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Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6023, pp. 1439 - 1443
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2018, Volume 9, Issue 4, pp. 354 - 358
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening... 
tirasemtiv | imidazo[4,5-b]pyrazin-2-one | troponin | Amyotrophic lateral sclerosis (ALS) | skeletal muscle activator | CHEMISTRY, MEDICINAL | SAFETY | HUMANS | AMYOTROPHIC-LATERAL-SCLEROSIS | POTENTIAL THERAPEUTIC APPROACH | YOUNG | CARDIAC MYOSIN | CONTRACTION | TOLERABILITY | DISEASE
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2010, Volume 1, Issue 9, pp. 472 - 477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit... 
cardiac myosin | small molecule enzyme activator | Omecamtiv mecarbil | systolic heart failure | MORTALITY | CHROMATOGRAPHIC ANALYSIS | CHEMISTRY, MEDICINAL | HUMAN SERUM-ALBUMIN | HEART-FAILURE | PROTEIN BINDING | CARBAMAZEPINE BINDING
Journal Article
Science (Washington), ISSN 0036-8075, 03/2011, Volume 331, Issue 6023, pp. 1439 - 1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling... 
Heart | Cascades | Myosin | Activation | Mathematical models | Catalysis | Failure | Ejection
Journal Article
ANALYST, ISSN 0003-2654, 06/2019, Volume 144, Issue 12, pp. 3853 - 3860
This article documents the effect of dielectrophoresis on living cells. Given the longer duration procedures performed on microfluidic platforms, the influence... 
APOPTOSIS | CHEMISTRY, ANALYTICAL | CHIP | SEPARATION | MODEL | LAB | CANCER | EXPOSURE | Cellular manufacture | Biotechnology | Deregulation | Genes | Gene expression | Crossovers | White blood cells | Red blood cells | Genetic engineering | Dielectrophoresis | Electric fields | Microfluidics | Apoptosis
Journal Article
by Renfree, Marilyn B and Papenfuss, Anthony T and Deakin, Janine E and Lindsay, James and Heider, Thomas and Belov, Katherine and Rens, Willem and Waters, Paul D and Pharo, Elizabeth A and Shaw, Geoff and Wong, Emily S.W and Lefèvre, Christophe M and Nicholas, Kevin R and Kuroki, Yoko and Wakefield, Matthew J and Zenger, Kyall R and Wang, Chenwei and Ferguson-Smith, Malcolm and Nicholas, Frank W and Hickford, Danielle and Yu, Hongshi and Short, Kirsty R and Siddle, Hannah V and Frankenberg, Stephen R and Chew, Keng Y and Menzies, Brandon R and Stringer, Jessica M and Suzuki, Shunsuke and Hore, Timothy A and Delbridge, Margaret L and Patel, Hardip and Mohammadi, Amir and Schneider, Nanette Y and Hu, Yanqiu and O'Hara, William and Al Nadaf, Shafagh and Wu, Chen and Feng, Zhi-Ping and Cocks, Benjamin G and Wang, Jianghui and Flicek, Paul and Searle, Stephen M.J and Fairley, Susan and Beal, Kathryn and Herrero, Javier and Carone, Dawn M and Suzuki, Yutaka and Sugano, Sumio and Toyoda, Atsushi and Sakaki, Yoshiyuki and Kondo, Shinji and Nishida, Yuichiro and Tatsumoto, Shoji and Mandiou, Ion and Hsu, Arthur and McColl, Kaighin A and Lansdell, Benjamin and Weinstock, George and Kuczek, Elizabeth and McGrath, Annette and Wilson, Peter and Men, Artem and Hazar-Rethinam, Mehlika and Hall, Allison and Davis, John and Wood, David and Williams, Sarah and Sundaravadanam, Yogi and Muzny, Donna M and Jhangiani, Shalini N and Lewis, Lora R and Morgan, Margaret B and Okwuonu, Geoffrey O and Ruiz, San J and Santibanez, Jireh and Nazareth, Lynne and Cree, Andrew and Fowler, Gerald and Kovar, Christie L and Dinh, Huyen H and Joshi, Vandita and Jing, Chyn and Lara, Fremiet and Thornton, Rebecca and Chen, Lei and Deng, Jixin and Liu, Yue and Shen, Joshua Y and Song, Xing-Zhi and Edson, Janette and Troon, Carmen and Thomas, Daniel and Stephens, Amber and Yapa, Lankesha and Levchenko, Tanya and Gibbs, Richard A and Cooper, Desmond W and Speed, Terence P and Fujiyama, Asao and M Graves, Jennifer A and ...
Genome Biology, ISSN 1474-7596, 12/2011, Volume 12, Issue 12, pp. 414 - 414
Journal Article
by Renfree, Marilyn B and Papenfuss, Anthony T and Deakin, Janine E and Lindsay, James and Heider, Thomas and Belov, Katherine and Rens, Willem and Waters, Paul D and Pharo, Elizabeth A and Shaw, Geoff and Wong, Emily S.W and Lefèvre, Christophe M and Nicholas, Kevin R and Kuroki, Yoko and Wakefield, Matthew J and Zenger, Kyall R and Wang, Chenwei and Ferguson-Smith, Malcolm and Nicholas, Frank W and Hickford, Danielle and Yu, Hongshi and Short, Kirsty R and Siddle, Hannah V and Frankenberg, Stephen R and Chew, Keng Y and Menzies, Brandon R and Stringer, Jessica M and Suzuki, Shunsuke and Hore, Timothy A and Delbridge, Margaret L and Mohammadi, Amir and Schneider, Nanette Y and Hu, Yanqiu and O'Hara, William and Al Nadaf, Shafagh and Wu, Chen and Feng, Zhi-Ping and Cocks, Benjamin G and Wang, Jianghui and Flicek, Paul and Searle, Stephen M.J and Fairley, Susan and Beal, Kathryn and Herrero, Javier and Carone, Dawn M and Suzuki, Yutaka and Sugano, Sumio and Toyoda, Atsushi and Sakaki, Yoshiyuki and Kondo, Shinji and Nishida, Yuichiro and Tatsumoto, Shoji and Mandiou, Ion and Hsu, Arthur and McColl, Kaighin A and Lansdell, Benjamin and Weinstock, George and Kuczek, Elizabeth and McGrath, Annette and Wilson, Peter and Men, Artem and Hazar-Rethinam, Mehlika and Hall, Allison and Davis, John and Wood, David and Williams, Sarah and Sundaravadanam, Yogi and Muzny, Donna M and Jhangiani, Shalini N and Lewis, Lora R and Morgan, Margaret B and Okwuonu, Geoffrey O and Ruiz, San J and Santibanez, Jireh and Nazareth, Lynne and Cree, Andrew and Fowler, Gerald and Kovar, Christie L and Dinh, Huyen H and Joshi, Vandita and Jing, Chyn and Lara, Fremiet and Thornton, Rebecca and Chen, Lei and Deng, Jixin and Liu, Yue and Shen, Joshua Y and Song, Xing-Zhi and Edson, Janette and Troon, Carmen and Thomas, Daniel and Stephens, Amber and Yapa, Lankesha and Levchenko, Tanya and Gibbs, Richard A and Cooper, Desmond W and Speed, Terence P and Fujiyama, Asao and M Graves, Jennifer A and O'Neill, Rachel J and ...
Genome Biology, ISSN 1474-7596, 08/2011, Volume 12, Issue 8, pp. R81 - R81
Journal Article
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