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1. Full Text ISY-11-3Development of RNAi-based anticancer drug: What is problem for clinical application and how establish a useful RNAi drug
by Ishida, Tatsuhiro
Annals of Oncology, ISSN 0923-7534, 11/2016, Volume 27, Issue suppl_7
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2. Full Text Development of efficient and safe drug delivery system with liposomes for clinical application: 11th Mizushima award, Japan society of DDS
by Ishida, Tatsuhiro
Drug Delivery System, ISSN 0913-5006, 2018, Volume 33, Issue 4, pp. 318 - 328
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3. Development of efficient and safe drug delivery system with liposomes for clinical application ： 11th Mizushima Award, Japan Society of DDS
by Tatsuhiro Ishida
ISSN 0913-5006, 01/2018, Volume 33, Issue 4, p. 318
Drug delivery systems | Drug delivery | Liposomes
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4. Full Text Liposomal Delivery Systems: Design Optimization and Current Applications
by Abu Lila, Amr Selim and Ishida, Tatsuhiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 1, pp. 1 - 10
The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the... 
gene therapy | theranostics | PEGylation | drug delivery system | liposome | immunotherapy | Liposome | Gene therapy | Drug delivery system | Theranostics | Immunotherapy | DRUG-DELIVERY | ANTISENSE OLIGODEOXYNUCLEOTIDES | LARGE UNILAMELLAR LIPOSOMES | ANTITUMOR-ACTIVITY | TRIGGERED RELEASE | TUMOR-TARGETED DELIVERY | PH-SENSITIVE LIPOSOMES | IN-VIVO | PHARMACOLOGY & PHARMACY | SOLID TUMOR | LIPID-COMPOSITION | Liposomes - chemistry | Liposomes - therapeutic use | Animals | Humans | Drug Delivery Systems | Biodegradation | Drugs | Drug delivery systems | Biodegradability | Phospholipids | Pharmacology | Drug delivery | Hydrophobicity | Drug development | Chemical compounds | Optimization | Design optimization | Biocompatibility | Liposomes | System effectiveness
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5. Full Text Liposomal Delivery Systems : Design Optimization and Current Applications
by Amr Selim Abu Lilaa and b and c and Tatsuhiro Ishidaa and Tokushima University and cDepartment of Pharmaceutics and aDepartment qf Pharmacokinetics and Biopharmaceutics and Zagazig University and Institute of Medical Biosciences and bDepartment of Pharmaceutics and Industrial Pharmacy and Faculty of Pharmacy and Hail University
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 1, pp. 1 - 10
The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the... 
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6. Full Text Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
by Ishida, Tatsuhiro and Kiwada, Hiroshi
International Journal of Pharmaceutics, ISSN 0378-5173, 2008, Volume 354, Issue 1, pp. 56 - 62
We and a Dutch group reported that “empty” PEGylated liposomes (approximately 100 nm) lose their long-circulating characteristic when they are administrated... 
Complement activation | Liposomes | Repeated injection | Polyethylene glycol (PEG) | IgM | Accelerated blood clearance (ABC) phenomenon | ADVANCED HEPATOCELLULAR-CARCINOMA | accelerated blood clearance (ABC) phenomenon | STERICALLY STABILIZED LIPOSOMES | liposomes | REFRACTORY OVARIAN | OVARIAN-CANCER | polyethylene glycol (PEG) | complement activation | PHYSICOCHEMICAL PROPERTIES | PHASE-II TRIAL | CIRCULATION TIME | PROTEIN ADSORPTION | POLY(ETHYLENE GLYCOL) | METASTATIC BREAST-CANCER | PHARMACOLOGY & PHARMACY | repeated injection | Animals | Injections, Intravenous | Complement Activation | Drug Administration Schedule | Liposomes - administration & dosage | Drug Carriers - administration & dosage | Polyethylene Glycols - chemistry | Drug Carriers - pharmacokinetics | Immunoglobulin M - immunology | Liposomes - pharmacokinetics | Polyethylene Glycols - administration & dosage | Liposomes - immunology | Polyols | Immunoglobulins | Television broadcasting industry
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7. Full Text Anti-PEG IgM production via a pegylated nanocarrier system for nucleic acid delivery
by Abu Lila, Amr S and Ishida, Tatsuhiro
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1943, pp. 333 - 346
For the systemic application of nucleic acids [plasmid DNA (pDNA) and small interfering RNA (siRNA)], safe and efficient carriers that overcome the poor... 
