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1. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
by Wiegand, Irith and Hilpert, Kai and Hancock, Robert E.W
Nature Protocols, ISSN 1754-2189, 02/2008, Volume 3, Issue 2, pp. 163 - 175
The aim of broth and agar dilution methods is to determine the lowest concentration of the assayed antimicrobial agent (minimal inhibitory concentration, MIC)... 
HOST-DEFENSE PEPTIDES | BROAD-SPECTRUM | ETEST | PSEUDOMONAS-AERUGINOSA | SUSCEPTIBILITY | BIOCHEMICAL RESEARCH METHODS | RESISTANCE | TETRACYCLINE | IN-VITRO ACTIVITY | ENTEROBACTERIACEAE | PENICILLIN | Time Factors | Culture Media | Agar | Drug Resistance, Bacterial | Bacteria, Aerobic - drug effects | Anti-Bacterial Agents - pharmacology | Microbial Sensitivity Tests - methods
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2. Full Text Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS
by Fernández, Lucía and Gooderham, W. James and Bains, Manjeet and McPhee, Joseph B and Wiegand, Irith and Hancock, Robert E. W
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2010, Volume 54, Issue 8, pp. 3372 - 3382
As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly being used in the clinic to treat serious Pseudomonas aeruginosa... 
LIPID-A | SALMONELLA-TYPHIMURIUM | PMRA-PMRB | PHOP-PHOQ | LIPOPOLYSACCHARIDE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CATIONIC ANTIMICROBIAL PEPTIDES | CYSTIC-FIBROSIS AIRWAY | SENSOR KINASE | EXPRESSION | BIOFILM FORMATION | Adaptation, Physiological | Polymyxin B - pharmacology | Signal Transduction | Humans | Bacterial Proteins - genetics | Repressor Proteins - genetics | Pseudomonas aeruginosa - drug effects | Microbial Sensitivity Tests | Colistin - pharmacology | Pseudomonas aeruginosa - genetics | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Mutation | Drug Resistance, Bacterial - genetics | Gene Expression Regulation, Bacterial | Repressor Proteins - metabolism
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3. Full Text The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS
by Lucía Fernández and Håvard Jenssen and Manjeet Bains and Irith Wiegand and W. James Gooderham and Robert E. W. Hancock
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2012, Volume 56, Issue 12, pp. 6212 - 6222
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CELL ENVELOPES | DESIGN | CHEMICAL ALTERATIONS | PMRA-PMRB | PHOP-PHOQ | CLASSIFICATION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ANTIMICROBIAL PEPTIDES | EXPRESSION | POLYMYXIN-B | REGULATORY SYSTEM | Polymyxin B - pharmacology | Protein Kinases - genetics | Pseudomonas aeruginosa - growth & development | Peptides - genetics | Molecular Sequence Data | Pseudomonas aeruginosa - physiology | Genetic Complementation Test | Microbial Sensitivity Tests | Cations - pharmacology | Microarray Analysis | Anti-Bacterial Agents - chemistry | Computer Simulation | DNA Transposable Elements - genetics | Plasmids - genetics | Drug Resistance, Bacterial - genetics | Amino Acid Sequence | Cations - chemistry | Peptides - physiology | Bacterial Proteins - genetics | Bacterial Proteins - physiology | Operon - genetics | Pseudomonas aeruginosa - genetics | Protein Kinases - physiology | Drug Resistance, Bacterial - physiology | Anti-Bacterial Agents - pharmacology | Mechanisms of Resistance
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4. Full Text Genetic Determinants Involved in the Susceptibility of Pseudomonas aeruginosa to β-Lactam Antibiotics
