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clopidogrel (17) 17
coronary heart disease (17) 17
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heterocyclic compounds (16) 16
organic chemistry (16) 16
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retrospective studies (15) 15
medicine & public health (14) 14
prasugrel (14) 14
preparations for medical, dental, or toilet purposes (14) 14
specific therapeutic activity of chemical compounds ormedicinal preparations (14) 14
cardiac patients (13) 13
care and treatment (13) 13
drug-eluting stents (13) 13
platelet aggregation inhibitors - therapeutic use (13) 13
registries (13) 13
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cardiology and cardiovascular medicine (12) 12
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1. Full Text Efficacy and safety of adjusted-dose prasugrel compared with clopidogrel in Japanese patients with acute coronary syndrome - The PRASFIT-ACS study
by Saito, Shigeru and Isshiki, Takaaki and Kimura, Takeshi and Ogawa, Hisao and Yokoi, Hiroyoshi and Nanto, Shinsuke and Takayama, Morimasa and Kitagawa, Kazuo and Nishikawa, Masakatsu and Miyazaki, Shunichi and Nakamura, Masato
Circulation Journal, ISSN 1346-9843, 2014, Volume 78, Issue 7, pp. 1684 - 1692
Background: Prasugrel is an antiplatelet agent that shows more prompt, potent, and consistent platelet inhibition than clopidogrel. The objective of this study... 
Prasugrel | Clopidogrel | Percutaneous coronary intervention | Major adverse cardiovascular events | Acute coronary syndrome | CARDIAC & CARDIOVASCULAR SYSTEMS | Piperazines - administration & dosage | Myocardial Infarction - chemically induced | Prasugrel Hydrochloride | Myocardial Infarction - mortality | Purinergic P2Y Receptor Antagonists - administration & dosage | Follow-Up Studies | Thiophenes - adverse effects | Humans | Middle Aged | Acute Coronary Syndrome - mortality | Hemorrhage - mortality | Thiophenes - administration & dosage | Aspirin - administration & dosage | Purinergic P2Y Receptor Antagonists - adverse effects | Time Factors | Aspirin - adverse effects | Platelet Aggregation Inhibitors - administration & dosage | Ticlopidine - adverse effects | Aged, 80 and over | Ticlopidine - administration & dosage | Adult | Drug Therapy, Combination | Platelet Aggregation Inhibitors - adverse effects | Japan | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Asian Continental Ancestry Group | Aged | Hemorrhage - chemically induced | Index Medicus
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2. Full Text PREDICTIVE IMPACT OF MULTIVESSEL CORONARY ARTERY DISEASE FOR SCREENING OF ABDOMINAL AORTIC ANEURYSM
by Yokoyama, Naoyuki and Maruyama, Yasuyuki and Isshiki, Takaaki
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 10, pp. A2108 - A2108
  Multivariate logistic regression analysis was used to study multiple risk factors (HT, DM, ets) for AAA among all study patients. 
Cardiovascular | Internal Medicine | Aneurysms | Medical screening | Coronary heart disease | Confidence intervals | Coronary vessels | Men | Cardiovascular disease | Multivariate analysis | Abdomen
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3. Full Text Usefulness of Everolimus-Eluting Coronary Stent Implantation in Patients on Maintenance Hemodialysis
by Ikari, Yuji, MD, PhD and Kyono, Hiroyuki, MD and Isshiki, Takaaki, MD, PhD and Ishizuka, Shuichi, MD and Nasu, Kenya, MD and Sano, Koichi, MD, PhD and Okada, Hisayuki, MD and Sugano, Teruyasu, MD, PhD and Uehara, Yoshiki, MD
American Journal of Cardiology, The, ISSN 0002-9149, 2015, Volume 116, Issue 6, pp. 872 - 876
The outcomes of second-generation drug-eluting stent (DES) are unknown in patients on maintenance hemodialysis (HD) although HD has been reported as a strong... 
