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1. Serious Non-AIDS Events: Therapeutic Targets of Immune Activation and Chronic Inflammation in HIV Infection
by Hsu, Denise C and Sereti, Irini
Drugs, ISSN 0012-6667, 04/2016, Volume 76, Issue 5, pp. 533 - 549
In the antiretroviral therapy (ART) era, serious non-AIDS events (SNAEs) have become the major causes of morbidity and mortality in HIV-infected persons. Early... 
C-REACTIVE PROTEIN | SUSTAINED VIROLOGICAL RESPONSE | INDIVIDUAL PARTICIPANT METAANALYSIS | ACTIVE ANTIRETROVIRAL THERAPY | T-CELL-ACTIVATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PLACEBO-CONTROLLED TRIAL | HUMAN-IMMUNODEFICIENCY-VIRUS | CORONARY-HEART-DISEASE | HEPATITIS-C | TISSUE FACTOR EXPRESSION | HIV-1 - drug effects | Humans | Inflammation - immunology | Acquired Immunodeficiency Syndrome - drug therapy | Randomized Controlled Trials as Topic | Acquired Immunodeficiency Syndrome - immunology | HIV Infections - immunology | Clinical Trials, Phase III as Topic | HIV-1 - immunology | Inflammation - drug therapy | Lymphocyte Activation - drug effects | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Antiretroviral Therapy, Highly Active - methods
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2. Full Text Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection
by Netanya G. Sandler and Handan Wand and Annelys Roque and Matthew Law and Martha C. Nason and Daniel E. Nixon and Court Pedersen and Kiat Ruxrungtham and Sharon R. Lewin and Sean Emery and James D. Neaton and Jason M. Brenchley and Steven G. Deeks and Irini Sereti and Daniel C. Douek and INSIGHT SMART Study Grp and INSIGHT SMART Study Group
The Journal of Infectious Diseases, ISSN 0022-1899, 3/2011, Volume 203, Issue 6, pp. 780 - 790
Background. Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to... 
T lymphocytes | HIV/AIDS | HIV infections | Enterocytes | HIV | RNA | Mortality | Ribosomal DNA | AIDS | Biological markers | Operating rooms | VIRAL LOAD | INFECTIOUS DISEASES | GASTROINTESTINAL-TRACT | ENDOTOXIN | MICROBIOLOGY | IMMUNOLOGY | ACTIVE ANTIRETROVIRAL THERAPY | T-CELL-ACTIVATION | DISEASE | IMMUNE ACTIVATION | LIPOPOLYSACCHARIDE | MICROBIAL TRANSLOCATION | EXPRESSION | HIV Infections - blood | Humans | Middle Aged | Logistic Models | Male | Biomarkers - blood | Case-Control Studies | Cause of Death | Lipopolysaccharide Receptors - blood | Young Adult | Lipopolysaccharides - blood | RNA, Viral | Fatty Acid-Binding Proteins - blood | Adult | HIV Infections - mortality | CD4-Positive T-Lymphocytes | Natural immunity | Immune response | Research | HIV infection | Patient outcomes | Major and Brief Reports
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3. Full Text Immune reconstitution inflammatory syndrome: The trouble with immunity when you had none
by Barber, Daniel L and Andrade, Bruno B and Sereti, Irini and Sher, Alan
Nature Reviews Microbiology, ISSN 1740-1526, 02/2012, Volume 10, Issue 2, pp. 150 - 156
Some individuals who are infected with HIV rapidly deteriorate shortly after starting antiretroviral therapy, despite effective viral suppression. This... 
MYCOBACTERIUM-TUBERCULOSIS | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | ORGAN TRANSPLANT RECIPIENTS | RISK-FACTORS | PNEUMOCYSTIS-CARINII-PNEUMONIA | CD4(+) T-CELLS | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | RESTORATION DISEASE | HOMEOSTATIC PROLIFERATION | HIV-INFECTED PATIENTS | Antibodies, Monoclonal, Humanized - adverse effects | Immune Reconstitution Inflammatory Syndrome - etiology | Antibodies, Monoclonal, Humanized - therapeutic use | Natalizumab | Immune Reconstitution Inflammatory Syndrome - immunology | AIDS-Related Opportunistic Infections - immunology | Humans | Risk Factors | HIV Infections - immunology | Immunity, Innate - immunology | Models, Immunological | Animals | Immune Tolerance - immunology | Immunity, Innate - physiology | Multiple Sclerosis - immunology | HIV Infections - drug therapy | Lymphopenia - immunology | Mice | Disease Models, Animal | Multiple Sclerosis - drug therapy | Immunotherapy | Physiological aspects | Development and progression | Inflammation | Research | T cells | Health aspects | HIV infection | Risk factors
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4. Full Text Higher Levels of CRP, D-dimer, IL-6, and Hyaluronic Acid Before Initiation of Antiretroviral Therapy (ART) Are Associated With Increased Risk of AIDS or Death
by David R. Boulware and Katherine Huppler Hullsiek and Camille E. Puronen and Adam Rupert and Jason V. Baker and Martyn A. French and Paul R. Bohjanen and Richard M. Novak and James D. Neaton and Irini Sereti and INSIGHT Study Grp and INSIGHT Study Group
The Journal of Infectious Diseases, ISSN 0022-1899, 6/2011, Volume 203, Issue 11, pp. 1637 - 1646
Background. Substantial morbidity occurs during the first year of antiretroviral therapy (ART) in persons with advanced human immunodeficiency virus (HIV)... 
