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1. Interview with Donald E Ingber
by Ingber, Donald E
Nanomedicine (London, England), ISSN 1743-5889, 05/2014, Volume 9, Issue 7, pp. 949 - 954
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NANOSCIENCE & NANOTECHNOLOGY | Nanotechnology - methods | Tissue Engineering
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2. Full Text Modelling cancer in microfluidic human organs-on-chips
by Sontheimer-Phelps, Alexandra and Hassell, Bryan A and Ingber, Donald E
Nature Reviews Cancer, ISSN 1474-175X, 02/2019, Volume 19, Issue 2, pp. 65 - 81
One of the problems that has slowed the development and approval of new anticancer therapies is the lack of preclinical models that can be used to identify key... 
TUMOR-CELL EXTRAVASATION | BREAST-CANCER | STEM-CELLS | KIDNEY PROXIMAL TUBULE | ONCOLOGY | IN-VITRO MODEL | TISSUE-CULTURE | COCULTURE | A-CHIP | BLOOD-BRAIN-BARRIER | ENDOTHELIAL BARRIER | Cell culture | Biotechnology | Gels | Chips | Organs | Fluid flow | Two dimensional models | Tissues | Spheroids | Substrates | Interfaces | Organic chemistry | Molecular modelling | Organoids | Extracellular matrix | Microenvironments | Human behavior | Microfluidics | Cancer | Tumors
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3. Full Text Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology
by Ingber, Donald E
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 11/2002, Volume 91, Issue 10, pp. 877 - 887
ABSTRACT—Great advances have been made in the identification of the soluble angiogenic factors, insoluble extracellular matrix (ECM) molecules, and receptor... 
Capillary morphogenesis | Cytoskeleton | Mechanotransduction | Integrin | Tensegrity | Cardiovascular Physiological Phenomena | Endothelium, Vascular - cytology | Humans | Extracellular Matrix - metabolism | Stress, Mechanical | Capillaries - growth & development | Cell Movement - physiology | Endothelium, Vascular - physiology | Capillaries - physiology | Cell Division - physiology | Neovascularization, Physiologic - physiology | Animals | Capillaries - cytology | Signal Transduction - physiology | Cytoskeleton - physiology | Cell Differentiation - physiology
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4. Full Text Cellular mechanotransduction: Putting all the pieces together again
by Ingber, Donald E
FASEB Journal, ISSN 0892-6638, 05/2006, Volume 20, Issue 7, pp. 811 - 827
Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of... 
Mechanosensation | Mechanochemical | Prestress | Tensegrity | Mechanical | SENSORY HAIR-CELLS | FLUID SHEAR-STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | mechanical | FOCAL ADHESIONS | CELL BIOLOGY | EPITHELIAL-CELLS | prestress | MECHANICAL FORCE | BIOLOGY | CYTOSKELETAL TENSION | mechanochemical | CAPILLARY ENDOTHELIAL-CELLS | FIBROBLAST GROWTH-FACTOR | EXTRACELLULAR-MATRIX | tensegrity | mechanosensation | LIVING CELLS | Ear - anatomy & histology | Biomechanical Phenomena | Animals | Ear - physiology | Mechanotransduction, Cellular - physiology
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5. Full Text Reverse Engineering Human Pathophysiology with Organs-on-Chips
by Ingber, Donald E
Cell, ISSN 0092-8674, 03/2016, Volume 164, Issue 6, pp. 1105 - 1109
While studies of cultured cells have led to new insights into biological control, greater understanding of human pathophysiology requires the development of... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | CELL BIOLOGY | Microfluidic Analytical Techniques - methods | Tissue Engineering - methods | Neoplasms - physiopathology | Humans | Organ Culture Techniques | Blood-Brain Barrier | Biological control | Analysis | Pests
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6. Full Text Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
by Tovaglieri, Alessio and Sontheimer-Phelps, Alexandra and Geirnaert, Annelies and Prantil-Baun, Rachelle and Camacho, Diogo M and Chou, David B and Jalili-Firoozinezhad, Sasan and De Wouters, Tomás and Kasendra, Magdalena and Super, Michael and Cartwright, Mark J and Richmond, Camilla A and Breault, David T and Lacroix, Christophe and Ingber, Donald E
Microbiome, ISSN 2049-2618, 03/2019, Volume 7, Issue 1, pp. 43 - 21
Background: Species-specific differences in tolerance to infection are exemplified by the high susceptibility of humans to enterohemorrhagic Escherichia coli... 
