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1. Full Text IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury
: IL-4 in SCI
by Francos-Quijorna, Isaac and Amo-Aparicio, Jesús and Martinez-Muriana, Anna and López-Vales, Rubèn
Glia, ISSN 0894-1491, 12/2016, Volume 64, Issue 12, pp. 2079 - 2092
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2. Full Text Maresin 1 promotes inflammatory resolution, neuroprotection, and functional neurological recovery after spinal cord injury
by Francos-Quijorna, Isaac and Santos-Nogueira, Eva and Gronert, Karsten and Sullivan, Aaron B and Kopp, Marcel A and Brommer, Benedikt and David, Samuel and Schwab, Jan M and López-Vales, Ruben
Journal of Neuroscience, ISSN 0270-6474, 11/2017, Volume 37, Issue 48, pp. 11731 - 11743
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and remodeling and leads to functional deficits.... 
Maresin-1 | Neuroprotection | Lipid mediators | Spinal cord injury | Resolution | spinal cord injury | SURVIVAL | ACTIVATION | MACROPHAGE | PHENOTYPE | resolution | NEUROSCIENCES | lipid mediators | REPAIR | PAIN | neuroprotection | OMEGA-3 | POLYUNSATURATED FATTY-ACIDS | RESOLVING LIPID MEDIATORS | POLARIZATION | Macrophages - physiology | Spinal Cord Injuries - drug therapy | Recovery of Function - drug effects | Mice, Inbred C57BL | Neutrophils - drug effects | Neutrophils - physiology | Docosahexaenoic Acids - administration & dosage | Animals | Thoracic Vertebrae | Recovery of Function - physiology | Anti-Inflammatory Agents - administration & dosage | Female | Macrophages - drug effects | Mice | Spinal Cord Injuries - physiopathology | Locomotion - physiology | Neuroprotective Agents - administration & dosage | Locomotion - drug effects
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3. Full Text IL‐4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury
by Francos‐Quijorna, Isaac and Amo‐Aparicio, Jesús and Martinez‐Muriana, Anna and López‐Vales, Rubèn
Glia, ISSN 0894-1491, 12/2016, Volume 64, Issue 12, pp. 2079 - 2092
Macrophages and microglia play a key role in the maintenance of nervous system homeostasis. However, upon different challenges, they can adopt several... 
spinal cord injury | IL‐4 | macrophage | polarization | neuroprotection | IL-4 | ACTIVATION | RESOLUTION-PHASE MACROPHAGES | REGENERATION | IDENTIFICATION | NEUROSCIENCES | IMMUNE-SYSTEM | MEDIATORS | INFLAMMATORY RESPONSE | EXPRESSION | PLASTICITY | Microglia - metabolism | Spinal Cord Injuries - drug therapy | Cytokines - metabolism | Recovery of Function - drug effects | Spinal Cord Injuries - metabolism | Evoked Potentials, Motor - physiology | Interleukin-4 - metabolism | Mice, Inbred C57BL | Arginase - metabolism | Receptors, Cell Surface - metabolism | Evoked Potentials, Motor - drug effects | Interleukin-4 - pharmacology | Macrophages - metabolism | Animals | Flow Cytometry | Nitric Oxide Synthase Type II - genetics | Time Factors | Muscle, Skeletal - physiopathology | Recovery of Function - physiology | Female | Mice | Nitric Oxide Synthase Type II - metabolism | Macrophages | Spinal cord injuries | Genetic aspects | Genotype & phenotype | Rodents
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4. Full Text CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
by Martínez-Muriana, Anna and Mancuso, Renzo and Francos-Quijorna, Isaac and Olmos-Alonso, Adrian and Osta, Rosario and Perry, V. Hugh and Navarro, Xavier and Gomez-Nicola, Diego and López-Vales, Ruben
Scientific Reports, ISSN 2045-2322, 05/2016, Volume 6, Issue 1, p. 25663
Inflammation is a common neuropathological feature in several neurological disorders, including amyotrophic lateral sclerosis (ALS). We have studied the... 