HIV/AIDS | Antiretrovirals | Hepatitis | HIV | RNA | Interleukins | Mortality | AIDS | Infections | Biological markers | Arts | MORTALITY | INFECTIOUS DISEASES | TUBERCULOSIS | MICROBIOLOGY | IMMUNOLOGY | IMMUNE RESTORATION DISEASE | INDIVIDUALS | CASE DEFINITIONS | INTERFERON-ALPHA | HIV-INFECTION | MORBIDITY | RECONSTITUTION INFLAMMATORY SYNDROME | PROGRESSION | Biomarkers - metabolism | HIV Infections - blood | Anti-Retroviral Agents - therapeutic use | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Middle Aged | Risk Factors | Immune Reconstitution Inflammatory Syndrome - blood | Male | RNA, Viral - blood | Biomarkers - blood | Acquired Immunodeficiency Syndrome - drug therapy | Case-Control Studies | Disease Progression | Morbidity | C-Reactive Protein - metabolism | Immune Reconstitution Inflammatory Syndrome - virology | Interleukin-6 - blood | Adult | Female | HIV Infections - drug therapy | Acquired Immunodeficiency Syndrome - blood | Hyaluronic Acid - blood | Antiviral agents | Complications and side effects | Composition | Care and treatment | AIDS (Disease) | Causes of | HIV patients | Dosage and administration | Health aspects | Major and Brief Reports
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5. Full Text Where have all the T cells gone?
by Sereti, Irini
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 4, pp. 751 - 752
In this issue of Blood, Beq and colleagues describe the massive yet transient exodus of T cells from peripheral blood to lymph nodes, skin, and gut lymphoid... 
HEMATOLOGY | EXPANSION
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6. Full Text Changing lanes in ICL
by Sereti, Irini
Blood, ISSN 0006-4971, 05/2010, Volume 115, Issue 18, pp. 3648 - 3649
HEMATOLOGY | T-CELLS | IDIOPATHIC CD4+ LYMPHOCYTOPENIA
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7. Residual Immune Activation and Latency
by Bruzzesi, Elena and Sereti, Irini
Current Topics in Microbiology and Immunology, ISSN 0070-217X, 2018, Volume 417, pp. 157 - 180
The introduction of combination antiretroviral therapy (cART) in the 1990s has dramatically changed the course of HIV infection, decreasing the risk for both... 
LYMPHATIC TISSUE FIBROSIS | HUMAN CYTOMEGALOVIRUS TROPISM | INCREASED RISK | PRIMARY HIV-1 INFECTION | CD4(+) T-CELLS | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | VIRUS TYPE-1 INFECTION | MICROBIAL TRANSLOCATION | RALTEGRAVIR INTENSIFICATION | VIRAL RESERVOIR
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8. Full Text Impact of multi-targeted antiretroviral treatment on gut t cell depletion and hiv reservoir seeding during acute hiv infection
by Ananworanich, Jintanat and Schuetz, Alexandra and Vandergeeten, Claire and Sereti, Irini and Souza Mark, M and Rerknimitr, Rungsun and Dewar, Robin and Marovich, Mary and Griensven Frits, F and Sekaly, Rafick and Pinyakorn, Suteeraporn and Phanuphak, Nittaya and Trichavaroj, Rapee and Rutvisuttinunt, Wiriya and Chomchey, Nitiya and Paris, Robert and Peel, Sheila and Valcour, Victor and Maldarelli, Frank and Chomont, Nicolas and Michael, Nelson and Phanuphak, Praphan and Kim, Jerome H and RV and RV254/SEARCH 010 Study Group and on behalf of the RV254/SEARCH 010 Study Group
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33948
Background: Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest... 
