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1. Full Text Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches Masashi Ikeda
by Ikeda, M and Tomita, Y and Mouri, A and Koga, M and Okochi, T and Yoshimura, R and Yamanouchi, Y and Kinoshita, Y and Hashimoto, R and Williams, HJ and Takeda, M and Nakamura, J and Nabeshima, T and Owen, MJ and O'Donovan, MC and Honda, H and Arinami, T and Ozaki, N and Iwata, N
BIOLOGICAL PSYCHIATRY, ISSN 0006-3223, 02/2010, Volume 67, Issue 3, pp. 263 - 269
Background: Pharmacogenomic approaches based on genomewide sets of single nucleotide polymorphisms (SNPs) are now feasible and offer the potential to uncover... 
Expression: PDE7B | PSYCHIATRY | risperidone | LOCI | schizophrenia | NEUROSCIENCES | AHI1 | pharmacogenomics | DOPAMINE | NEURONS | WHOLE-GENOME ASSOCIATION | WIDE ASSOCIATION | DIFFERENTIATION
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2. Animēshon no jiten
by Yokota, Masao, 1954 and Ikeda, Hiroshi, 1934 and Koide, Masashi, 1957
2012, Shohan., ISBN 425468021X, viii, 462 p., [4] p. of plates
History and criticism | Animated films | Animation (Cinematography)
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3. Full Text Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial
by Mizokami, Masashi, Prof|Yokosuka, Osamu, Prof|Takehara, Tetsuo, Prof|Sakamoto, Naoya, Prof|Korenaga, Masaaki, MD|Mochizuki, Hitoshi, MD|Nakane, Kunio, MD|Enomoto, Hirayuki, MD|Ikeda, Fusao, MD|Yanase, Mikio, MD|Toyoda, Hidenori, MD|Genda, Takuya, MD|Umemura, Takeji, MD|Yatsuhashi, Hiroshi, Prof|Ide, Tatsuya, MD|Toda, Nobuo, MD|Nirei, Kazushige|Ueno, Yoshiyuki, Prof|Nishigaki, Yoichi, MD|Betular, Juan, BS|Gao, Bing, PhD|Ishizaki, Akinobu, BA|Omote, Masa, PhD|Mo, Hongmei, MD|Garrison, Kim, PhD|Pang, Phillip S, MD|Knox, Steven J, BS|Symonds, William T, PharmD|McHutchison, John G, MD|Izumi, Namiki, Prof|Omata, Masao, Prof
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 6, pp. 645 - 653
Summary Background Compared with other countries, patients with chronic hepatitis C infection in Japan tend to be older, have more advanced liver disease, and... 
Infectious Disease | INFECTIOUS DISEASES | SIMEPREVIR | INFECTION | CHRONIC HCV | Uridine Monophosphate - administration & dosage | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | Drug-Related Side Effects and Adverse Reactions - pathology | Young Adult | Benzimidazoles - administration & dosage | Time Factors | Ribavirin - administration & dosage | Aged, 80 and over | Adult | Female | Fluorenes - administration & dosage | Fluorenes - adverse effects | Uridine Monophosphate - adverse effects | Benzimidazoles - adverse effects | Hepacivirus - isolation & purification | Administration, Oral | Japan | Genotype | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Drug-Related Side Effects and Adverse Reactions - epidemiology | Asian Continental Ancestry Group | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Aged | Hepacivirus - classification | Sofosbuvir | Care and treatment | Liver | Dosage and administration | Product development | Drug therapy, Combination | Hepatitis C virus | Hepatitis C | Health aspects | Ribavirin | Hepatitis | Genotype & phenotype | Liver cancer | Heart attacks | Liver diseases | Human immunodeficiency virus--HIV | Hepatology | Response rates | Interferon | Infections | Drug dosages | Patients | Index Medicus
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4. Full Text Anemia in Patients with Severe Aortic Stenosis
by Nagao, Kazuya and Taniguchi, Tomohiko and Morimoto, Takeshi and Shiomi, Hiroki and Ando, Kenji and Kanamori, Norio and Murata, Koichiro and Kitai, Takeshi and Kawase, Yuichi and Izumi, Chisato and Miyake, Makoto and Mitsuoka, Hirokazu and Kato, Masashi and Hirano, Yutaka and Matsuda, Shintaro and Inada, Tsukasa and Murakami, Tomoyuki and Takeuchi, Yasuyo and Yamane, Keiichiro and Toyofuku, Mamoru and Ishii, Mitsuru and Minamino-Muta, Eri and Kato, Takao and Inoko, Moriaki and Ikeda, Tomoyuki and Komasa, Akihiro and Ishii, Katsuhisa and Hotta, Kozo and Higashitani, Nobuya and Kato, Yoshihiro and Inuzuka, Yasutaka and Maeda, Chiyo and Jinnai, Toshikazu and Morikami, Yuko and Saito, Naritatsu and Minatoya, Kenji and Kimura, Takeshi and Takahashi, Naoki and Fukuchi, Kohei and Imai, Masao and