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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2013, Volume 110, Issue 49, pp. 19754 - 19759
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7327, pp. 1067 - 1073
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2013, Volume 56, Issue 24, pp. 10183 - 10187
Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable,... 
CHEMISTRY, MEDICINAL | IDENTIFICATION | PROTEINS | ACETYL-LYSINE BINDING | Zinc Fingers - drug effects | Humans | Drug Design | Models, Molecular | Ligands | Molecular Structure | Structure-Activity Relationship | Proteins - antagonists & inhibitors | Index Medicus | Brief
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 5, pp. 1386 - 1398
Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein... 
Hsp90 | cyclin D | kinase | chaperone | INK | Cdc37 | CDK | CIP/KIP | palbociclib | ribociclib | DEPENDENT KINASE CDK6 | HSP90 | CYCLIN-D | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | GERMLINE MUTATIONS | CELL-CYCLE | INHIBITORS | MURINE FIBROBLASTS | P27(KIP1) | CELL BIOLOGY | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Surface Plasmon Resonance | Pyridines - chemistry | Humans | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Aminopyridines - chemistry | Cell Cycle Proteins - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Adenosine Triphosphate - metabolism | Cell Cycle Proteins - genetics | Fluorescence Resonance Energy Transfer | Inhibitory Concentration 50 | HSP90 Heat-Shock Proteins - genetics | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Purines - metabolism | Cell Cycle Proteins - metabolism | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Chaperonins - metabolism | Purines - chemistry | Pyridines - metabolism | Benzimidazoles - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Kinetics | Adenosine Triphosphate - chemistry | Chaperonins - genetics | Chaperonins - antagonists & inhibitors | Cyclin D - metabolism | Index Medicus
Journal Article
Molecular BioSystems, ISSN 1742-206X, 10/2011, Volume 7, Issue 10, pp. 2899 - 2908
Histone lysine acetylation is a key component of epigenetic regulation of gene transcription. Bromodomains, found in histone acetyl transferases and other... 
ACTIVATION | PROTEIN | STRUCTURAL BASIS | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE RECOGNITION | ACETYLATED HISTONE TAILS | BINDING | BRD4 | COACTIVATORS | Peptides - antagonists & inhibitors | Peptides - chemistry | Histones - chemistry | Humans | Acetylation | Phylogeny | Drug Discovery | Index Medicus
Journal Article
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