Cardiovascular | UNITED-STATES | CYPHER STENT | REVASCULARIZATION | CARDIAC & CARDIOVASCULAR SYSTEMS | DIALYSIS PATIENTS | THROMBOSIS | LONG-TERM SURVIVAL | BARE-METAL STENTS | ACUTE MYOCARDIAL-INFARCTION | Coronary Artery Disease - surgery | Drug-Eluting Stents | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Prospective Studies | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Treatment Outcome | Kidney Failure, Chronic - therapy | Coronary Angiography | Coronary Artery Disease - diagnostic imaging | Coronary Artery Disease - complications | Kidney Failure, Chronic - complications | Female | Registries | Aged | Everolimus | Percutaneous Coronary Intervention | Renal Dialysis | Heart | Medical colleges | Angiogenesis inhibitors | Hemodialysis | Stent (Surgery) | Heart attacks | Cardiology | Stents | Mortality | Index Medicus | Abridged Index Medicus
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4. Full Text Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors
by Suda, Atsushi and Kawasaki, Ken-ichi and Komiyama, Susumu and Isshiki, Yoshiaki and Yoon, Dong-Oh and Kim, Sung-Jin and Na, Young-Jun and Hasegawa, Kiyoshi and Fukami, Takaaki A and Sato, Shigeo and Miura, Takaaki and Ono, Naomi and Yamazaki, Toshikazu and Saitoh, Ryoichi and Shimma, Nobuo and Shiratori, Yasuhiko and Tsukuda, Takuo
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2014, Volume 22, Issue 2, pp. 892 - 905
A novel series of 2-amino-1,3,5-triazines bearing a tricyclic moiety as Hsp90 inhibitors were identified through structure-based drug design. Among them,... 
Lead optimization | Structure-based drug design | Hsp90 inhibitor | Antitumor agent | TARGET | CHAPERONE HSP90 | COMPLEX | CHEMISTRY, MEDICINAL | SHOCK-PROTEIN 90 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CONFORMATION | Humans | Biological Availability | Crystallography, X-Ray | Structure-Activity Relationship | Dose-Response Relationship, Drug | Benzopyrans - chemical synthesis | Drug Design | Female | Molecular Structure | Benzopyrans - pharmacology | Triazines - pharmacology | Administration, Oral | HCT116 Cells | Models, Molecular | Benzopyrans - administration & dosage | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Triazines - administration & dosage | Triazines - chemical synthesis | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Heat shock proteins | Index Medicus
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5. Full Text Add-on Antiplatelet Effects of Eicosapentaenoic Acid With Tailored Dose Setting in Patients on Dual Antiplatelet Therapy
by Hosogoe, Naoyoshi and Ishikawa, Shuichi and Yokoyama, Naoyuki and Kozuma, Ken and Isshiki, Takaaki
International Heart Journal, ISSN 1349-2365, 2017, Volume 58, Issue 4, pp. 481 - 485
The aim of this study was to investigate the antiplatelet effects of eicosapentaenoic acid (EPA) at a sufficient dose following coronary stent implantation.... 
Clopidogrel | EPA/AA ratio | Coronary artery disease | Platelet function | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | OMEGA-3-FATTY-ACIDS | PLATELET-FUNCTION | ASPIRIN | PERCUTANEOUS CORONARY INTERVENTION | IMPLANTATION | DISEASE | CLINICAL-OUTCOMES | Aspirin | Adenosine | Collagen | Implants | Platelet aggregation | Arachidonic acid | Stents | Patients | Eicosapentaenoic acid
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6. Full Text Reply
by Hibi, Kiyoshi and Kozuma, Ken and Kimura, Kazuo and Isshiki, Takaaki
JACC: Cardiovascular Interventions, ISSN 1936-8798, 12/2018, Volume 11, Issue 24, pp. 2545 - 2546
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7. Full Text Sirolimus eluting coronary stent implantation in patients on maintenance hemodialysis - The OUCH study (Outcome of Cypher stent in hemodialysis patients)
by Ikari, Yuji and Tanabe, Kengo and Koyama, Yutaka and Kozuma, Ken and Sano, Koichi and Isshiki, Takaaki and Katsuki, Takaaki and Kimura, Kazuo and Yamane, Masahisa and Takahashi, Nozomu and Hibi, Kiyoshi and Hasegawa, Kotaro and Ishiwata, Sugao and Kiyooka, Takahiko and Yokoi, Hiroyoshi and Uehara, Yoshiki and Hara, Kazuhiro
Circulation Journal, ISSN 1346-9843, 2012, Volume 76, Issue 8, pp. 1856 - 1863
Background: Pivotal studies on drug-eluting stents have excluded hemodialysis (HD) patients. No quantitative coronary angiography (QCA) analysis has been... 
