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1. Sleep and neurological autoimmune diseases
by Iranzo, Alex
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 07/2019
Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients... 
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2. Full Text The REM sleep circuit and how its impairment leads to REM sleep behavior disorder
by Iranzo, Alex
Cell and Tissue Research, ISSN 0302-766X, 7/2018, Volume 373, Issue 1, pp. 245 - 266
REM sleep is characterized by rapid eye movements, desynchronized electroencephalographic activity, dreams and muscle paralysis that preclude the individual... 
Human Genetics | Biomedicine | Proteomics | Subcoeruleus nucleus | Parkinson disease | Ventral medial medulla | Molecular Medicine | REM sleep | REM sleep behavior disorder | MOTOR ATONIA | ALPHA-SYNUCLEIN DEPOSITS | PHASIC EVENTS | BRAIN PATHOLOGY | PARADOXICAL SLEEP | LESIONS | RETICULAR-FORMATION | CELL BIOLOGY | RAPID-EYE-MOVEMENT | GABAERGIC NEURONS | SPORADIC PARKINSONS-DISEASE | Animals | REM Sleep Behavior Disorder - physiopathology | Sleep, REM - physiology | Humans | Muscles - physiopathology | Paralysis - physiopathology | Polysomnography | Disease Models, Animal | Sleep disorders | Nervous system diseases | Sleep | Parkinson's disease | Neurons | GABA | Electroencephalography | Genetic engineering | Neuroprotection | Motor neurons | Spinal cord | Animal models | Neurodegenerative diseases | EEG | Reticular formation | Sleep (REM) | Medulla | Twitching | Behavior disorders | Synchronization | Dreams | γ-Aminobutyric acid | Paralysis | Glutamatergic transmission | Tegmentum | Movement disorders | Neurotransmission | EMG
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3. Full Text Dissecting premotor Parkinson's disease with multimodality neuroimaging
by Iranzo, Alex
The Lancet Neurology, ISSN 1474-4422, 07/2018, Volume 17, Issue 7, pp. 574 - 576
Patients with this disorder recall nightmares and have dream-enacting behaviours, while video polysomnography results show excessive motor activity during REM... 
CLINICAL NEUROLOGY | SLEEP BEHAVIOR DISORDER | Neuroimaging | Hypotheses | Parkinson's disease | Sleep | Medical imaging | Neurodegenerative diseases | Neuropathology | Parkinsons disease | Nervous system | Constipation | Movement disorders
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4. Full Text Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions
by Iranzo, Alex, Dr and Santamaria, Joan, MD and Tolosa, Eduardo, MD
Lancet Neurology, The, ISSN 1474-4422, 2016, Volume 15, Issue 4, pp. 405 - 419
Summary Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) manifests as unpleasant dreams and vigorous behaviours during REM sleep that can... 
Neurology | NEURODEGENERATIVE DISEASE | DREAM CONTENT | THERAPY | RISK | PARKINSONIAN DISORDER | ASSOCIATION | EARLY MARKER | CLINICAL NEUROLOGY | SUBSTANTIA-NIGRA ECHOGENICITY | REM-SLEEP | DELAYED EMERGENCE | REM Sleep Behavior Disorder - drug therapy | Neuroprotective Agents | REM Sleep Behavior Disorder - therapy | Humans | Neurodegenerative Diseases - diagnosis | Prodromal Symptoms | REM Sleep Behavior Disorder - diagnosis | Sleep disorders | Development and progression | Nervous system diseases | Parkinson's disease | Sleep | Diagnosis | Studies | Antidepressants | Older people | Parkinsons disease | Eye movements | Behavior | Alzheimers disease | Epidemiology | Patients | Dreams | Dementia
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5. Full Text A forensic sleep thriller
by Iranzo, Alex
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 7, pp. 635 - 635
Neurology
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6. Parasomnias and Sleep-Related Movement Disorders in Older Adults
by Iranzo, Alex
Sleep Medicine Clinics, ISSN 1556-407X, 03/2018, Volume 13, Issue 1, pp. 51 - 61
Parasomnias and sleep-related movement disorders are important problems in older adults. Sleep paralysis is rare, but may occur in families. In a minority of... 
