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Drug Metabolism and Disposition, ISSN 0090-9556, 05/2018, Volume 46, Issue 5, p. 667
To estimate the clinical impact of pharmacokinetic modulation via breast cancer resistance protein (BCRP), in vivo approaches in nonclinical settings are... 
Glycoprotein | Glycoproteins | Breast cancer | Pharmacology | Exposure | Monkeys | Bioavailability | Fexofenadine | Drug development | Substrates | Inhibitors | Intestine | Sulfasalazine | Curcumin | Inhibition | Pretreatment | Midazolam | P-Glycoprotein | Cancer
Journal Article
Biopharmaceutics & Drug Disposition, ISSN 0142-2782, 10/2019
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 05/2015, Volume 32, Issue 5, pp. 1634 - 1647
To evaluate whether the impact of functional modulation of the breast cancer resistance protein (BCRP, ABCG2 421C > A) on human pharmacokinetics after oral... 
BCRP | Gastrointestinal absorption | ABCG2 421C>A | Cynomolgus monkey | Knockout mouse | QUALITATIVE EVALUATION | DRUG-INTERACTIONS | BINDING CASSETTE TRANSPORTERS | GENE POLYMORPHISMS | CHEMISTRY, MULTIDISCIPLINARY | ABCG2 BCRP | SULFASALAZINE | ABCG2 421C > A | PHARMACOLOGY & PHARMACY | CYNOMOLGUS MONKEYS | IN-VIVO PROBE | CACO-2 CELLS | C421A POLYMORPHISM | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Quinolines - blood | Area Under Curve | Fatty Acids, Monounsaturated - administration & dosage | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Intestinal Absorption - drug effects | Macaca fascicularis | Male | Quinolines - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - blood | Rosuvastatin Calcium - administration & dosage | Indoles - administration & dosage | Quinolines - pharmacokinetics | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfasalazine - pharmacokinetics | ATP-Binding Cassette Transporters - genetics | Sulfasalazine - blood | ATP-Binding Cassette Transporters - metabolism | Fatty Acids, Monounsaturated - blood | Female | Rosuvastatin Calcium - blood | Caco-2 Cells | Tetrahydroisoquinolines - pharmacology | Rosuvastatin Calcium - pharmacokinetics | Indoles - blood | Mice, Knockout | Sulfasalazine - administration & dosage | Animals | Acridines - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | ATP-Binding Cassette Transporters - antagonists & inhibitors | Sulfasalazine | Breast cancer | Proteins | Pharmacology | Kinetics | Drug resistance | Monkeys & apes | Substrates
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 08/2019, Volume 9, Issue 1, pp. 11990 - 18
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by the SFTS phlebovirus (SFTSV). SFTS patients were first reported... 
FELINE | ANIMALS | TO-PERSON TRANSMISSION | SYNDROME VIRUS-INFECTION | SOUTH-KOREA | MULTIDISCIPLINARY SCIENCES | PATIENT | DEATH | FAMILY CLUSTER | BUNYAVIRUS | EXPRESSION | Jaundice | Spleen | Thrombocytopenia | Urine | Epidemics | Anorexia | Hemorrhagic fever | Leukopenia | Cell lineage | Gastrointestinal tract | Ribonucleic acid--RNA | Pax5 protein | Hemorrhage | Lymph nodes | Lymphocytes B | Rectum | CD20 antigen | Lymphadenitis | Saliva
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2014, Volume 42, Issue 4, pp. 520 - 528
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2019, Volume 10, Issue 5, pp. 737 - 742
To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1,... 
FER | inhibitor | pyrido-pyridazinone | antitumor | FES | tyrosine kinase | CHEMISTRY, MEDICINAL
Journal Article
by Kinoshita, Yoshikazu and Hongo, Michio and Mitsui, Shinya and Hagiwara, Takeshi and Kobayashi, Takeaki and Karasawa, Gakuyo and Yoshida, Yukinari and Tominaga, Gen and Komatsu, Masafumi and Oizumi, Harufumi and Igarashi, Tadayuki and Kamoshida, Toshiro and Masuyama, Hironori and Kusano, Motoyasu and Kawamura, Osamu and Shimoyama, Yasuyuki and Watanabe, Kazuyoshi and Matsukura, Akira and Takamori, Akitaka and Hamashima, Hideki and Misaka, Kazuharu and Tsunomiya, Shin and Kikuchi, Junko and Sano, Atsushi and Nishino, Takayoshi and Shiratori, Keiko and Uemura, Naomi and Akiyama, Junichi and Nagata, Naoyoshi and Sasajima, Keita and Iwakiri, Katsuhiko and Yoshida, Katsutoshi and Miwa, Jun and Kuyama, Yasushi and Murakami, Tomofumi and Suemori, Shoichi and Otsuka, Seiji and Akita, Kuniharu and Shimizu, Masaru and Ito, Yasufumi and Yamakita, Noriyoshi and Murai, Toshihiro and Kitamura, Tadashi and Furuta, Takahisa and Kajimura, Masayoshi and Shirai, Naohito and Takeuchi, Yasuo and Wada, Tomohiko and Okazaki, Takahiro and Kubota, Hiroyuki and Morishita, Muneji and Maruyama, Yasuhiko and Niwa, Yasumasa and Ando, Takafumi and Joh, Takashi and Sasaki, Makoto and Kamiya, Takeshi and Wada, Tsuneya and Kataoka, Hiromi and Ogasawara, Naotaka and Kubota, Eiji and Tanida, Satoshi and Kasugai, Kunio and Funaki, Yasushi and Koyama, Shigeki and Yasuda, Kenjiro and Yoshida, Norimasa and Maekawa, Takama and Fujiwara, Yasuhiro and Yazumi, Shujiro and Ashida, Kiyoshi and Habu, Yasuki and Morikawa, Hiroshi and Miwa, Hiroto and Hayashi, Eijiro and Hashimoto, Naohisa and Hirakawa, Hideyuki and Fujimura, Kazuyo and Fujisawa, Tomoo and Inoue, Kazuhiko and Adachi, Kyoichi and Furuta, Kenji and Imaoka, Tomonori and Miyaoka, Yoichi and Fujimura, Yoshinori and Tari, Akira and Obata, Shinichiro and Kawano, Toyokazu and Inaba, Tomoki and Inoue, Shuji and Kuniyoshi, Nobutoshi and Kumemura, Hiroto and Matsui, Toshiyuki and Takaki, Yasuhiro and Higashi, Kyota and Maekawa, Ryuichiro and Fukushima, Hirofumi and Ogata, Shinichi and Fujimoto, Kazuma and Sakata, Hiroyuki and ... and Japan TWICE Study Grp and Japan TWICE Study Group
American Journal of Gastroenterology, ISSN 0002-9270, 04/2012, Volume 107, Issue 4, pp. 522 - 530
Journal Article
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 02/2007, Volume 71, Issue 2, pp. 619 - 627
Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal failure is their dose-limiting... 
Journal Article
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