya, Makoto and Sato, Shinichi and Kadono, Takafumi
Arthritis & Rheumatology, ISSN 2326-5191, 12/2015, Volume 67, Issue 12, pp. 3245 - 3255
Objective Progranulin is a growth factor that is active in wound repair and is an antagonist of tumor necrosis factor (TNF) receptors, regulating fibroblast... 
COLLAGEN PRODUCTION | GROWTH-FACTOR-BETA | SCLERODERMA FIBROBLASTS | TGF-BETA | INCREASED EXPRESSION | DOWN-REGULATION | GRANULIN-EPITHELIN PRECURSOR | PROTEIN-ASSOCIATED FACTOR | RHEUMATOLOGY | TRANSCRIPTION FACTOR FLI1 | FACTOR-ALPHA | Scleroderma, Diffuse - metabolism | Up-Regulation | Humans | Middle Aged | Male | RNA, Messenger - metabolism | Case-Control Studies | Scleroderma, Diffuse - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - metabolism | Female | Dermis - cytology | Fibroblasts - metabolism | RNA, Messenger - drug effects | Dermis - metabolism | Enzyme-Linked Immunosorbent Assay | Proto-Oncogene Protein c-fli-1 - genetics | Scleroderma, Systemic - metabolism | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Scleroderma, Systemic - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Necrosis Factor-alpha - pharmacology | Animals | Fibroblasts - drug effects | Aged | Mice | Skin | Gangrene | Fibroblasts | Tumor necrosis factor-TNF
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13. Full Text Association of anti‐RNA polymerase III antibody and silicone breast implants in patients with systemic sclerosis
by Saigusa, Ryosuke and Asano, Yoshihide and Nakamura, Kouki and Yamashita, Takashi and Ichimura, Yohei and Takahashi, Takehiro and Toyama, Tetsuo and Taniguchi, Takashi and Yoshizaki, Ayumi and Miyazaki, Miki and Tamaki, Zenshiro and Sato, Shinichi
The Journal of Dermatology, ISSN 0385-2407, 07/2016, Volume 43, Issue 7, pp. 808 - 810
Systemic sclerosis (SSc) is believed to be caused by a complex interplay between genetic factors and environmental influences. Although silicone has been... 
environmental factor | systemic sclerosis | silicone breast implant | anti‐RNA polymerase III antibody | chronic inflammation | anti-RNA polymerase III antibody | Breast Implants - adverse effects | Humans | Middle Aged | Adult | Female | Male | Silicones - adverse effects | Aged | Scleroderma, Systemic - immunology | RNA Polymerase III - immunology | Viral antibodies | Care and treatment | Systemic scleroderma | RNA | Implants, Artificial | Prosthesis | Scleroderma (Disease) | Antibodies | Silicones | RNA polymerases | Transplants & implants | RNA polymerase
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14. Full Text Association of anti‐RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis
by Saigusa, Ryosuke and Asano, Yoshihide and Nakamura, Kouki and Miura, Shunsuke and Ichimura, Yohei and Takahashi, Takehiro and Toyama, Tetsuo and Taniguchi, Takashi and Noda, Shinji and Aozasa, Naohiko and Akamata, Kaname and Sumida, Hayakazu and Miyazaki, Miki and Tamaki, Zenshiro and Yanaba, Koichi and Kuwano, Yoshihiro and Sato, Shinichi
The Journal of Dermatology, ISSN 0385-2407, 05/2015, Volume 42, Issue 5, pp. 524 - 527
Patients with systemic sclerosis (SSc) have an increased risk of malignancy compared with the general population. Recently, SSc patients with anti‐RNA... 
systemic sclerosis | malignancy | synchronous onset | anti‐RNA polymerase III antibody | Japanese | anti-RNA polymerase III antibody | SCLERODERMA | DISEASE | POPULATION-BASED COHORT | CANCER | DERMATOLOGY | DNA Topoisomerases, Type I - immunology | Japan - epidemiology | Scleroderma, Systemic - blood | Neoplasms - ethnology | Antibodies, Antinuclear - blood | Humans | Middle Aged | Female | Male | RNA Polymerase III - immunology | Neoplasms - epidemiology | Incidence | Autoimmunity | Viral antibodies | Antibodies | Systemic scleroderma | RNA | Scleroderma (Disease)
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