Tazaki, Junichi and Toyota, Toshiaki and Higami, Hirooki and Kawaji, Tetsuma and Shirai, Shinichi and Kourai, Kengo and Arita, Takeshi and Miura, Shiro and Yamaji, Kyohei and Onodera, Tomoya and Furukawa, Yutaka and Kim, Kitae and Kadota, Kazushige and Iwasaki, Keiichiro and Miyawaki, Hiroshi and Misao, Ayumi and Kuwayama, Akimune and Ohya, Masanobu and Shimada, Takenobu and Amano, Hidewo and Nakagawa, Yoshihisa and Amano, Masashi and Takahashi, Yusuke and Yoshikawa, Yusuke and Nishimura, Shunsuke and Kuroda, Maiko and Shirotani, Manabu and Miki, Shinji and Mizoguchi, Tetsu and Yokomatsu, Takafumi and Kushiyama, Akihiro and Yaku, Hidenori and Watanabe, Toshimitsu and Miyazaki, Shunichi and Takeda, Teruki and Sakaguchi, Tomoko and Maeda, Keiko and Yamaji, Masayuki and Motoyoshi, Maenaka and Tadano, Yutaka and Sakamoto, Hiroki and Motooka, Makoto and Nishikawa, Ryusuke and Eizawa, Hiroshi and Kawato, Mitsunori and Kinoshita, Minako and Aida, Kenji and Tamura, Takashi and Takahashi, Kousuke and Ko, Euihong and Akao, Masaharu and Masunaga, Nobutoyo and Ogawa, Hisashi and Iguchi, Moritake and Unoki, Takashi and Takabayashi, Kensuke and Hamatani, Yasuhiro and Yamashita, Yugo and Himura, Yoshihiro and Sato, Yukihito and ... and CURRENT AS Registry Investigators
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1924 - 11
Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes... 
REPLACEMENT | PROGNOSTIC IMPACT | VALVE IMPLANTATION | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | HEART-FAILURE | DISEASE | FERRIC CARBOXYMALTOSE | PREVALENCE | END-POINT DEFINITIONS | CONSENSUS REPORT | Anemia | Risk assessment | Hemoglobin | Stenosis | Aorta | Management | Aortic valve | Heart diseases | Bleeding
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5. Full Text Biological insights from 108 schizophrenia-associated genetic loci
by Ripke, Stephan and Neale, Benjamin M and Corvin, Aiden and Walters, James T. R and Farh, Kai-How and Holmans, Peter A and Lee, Phil and Bulik-Sullivan, Brendan and Collier, David A and Huang, Hailiang and Pers, Tune H and Agartz, Ingrid and Agerbo, Esben and Albus, Margot and Alexander, Madeline and Amin, Farooq and Bacanu, Silviu A and Begemann, Martin and Belliveau, Richard A and Bene, Judit and Bergen, Sarah E and Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W and Bruggeman, Richard and Buccola, Nancy G and Buckner, Randy L and Byerley, William and Cahn, Wiepke and Cai, Guiqing and Campion, Dominique and Cantor, Rita M and Carr, Vaughan J and Carrera, Noa and Catts, Stanley V and Chambert, Kimberly D and Chan, Raymond C. K and Chen, Ronald Y. L and Chen, Eric Y. H and Cheng, Wei and Cheung, Eric F. C and Chong, Siow Ann and Cloninger, C. Robert and Cohen, David and Cohen, Nadine and Cormican, Paul and Craddock, Nick and Crowley, James J and Curtis, David and Davidson, Michael and Davis, Kenneth L and Degenhardt, Franziska and del Favero, Jurgen and Demontis, Ditte and Dikeos, Dimitris and Dinan, Timothy and Djurovic, Srdjan and Donohoe, Gary and peau, Elodie and Duan, Jubao and Dudbridge, Frank and Durmishi, Naser and Eichhammer, Peter and Eriksson, Johan and Escott-Price, Valentina and Essioux, Laurent and Fanous, Ayman H and Farrell, Martilias S and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson B and Friedl, Marion and Friedman, Joseph I and Fromer, Menachem and Genovese, Giulio and Georgieva, Lyudmila and Giegling, Ina and Giusti-Roíguez, Paola and Godard, Stephanie and Goldstein, Jacqueline I and Golimbet, Vera and Gopal, Srihari and Gratten, Jacob and de Haan, Lieuwe and Hammer, Christian and Hamshere, Marian L and Hansen, Mark and Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette M and Henskens, Frans A and Herms, Stefan and Hirschhorn, Joel N and Hoffmann, Per and Hofman, Anea and Hollegaard, Mads V and Hougaard, David M and Ikeda, Masashi and Joa, Inge and ... and Psychiat Genomics Consortium and Wellcome Trust Case-Control Consor and Psychosis Endophenotypes Int Conso and Schizophrenia Working Group of the Psychiatric Genomics Consortium and Medicinska fakulteten and Institutionen för klinisk vetenskap and Psykiatri and Umeå universitet
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7510, pp. 421 - 427
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be... 