by Carolina Alvarez-Ortega and Irith Wiegand and Jorge Olivares and Robert E. W. Hancock and José Luis Martínez
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2010, Volume 54, Issue 10, pp. 4159 - 4167
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RESISTANCE MECHANISMS | CELL-DIVISION | AMPC | CYSTIC-FIBROSIS PATIENTS | MUTANT LIBRARY | ESCHERICHIA-COLI | BIOCHEMICAL-CHARACTERIZATION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MEXAB-OPRM | EXPRESSION | MEXCD-OPRJ | Microbial Sensitivity Tests | Phenotype | beta-Lactams - pharmacology | beta-Lactamases - genetics | Pseudomonas aeruginosa - genetics | Bacterial Proteins - genetics | Serine Endopeptidases - genetics | Mutation | Pseudomonas aeruginosa - drug effects | Sigma Factor - genetics | Genetic Complementation Test | Mechanisms of Resistance
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5. Full Text Characterization of the Polymyxin B Resistome of Pseudomonas aeruginosa
by Lucía Fernández and Carolina Álvarez-Ortega and Irith Wiegand and Jorge Olivares and Dana Kocíncová and Joseph S. Lam and José Luis Martínez and Robert E. W. Hancock
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2013, Volume 57, Issue 1, pp. 110 - 119
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POLYACRYLAMIDE-GELS | 2-COMPONENT REGULATORY SYSTEM | OUTER-MEMBRANE | GENETIC-DETERMINANTS | CYSTIC-FIBROSIS PATIENTS | IN-VIVO | PMRA-PMRB | PHOP-PHOQ | RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CORE OLIGOSACCHARIDE | Polymyxin B - pharmacology | Genes, Bacterial | Gene Library | Transcriptome | Pseudomonas aeruginosa - drug effects | DNA Transposable Elements | Lipopolysaccharides - genetics | Cell Membrane - chemistry | Pseudomonas aeruginosa - genetics | Cell Membrane Permeability - drug effects | Anti-Bacterial Agents - pharmacology | Cell Membrane - metabolism | Lipopolysaccharides - chemistry | Mutation | Drug Resistance, Bacterial - genetics | Cell Membrane - drug effects | Mechanisms of Resistance
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6. Full Text Detection of Extended-Spectrum Beta-Lactamases among Enterobacteriaceae by Use of Semiautomated Microbiology Systems and Manual Detection Procedures
by Irith Wiegand and Heinrich K. Geiss and Dietrich Mack and Enno Stürenburg and Harald Seifert
Journal of Clinical Microbiology, ISSN 0095-1137, 04/2007, Volume 45, Issue 4, pp. 1167 - 1174
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STRAINS | ETEST ESBL | TESTS | CEFEPIME | ESCHERICHIA-COLI | CONFIRMATION PANEL | KLEBSIELLA | RESISTANCE | MICROBIOLOGY | BD PHOENIX | PREVALENCE | Morganella morganii - enzymology | Predictive Value of Tests | Enterobacteriaceae - enzymology | beta-Lactam Resistance | Serratia marcescens - drug effects | Escherichia coli - drug effects | Enterobacter - enzymology | beta-Lactamases - biosynthesis | Morganella morganii - genetics | Morganella morganii - drug effects | Citrobacter freundii - drug effects | beta-Lactamases - genetics | beta-Lactamases - analysis | Sensitivity and Specificity | Serratia marcescens - enzymology | Citrobacter freundii - genetics | Proteus - genetics | Enterobacter - genetics | Escherichia coli - enzymology | Klebsiella - genetics | Enterobacteriaceae - genetics | Klebsiella - enzymology | Proteus - drug effects | Proteus - enzymology | Serratia marcescens - genetics | Klebsiella - drug effects | Escherichia coli - genetics | Enterobacteriaceae - drug effects | Citrobacter freundii - enzymology | Enterobacter - drug effects | Microbial Sensitivity Tests - methods | Bacteriology