Anti-IgLON5 disease | Restless legs syndrome | Disorders of arousal | Sleep paralysis | Periodic limb movement disorder | Idiopathic REM sleep behavior disorder | Autoimmune Diseases - physiopathology | Parasomnias - physiopathology | Parkinson Disease - complications | Restless Legs Syndrome - physiopathology | Sleep Paralysis | REM Sleep Behavior Disorder - complications | Humans | Autoimmune Diseases - immunology | Dopamine Agonists - therapeutic use | Lewy Body Disease - complications | Multiple System Atrophy - complications | Parkinson Disease - physiopathology | Autoantibodies - immunology | Restless Legs Syndrome - drug therapy | Sleep | REM Sleep Behavior Disorder - physiopathology | Arousal | Aged | Multiple System Atrophy - physiopathology | Nocturnal Myoclonus Syndrome - physiopathology | Cell Adhesion Molecules, Neuronal - immunology | Lewy Body Disease - physiopathology
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7. Full Text Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study
by Iranzo, Alex, Dr and Tolosa, Eduard, Prof and Gelpi, Ellen, MD and Molinuevo, José Luis, MD and Valldeoriola, Francesc, MD and Serradell, Mónica, BSc and Sanchez-Valle, Raquel, MD and Vilaseca, Isabel, MD and Lomeña, Francisco, MD and Vilas, Dolores, MD and LLadó, Albert, MD and Gaig, Carles, MD and Santamaria, Joan, MD
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 5, pp. 443 - 453
Summary Background We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) represents the prodromal phase of a Lewy body... 
Neurology | LEWY-BODY DISEASE | MULTIPLE SYSTEM ATROPHY | ALZHEIMERS ASSOCIATION GUIDELINES | OLFACTORY DYSFUNCTION | NATIONAL INSTITUTE | BRAINNET EUROPE CONSORTIUM | MILD COGNITIVE IMPAIRMENT | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | REM-SLEEP | NEUROPATHOLOGIC ASSESSMENT | Humans | Lewy Body Disease - pathology | Male | Prodromal Symptoms | REM Sleep Behavior Disorder - pathology | Disease Progression | Nerve Degeneration - metabolism | Nerve Degeneration - pathology | Brain - metabolism | Lewy Body Disease - metabolism | Disease-Free Survival | Aged, 80 and over | Brain - pathology | Female | Aged | REM Sleep Behavior Disorder - metabolism | alpha-Synuclein - metabolism | Cohort Studies | Medical research | Nervous system diseases | Sleep | Analysis | Medicine, Experimental | Mental illness | Dementia
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8. Full Text Issue Information - Masthead
Movement Disorders, ISSN 0885-3185, 05/2017, Volume 32, Issue 5, pp. 1 - 1
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9. Full Text Issue Information - Table of Contents
Movement Disorders, ISSN 0885-3185, 05/2017, Volume 32, Issue 5, pp. 1 - 4
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10. Full Text Sleep–wake changes in the premotor stage of Parkinson disease
by Iranzo, Alex
Journal of the Neurological Sciences, ISSN 0022-510X, 2011, Volume 310, Issue 1, pp. 283 - 285
Abstract Longitudinal studies in Parkinson disease (PD) have shown that the prevalence of sleep disorders increases with advanced disease. However, two sleep... 
Neurology | Parkinson disease | Sleep disorders | Excessive daytime sleepiness | REM sleep behavior disorder | BEHAVIOR DISORDER | DAYTIME SLEEPINESS | NEUROSCIENCES | CLINICAL NEUROLOGY | Disorders of Excessive Somnolence - epidemiology | Humans | REM Sleep Behavior Disorder - epidemiology | Aged, 80 and over | Parkinson Disease - epidemiology | Wakefulness - physiology | Male | Aged | Sleep - physiology | Parkinson Disease - physiopathology | Parkinson's disease | Sleep | Prevalence studies (Epidemiology)
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11. Full Text A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study
by Sabater, Lidia, PhD and Gaig, Carles, MD and Gelpi, Ellen, MD and Bataller, Luis, MD and Lewerenz, Jan, MD and Torres-Vega, Estefanía, BSc and Contreras, Angeles, MD and Giometto, Bruno, MD and Compta, Yaroslau, MD and Embid, Cristina, MD and Vilaseca, Isabel, MD and Iranzo, Alex, MD and Santamaría, Joan, MD and Dalmau, Josep, Prof and Graus, Francesc, Dr Prof
Lancet Neurology, The, ISSN 1474-4422, 2014, Volume 13, Issue 6, pp. 575 - 586
Summary Background Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel... 