COMMON VARIANTS | MUTATIONS | MULTIDISCIPLINARY SCIENCES | CONFERRING RISK | GENOME-WIDE ASSOCIATION | Schizophrenia | Genetic research | Research | Health aspects | Analysis | Studies | Confidence intervals | Hypotheses | Genealogy | Sample size | Genomics | Genetics | Trends | Index Medicus | Clinical Medicine | Psykiatri | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Psychiatry
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6. Full Text Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity
by Yoshida, Masashi|Shiojima, Ichiro|Ikeda, Hiroyuki|Komuro, Issei
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2009, Volume 47, Issue 5, pp. 698 - 705
Abstract Doxorubicin is known to have cumulative dose-dependent cardiotoxicity, and a tumor suppressor protein p53 has been implicated in the pathogenesis of... 
Cardiovascular | Cardiomyopathy | Doxorubicin | Statins | p53 | Apoptosis | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIAC TOXICITY | INJURY | DAMAGE | CELL BIOLOGY | HYPERTROPHY | OVEREXPRESSION | THERAPY | OXIDASE | MICE | P53-INDUCED INHIBITION | Oxidative Stress | Apoptosis - drug effects | Quinolines - pharmacology | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - physiology | DNA Damage - physiology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Animals, Newborn | DNA Damage - drug effects | DNA-Binding Proteins - physiology | Echocardiography | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Enzyme Activation - drug effects | Blotting, Western | Tumor Suppressor Proteins - physiology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Mice | Apoptosis - physiology | Cell Cycle Proteins - physiology | Doxorubicin - pharmacology | rac1 GTP-Binding Protein - metabolism | Antioxidants | Anthracyclines | Automated teller machines | Tumor proteins | DNA | Index Medicus
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7. Full Text Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
by Kanai, Masahiro and Akiyama, Masato and Takahashi, Atsushi and Matoba, Nana and Momozawa, Yukihide and Ikeda, Masashi and Iwata, Nakao and Ikegawa, Shiro and Hirata, Makoto and Matsuda, Koichi and Kubo, Michiaki and Okada, Yukinori and Kamatani, Yoichiro
Nature Genetics, ISSN 1061-4036, 03/2018, Volume 50, Issue 3, pp. 390 - 400
Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights... 
AUTOIMMUNE | RARE VARIANTS | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | BODY-MASS INDEX | COMMON | RISK | MENDELIAN RANDOMIZATION | LD SCORE REGRESSION | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | Genetics, Population | Japan - epidemiology | Multifactorial Inheritance - genetics | Genetic Predisposition to Disease | Disease - genetics | Genetic Association Studies | Humans | Asian Continental Ancestry Group - genetics | Male | Sequence Analysis, DNA | Phenotype | Adult | Female | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Quantitative Trait Loci | Asian Continental Ancestry Group - statistics & numerical data | Cell Lineage - genetics | Phenotypes | Pathogenesis | Genomes | Biology | Metabolism | Diseases | Studies | Consortia | Genotype & phenotype | Pleiotropy | Etiology | Genetic analysis | Genetics | Blood pressure | Bioinformatics | Polygenic inheritance | Index Medicus
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8. Full Text Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
by Sato, Atsushi and Kasai, Shinya and Kobayashi, Toshiyuki and Takamatsu, Yukio and Hino, Okio and Ikeda, Kazutaka and Mizuguchi, Masashi
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 1292 - 1292
Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder. Genetic disorders frequently accompany autism spectrum disorder,... 