THERAPY | REPLICATION | RALTEGRAVIR | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | IMMUNE ACTIVATION | DYNAMICS | RISK | RESTORATION | INTENSIFICATION | INTERRUPTION | HIV Infections - virology | Humans | Male | Treatment Outcome | CD4 Lymphocyte Count | Leukocytes, Mononuclear - virology | Intestines - immunology | Viral Load | Antiretroviral Therapy, Highly Active | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - immunology | Receptors, CCR5 - metabolism | Intestines - virology | Adult | Female | HIV Infections - drug therapy | T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - virology | Virus Latency - immunology | Cytokines - blood | Medical research | Antiviral agents | Usage | RNA | Biological products industry | Development and progression | T cells | HIV (Viruses) | Anti-HIV agents | Highly active antiretroviral therapy | Medicine, Experimental | Health aspects | HIV infection | Laboratories | Viruses | Infections | Lymphocytes T | Medical diagnosis | Seeding | Efavirenz | Blood | Tenofovir | Restoration | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Antiretroviral agents | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Remission | Armed forces | Drug therapy | Public health | Deoxyribonucleic acid--DNA | Emtricitabine | Antiretroviral drugs | CCR5 protein | Research & development--R&D | Ribonucleic acid--RNA | Disease control | CD4 antigen | Medicine | Depletion | Collaboration | Gene therapy | Research & development | Acquired immune deficiency syndrome | Deoxyribonucleic acid | Ribonucleic acid | AIDS | R&D | HIV | DNA | Human immunodeficiency virus
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9. Full Text Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation
by Schuetz, Alexandra and Deleage, Claire and Sereti, Irini and Rerknimitr, Rungsun and Phanuphak, Nittaya and Phuang-Ngern, Yuwadee and Estes, Jacob D and Sandler, Netanya G and Sukhumvittaya, Suchada and Marovich, Mary and Jongrakthaitae, Surat and Akapirat, Siriwat and Fletscher, James L. K and Kroon, Eugene and Dewar, Robin and Trichavaroj, Rapee and Chomchey, Nitiya and Douek, Daniel C and O′Connell, Robert J and Ngauy, Viseth and Robb, Merlin L and Phanuphak, Praphan and Michael, Nelson L and Excler, Jean-Louis and Kim, Jerome H and de Souza, Mark S and Ananworanich, Jintanat and RV254 SEARCH 010 Study Grp and RV304 SEARCH 013 Study Grp and RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups and on behalf of the RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups
PLoS Pathogens, ISSN 1553-7366, 12/2014, Volume 10, Issue 12, p. e1004543
Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is... 
MICROBIOLOGY | ANTIRETROVIRAL THERAPY | PERIPHERAL LYMPHOCYTES | HUMAN-IMMUNODEFICIENCY-VIRUS | TYPE-1 INFECTION | VIROLOGY | LYMPHOID-TISSUE | LENTIVIRAL INFECTIONS | REGULATORY T-CELLS | GENE-EXPRESSION | MICROBIAL TRANSLOCATION | PARASITOLOGY | DISEASE PROGRESSION | Acute Disease | Anti-Retroviral Agents - therapeutic use | Th17 Cells - physiology | Prospective Studies | Humans | Middle Aged | Anti-Retroviral Agents - pharmacology | Male | Treatment Outcome | Biomarkers - blood | Immunity, Mucosal - drug effects | Intestinal Mucosa - physiology | HIV Infections - pathology | Time Factors | Biopsy | Adult | Female | HIV Infections - drug therapy | Immunity, Mucosal - physiology | HIV Infections - physiopathology | Colon, Sigmoid - pathology | Cytokines - blood | Intestinal Mucosa - pathology | Th17 Cells - pathology | Prevention | Antiviral agents | Dosage and administration | Host-virus relationships | Drug therapy | T cells | HIV infection | Health aspects | Antiretroviral drugs | Laboratories | Mortality | AIDS | Infections | Blood | Immunology | HIV | Acquired immune deficiency syndrome | Lymphocytes | Human immunodeficiency virus | Immune system
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10. Full Text HIV infection and immune activation: the role of coinfections
by Boulougoura, Afroditi and Sereti, Irini
Current Opinion in HIV and AIDS, ISSN 1746-630X, 03/2016, Volume 11, Issue 2, pp. 191 - 200
PURPOSE OF REVIEWThis article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a... 