CELLS | COLONY-STIMULATING FACTOR | MOTOR-NEURON DEGENERATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | ALS | CENTRAL-NERVOUS-SYSTEM | EXTEND SURVIVAL | MICE | MUTANT SUPEROXIDE-DISMUTASE | FACTOR-I
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5. Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury
by Isaac Francos-Quijorna and Eva Santos-Nogueira and Karsten Gronert and Aaron B Sullivan and Marcel A Kopp and Benedikt Brommer and Samuel David and Jan M Schwab and Ruben López-Vales
The Journal of Neuroscience, ISSN 0270-6474, 11/2017, Volume 37, Issue 48, p. 11731
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and remodeling and leads to functional deficits.... 
Neuroprotection | Spinal cord | Carbon tetrachloride | Recovery of function | Homeostasis | Intracellular signalling | Biosynthesis | Spinal cord injury | Macrophages | Interleukin 6 | Recovering | Phagocytes | Reduction | Cell activation | Cascades | Rodents | Stat1 protein | Injuries | Phenotypes | Wound healing | Cytokines | Neutrophils | Stat3 protein | Extracellular signal-regulated kinase | CCL3 protein | Leukocytes (neutrophilic) | Pharmacology | Inflammation | Stat5 protein | CCL4 protein | Mice | Spinal cord injuries
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6. Beneficial effects of IL-37 after spinal cord injury in mice
by Marina Coll-Miró and Isaac Francos-Quijorna and Eva Santos-Nogueira and Abel Torres-Espin and Philip Bufler and Charles A Dinarello and Rubèn López-Vales
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2016, Volume 113, Issue 5, p. 1411
  IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend... 
Side effects | Cytokines | Medical treatment | Nervous system | Protein expression | Spinal cord injuries
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7. Beneficial effects of IL-37 after spinal cord injury in mice
by Coll-Miro, Marina and Francos-Quijorna, Isaac and Santos-Nogueira, Eva and Torres-Espin, Abel and Bufler, Philip and Dinarello, Charles A and Lopez-Vales, Ruben
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 02/2016, Volume 113, Issue 5, pp. 1411 - 1411
IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend... 
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8. Full Text Beneficial effects of αB-crystallin in spinal cord contusion injury
by Klopstein, Armelle and Santos-Nogueira, Eva and Francos-Quijorna, Isaac and Redensek, Adriana and David, Samuel and Navarro, Xavier and López-Vales, Rubèn
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 42, pp. 14478 - 14488
alpha B-crystallin is a member of the heat shock protein family that exerts cell protection under several stress-related conditions. Recent studies have... 
INDUCED CELL-DEATH | HEAT-SHOCK PROTEINS | INFLAMMATORY MONOCYTES | IMPROVES FUNCTIONAL RECOVERY | RATS | ENDOPLASMIC-RETICULUM STRESS | IDENTIFICATION | ASTROCYTES | NEUROSCIENCES | BRAIN | DEGENERATION | Recombinant Proteins - therapeutic use | Macrophages - pathology | Spinal Cord Injuries - metabolism | alpha-Crystallin B Chain - therapeutic use | Humans | Mice, Inbred C57BL | Rats | Inflammation Mediators - therapeutic use | Treatment Outcome | alpha-Crystallin B Chain - antagonists & inhibitors | Spinal Cord Injuries - pathology | alpha-Crystallin B Chain - biosynthesis | Down-Regulation - physiology | Animals | Up-Regulation - physiology | Female | Granulocytes - pathology | Mice | Spinal Cord Injuries - therapy | Cell Migration Inhibition - physiology
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9. Full Text Beneficial effects of IL-37 after spinal cord injury in mice
by Marina Coll-Miró and Isaac Francos-Quijorna and Eva Santos-Nogueira and Abel Torres-Espin and Philip Bufler and Charles A. Dinarello and Rubèn López-Vales
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 5, pp. 1411 - 1416
IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend... 