Anti-PEG IgM | Enzyme-linked immunosorbent assay (ELISA) | Polyethylene glycol (PEG) | Accelerated blood clearance (ABC) phenomenon | PEGylated nanocarrier
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8. Full Text Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model
by Abu Lila, Amr S and Moriyoshi, Naoto and Fukushima, Masakazu and Huang, Cheng-Long and Wada, Hiromi and Ishida, Tatsuhiro, Ph.D
Cancer Letters, ISSN 0304-3835, 2016, Volume 400, pp. 223 - 231
Abstract Metronomic chemotherapy is currently considered an emerging therapeutic option in clinical oncology. S-1, an oral formulation of Tegafur (TF), a... 
Hematology, Oncology and Palliative Medicine | RNAi | PEG-coated shRNA-lipoplex | Short hairpin RNA | Thymidylate synthase | S-1 | Colorectal cancer | THERAPEUTICS | DIHYDROPYRIMIDINE DEHYDROGENASE | RNA-INTERFERENCE | CHEMOTHERAPY | LUNG-CANCER | ONCOLOGY | GASTRIC-CANCER | IN-VIVO | EXPRESSION LEVELS | TUMOR-GROWTH | THYMIDINE PHOSPHORYLASE | Administration, Metronomic | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Male | Antimetabolites, Antineoplastic - administration & dosage | Colorectal Neoplasms - therapy | Transfection | RNA Interference | Time Factors | Antimetabolites, Antineoplastic - metabolism | Oxonic Acid - metabolism | Colorectal Neoplasms - enzymology | Thymidylate Synthase - metabolism | Oxonic Acid - administration & dosage | Thymidylate Synthase - genetics | RNAi Therapeutics - methods | Xenograft Model Antitumor Assays | Animals | Tegafur - metabolism | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Tegafur - administration & dosage | Cell Proliferation - drug effects | Mice, Inbred BALB C | Colorectal Neoplasms - pathology | Drug Combinations | Chemotherapy | RNA | Cancer | Polyethylenes | 5-Fluorouracil | Toxicity | Tegafur | Lung cancer | Colorectal carcinoma | Metastasis | Kinases | Drug resistance | Cancer therapies | Metastases | Anticancer properties | Proteins | Polyethylene glycol | Xenografts | Chemical synthesis | Drug dosages | Dosing | RNA-mediated interference | Gene expression | Ribonucleic acid--RNA | Antitumor activity | Combined treatment | Viral infections | Apoptosis | Index Medicus
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9. Full Text Metronomic chemotherapy and nanocarrier platforms
by Abu Lila, Amr S and Ishida, Tatsuhiro
Cancer Letters, ISSN 0304-3835, 2016, Volume 400, pp. 232 - 242
Abstract The therapeutic concept of administering chemotherapeutic agents continuously at lower doses, relative to the maximum tolerated dose (MTD) without... 
Hematology, Oncology and Palliative Medicine | Nanoparticles | Tumor priming | Maximum tolerated dose | Liposomes | Dosing schedule | Metronomic chemotherapy | ADVANCED HEPATOCELLULAR-CARCINOMA | PEGYLATED LIPOSOMAL DOXORUBICIN | LOW-DOSE CYCLOPHOSPHAMIDE | STEM-LIKE CELLS | ONCOLOGY | ACCELERATED BLOOD CLEARANCE | METASTATIC BREAST-CANCER | COATED CATIONIC LIPOSOMES | RECURRENT OVARIAN-CANCER | COLORECTAL TUMOR-MODEL | ENDOTHELIAL GROWTH-FACTOR | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Administration, Metronomic | Humans | Neoplasms - blood supply | Drug Carriers | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Maximum Tolerated Dose | Animals | Neoplasms - immunology | Nanomedicine - methods | Drug Compounding | Neoplasms - pathology | Angiogenesis Inhibitors - adverse effects | Angiogenesis Inhibitors - chemistry | Drugs | Antimitotic agents | Chemotherapy | Drug delivery systems | Pharmacy | Drugstores | Development and progression | Antineoplastic agents | Cancer | Vehicles | CD8 antigen | Cytotoxicity | Metastasis | Drug resistance | Cancer therapies | Blood | Anticancer properties | Metastases | Angiogenesis | Breast carcinoma | Bone marrow | CD25 antigen | Inhibition | Drug dosages | Antigens | Macromolecules | Blood vessels | Exposure | Ablation | Carriers | Inhibitors | Surveillance | Antigen-presenting cells | Stem cells | Angiogenesis inhibitors | Accessibility | Toxicity | Dormancy | Lymphocytes | Modulation | Immune system | Effectiveness | Tumor cells | Vessels | Pharmacology | Breast cancer | Inflammation | Permeability | CD4 antigen | Hypotheses | Cell death | Antigen (tumor-associated) | Breast | Antitumor activity | Microenvironments | Cations | Pharmacokinetics | Tumors | Apoptosis | Index Medicus
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10. Full Text Preparation of an Ultrafine Rebamipide Ophthalmic Suspension with High Transparency
by Takakuni Matsudaa and b and Shogo Hiraokab and Hiroki Urashimac and Ako Ogurab and Tatsuhiro Ishidaa and Tokushima University and cDepartment of Medical Innovations and Ltd and Otsuka Pharmaceutical Co and aDepartment of Pharmacokinetics and Biopharmaceutics and bFormulation Research Institute and Institute of Biomedical Sciences
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 5, pp. 665 - 674
A 2% commercially available, milky-white, rebamipide micro-particle suspension is used to treat dry eyes, and it causes short-term blurring of the patient's... 