immune reconstitution inflammatory syndrome | myeloid cells | innate immunity | biomarkers | tuberculosis | INTIMA-MEDIA THICKNESS | INFECTIOUS DISEASES | SIMPLEX-VIRUS TYPE-2 | OPPORTUNISTIC INFECTIONS | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | CEREBROSPINAL-FLUID | HEPATITIS-C VIRUS | RECONSTITUTION INFLAMMATORY SYNDROME | T-CELL-ACTIVATION | CRYPTOCOCCAL MENINGITIS | HIV Infections - immunology | Immune Reconstitution Inflammatory Syndrome - physiopathology | Coinfection | Immune Reconstitution Inflammatory Syndrome - immunology | Humans | Immune Reconstitution Inflammatory Syndrome - complications | HIV Infections - complications | Biomarkers | HIV Infections - physiopathology | Immunity, Innate
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11. Full Text Upbeat nystagmus in an HIV-positive patient with a tuberculoma in the medulla
by Coleman, Benjamin W and Sereti, Irini and Bishop, Rachel and Smith, Bryan R
The Lancet Infectious Diseases, ISSN 1473-3099, 02/2018, Volume 18, Issue 2, pp. 225 - 225
A 33-year-old woman, with HIV infection (CD4 count of 13 cells per μL; viral load of 1·2 x 106 copies per mL) and Mycobacterium tuberculosis diagnosed 2 months... 
INFECTIOUS DISEASES | Nystagmus, Pathologic - pathology | Tuberculosis, Central Nervous System - diagnostic imaging | Brain - diagnostic imaging | Tuberculoma - diagnostic imaging | Humans | Tuberculosis, Central Nervous System - complications | Tuberculoma - complications | Magnetic Resonance Imaging | HIV Infections - complications | Brain - pathology | Adult | Female | Nystagmus, Pathologic - etiology | Tuberculoma | Medulla | Tuberculosis | Brain research | Human immunodeficiency virus--HIV | Nystagmus
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12. Full Text Immune activation and HIV: an enduring relationship
by Sereti, Irini and Altfeld, Marcus
Current Opinion in HIV and AIDS, ISSN 1746-630X, 03/2016, Volume 11, Issue 2, pp. 129 - 130
INFECTIOUS DISEASES | INFECTION | IMMUNOLOGY | LOAD | T-CELLS | HIV Infections - immunology | HIV-1 - immunology | Animals | Humans | Primates | HIV Infections - transmission | Host-Pathogen Interactions - immunology
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13. Full Text Risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred ART during an opportunistic infection
by Grant, Philip M and Komarow, Lauren and Andersen, Janet and Sereti, Irini and Pahwa, Savita and Lederman, Michael M and Eron, Joseph and Sanne, Ian and Powderly, William and Hogg, Evelyn and Suckow, Carol and Zolopa, Andrew
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, p. e11416
Background: Immune reconstitution inflammatory syndrome (IRIS) is reported widely in patients initiating antiretroviral therapy (ART). However, few studies are... 
MORTALITY | ANTIRETROVIRAL THERAPY | HIV | INITIATION | MULTIDISCIPLINARY SCIENCES | CRYPTOCOCCAL MENINGITIS | Immune Reconstitution Inflammatory Syndrome - etiology | Anti-Retroviral Agents - therapeutic use | Humans | Middle Aged | Risk Factors | Anti-Retroviral Agents - adverse effects | Anti-Retroviral Agents - pharmacology | Proportional Hazards Models | Male | HIV - drug effects | Young Adult | Analysis of Variance | Time Factors | T-Lymphocyte Subsets - drug effects | Opportunistic Infections - drug therapy | Adult | Female | RNA, Viral - metabolism | Infection | Antiviral agents | Medical research | Highly active antiretroviral therapy | Tuberculosis | RNA | Immunotherapy | Medicine, Experimental | Mycoses | T cells | Health aspects | Risk factors | Corticoids | Antiretroviral drugs | Bacterial infections | Corticosteroids | Opportunist infection | Immune reconstitution | Lymphocytes T | Inflammation | Infections | Regression analysis | Ribonucleic acid--RNA | Medical diagnosis | Patients | Antiretroviral therapy | CD4 antigen | Fungi | Immunosuppression | Randomization | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Acquired immune deficiency syndrome | Ribonucleic acid | AIDS | Human immunodeficiency virus
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14. Full Text HIV Infection and Immune activation: the role of co-infections
by Boulougoura, Afroditi and Sereti, Irini
Current opinion in HIV and AIDS, ISSN 1746-630X, 3/2016, Volume 11, Issue 2, pp. 191 - 200
Immune reconstitution inflammatory syndrome | Biomarkers | Innate immunity | Myeloid cells | Tuberculosis
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