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7. Full Text Complex Ciprofloxacin Resistome Revealed by Screening a Pseudomonas aeruginosa Mutant Library for Altered Susceptibility
by Elena B. M. Breidenstein and Bhavjinder K. Khaira and Irith Wiegand and Joerg Overhage and Robert E. W. Hancock
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2008, Volume 52, Issue 12, pp. 4486 - 4491
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RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MECHANISMS | CYSTIC-FIBROSIS | GYRASE | Microbial Sensitivity Tests | Gene Library | Pseudomonas aeruginosa - genetics | Fluoroquinolones - pharmacology | Humans | Bacterial Proteins - genetics | Ciprofloxacin - pharmacology | Drug Resistance, Bacterial | Anti-Bacterial Agents - pharmacology | Mutation | Pseudomonas aeruginosa - drug effects | Mechanisms of Resistance
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8. Full Text Induction by Cationic Antimicrobial Peptides and Involvement in Intrinsic Polymyxin and Antimicrobial Peptide Resistance, Biofilm Formation, and Swarming Motility of PsrA in Pseudomonas aeruginosa
by W. James Gooderham and Manjeet Bains and Joseph B. McPhee and Irith Wiegand and Robert E. W. Hancock
Journal of Bacteriology, ISSN 0021-9193, 08/2008, Volume 190, Issue 16, pp. 5624 - 5634
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Biofilms - drug effects | Oligonucleotide Array Sequence Analysis | Antimicrobial Cationic Peptides - pharmacology | Drug Resistance, Bacterial | Transcription Factors - biosynthesis | Gene Expression Profiling | Pseudomonas aeruginosa - physiology | Microbial Viability | Permeability | Pseudomonas aeruginosa - drug effects | Genetic Complementation Test | Bacterial Adhesion | Polymyxins - pharmacology | Gene Deletion | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - biosynthesis | Mutagenesis, Insertional | DNA-Binding Proteins - biosynthesis | Locomotion - drug effects | Physiological aspects | Pseudomonas aeruginosa | Anti-infective agents | Genetic aspects | Research | Peptides | Index Medicus | Gene Regulation
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9. Full Text Swarming of Pseudomonas aeruginosa Is Controlled by a Broad Spectrum of Transcriptional Regulators, Including MetR
by Amy T. Y. Yeung and Ellen C. W. Torfs and Farzad Jamshidi and Manjeet Bains and Irith Wiegand and Robert E. W. Hancock and Joerg Overhage
Journal of Bacteriology, ISSN 0021-9193, 09/2009, Volume 191, Issue 18, pp. 5592 - 5602
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METHIONINE SYNTHESIS | VIRULENCE FACTORS | QUORUM | GLYA GENE | FLAGELLAR | ESCHERICHIA-COLI | GENE-EXPRESSION | MICROBIOLOGY | RHAMNOLIPID SYNTHESIS | BIOFILM FORMATION | MOTILITY | Oligonucleotide Array Sequence Analysis | Signal Transduction | Bacterial Proteins - genetics | Gene Expression Profiling | Pseudomonas aeruginosa - physiology | DNA Transposable Elements | DNA, Bacterial - genetics | ATP-Binding Cassette Transporters - genetics | Pseudomonas aeruginosa - genetics | Pseudomonas aeruginosa - metabolism | Trans-Activators - genetics | ATP-Binding Cassette Transporters - metabolism | Bacterial Proteins - metabolism | Trans-Activators - metabolism | Mutagenesis, Insertional | Mutation | Gene Expression Regulation, Bacterial | Physiological aspects | Pseudomonas aeruginosa | Genetic transcription | Research | Bacterial genetics | Index Medicus | Physiology and Metabolism