Neurology | Immunoglobulin G - blood | Sleep Apnea, Obstructive - immunology | Tauopathies - immunology | tau Proteins - immunology | Autoantibodies - blood | Humans | Middle Aged | Tauopathies - pathology | Male | Autoantibodies - biosynthesis | Sleep Apnea, Obstructive - pathology | Immunoglobulin G - biosynthesis | Parasomnias - immunology | Mass Spectrometry | Female | Paraproteins - immunology | REM Sleep Parasomnias - diagnosis | Parasomnias - diagnosis | Polysomnography | Disease Progression | REM Sleep Parasomnias - pathology | Syndrome | REM Sleep Parasomnias - immunology | Tauopathies - diagnosis | Parasomnias - pathology | Aged | Sleep Apnea, Obstructive - diagnosis | Cell Adhesion Molecules, Neuronal - immunology | Viral antibodies | Autoimmunity | Antigens | Nervous system diseases | Sleep | Antibodies | Respiratory tract diseases | Proteins | Sleep disorders | Encephalitis | Intensive care | Neurodegeneration | Insomnia | Colleges & universities | Patients
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12. Sleep in Neurodegenerative Diseases
by Iranzo, Alex
Sleep Medicine Clinics, ISSN 1556-407X, 2016, Volume 11, Issue 1, pp. 1 - 18
Disorders of sleep are an integral part of neurodegenerative diseases and include insomnia, sleep-wake cycle disruption, excessive daytime sleepiness that may... 
Restless legs syndrome | Nocturnal stridor | Insomnia | Parkinson disease | Excessive daytime sleepiness | Obstructive sleep apnea | Periodic leg movements in sleep | REM sleep behavior disorder | Neurodegenerative Diseases - physiopathology | Sleep | Humans | Sleep Wake Disorders - therapy | Neurodegenerative Diseases - therapy | Sleep Wake Disorders - complications | Sleep Wake Disorders - physiopathology | Neurodegenerative Diseases - complications
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13. Full Text ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
by Faraco, J and Lin, L and Kornum, B.R and Kenny, E.E and Trynka, G and Einen, M and Rico, T.J and Lichtner, P and Dauvilliers, Y and Arnulf, I and Leceneux, M and Javidi, S and Geisler, P and Mayer, G and Pizza, F and Poli, F and Plazzi, G and Overeem, S and Lammers, G.J and Kemlink, D and Sonka, K and Nevsimalova, S and Rouleau, G and Desautels, A and Montplaisir, J and Frauscher, B and Ehrmann, L and Hogl, B and Jennum, P and Bourgin, P and Peraita-Aados, R and Iranzo, A and Bassetti, C and Chen, W.M and Concannon, P and Thompson, S.D and Damotte, V and Fontaine, B and Breban, M and Gieger, C and Klopp, N and Deloukas, P and Wijmenga, C and Hallmayer, J and Onengut-Gumuscu, S and Rich, S.S and Winkelmann, J and Mignot, E
PLOS Genetics, ISSN 1553-7390, 2013, Volume 9, Issue 2, p. e1003270
Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for... 
CONFERS SUSCEPTIBILITY | METAANALYSIS | DISEASES | OX40L | GENETICS & HEREDITY | RISK | LOCI | HAPLOTYPE | POLYMORPHISM | GENOME-WIDE ASSOCIATION | Genetic Association Studies | Orexins | Humans | Autoimmune Diseases - immunology | HLA Antigens - immunology | Antigen Presentation - genetics | European Continental Ancestry Group | Intracellular Signaling Peptides and Proteins - immunology | Neuropeptides - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | HLA Antigens - genetics | Antigen Presentation - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | Narcolepsy - physiopathology | Autoimmune Diseases - genetics | Narcolepsy - immunology | Narcolepsy - genetics | Neuropeptides - immunology | Neuropeptides - genetics | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Autoimmune Diseases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Antigens | Physiological aspects | Genetic aspects | Narcolepsy | Disease susceptibility | Research | T cells | Gene expression | Health aspects | Haplotypes | Health sciences | Genealogy | Disease | Principal components analysis | T cell receptors | Genomes | Grants | Confidence intervals | Sleep disorders | Lymphocytes | Genetics | Autoimmune diseases
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14. Full Text Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study
by Iranzo, Alex, Dr and Valldeoriola, Francesc, MD and Lomeña, Francisco, MD and Molinuevo, José Luis, MD and Serradell, Mónica, BSc and Salamero, Manel, MD and Cot, Albert, MD and Ros, Domènec, MD and Pavía, Javier, PhD and Santamaria, Joan, MD and Tolosa, Eduardo, Prof
Lancet Neurology, The, ISSN 1474-4422, 2011, Volume 10, Issue 9, pp. 797 - 805
Summary Background Serial dopamine transporter (DAT) imaging in patients with Parkinson's disease (PD) and other synucleinopathies shows progressive... 
