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Journal Article
Kidney International, ISSN 0085-2538, 12/2016, Volume 90, Issue 6, pp. 1146 - 1148
A new study by Kuwagata et al. now shows that aberrant activation of the mechanistic target of rapamycin complex 1 in renal tubular cells causes their injury... 
microRNA | mTORC1 | diabetic nephropathy | UROLOGY & NEPHROLOGY | TOR Serine-Threonine Kinases | Animals | Signal Transduction | Receptors, Tumor Necrosis Factor, Type II | Apoptosis | Mechanistic Target of Rapamycin Complex 1 | Diabetic nephropathy
Journal Article
The EMBO Journal, ISSN 1460-2075, 2008, Volume 27, Issue 14, pp. 1919 - 1931
Protein kinase C (PKC) is involved in a wide array of cellular processes such as cell proliferation, differentiation and apoptosis. Phosphorylation of both... 
mTOR | PKC | TORC2 | Akt | RAPAMYCIN | PROTEIN-KINASE-C | ACTIVATION | AKT/PKB | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | INSULIN | RICTOR-MTOR COMPLEX | SUBSTRATE | GROWTH | Cellular biology | Kinases | Signal transduction
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 11/2013, Volume 24, Issue 11, pp. 1711 - 1713
Journal Article
Current opinion in nephrology and hypertension, ISSN 1062-4821, 1/2016, Volume 25, Issue 1, pp. 28 - 34
Journal Article
The FASEB journal, ISSN 1530-6860, 2001, Volume 16, Issue 2, pp. 1 - 27
ABSTRACT Vascular endothelial growth factor (VEGF) is a strong angiogenic mitogen and plays important roles in angiogenesis under various pathophysiological... 
antiangiogenesis | fibrosis | cartilage | RHEUMATOID-ARTHRITIS | CELLS | FACTOR-BETA | ENDOCHONDRAL BONE-FORMATION | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CELL BIOLOGY | IN-VIVO | BIOLOGY | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | PLATELET FACTOR-IV | Endothelium, Vascular - cytology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Blood Vessels - growth & development | Endothelial Growth Factors - metabolism | Saccharomyces cerevisiae - genetics | Vascular Endothelial Growth Factors | Humans | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Immediate-Early Proteins - metabolism | Growth Substances - genetics | Lymphokines - genetics | Injections, Subcutaneous | Lymphokines - metabolism | Lymphokines - pharmacology | Cell Line | von Willebrand Factor - analysis | Blood Vessels - chemistry | Neovascularization, Physiologic - genetics | Intercellular Signaling Peptides and Proteins | Mice, Inbred C57BL | Skin - blood supply | Neovascularization, Physiologic - physiology | Skin - chemistry | Two-Hybrid System Techniques | Animals | Immediate-Early Proteins - genetics | Endothelium, Vascular - metabolism | Endothelial Growth Factors - genetics | Immediate-Early Proteins - pharmacology | Blood Vessels - drug effects | Growth Substances - pharmacology | Protein Binding | Mice | Skin - drug effects | Connective Tissue Growth Factor | Growth Substances - metabolism
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 332, Issue 6032, pp. 966 - 970
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2181 - 2196
Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and type 2 diabetics. Podocyte dysfunction is postulated to be a critical... 
EPITHELIAL-MESENCHYMAL TRANSITION | MAMMALIAN TARGET | KIDNEY-DISEASE | MEDICINE, RESEARCH & EXPERIMENTAL | SLIT DIAPHRAGM | GLOMERULAR PROTEIN | ER STRESS | NOTCH PATHWAY | NEPHRIN EXPRESSION | ANGIOTENSIN-II | TUBEROUS-SCLEROSIS | Phosphorylation | Ribosomal Protein S6 Kinases - metabolism | Diabetic Nephropathies - etiology | Diabetes Mellitus, Type 2 - genetics | Multiprotein Complexes | Podocytes - enzymology | Diabetic Nephropathies - drug therapy | Endoplasmic Reticulum - metabolism | Male | Mechanistic Target of Rapamycin Complex 1 | Mice, Mutant Strains | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Glomerular Basement Membrane - pathology | Regulatory-Associated Protein of mTOR | Cell Differentiation | Membrane Proteins - metabolism | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Disease Models, Animal | Carrier Proteins - physiology | Proteins - physiology | Sirolimus - therapeutic use | Mice, Inbred C57BL | Podocytes - pathology | Mice, Knockout | Carrier Proteins - genetics | Tumor Suppressor Proteins - physiology | Adaptor Proteins, Signal Transducing | Glomerular Mesangium - pathology | Animals | Podocytes - drug effects | Podocytes - physiology | Mice | Protein Processing, Post-Translational | TOR Serine-Threonine Kinases | Enzyme Activation | Proteins - antagonists & inhibitors | Diabetic nephropathies
Journal Article
Journal Article