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10. Full Text Novel Genetic Determinants of Low-Level Aminoglycoside Resistance in Pseudomonas aeruginosa
by Kristen N. Schurek and Alexandra K. Marr and Patrick K. Taylor and Irith Wiegand and Lucie Semenec and Bhavjinder K. Khaira and Robert E. W. Hancock
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2008, Volume 52, Issue 12, pp. 4213 - 4219
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CELLS | TRANSPORT | BAND LIPOPOLYSACCHARIDE | A-BAND | MUTANT LIBRARY | MEMBRANE | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | GENTAMICIN | STREPTOMYCIN | Genes, Bacterial | Gene Library | Humans | Pseudomonas aeruginosa - growth & development | Tobramycin - pharmacology | Bacterial Proteins - genetics | Pseudomonas aeruginosa - drug effects | DNA Transposable Elements | Microbial Sensitivity Tests | Pseudomonas aeruginosa - genetics | Culture Media | Anti-Bacterial Agents - pharmacology | Mutation | Aminoglycosides - pharmacology | Drug Resistance, Bacterial - genetics | Mechanisms of Resistance
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11. Full Text The intrinsic resistome of Pseudomonas aeruginosa to β-lactams
by Alvarez-Ortega, Carolina and Wiegand, Irith and Olivares, Jorge and Hancock, Robert E.W and Martínez, José Luis
Virulence, ISSN 2150-5594, 03/2011, Volume 2, Issue 2, pp. 144 - 146
Pseudomonas aeruginosa is a relevant opportunistic pathogen particularly problematic due to its low intrinsic susceptibility to antibiotics. Intrinsic... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Pseudomonas aeruginosa | Intrinsic resistance | Resistome | β-lactam resistance | β-lactamase | BACTERIA | INFECTIONS | ESCHERICHIA-COLI | SUSCEPTIBILITY | ANTIBIOTIC-RESISTANCE | resistome | MICROBIOLOGY | MECHANISMS | IMMUNOLOGY | EFFLUX | GENETIC-DETERMINANTS | ADAPTATION | beta-lactamase | beta-lactam resistance | HYPERMUTATION | Genes, Bacterial | beta-Lactam Resistance | beta-Lactams - pharmacology | DNA, Bacterial - genetics | Pseudomonas aeruginosa - genetics | Humans | Anti-Bacterial Agents - pharmacology | Mutagenesis, Insertional | Pseudomonas aeruginosa - drug effects | Pseudomonas Infections - microbiology | DNA Transposable Elements
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12. Full Text Surveillance for control of antimicrobial resistance
by Tacconelli, Evelina and Sifakis, Frangiscos and Harbarth, Stephan and Schrijver, Remco and van Mourik, Maaike and Voss, Andreas and Sharland, Mike and Rajendran, Nithya Babu and Rodríguez-Baño, Jesús and Bielicki, Julia and de Kraker, Marlieke and Gandra, Sumanth and Gastmeier, Petra and Gilchrist, Kim and Gikas, Achilleas and Gladstone, Beryl Primrose and Goossens, Herman and Jafri, Hasan and Kahlmeter, Gunnar and Leus, Frank and Luxemburger, Christine and Malhotra-Kumar, Surbhi and Marasca, Giuseppe and McCarthy, Michael and Navarro, María Dolores and Nuñez-Nuñez, María and Oualim, Abdel and Price, Jessica and Robert, Jérôme and Sommer, Harriet and von Cube, Maja and Vuong, Cuong and Wiegand, Irith and Witschi, Anne Therese and Wolkewitz, Martin and EPI-Net COMBACTE-MAGNET Grp and EPI-Net COMBACTE-MAGNET Group
The Lancet Infectious Diseases, ISSN 1473-3099, 03/2018, Volume 18, Issue 3, pp. e99 - e106
Antimicrobial resistance poses a growing threat to public health and the provision of health care. Its surveillance should provide up-to-date and relevant... 