Neurology | NEURODEGENERATIVE DISEASE | NONLINEAR PROGRESSION | DEMENTIA | NETWORK ACTIVITY | FOLLOW-UP | BINDING | EARLY PARKINSONS-DISEASE | LEWY BODIES | SPECT | CLINICAL NEUROLOGY | DELAYED EMERGENCE | Dopamine Plasma Membrane Transport Proteins - metabolism | Tomography, Emission-Computed, Single-Photon - methods | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Male | Substantia Nigra - metabolism | Corpus Striatum - metabolism | REM Sleep Behavior Disorder - diagnostic imaging | Substantia Nigra - diagnostic imaging | Time Factors | Female | Aged | Corpus Striatum - diagnostic imaging | REM Sleep Behavior Disorder - metabolism | Cohort Studies | Medical research | Care and treatment | Parkinson's disease | Sleep | Tracers (Biology) | Medicine, Experimental | Phenols | Mental illness | Neuroimaging | Dopamine | Neurodegenerative diseases | Cortex (occipital) | Sleep (REM) | Putamen | Single photon emission computed tomography | Caudate nucleus | Neostriatum | Dopamine transporter | Degeneration | Movement disorders | Tracers
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15. Full Text Movement Disorders: Volume 32, Number 5, May 2017
by Silber, Michael H and Iranzo, Alex
Movement Disorders, ISSN 0885-3185, 05/2017, Volume 32, Issue 5, pp. 1 - 1
Movement disorders
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16. Full Text Parkinson Disease and Sleep: Sleep–Wake Changes in the Premotor Stage of Parkinson Disease; Impaired Olfaction and Other Prodromal Features
by Iranzo, Alex
Current Neurology and Neuroscience Reports, ISSN 1528-4042, 9/2013, Volume 13, Issue 9, pp. 1 - 9
Parkinson disease (PD) has a premotor stage where neurodegeneration occurs before parkinsonism becomes apparent. Identification of individuals at this stage... 
Sleep–wake changes | Neurology | Neurosciences | Olfactory dysfunction | Sleep | Medicine & Public Health | Excessive daytime sleepiness REM sleep behavior disorder | Premotor stage | Parkinson disease | Disease-modifying interventions | Depression | Constipation | Sleep-wake changes | LEWY-BODY DISEASE | BEHAVIOR DISORDER | NEURODEGENERATIVE DISEASE | DAYTIME SLEEPINESS | COGNITIVE IMPAIRMENT | RISK | ALPHA-SYNUCLEIN | BRAIN PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | ODOR IDENTIFICATION | REM-SLEEP | Development and progression | Parkinson's disease | Depression, Mental
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17. Full Text Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study
by Iranzo, Alex, Dr and Lomeña, Francisco, MD and Stockner, Heike, MD and Valldeoriola, Francesc, MD and Vilaseca, Isabel, MD and Salamero, Manel, PhD and Molinuevo, Jose Luis, MD and Serradell, Monica, BSc and Duch, Joan, MD and Pavía, Javier, PhD and Gallego, Judith, MD and Seppi, Klaus, MD and Högl, Birgit, MD and Tolosa, Eduard, Prof and Poewe, Werner, Prof and Santamaria, Joan, MD and Sleep Innsbruck Barcelona SINBAR and Sleep Innsbruck Barcelona (SINBAR) group
Lancet Neurology, The, ISSN 1474-4422, 2010, Volume 9, Issue 11, pp. 1070 - 1077
Summary Background Patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) may develop neurodegenerative conditions associated with... 
Neurology | I-123-FP-CIT SPECT | MULTIPLE SYSTEM ATROPHY | DIFFERENTIAL-DIAGNOSIS | DEMENTIA | FP-CIT-SPECT | TRANSCRANIAL SONOGRAPHY | EARLY PARKINSONS-DISEASE | LEWY BODIES | ESSENTIAL TREMOR | CLINICAL NEUROLOGY | DEGENERATION | Biomarkers - metabolism | Dopamine Plasma Membrane Transport Proteins - metabolism | Tomography, Emission-Computed, Single-Photon - methods | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Male | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Synucleins - metabolism | REM Sleep Behavior Disorder - diagnostic imaging | Substantia Nigra - diagnostic imaging | Female | Aged | Corpus Striatum - diagnostic imaging | REM Sleep Behavior Disorder - metabolism | Protein Binding - physiology | Phenols | Care and treatment | Sleep | Mental illness | Basal ganglia
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