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Molecular Biology of the Cell, ISSN 1059-1524, 04/2009, Volume 20, Issue 7, pp. 1981 - 1991
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2018, Volume 115, Issue 18, p. E4199
Although mechanisms for protein homeostasis in the cytosol have been studied extensively, those in the nucleus remain largely unknown. Here, we identified that... 
Ubiquitin | Nuclear magnetic resonance--NMR | Homeostasis | Cytosol | Substrates | Nuclear transport | Exports | Proteins | Atomic physics | Nuclear pores | Protein transport | Transporter | Nuclear physics
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/2008, Volume 181, Issue 3, pp. 497 - 510
Autophagy is a membrane-mediated intracellular degradation system. The serine/threonine kinase Atg1 plays an essential role in autophagosome formation.... 
Yeasts | Starvation | NIH 3T3 cells | Microscopy | Neurons | Cell lines | Antibodies | Cultured cells | Focal adhesions | Gene expression regulation | COMPLEX | MOLECULAR MACHINERY | FOCAL ADHESION | GENE | C-ELEGANS | AXONAL ELONGATION | HUMAN BREAST-CANCER | SACCHAROMYCES-CEREVISIAE | SERINE/THREONINE KINASE | SELF-DIGESTION | CELL BIOLOGY | Protein Kinases - metabolism | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Fibroblasts - physiology | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Autophagy - physiology | Recombinant Fusion Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Intracellular Membranes - ultrastructure | Protein-Tyrosine Kinases - genetics | Protein-Serine-Threonine Kinases - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Phagosomes - metabolism | Protein-Serine-Threonine Kinases - genetics | Fungal Proteins - genetics | Mice, Knockout | Focal Adhesion Protein-Tyrosine Kinases - genetics | Animals | Autophagy-Related Protein 5 | Recombinant Fusion Proteins - genetics | Fibroblasts - cytology | Mice | TOR Serine-Threonine Kinases | Intracellular Membranes - metabolism | Fungal Proteins - metabolism | Allelomorphism | Muridae | Physiological aspects | Cell physiology | Research | Properties | Binding proteins | Identification and classification | Phosphotransferases
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 213 - 223
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of... 
OXIDATIVE STRESS | PROTEIN | MECHANISM | CUL3-BASED E3 LIGASE | STRUCTURAL BASIS | DLG MOTIFS | DEGRADATION | MICE | BETA-CELL MASS | INDUCTION | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Liver - pathology | Microtubule-Associated Proteins - genetics | Cytoskeletal Proteins - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Sequestosome-1 Protein | Humans | Oxidative Stress - physiology | Crystallography, X-Ray | Hepatocytes - pathology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Liver - physiopathology | Heat-Shock Proteins - genetics | Mutation - physiology | Transfection | Organ Size - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Inclusion Bodies - metabolism | Kelch-Like ECH-Associated Protein 1 | Cell Line | Binding, Competitive - physiology | Heat-Shock Proteins - metabolism | Liver - metabolism | Models, Molecular | Mice, Transgenic | Cytoskeletal Proteins - chemistry | Mice, Knockout | Protein Interaction Mapping | Autophagy-Related Protein 7 | Animals | Models, Biological | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Calorimetry | Signal Transduction - physiology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Protein Binding - physiology | Autophagy (Cytology) | Care and treatment | Transcription factors | Liver diseases | Physiological aspects | Genetic aspects | Research
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 11/2018, Volume 9, Issue 88, pp. 35844 - 35855
Tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, regulates various intracellular responses, such as telomere maintenance, Wnt/β-catenin... 
Tankyrase | Cancer chemotherapy | DNA damage response | MERIT40 | DNA repair
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2016, Volume 590, Issue 9, pp. 1291 - 1303
The stability of β‐catenin is very important for canonical Wnt signaling. A protein complex including Axin/ APC / GSK 3β phosphorylates β‐catenin to be... 
Axin1 | WDR | β‐catenin | Wnt | ubiquitination | β-catenin | WDR26 | Xenopus | Ubiquitination | Animals | Proteins - metabolism | Humans | HEK293 Cells | Protein Binding | beta Catenin - metabolism | Axin Protein - metabolism | Wnt Signaling Pathway | Research Letters | Research Letter
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7309, pp. 941 - 946
Journal Article