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11. Full Text Lightning damage suppression in a carbon fiber-reinforced polymer with a polyaniline-based conductive thermoset matrix
by Hirano, Yoshiyasu and Yokozeki, Tomohiro and Ishida, Yuichi and Goto, Teruya and Takahashi, Tatsuhiro and Qian, Danna and Ito, Shoji and Ogasawara, Toshio and Ishibashi, Masaru
Composites Science and Technology, ISSN 0266-3538, 04/2016, Volume 127, pp. 1 - 7
In this paper, the effectiveness of lightning damage suppression by a carbon-fiber-reinforced polymer (CFRP) laminate with a newly developed polyaniline... 
Mechanical properties (B) | Lightning damage | Conductive thermosetting composite | Electrical properties (B) | Thermal properties (B) | MATERIALS SCIENCE, COMPOSITES | COMPOSITES | Crosslinked polymers | Electrical conductivity | Polymer industry | Laminated materials | Epoxy resins | Electric properties | Polymer matrix composites | Simulation | Electrical resistivity | Lightning | Resistivity | Carbon fiber reinforced plastics | Thermosetting resins | Damage
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12. Anti-polyethyleneglycol Antibody Response to PEGylated Substances
by Tatsuhiro Ishida and Hiroshi Kiwada
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 06/2013, Volume 36, Issue 6, p. 889
  In contrast to the general assumption that polyethyleneglycol (PEG)-conjugated substances lack immunogenicity and antigenic, it has been reported that they... 
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13. Full Text Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice
by Emam, Sherif E and Ando, Hidenori and Abu Lila, Amr Selim and Kobayashi, Shinya and Shimizu, Taro and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 7, pp. 1078 - 1083
Modulation of tumor immunity is a known factor in the antitumor activity of many chemotherapeutic agents. Exosomes are extracellular nanometric vesicles that... 
chemotherapeutic agent | doxorubicin | exosome | splenectomy | liposomal doxorubicin | Liposomal doxorubicin | Splenectomy | Chemotherapeutic agent | Exosome | Doxorubicin | RESPONSES | SPLEEN | EXTRACELLULAR VESICLES | PHARMACOLOGY & PHARMACY | RELEASE | CELL-DERIVED EXOSOMES | CHEMOTHERAPY | Spleen | Size distribution | CD9 antigen | Intravenous administration | CD63 antigen | Secretion | Injection | Secretions | Exosomes | Immunity | Immunosuppressive agents | Anticancer properties | Time dependence | Vesicles | Chemotherapy | Antitumor agents | Antitumor activity | Mice | In vivo methods and tests | Cancer | Tumors | Immune system
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14. Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers
by Tatsuhiro Ishida and Hiroshi Kiwada
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 05/2013, Volume 36, Issue 5, p. 692
  Nanocarrier-based cancer chemotherapeutics are thought to increase therapeutic efficiency and reduce the side effects of associated chemotherapeutic agents... 
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15. Full Text The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
by Abu Lila, Amr S and Kiwada, Hiroshi and Ishida, Tatsuhiro
Journal of Controlled Release, ISSN 0168-3659, 11/2013, Volume 172, Issue 1, pp. 38 - 47
Despite the clinical introduction of an increasing number of polyethylene glycol (PEG)-conjugated substances, PEG has been named as the cause of an unexpected... 