TUMOR-NECROSIS-FACTOR | HEMOLYTIC-UREMIC SYNDROME | EPITHELIUM | CULTURE-SYSTEM | CHAIN FATTY-ACIDS | ENDOTHELIAL-CELLS | STEM-CELL | MICROBIOLOGY | COLONIZATION | SHIGA-TOXIN | EXPRESSION | Organ Culture Techniques - methods | Bacteria - metabolism | Species Specificity | Caproates - pharmacology | Humans | Cells, Cultured | Gastrointestinal Microbiome | Escherichia coli Infections - microbiology | Male | Enterohemorrhagic Escherichia coli - metabolism | Enterohemorrhagic Escherichia coli - pathogenicity | Microchip Analytical Procedures | Animals | Intestines - microbiology | Escherichia coli Infections - pathology | Benzoates - pharmacology | Female | Mice | Heptanoic Acids - pharmacology | Intestines - cytology | Benzoic acid | Medical research | Bacterial infections | Escherichia coli | Disease susceptibility | Research | Fatty acids | Infection | Metabolites | Resveratrol | Medicine, Experimental | Health aspects | Microfluidics | Pathogens | Cell culture | Motility | Microbiomes | Flagellin | Infections | Epithelium | Pathogenicity | E coli | Intestine | Bacteria | Random variables | Colon | Species | Bioinformatics
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7. Full Text Cycling through the menstrual cycle — an out-of-body experience
by Ingber, Donald E
Nature Reviews Endocrinology, ISSN 1759-5029, 07/2017, Volume 13, Issue 7, pp. 380 - 382
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8. Full Text Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
by Park, Tae-Eun and Mustafaoglu, Nur and Herland, Anna and Hasselkus, Ryan and Mannix, Robert and FitzGerald, Edward A and Prantil-Baun, Rachelle and Watters, Alexander and Henry, Olivier and Benz, Maximilian and Sanchez, Henry and McCrea, Heather J and Goumnerova, Liliana Christova and Song, Hannah W and Palecek, Sean P and Shusta, Eric and Ingber, Donald E
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2621 - 12
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous... 
IN-VITRO | EFFLUX TRANSPORTERS | INHIBITION | VIVO | PERMEABILITY | MODELS | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | DIFFERENTIATION | HIF-1-ALPHA | P-GLYCOPROTEIN | Drugs | Efflux | Cell culture | Brain | Drug delivery systems | Immunoglobulins | Peptides | Astrocytes | Brain stem | Central nervous system | Antibodies | Selectivity | Drug delivery | Drug development | Endothelium | Blood-brain barrier | Stem cells | Pericytes | Hypoxia | Microvasculature | Pluripotency | Microfluidics
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9. Full Text Microfluidic organs-on-chips
by Bhatia, Sangeeta N and Ingber, Donald E
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 8, pp. 760 - 772
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by... 
BREAST-CANCER | PRIMARY HUMAN HEPATOCYTES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VITRO MODEL | ENDOTHELIAL-CELLS | GENE-EXPRESSION | HUMAN LIVER | EXTRACELLULAR-MATRIX | PLURIPOTENT STEM-CELL | A-CHIP | HEPATIC-CLEARANCE | Bioengineering | Caco-2 Cells | Models, Biological | Humans | Biosensing Techniques | Drug Design | Artificial Organs | Drug Discovery | Microfluidics | Cell culture | Medical research | Biomedical microelectromechanical systems | Medicine, Experimental | Design and construction | Research | Methods | Fluid dynamics | Toxicity | Index Medicus
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10. Full Text Cellular nanoscale stiffness patterns governed by intracellular forces
by Mandriota, Nicola and Friedsam, Claudia and Jones-Molina, John A and Tatem, Kathleen V and Ingber, Donald E and Sahin, Ozgur
Nature Materials, ISSN 1476-1122, 2019, Volume 18, Issue 10, pp. 1071 - 1071
Cell stiffness measurements have led to insights into various physiological and pathological processes. Although many cellular behaviours are influenced by... 
PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | MECHANOBIOLOGY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | MECHANICAL RESPONSE | MEMBRANE TENSION | FIBROBLASTS | ORGANIZATION | STRESS FIBERS | ADHESION | SHAPE | LIVING CELLS | GEOMETRY | Resolution cell | Image resolution | High resolution | Stiffness | Spatial resolution | Material properties
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11. Full Text Seeing Your Way to New Insights in Biology
by Reilly, Charles and Ingber, Donald E
Journal of Molecular Biology, ISSN 0022-2836, 06/2019, Volume 431, Issue 14, pp. 2485 - 2486
BIOCHEMISTRY & MOLECULAR BIOLOGY
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12. Full Text Can cancer be reversed by engineering the tumor microenvironment?
by Ingber, Donald E
Seminars in Cancer Biology, ISSN 1044-579X, 2008, Volume 18, Issue 5, pp. 356 - 364
Abstract To advance cancer research in a transformative way, we must redefine the problem. Although epithelial cancers, such as breast cancer, may be caused by... 
Hematology, Oncology and Palliative Medicine | Stroma | Extracellular matrix | Cytoskeleton | Cell traction | Cancer therapy | Mechanical | SHAPE-DEPENDENT CONTROL | UROGENITAL SINUS | cytoskeleton | stroma | BRANCHING MORPHOGENESIS | mechanical | cancer therapy | BASAL LAMINA | ONCOLOGY | cell traction | GENE-EXPRESSION | NEOPLASTIC DISORGANIZATION | EXTRACELLULAR-MATRIX | MESENCHYMAL INTERACTIONS | extracellular matrix | MAMMARY EPITHELIAL-CELLS | BASEMENT-MEMBRANE | Neoplasms - metabolism | Neoplasms - therapy | Animals | Epithelium - metabolism | Humans | rho GTP-Binding Proteins - metabolism | Cytoskeleton - metabolism | Extracellular Matrix - metabolism | Neoplasms - pathology | Cell Adhesion | Physiological aspects | Development and progression | Health aspects | Cancer
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13. Full Text Tensegrity-based mechanosensing from macro to micro
by Ingber, Donald E
Progress in Biophysics and Molecular Biology, ISSN 0079-6107, 2008, Volume 97, Issue 2, pp. 163 - 179
This article is a summary of a lecture on cellular mechanotransduction that was presented at a symposium on “Cardiac Mechano-Electric Feedback and Arrhythmias”... 
Cytoskeleton | Mechanotransduction | Tension | Integrin | Tensegrity | Cell mechanics | tension | cytoskeleton | mechanotransduction | cell mechanics | BIOCHEMISTRY & MOLECULAR BIOLOGY | GEOMETRIC CONTROL | BIOPHYSICS | EPITHELIAL-CELLS | CYTOSKELETAL TENSION | DEPENDENT CONTROL | CAPILLARY ENDOTHELIAL-CELLS | EXTRACELLULAR-MATRIX | tensegrity | integrin | INTERMEDIATE-FILAMENTS | LIVING CELLS | CELLULAR MECHANOTRANSDUCTION | BASEMENT-MEMBRANE | Humans | Mechanoreceptors - physiology | Extracellular Matrix - metabolism | Cell Size | Mechanotransduction, Cellular - physiology | Integrins - metabolism | Biomechanical Phenomena | Animals | Cell Adhesion - physiology | Models, Biological | Signal Transduction - physiology | Cytoskeleton - physiology | Cell Shape - physiology | Analysis | Integrins
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