INFECTIOUS DISEASES | Animals | Humans | Bacteria - drug effects | Bacterial Infections - epidemiology | Drug Resistance, Bacterial | Europe - epidemiology | Anti-Bacterial Agents - pharmacology | Population Surveillance | Bacterial Infections - microbiology | Health care | Regulators | Target recognition | Warning systems | Disease | Laboratories | Systematic review | Drug resistance | Veterinary medicine | Antiinfectives and antibacterials | Epidemiology | Management reports | Clinical outcomes | Microorganisms | E coli | Food chains | Information sharing | Nosocomial infections | Pharmaceutical industry | Strains (organisms) | Public health | Typing | Health risks | Antimicrobial agents | Early warning systems | Disease prevention | Regeneration | Surveillance systems | Hospitals | Surveillance | Antibiotics | Collaboration | Data collection | Food safety | Antimicrobial resistance | Drug discovery
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13. Full Text Cost of hospitalised patients due to complicated urinary tract infections: a retrospective observational study in countries with high prevalence of multidrug-resistant Gram-negative bacteria: the COMBACTE-MAGNET, RESCUING study
by Vallejo-Torres, Laura and Pujol, Miquel and Shaw, Evelyn and Wiegand, Irith and Vigo, Joan Miquel and Stoddart, Margaret and Grier, Sally and Gibbs, Julie and Vank, Christiane and Cuperus, Nienke and van den Heuvel, Leo and Eliakim-Raz, Noa and Carratala, Jordi and Vuong, Cuong and MacGowan, Alasdair and Babich, Tanya and Leibovici, Leonard and Addy, Ibironke and Morris, Stephen and RESCUING Study Grp Study Sites and RESCUING Study Group and Study Sites
BMJ Open, ISSN 2044-6055, 04/2018, Volume 8, Issue 4, p. e020251
ObjectiveComplicated urinary tract infections (cUTIs) impose a high burden on healthcare systems and are a frequent cause of hospitalisation. The aims of this... 
cost of illness | urinary tract infections | health economics | MEDICINE, GENERAL & INTERNAL | IMPACT | MANAGEMENT | MORBIDITY | ERA | PATTERNS | CARE | EPIDEMIOLOGY | Prevalence | Humans | Middle Aged | Male | Urinary Tract Infections - economics | Gram-Negative Bacteria - isolation & purification | Magnets | Greece | Drug Resistance, Multiple, Bacterial | Aged, 80 and over | Female | Urinary Tract Infections - microbiology | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Bulgaria | Anti-Bacterial Agents - economics | Romania | Hungary | Spain | Gram-Negative Bacterial Infections - economics | Health Care Costs | Turkey | Italy | Aged | Israel | Hospitalization - economics | Disease | Antimicrobial agents | Drug resistance | Epidemiology | Cost control | Urinary tract diseases | Studies | Hospitals | E coli | Cost estimates | Urinary tract infections | Bacteria | Gram-negative bacteria | Urogenital system
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14. Full Text Development of Resistance in Wild-Type and Hypermutable Pseudomonas aeruginosa Strains Exposed to Clinical Pharmacokinetic Profiles of Meropenem and Ceftazidime Simulated In Vitro
by Beate Henrichfreise and Irith Wiegand and Ingeborg Luhmer-Becker and Bernd Wiedemann
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2007, Volume 51, Issue 10, pp. 3642 - 3649
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BETA-LACTAM RESISTANCE | INVITRO MODEL | ANTIBACTERIAL ACTIVITY | INTERMITTENT INFUSION | EFFLUX PUMPS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MECHANISMS | CYSTIC-FIBROSIS | ANTIMICROBIAL RESISTANCE | LUNG INFECTIONS | AMPD | Porins - genetics | Ceftazidime - pharmacology | Humans | Middle Aged | Enzyme Inhibitors - pharmacology | Thienamycins - pharmacokinetics | Genotype | Male | Colony Count, Microbial | Pseudomonas aeruginosa - drug effects | Thienamycins - pharmacology | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Ceftazidime - pharmacokinetics | Microbial Sensitivity Tests | Phenotype | DNA, Bacterial - genetics | Pseudomonas aeruginosa - genetics | Anti-Bacterial Agents - pharmacokinetics | Anti-Bacterial Agents - pharmacology | beta-Lactamase Inhibitors | Drug Resistance, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - genetics | Experimental Therapeutics
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15. Full Text Retrospective observational study to assess the clinical management and outcomes of hospitalised patients with complicated urinary tract infection in countries with high prevalence of multidrug resistant Gram-negative bacteria (RESCUING)
by Shaw, Evelyn and Addy, Ibironke and Stoddart, Margaret and Vank, Christiane and Grier, Sally and Wiegand, Irith and Leibovici, Leonard and Eliakim-Raz, Noa and Vallejo-Torres, Laura and Morris, Stephen and MacGowan, Alasdair and Carratalà, Jordi and Pujol, Miquel and COMBACTE-MAGNET Consortium
BMJ Open, ISSN 2044-6055, 07/2016, Volume 6, Issue 7, p. e011500
IntroductionThe emergence of multidrug resistant (MDR) Gram-negative bacteria (GNB), including carbapenemase-producing strains, has become a major therapeutic... 
