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Frontiers in oncology, ISSN 2234-943X, 2020, Volume 10, p. 2
Activity of heparanase, responsible for cleavage of heparan sulfate (HS), is strongly implicated in tumor metastasis. This is due primarily to remodeling of... 
HEAD | PROTEOGLYCANS | Src | KINASE | heparanase | IDENTIFICATION | E-cadherin | ADHESION | ONCOLOGY | CANCER METASTASIS | SULFATE | cell migration | PROTEINS | phosphorylation | EXPRESSION | CLINICAL-SIGNIFICANCE | Metastasis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2020, Volume 186, p. 111831
Heparanase is regarded as a promising target for anticancer drugs and Ronepastat is one of the most promising heparanase inhibitors insert in clinical study... 
Antimetastatic agents | Biotinylated agents | Heparanase inhibitors | Anticancer agents | Roneparstat
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 01/2020, Volume 80, Issue 1, pp. 57 - 68
The emerging role of heparanase in tumor initiation, growth, metastasis, and chemoresistance is well recognized, encouraging the development of heparanase... 
INHIBITION | ANGIOGENESIS | EFFICACY | ONCOLOGY | CANCER METASTASIS | ALPHA | CHEMORESISTANCE | MECHANISMS | RECEPTORS | EXPRESSION | LYMPHOCYTES
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2019, Volume 145, Issue 6, pp. 1596 - 1608
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 06/2019, Volume 131, pp. 29 - 40
Although cancer cells use heparanase for tumor metastasis, favourable effects of heparanase have been reported in the management of Alzheimer's disease and... 
Heparanase | Energy balance | Cardioprotection | Autophagy | Unfolded protein response | CARDIAC & CARDIOVASCULAR SYSTEMS | ER STRESS | ISCHEMIA | ENDOPLASMIC-RETICULUM STRESS | QUALITY-CONTROL | CELL BIOLOGY | OVEREXPRESSION | ROLES | NEURONAL DEATH | TRANSCRIPTION FACTOR | ATF6 | Proteins | Cell death | Analysis | Genes | Metastasis | Cardiology | Gene expression | Heart diseases
Journal Article
ISCIENCE, ISSN 2589-0042, 05/2019, Volume 15, pp. 360 - 390
Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological... 
LAMBDA-CARRAGEENAN | POTENT INHIBITOR | SULFATE MIMETIC PG545 | OLIGOMANNURARATE SULFATE | MULTIDISCIPLINARY SCIENCES | MOLECULAR-WEIGHT HEPARIN | FACTOR-2 RECEPTOR-BINDING | P-SELECTIN | MAMMALIAN HEPARANASE | FIBROBLAST-GROWTH-FACTOR | TUMOR-GROWTH
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. S-1044 - S-1044
Journal Article
Matrix Biology, ISSN 0945-053X, 04/2019, Volume 77, pp. 58 - 72
It is now well recognized that heparanase, an endo-β-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites,... 
Heparanase | ER stress | Lymphoma | PG545 | Apoptosis | TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN HEPARANASE | MECHANISMS | AUTOPHAGY | RELEASE | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | MICROENVIRONMENT | DEGRADATION | TUMOR-GROWTH | Antimitotic agents | Cell death | Therapeutics | Lymphomas | Drug therapy | Antineoplastic agents | Sulfates | Homeopathy | Materia medica and therapeutics
Journal Article
Rambam Maimonides medical journal, ISSN 2076-9172, 01/2019, Volume 10, Issue 1
Journal Article
ACS Applied Materials and Interfaces, ISSN 1944-8244, 01/2019, Volume 11, Issue 1, pp. 244 - 254
Heparanase, the heparan sulfate polysaccharide degrading endoglycosidase enzyme, has been correlated with tumor angiogenesis and metastasis and therefore has... 
heparanase | cancer therapeutic | metastasis | glycopolymer | biolayer interferometry | POLYMERS | MATERIALS SCIENCE, MULTIDISCIPLINARY | MEDIATED DEGRADATION | IMINOSUGARS | NANOSCIENCE & NANOTECHNOLOGY | POLYMERIZATION | HEPARIN | MULTIVALENCY | GLYCOSIDASE INHIBITION | AFFINITY | EXTRACELLULAR-MATRIX | INSIGHTS
Journal Article
ISSN 2045-2322, 2019
Amyloid-β (Aβ) is the main constituent of amyloid deposits in Alzheimer’s disease (AD). The neuropathology is associated with neuroinflammation. Here, we... 
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 12/2018, Volume 13, Issue 12, pp. 3236 - 3242
Heparanase is a mammalian endoglycosidase that cleaves heparan sulfate (HS) polysaccharides and contributes to remodelling of the extracellular matrix and... 
BETA-SECRETASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PG545 | MECHANISMS | TUMOR-GROWTH | CANCER | PROGRESSION | DISCOVERY
Journal Article
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