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by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Masayoshi, Takigami and Kenji, Kamiyama and Kiyohiro, Houkin and Shougo, Nishi and Tetsuyuki, Yoshimoto and Sadao, Kaneko and Koji, Oka and Hiroshi, Ooyama and Kyousuke, Kamada and Kenichi, Makino and Naoki, Tokumitsu and Kazuhiro, Sako and Susumu, Suzuki and Nozomi, Suzuki and Naoto, Izumi and Kazumi, Nitta and Masahumi, Ootaki and Masanori, Isobe and Mikio, Nishiya and Takaaki, Yamazaki and Syouji, Mabuchi and Kuniaki, Ogasawara and Naohiko, Kubo and Yukihiko, Shimizu and Keiichi, Saito and Tatumi, Yamanome and Atsuo, Yoshino and Mitsuyuki, Fujitsuka and Masaaki, Takami and Hirotoshi, Ohtaka and Teruyuki, Hirano and Yosiaki, Shiokawa and Takaharu, Okada and Ichiro, Suzuki and Michihiro, Kohno and Jou, Haraoka and Yoshinori, Arai and Noriyoshi, Kawamura and Akira, Isoshima and Masaharu, Yasue and Mitsuhiko, Hokari and Takayoshi, Kobayashi and Kensuke, Kawai and Taketoshi, Maehara and Hajime, Arai and Makoto, Noguchi and Haruhiko, Hoshino and Hirofumi, Hiyama and Kensaku, Yoshida and Osamu, Utsugi and Yasuaki, Takeda and Kouichi, Tamaki and Hirohide, Karasudani and Takao, Urabe and Shiro, Kobayashi and Michio, Nakamura and Yorio, Koguchi and Junichi, Ono and Sumio, Suda and Hiromu, Hadeishi and Toshio, Fukutake and Kenji, Wakui and Hirokazu, Tanno and Naoki, Ishige and Takashi, Ohasi and Hideki, Sakai and Yasuaki, Nishimura and Takayuki, Watanabe and Takashi, Matsumoto and Naoki, Koketsu and Yuichi, Hirose and Manabu, Doyu and Toshinori, Hasegawa and Naoto, Kuwayama and Shinichi, Terao and Nobuhiko, Mizutani and Noriyuki, Suzaki and Satoshi, Okuda and Keizo, Yasui and Yukio, Seki and Yasuhiro, Hasegawa and Akira, Ikeda and Youtarou, Takeuchi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 2019
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | Index Medicus
Journal Article
Yakugaku Zasshi, ISSN 0031-6903, 04/2015, Volume 135, Issue 4, pp. 567 - 578
Journal Article
Drug Delivery System, ISSN 0913-5006, 02/2016, Volume 30, Issue 5, p. 420
Journal Article
Drug Delivery System, ISSN 0913-5006, 2015, Volume 30, Issue 5, pp. 420 - 420
Journal Article
Lancet, The, ISSN 0140-6736, 2011, Volume 378, Issue 9796, pp. 1094 - 1105
Summary People in Japan have the longest life expectancy at birth in the world. Here, we compile the best available evidence about population health in Japan... 
Internal Medicine | Universal Coverage | Demography | Humans | Japan | Male | Socioeconomic Factors | Young Adult | Life Expectancy | Adolescent | Preventive Health Services | Adult | Female | Aged | Health Status | Child | Index Medicus | Abridged Index Medicus
Journal Article
by Kajimoto, Katsuya and Minami, Yuichiro and Otsubo, Shigeru and Sato, Yukihito and Sato, Takatoshi and Sato, Takamasa and Sato, Naoki and Asai, Kuniya and Munakata, Ryo and Aokage, Toshiyuki and Yoshida, Asuka and Yoshida, Daisuke and Yoshida, Kentaro and Yumino, Dai and Mizuno, Kiyo-o and Mizuno, Masayuki and Kawada, Erisa and Ozaki, Yuri and Kogure, Tomohito and Haruki, Shintaro and Nakao, Koichi and Sawamura, Tadashi and Sawamura, Akinori and Nuki, Toshiaki and Ishiki, Ryoji and Yokota, Yuya and Yokota, Shigeki and Fujinaga, Hiroyuki and Yamamoto, Takashi and Harada, Kenji and Saito, Taro and Saito, Akihiro and Kageyama, Norihito and Okumura, Takanobu and Hata, Noritake and Murai, Koji and Nozaki, Ayaka and Kawanaka, Hidekazu and Tanabe, Jun and Ishii, Katsuhisa and Oiwa, Hitoshi and Matsumoto, Tomoaki and Kato, Hiromasa and Kato, Nobuo and Kato, Masahiko and Suzuki, Hiroshi and Shimizu, Nobuyuki and Shimizu, Hayato and Keida, Takehiko and Fujita, Takashi and Fujita, Masaki and Nakamura, Keita and Nakamura, Makiko and Nakamura, Kentaro and Chinen, Toshiya and Meguro, Kentaro and Kikuchi, Tatsuro and