Quantitative coronary angiography | Chronic kidney disease | Prognosis | Hemodialysis | Drug eluting stent | C-REACTIVE PROTEIN | ANGIOGRAPHIC OUTCOMES | REVASCULARIZATION | CARDIAC & CARDIOVASCULAR SYSTEMS | STANDARD STENT | RANDOMIZED CONTROLLED-TRIAL | DIALYSIS PATIENTS | TERM CLINICAL-OUTCOMES | RESTENOSIS | J-PMS | REGISTRY | Drug-Eluting Stents | Myocardial Infarction - mortality | Prospective Studies | Humans | Middle Aged | Coronary Disease - physiopathology | Male | Sirolimus - pharmacology | Coronary Disease - mortality | Kidney Function Tests | Myocardial Revascularization | Myocardial Infarction - therapy | Time Factors | Coronary Disease - therapy | Vascular Calcification - mortality | Vascular Calcification - physiopathology | Death | Female | Myocardial Infarction - physiopathology | Aged | Vascular Calcification - therapy | Immunosuppressive Agents - pharmacology | Myocardial Infarction - etiology | Renal Dialysis | Index Medicus
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8. Coronary artery disease. Introduction
by Isshiki, Takaaki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 09/2011, Volume 69 Suppl 7, p. 1
Coronary Artery Disease | Humans
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9. Full Text Prasugrel, a Third-Generation P2Y12 receptor antagonist, in patients with coronary artery disease undergoing elective percutaneous coronary Intervention: Phase III, randomized, double-blind study
by Isshiki, Takaaki and Kimura, Takeshi and Ogawa, Hisao and Yokoi, Hiroyoshi and Nanto, Shinsuke and Takayama, Morimasa and Kitagawa, Kazuo and Nishikawa, Masakatsu and Miyazaki, Shunichi and Ikeda, Yasuo and Nakamura, Masato and Saito, Shigeru and PRASFIT-Elective Investigators and on behalf of the PRASFIT-Elective Investigators
Circulation Journal, ISSN 1346-9843, 2014, Volume 78, Issue 12, pp. 2926 - 2934
Background: Prasugrel is being developed in Japan as an antiplatelet therapy for use during percutaneous coronary intervention (PCI). Up to 70% of Japanese... 
Prasugrel | Clopidogrel | Elective percutaneous coronary intervention | Coronary artery disease | Japanese | CARDIAC & CARDIOVASCULAR SYSTEMS | EFFICACY | THROMBOSIS | OF-FUNCTION POLYMORPHISM | CYP2C19 | ANTIPLATELET THERAPY | TRIAL | PACLITAXEL-ELUTING STENT | IMPLANTATION | JAPANESE PATIENTS
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10. Full Text Hyper-Response to Clopidogrel in Japanese Patients Undergoing Transcatheter Aortic Valve Implantation
by Watanabe, Yusuke and Kozuma, Ken and Ishikawa, Shuichi and Hosogoe, Naoyoshi and Isshiki, Takaaki
International Heart Journal, ISSN 1349-2365, 2016, Volume 57, Issue 2, pp. 190 - 197
Dual antiplatelet therapy is empirically recommended following transcatheter aortic valve implantation (TAVI). The aims of the present study were to analyze... 
Antiplatelet therapy | Platelet function tests
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11. Full Text Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry
by Daida, Hiroyuki and Miyauchi, Katsumi and Ogawa, Hisao and Yokoi, Hiroyoshi and Matsumoto, Masayasu and Kitakaze, Masafumi and Kimura, Takeshi and Matsubara, Tetsuo and Ikari, Yuji and Kimura, Kazuo and Tsukahara, Kengo and Origasa, Hideki and Morino, Yoshihiro and Tsutsui, Hiroyuki and Kobayashi, Masayuki and Isshiki, Takaaki and PACIFIC Investigators and PACIFIC investigators
Circulation Journal, ISSN 1346-9843, 2013, Volume 77, Issue 4, pp. 934 - 943
Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status... 