MEDICINE, GENERAL & INTERNAL | MORBIDITY | SMART | EPIDEMIOLOGY | ESCHERICHIA-COLI | Prevalence | Outcome Assessment (Health Care) | Humans | Middle Aged | Risk Factors | Clinical Protocols | Gram-Negative Bacterial Infections - drug therapy | Male | Urinary Tract Infections - drug therapy | Anti-Bacterial Agents - therapeutic use | Gram-Negative Bacteria - drug effects | Urinary Tract Infections - epidemiology | Gram-Negative Bacterial Infections - epidemiology | Female | Aged | Retrospective Studies | Drug Resistance, Multiple, Bacterial - drug effects | Drug side effects | Ús terapèutic | Resistència als medicaments | Urinary tract infections | Efectes secundaris dels medicaments | Gram-negative bacteria | Medicaments antibacterians | Drug resistance | Bacteris gramnegatius | Antibacterial agents | Therapeutic use | Infeccions del tracte urinari
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16. Full Text Risk Factors for Treatment Failure and Mortality Among Hospitalized Patients With Complicated Urinary Tract Infection: A Multicenter Retrospective Cohort Study (RESCUING Study Group)
by Eliakim-Raz, Noa and Babitch, Tanya and Shaw, Evelyn and Addy, Ibironke and Wiegand, Irith and Vank, Christiane and Torre-Vallejo, Laura and Joan-Miquel, Vigo and Steve, Morris and Grier, Sally and Stoddart, Margaret and Nienke, Cuperus and Leo, van den Heuvel and Vuong, Cuong and MacGowan, Alasdair and Carratalà, Jordi and Leibovici, Leonard and Pujol, Miquel and RESCUING Study Grp and RESCUING Study Group
Clinical Infectious Diseases, ISSN 1058-4838, 01/2019, Volume 68, Issue 1, pp. 29 - 36
In patients with complicated urinary tract infections, we found no benefit of early appropriate empirical treatment on survival rates or other outcomes.... 
pyelonephritis | risk factors | treatment failure | complicated urinary tract infection | bacterial resistance | INFECTIOUS DISEASES | EMPIRICAL ANTIBIOTIC-TREATMENT | ESCHERICHIA-COLI | ADULTS | MICROBIOLOGY | IMMUNOLOGY | ACUTE PYELONEPHRITIS | IMPACT | THERAPY | BACTEREMIA | OUTCOMES | EPIDEMIOLOGY
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17. Full Text Mutator Genes Giving Rise to Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa
by Irith Wiegand and Alexandra K. Marr and Elena B. M. Breidenstein and Kristen N. Schurek and Patrick Taylor and Robert E. W. Hancock
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2008, Volume 52, Issue 10, pp. 3810 - 3813
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SYSTEM | REPAIR | MUTL | MUTANT LIBRARY | ESCHERICHIA-COLI | PREVENTION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | CYSTIC-FIBROSIS | HYPERMUTATION | Genes, Bacterial | Pseudomonas aeruginosa - isolation & purification | Cystic Fibrosis - microbiology | Pseudomonas Infections - drug therapy | Humans | Ciprofloxacin - pharmacology | Genomic Library | Pseudomonas Infections - complications | DNA Repair - genetics | Pseudomonas aeruginosa - drug effects | Cystic Fibrosis - complications | Pseudomonas Infections - microbiology | Phenotype | DNA, Bacterial - genetics | Pseudomonas aeruginosa - genetics | DNA Transposable Elements - genetics | Anti-Bacterial Agents - pharmacology | Mutation | Drug Resistance, Multiple, Bacterial - genetics | Cystic Fibrosis - drug therapy | Mechanisms of Resistance
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18.