MULTIDISCIPLINARY SCIENCES | FRAGILE-X-SYNDROME | EMBRYONIC LETHALITY | CEREBRAL-LESIONS | EKER RAT MODEL | SYNDROMIC AUTISM | MICE | AUTISM SPECTRUM DISORDERS | IDENTIFICATION | DEFICITS | TSC2 MUTATION | Sirolimus - therapeutic use | Mice, Inbred C57BL | Male | Sirolimus - pharmacology | Mice, Knockout | TOR Serine-Threonine Kinases - antagonists & inhibitors | Tumor Suppressor Proteins - physiology | Phenotype | Animals | Tuberous Sclerosis - drug therapy | Social Behavior | Female | TOR Serine-Threonine Kinases - physiology | Mice | Tuberous Sclerosis - psychology | Disease Models, Animal | Index Medicus
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9. Full Text Role of Capsaicin-Sensitive C-Fiber Afferents in Neuropathic Pain-Induced Synaptic Potentiation in the Nociceptive Amygdala
by Nakao, Ayano and Takahashi, Yukari and Nagase, Masashi and Ikeda, Ryo and Kato, Fusao
Molecular Pain, ISSN 1744-8069, 7/2012, Volume 8, Issue 1, pp. 51 - 51
Background: Neurons in the capsular part of the central nucleus of the amygdala (CeC), a region also called “nociceptive amygdala,” receive nociceptive... 
Capsular part of the central nucleus of the amygdala | Excitatory postsynaptic currents | Parabrachial nucleus | Tactile allodynia | Emotion | Minimal stimulation | RAT SPINAL-CORD | NEONATAL CAPSAICIN | RECEPTOR | NEUROSCIENCES | PERIPHERAL-NERVE INJURY | ADULT-RAT | PRIMARY SENSORY NEURONS | SUBSTANCE-P | LAMINA-I | PLASTICITY | Amygdala - drug effects | Nerve Fibers, Unmyelinated - physiology | Rats, Wistar | Capsaicin - pharmacology | Amygdala - metabolism | Neuralgia - metabolism | Rats | Male | Synaptic Transmission | Animals | Afferent Pathways - physiology | Nerve Fibers, Unmyelinated - drug effects | Female | Pain Threshold | Nociceptors - metabolism | Neuralgia - physiopathology | Phenols | Neural transmission | Neurons | Amygdala (Brain) | Analysis | Medicine | Rodents | Behavior | Index Medicus
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10. Full Text Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
by Akiyama, Masato and Okada, Yukinori and Kanai, Masahiro and Takahashi, Atsushi and Momozawa, Yukihide and Ikeda, Masashi and Iwata, Nakao and Ikegawa, Shiro and Hirata, Makoto and Matsuda, Koichi and Iwasaki, Motoki and Yamaji, Taiki and Sawada, Norie and Hachiya, Tsuyoshi and Tanno, Kozo and Shimizu, Atsushi and Hozawa, Atsushi and Minegishi, Naoko and Tsugane, Shoichiro and Yamamoto, Masayuki and Kubo, Michiaki and Kamatani, Yoichiro
Nature Genetics, ISSN 1061-4036, 10/2017, Volume 49, Issue 10, pp. 1458 - 1467
Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n =... 
RHEUMATOID-ARTHRITIS | GENETIC-VARIATION | OBESITY | METAANALYSIS | VARIANTS | INSULIN-RESISTANCE | GENETICS & HEREDITY | RISK | FUNCTIONAL ANNOTATION | LD SCORE REGRESSION | HERITABILITY | Body Mass Index | Japan - epidemiology | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Comorbidity | Obesity - immunology | Diabetes Mellitus, Type 2 - genetics | Humans | Asian Continental Ancestry Group - genetics | Obesity - ethnology | Europe - epidemiology | Body Weight - genetics | Obesity - genetics | Diabetes Mellitus, Type 2 - ethnology | Lymphocyte Count | Polymorphism, Single Nucleotide | Body Weight - physiology | Quantitative trait loci | Obesity | Genome-wide association studies | Causes of | Genetic aspects | Health aspects | Japanese | Methods | CD19 antigen | Pathogenesis | Health problems | Body weight | Principal components analysis | Genomes | Males | Epidemiology | Loci | Risk factors | Studies | Body mass index | Body mass | Sexes | Lymphocytes | Cell number | Rheumatoid arthritis | Population | Insulin resistance | Health risk assessment | Index Medicus
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