Neuroprotection | IL-37 | Inflammation | Cytokines | Spinal cord injury | spinal cord injury | INTERLEUKIN-1 | IMMUNITY | IL-18R-ALPHA | REGENERATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | PROTECTS | inflammation | neuroprotection | IN-VIVO | REQUIRES | cytokines | INFLAMMATORY CYTOKINES | EXPRESSION | Interleukin-1 - genetics | Animals | Interleukin-1 - therapeutic use | Spinal Cord Injuries - drug therapy | Chemokines - antagonists & inhibitors | Cytokines - metabolism | Spinal Cord Injuries - metabolism | RNA, Messenger - genetics | Chemokines - metabolism | Mice | Cytokines - antagonists & inhibitors | Physiological aspects | Spinal cord injuries | Neural circuitry | Interleukins | Health aspects | Biological Sciences
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10. Full Text Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice
by López-Serrano, Clara and Santos-Nogueira, Eva and Francos-Quijorna, Isaac and Coll-Miró, Marina and Chun, Jerold and López-Vales, Rubèn
Brain Behavior and Immunity, ISSN 0889-1591, 02/2019, Volume 76, pp. 258 - 267
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled... 
Inflammation | Lysophosphatidic acid | Spinal cord injury | Demyelination | Neurodegeneration | Microglia | CANCER CELLS | PSYCHIATRY | PROLIFERATION | DEFICIENT MICE | IMMUNOLOGY | NEUROSCIENCES | OLIGODENDROCYTES | NEUROPROTECTION | RECOVERY | LYSOPHOSPHOLIPIDS | GENE-EXPRESSION | RETRACTION | LPA
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11. Full Text CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype
by Peluffo, Hugo and Solari-Saquieres, Patricia and Negro-Demontel, Maria Luciana and Francos-Quijorna, Isaac and Navarro, Xavier and López-Vales, Ruben and Sayós, Joan and Lago, Natalia
Journal of Neuroinflammation, ISSN 1742-2094, 08/2015, Volume 12, Issue 1, p. 145
Background: It has recently become evident that activating/inhibitory cell surface immune receptors play a critical role in regulating immune and inflammatory... 
Immunoreceptors | Macrophage M1/M2 phenotype | Regeneration | Wallerian degeneration | Schwann cell | CD300 | Phagocytosis | SYSTEM | AXON REGENERATION | INJURY | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | NEUROSCIENCES | MYELIN-ASSOCIATED GLYCOPROTEIN | SPATIOTEMPORAL QUANTIFICATION | SCIATIC-NERVE | RAT-BRAIN | TNF-ALPHA | Mannose-Binding Lectins - metabolism | Inflammation - pathology | Nitric Oxide Synthase Type II - biosynthesis | Wallerian Degeneration - pathology | Cricetulus | Male | Lectins, C-Type - metabolism | Immunoglobulin G - biosynthesis | Female | CHO Cells | Cricetinae | Macrophages - pathology | Nerve Crush | Receptors, Cell Surface - metabolism | Sciatic Neuropathy - pathology | Schwann Cells - pathology | Nerve Regeneration | Peripheral Nerves - pathology | Phenotype | Animals | Immunoglobulin G - genetics | Axons - pathology | Ligands | Mice | Receptors, Immunologic - genetics | Physiological aspects | Inflammation | Genetic aspects | Systemic lupus erythematosus | Macrophages | Analysis
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12. Full Text Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice
by López-Serrano, Clara and Santos-Nogueira, Eva and Francos-Quijorna, Isaac and Coll-Miró, Marina and Chun, Jerold and López-Vales, Rubèn
Brain, behavior, and immunity, 12/2018
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled... 
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13. Full Text Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons
by Mòdol, Laura and Mancuso, Renzo and Alé, Albert and Francos-Quijorna, Isaac and Navarro, Xavier
Frontiers in Cellular Neuroscience, ISSN 1662-5102, 01/2014, Volume 8, p. 7
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower... 
Spasticity | Hypereflexia | Motoneuron disease | mice | KCC2 transporter | SOD1 | Ventral horn | Animal models | Spinal cord | Interneurons | Spinal cord injury | Potassium-chloride cotransporter | Atrophy | Chloride | Transgenic animals | Rodents | Down-regulation | Paralysis | Injuries | Motor neurons | Neurodegenerative diseases | Serotonin | Muscles | Amyotrophic lateral sclerosis | Gephyrin | Potassium chloride | Neural networks | Mutation | Potassium | Sciatic nerve | SOD1G93A mice | hypereflexia | motoneuron disease
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14. MARESINS FOR USE IN THE TREATMENT OF CNS INJURIES
by FRANCOS QUIJORNA, Isaac and SCHWAB, Jan Markus and LOPEZ VALES, Ruben and SAMUEL, David
01/2019
The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and... 
HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
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