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Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2012, Volume 13, Issue 12, pp. 1141 - 1142
Interleukin 2 (IL-2) and IL-15 use receptors with the same signaling subunits. New structural data show that the signaling complexes they form are... 
INTERLEUKIN-2 | RECEPTOR | IMMUNOLOGY | TRANS | CRYSTAL-STRUCTURE | BIOLOGY | Animals | Interleukin-2 - immunology | Interleukin-15 - immunology | Humans
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2001, Volume 410, Issue 6828, pp. 608 - 611
Optimal immune responses require both an antigen-specific and a co-stimulatory signal. The shared ligands B7-1 and B7-2 on antigen-presenting cells deliver the... 
SYSTEM | ADHESION | RECOGNITION | SOLUBLE FORM | MULTIDISCIPLINARY SCIENCES | T-CELL ACTIVATION | RECEPTOR | CTLA-4 | COSTIMULATION | BLOCKADE | MOLECULAR-BASIS | B7-1 Antigen - genetics | Cricetulus | Humans | Crystallography, X-Ray | Abatacept | B7-1 Antigen - chemistry | CHO Cells | Cricetinae | B7-1 Antigen - immunology | Models, Molecular | Recombinant Proteins - chemistry | Macromolecular Substances | CTLA-4 Antigen | Immunity - physiology | Animals | Antigens, Differentiation - chemistry | Immunoconjugates | T-Lymphocytes - chemistry | Protein Conformation | T-Lymphocytes - immunology | Antigens, Differentiation - genetics | Mice | Mutation | Antigens, CD | Antigens, Differentiation - immunology | Cell culture | Residues | Animal models | Crystal lattices | CD86 antigen | Hydrogen | Central nervous system | Conservation | X-ray diffraction | Amino acids | Lymphocytes T | CD28 antigen | Crystallography | Cell surface | B7 antigen | Light sources | Proteins | T-cell receptor | Cell recognition | Cell activation | Immunology | Lymphocytes | Immunotherapy | Cell adhesion | Genetics | Dimerization | Elbow | Crystal structure | Antigens | Immunoglobulins | Oligomerization | Complementarity | Immune response | CD152 antigen | Macromolecules | Crystals | T cell receptors | Topology | Nitrogen | Computer programs | Interfaces | Diffraction | Antigen-presenting cells | Data collection | Ligands | B7-1 antigen | CD162 antigen | Binding sites | B7-2 antigen | CTLA-4 protein | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 17, pp. 11771 - 11785
PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and... 
RHEUMATOID-ARTHRITIS | SECONDARY STRUCTURE DETERMINATION | NMR ASSIGNMENT | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL DOMAIN | TISSUE INHIBITOR | QUANTITATIVE-ANALYSIS | MOLECULAR-BASIS | T-CELLS | PD-1 EXPRESSION | Surface Plasmon Resonance | Cell Communication - immunology | Programmed Cell Death 1 Receptor - chemistry | B7-1 Antigen - genetics | Humans | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Structure-Activity Relationship | B7-H1 Antigen - chemistry | Programmed Cell Death 1 Ligand 2 Protein - chemistry | T-Lymphocytes - metabolism | B7-1 Antigen - chemistry | Nuclear Magnetic Resonance, Biomolecular | Antigen-Presenting Cells - metabolism | Protein Structure, Secondary | B7-1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Programmed Cell Death 1 Receptor - metabolism | B7-1 Antigen - metabolism | Antigen-Presenting Cells - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Antigen-Presenting Cells - chemistry | B7-H1 Antigen - metabolism | Models, Immunological | Animals | T-Lymphocytes - chemistry | Protein Binding | T-Lymphocytes - immunology | Mice | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Index Medicus | Nuclear Magnetic Resonance | Signaling | Thermodynamics | Receptors | Immunology | Surface Plasmon Resonance (SPR) | Cell Surface Protein | Complex Formation | Affinity | Naturvetenskap | Natural Sciences
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2004, Volume 10, Issue 24, pp. 8293 - 8300
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2007, Volume 8, Issue 9, pp. 1001 - 1007
Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share... 
BETA-CHAIN | NATURAL-KILLER | LIGAND-BINDING | ALPHA-CHAIN | LYMPHOID HOMEOSTASIS | IN-VIVO | COMMON GAMMA-CHAIN | INTERLEUKIN-2 RECEPTOR | IMMUNOLOGY | IL-2 RECEPTOR | MEMORY T-CELLS
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2009, Volume 385, Issue 4, pp. 1221 - 1229
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2003, Volume 197, Issue 8, pp. 955 - 966
Journal Article