Anti-PEG IgM | Polyethylene glycol(PEG) | Repeated administration | Accelerated blood clearance (ABC) phenomenon | Splenic B cells | Accelerated blood clearance (ABC) | phenomenon | PEGYLATED LIPOSOMAL DOXORUBICIN | IMMUNE-RESPONSE | COVALENT ATTACHMENT | MARGINAL ZONE | PEG IgM | ANTITUMOR-ACTIVITY | REPEATED INJECTION | CHEMISTRY, MULTIDISCIPLINARY | PEG | PHARMACOKINETICS | POLY(ETHYLENE GLYCOL) | PHARMACOLOGY & PHARMACY | POLYETHYLENE-GLYCOL | Anti | Spleen - immunology | Complement Activation | Humans | Drug Carriers - administration & dosage | Polyethylene Glycols - chemistry | Immunoglobulin M - immunology | Drug Carriers - chemistry | Polyethylene Glycols - administration & dosage | Liposomes - chemistry | Animals | Immunoglobulin M - blood | Liposomes - blood | Liposomes - immunology | Polyols | Television broadcasting industry | B cells | Polyethylene glycol | Pharmacy | Blood
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16. Full Text A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research
by Emam, Sherif E and Ando, Hidenori and Abu Lila, Amr Selim and Shimizu, Taro and Ukawa, Masami and Okuhira, Keiichiro and Ishima, Yu and Mahdy, Mahmoud A and Ghazy, Fakhr-eldin S and Ishida, Tatsuhiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 5, pp. 733 - 742
Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic... 
exosome secretion | PEGylation | cationic lipid | liposome | stimulation | Liposome | Stimulation | Exosome secretion | Cationic lipid | DENSITY | DRUG-DELIVERY | IN-VIVO | NANOPARTICLE | MICROVESICLES | PHARMACOLOGY & PHARMACY | LIPOSOMES | Formulations | Biological properties | Drug delivery systems | Tumor cells | Secretion | Drug delivery | Tumor cell lines | Exosomes | Vesicles | Cations | Yield | Liposomes | Physicochemical properties | Tumors
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17. Full Text Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model
by Shimizu, Taro and Abu Lila, Amr S and Nishio, Miho and Doi, Yusuke and Ando, Hidenori and Ukawa, Masami and Ishima, Yu and Ishida, Tatsuhiro
Cancer Science, ISSN 1347-9032, 09/2017, Volume 108, Issue 9, pp. 1864 - 1869
Immune modulation of the tumor microenvironment has been reported to participate in the therapeutic efficacy of many chemotherapeutic agents. Recently, we... 
immunomodulation | Antitumor immunity | oxaliplatin | drug delivery system | liposome | TUMOR-MODEL | MECHANISM | ONCOLOGY | SUPPRESSOR-CELLS | CANCER | CHEMOTHERAPY | Neoplasm Transplantation | Immunologic Factors - administration & dosage | Male | Antineoplastic Agents - administration & dosage | Histocompatibility Antigens Class I - metabolism | Organoplatinum Compounds - administration & dosage | Animals | Colorectal Neoplasms - immunology | Mice, Nude | Colorectal Neoplasms - drug therapy | Cell Line, Tumor | Mice, Inbred BALB C | Liposomes | Drug Screening Assays, Antitumor | Drugs | Drug delivery systems | Chemotherapy | Colorectal cancer | T cells | Health aspects | Tumors | Vehicles | Cancer | Encapsulation | Peptides | CD8 antigen | Colorectal carcinoma | Cytotoxicity | Lymphocytes T | Macrophages | Suppressor cells | Cancer therapies | Oxaliplatin | Lymphocytes | Polyethylene glycol | Immunotherapy | Drug dosages | Immunoregulation | Immunomodulation | Tumor cells | Immunodeficiency | Studies | Major histocompatibility complex | Antitumor activity | Original
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18. Full Text Hydrodynamic Tail Vein Injection as a Simple Tool for Yielding Extended Transgene Expression in Solid Tumors
by Takuma Takayamaa and Masami Ukawaa and Yuki Kanazawaa and Hidenori Andoa and b and Taro Shimizua and Tatsuhiro Ishidaa and Tokushima University and bDepartment of Cancer Metabolism and Therapy and aDepartment of Pharmacokinetics and Biopharmaceutics and Subdivision of Biopharmaceutical Sciences and Institute of Biomedical Sciences
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 9, pp. 1555 - 1558
Hydrodynamic tail vein injection was considered an in vivo transfection method that yields a higher level of gene expression mainly in the liver. This method... 
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