Nishikido, Toshiyuki and Nakata, Masaya and Nakata, Marohito and Yamashita, Shizuya and Yamashita, Eiji and Yamashita, Tatsuya and Hirono, Akitoshi and Mitsudo, Kazuaki and Kadota, Kazushige and Makita, Noriko and Watanabe, Nagisa and Kawabata, Masaaki and Fujii, Kenichi and Fujii, Shinya and Okuda, Shinichi and Kobayashi, Hiroshi and Kobayashi, Shigeki and Moriuchi, Ikuo and Osato, Kazuo and Murakami, Tatsuaki and Shimada, Yoshifumi and Shimada, Katsunori and Misawa, Katsushi and Kokado, Hiromasa and Fukuoka, Yoshitomo and Takabatake, Syu and Takata, Yoshifumi and Miyagi, Manabu and Tanaka, Nobuhiro and Yamashina, Akira and Sudo, Shinji and Shimamura, Koichi and Nagashima, Michitaka and Kaneda, Tomoya and Ueda, Yasunori and Ueda, Kosei and Higashikata, Toshinori and Fujimori, Kanichi and Yagi, Masahiro and Takaki, Jyunko and Toyama, Takuji and Hirata, Tetsuo and Kamisihima, Kazuho and ... and Acute Decompensated Heart Failure and investigators of the Acute Decompensated Heart Failure Syndromes (ATTEND) registry
The American Journal of Cardiology, ISSN 0002-9149, 09/2017, Volume 120, Issue 5, pp. 809 - 816
The aim of this study was to evaluate the association of functional mitral regurgitation (FMR), preserved or reduced ejection fraction (EF), and ischemic or... 
VENTRICULAR SYSTOLIC DYSFUNCTION | PROGNOSTIC IMPLICATIONS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | DETERMINANTS | DISEASE | RISK | DILATED CARDIOMYOPATHY | ECHOCARDIOGRAPHY | QUANTITATIVE DOPPLER ASSESSMENT | SEVERITY | Japan - epidemiology | Prospective Studies | Humans | Heart Failure - physiopathology | Male | Mitral Valve Insufficiency - epidemiology | Heart Ventricles - diagnostic imaging | Incidence | Echocardiography, Doppler | Myocardial Ischemia - physiopathology | Female | Registries | Ventricular Function, Left - physiology | Myocardial Ischemia - diagnosis | Heart Failure - mortality | Severity of Illness Index | Heart Failure - complications | Acute Disease | Survival Rate - trends | Stroke Volume - physiology | Mitral Valve Insufficiency - diagnosis | Heart Ventricles - physiopathology | Myocardial Ischemia - complications | Cause of Death - trends | Mitral Valve Insufficiency - etiology | Heart failure | Care and treatment | Mitral valve insufficiency | Patient outcomes | Analysis | Cardiac patients | Hypertension | Heart attacks | Cardiomyopathy | Mortality | Color | Disorders | Cardiovascular disease | Hospitalization | Patients | Discharge | Confidence intervals | Ultrasonic imaging | Ischemia | Regurgitation | Acute coronary syndromes | Health risk assessment | Heart diseases | Failure | Ejection | Index Medicus | Abridged Index Medicus
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2011, Volume 26, Issue 1, pp. 60 - 70
Summary: Troglitazone induced an idiosyncratic, hepatocellular injury-type hepatotoxicity in humans. Statistically, double null genotype of glutathione... 
Journal Article
Materials, ISSN 1996-1944, 07/2016, Volume 9, Issue 8, pp. 633 - 633
Journal Article
International Journal of Clinical Oncology, ISSN 1341-9625, 2/2016, Volume 21, Issue 1, pp. 1 - 12
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Investigational New Drugs, ISSN 0167-6997, 10/2019, Volume 37, Issue 5, pp. 1061 - 1074
Background We conducted a first-in-Japanese, phase I study of ontuxizumab, a humanized, anti-endosialin monoclonal antibody, to confirm its tolerability,... 
CD248 antigen inhibitor | Phase I | Medicine & Public Health | Endosialin | Ontuxizumab | Oncology | Monoclonal antibody | Pharmacology/Toxicology | Chondrosarcoma | Toxicity | Identification methods | Hepatocellular carcinoma | Fatigue | Pharmacology | Shrinkage | Bilirubin | Patients | Chemotherapy | Monoclonal antibodies | Solid tumors | Pharmacokinetics | Constipation | Gastric cancer | Tumors | Cancer
Journal Article