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The Journal of biological chemistry, ISSN 0021-9258, 09/2019, Volume 294, Issue 44, pp. 16255 - 16265
Sequential activation of DNA replication origins is precisely programmed and critical to maintaining genome stability. RecQL4, a member of the conserved RecQ... 
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 2, pp. 379 - 383
RecQL4 has been shown to be involved in DNA replication and repair, but its role in DNA damage checkpoint pathway has not been reported. Here, we show that... 
ATM | Rothmund-Thomson syndrome | RecQL4 | DNA damage checkpoint pathway | DNA double strand break | BIOCHEMISTRY & MOLECULAR BIOLOGY | MCM10 | REPAIR | BIOPHYSICS | GENE | DNA | REQUIRES | MUTATIONS | ASSOCIATION
Journal Article
Genes & Development, ISSN 0890-9369, 04/2014, Volume 28, Issue 8, pp. 875 - 887
Many agents used for chemotherapy, such as doxorubicin, interfere with DNA replication, but the effect of this interference on transcription is largely... 
Journal Article
Journal Article
Biochemical and biophysical research communications, 12/2018
RecQL4 has been shown to be involved in DNA replication and repair, but its role in DNA damage checkpoint pathway has not been reported. Here, we show that... 
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2009, Volume 106, Issue 37, pp. 15628 - 15632
In eukaryotes, the activation of the prereplicative complex and assembly of an active DNA unwinding complex are critical but poorly understood steps required... 
Cdc7-Dbf4 kinase | Cyclin-dependent kinase | Cdc45-Mcm-GINS complex | Bimolecular fluorescence complementation | BUDDING YEAST | INITIATION | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC DNA-REPLICATION | POLYMERASE-ALPHA | SACCHAROMYCES-CEREVISIAE | CDC45 | ROTHMUND-THOMSON-SYNDROME | S-PHASE | TOPBP1 | bimolecular fluorescence complementation | cyclin-dependent kinase | PROGRESSION | Minichromosome Maintenance Proteins | Cyclin-Dependent Kinases - metabolism | RecQ Helicases - metabolism | Humans | Multiprotein Complexes | Bacterial Proteins - chemistry | RecQ Helicases - genetics | Minichromosome Maintenance Complex Component 7 | Minichromosome Maintenance Complex Component 2 | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Cell Cycle Proteins - genetics | Luminescent Proteins - chemistry | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Bacterial Proteins - genetics | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - metabolism | Cell Cycle | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | RecQ Helicases - chemistry | HeLa Cells | Chromosomal Proteins, Non-Histone - chemistry | Luminescent Proteins - metabolism | Proteins | DNA replication | HeLa cells | Physiological aspects | Genetic aspects | Research | Molecular biology | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 61 - 75.e5
Double-strand breaks (DSBs) of DNA in eukaryotic cells are predominantly repaired by non-homologous end joining (NHEJ). The histone chaperone anti-silencing... 
RNF168 | MDC1 | ubiquitination | 53BP1 | RNF8 | ATM | NHEJ | histone | ASF1a | CHROMATIN ASSEMBLY FACTORS | RESECTION | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | H2AX PROTEIN | HISTONE H2AX | CHECKPOINT | HOMOLOGOUS RECOMBINATION | BRCA1 | MAINTAINS GENOMIC STABILITY | CELL BIOLOGY | Chromatin - metabolism | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | DNA, Neoplasm - metabolism | Humans | Gene Expression Regulation, Neoplastic | Ubiquitin - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Ubiquitination | DNA End-Joining Repair | Gene Deletion | HEK293 Cells | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Chromatin - chemistry | Tumor Suppressor p53-Binding Protein 1 - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Ubiquitin - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | DNA - genetics | Histones - genetics | Cell Line, Tumor | Trans-Activators - metabolism | DNA, Neoplasm - genetics | HeLa Cells | Histones - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Cell Line, Transformed | Ubiquitin | Ligases | Medical colleges | bleomycin | E3 ligase | homologous recombination (HR) | non-homologous end joining (NHEJ)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 37, pp. 15628 - 15632
In eukaryotes, the activation of the prereplicative complex and assembly of an active DNA unwinding complex are critical but poorly understood steps required... 
Proteins | Yeasts | Chromatin | DNA replication | DNA | Cell cycle | HeLa cells | Small interfering RNA | Fluorescence | Gin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2009, Volume 106, Issue 37, p. 15628
  In eukaryotes, the activation of the prereplicative complex and assembly of an active DNA unwinding complex are critical but poorly understood steps required... 
Proteins | Eukaryotes | Yeast | Cyclin-dependent kinases | Cell cycle | Cells
Journal Article
EMBO reports, ISSN 1469-221X, 12/2013, Volume 14, Issue 12, pp. 1032 - 1033
Huang and colleagues identify a human primase‐polymerase that is required for stalled replication fork restart and the maintenance of genome integrity. 
POLYMERASE | PRIMASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-REPLICATION | CELL BIOLOGY | DNA Primase - metabolism | Genomic Instability | DNA Replication | DNA-Directed DNA Polymerase - metabolism | Multifunctional Enzymes - metabolism | Humans | Upfront
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2014, Volume 34, Issue 7, pp. 1459 - 1467
Journal Article