Prevention | Major adverse cardiac events | Prognosis | Acute coronary syndrome | Mortality | CARDIAC & CARDIOVASCULAR SYSTEMS | GLOBAL REGISTRY | RISK | BASE-LINE CHARACTERISTICS | RANDOMIZED TRIAL | ST-ELEVATION | MEDICAL THERAPY | ACUTE MYOCARDIAL-INFARCTION | UNSTABLE ANGINA | EVENTS GRACE | Japan - epidemiology | Acute Coronary Syndrome - epidemiology | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Atherosclerosis - complications | Male | Atherosclerosis - epidemiology | Incidence | Acute Coronary Syndrome - complications | Atherosclerosis - therapy | Thrombosis - etiology | Aged, 80 and over | Acute Coronary Syndrome - therapy | Adult | Female | Registries | Aged | Atherosclerosis - prevention & control | Percutaneous Coronary Intervention | Index Medicus
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12. Full Text Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice
by Kobayashi, Mikio and Yamamoto, Kimiko and Sokabe, Takaaki and Ohura, Norihiko and Masuda, Hirotake and Kawamura, Koichi and Fujita, Toshiro and Isshiki, Masashi and Fukuda, Toru and Kato, Shigeaki and Shibata, Masahiro and Ando, Joji and Sekine, Keisuke and Yoshimura, Kimihiro and Matsumoto, Takahiro and Kamiya, Akira and Sato, Takashi
Nature Medicine, ISSN 1078-8956, 01/2006, Volume 12, Issue 1, pp. 133 - 137
The structure and function of blood vessels adapt to environmental changes such as physical development and exercise. This phenomenon is based on the ability... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | FLUID SHEAR-STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | RELEASE | CELL BIOLOGY | SYNTHASE | P2X RECEPTORS | ENDOTHELIAL-CELLS | NITRIC-OXIDE | CHANNELS | ATP | Blood Pressure | Immunohistochemistry | Calcium - metabolism | Blood Vessels - pathology | Mesenteric Arteries - pathology | Acetylcholine - metabolism | Dose-Response Relationship, Drug | Time Factors | Receptors, Purinergic P2 - genetics | Polymerase Chain Reaction | NG-Nitroarginine Methyl Ester - pharmacology | Gene Transfer Techniques | Green Fluorescent Proteins - metabolism | Cells, Cultured | Mice, Transgenic | Regional Blood Flow | Blotting, Northern | Animals | Endothelium, Vascular - metabolism | Models, Biological | Receptors, Purinergic P2X4 | Receptors, Purinergic P2 - metabolism | Endothelium, Vascular - pathology | Carotid Arteries - pathology | Mice | Nitric Oxide - metabolism | Microscopy, Fluorescence | Index Medicus
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13. Full Text Randomized, Double-Blind, Dose-Finding, Phase II Study of Prasugrel in Japanese Patients Undergoing Elective Percutaneous Coronary Intervention
by Kimura, Takeshi and Isshiki, Takaaki and Ogawa, Hisao and Yokoi, Hiroyoshi and Yamaguchi, Tetsu and Ikeda, Yasuo
Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2015, Volume 22, Issue 6, pp. 557 - 569
Aim: Prasugrel is a novel platelet P2Y12 receptor blocker with a faster onset of action and greater platelet inhibition with less response variability than... 
Prasugrel | Elective PCI | Antiplatelet drugs | CYP2C19 | Coronary heart disease | CLOPIDOGREL RESISTANCE | THERAPY | ACUTE MYOCARDIAL-INFARCTION | PERIPHERAL VASCULAR DISEASE | ASPIRIN-TREATED PATIENTS | ARTERY-DISEASE | VASP PHOSPHORYLATION | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Male | Young Adult | Hemorrhage - etiology | Polymerase Chain Reaction | Aged, 80 and over | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Biomarkers - metabolism | Myocardial Infarction - surgery | Double-Blind Method | Risk Factors | Cytochrome P-450 CYP2C19 - genetics | Hemorrhage - diagnosis | Prasugrel Hydrochloride - therapeutic use | Myocardial Infarction - complications | Hemorrhage - drug therapy | Polymorphism, Single Nucleotide - genetics | Aged | Percutaneous Coronary Intervention - adverse effects | Index Medicus
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14. Full Text TCTAP A-122 Transcatheter Aortic Valve Implantation (TAVI) in Japanese Patients with Very Small Body Size, Data from OCEAN TAVI Registry
by Kawashima, Hideyuki and Watanabe, Yusuke and Kozuma, Ken and Isshiki, Takaaki and Takagi, Kensuke and Hayashida, Kentaro
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 17, pp. S62 - S62
  Background The purpose of this study was to investigate safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with very small... 
Cardiovascular | Internal Medicine | Heart valve diseases
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15. Full Text TCTAP A-062 Incidence, Predictors and Outcomes of Transient Slow Coronary Flow Appearing Just After Paclitaxel-Coated Balloon Angioplasty
by Kawashima, Hideyuki and Suzuki, Nobuaki and Watanabe, Yusuke and Kyono, Hiroyuki and Kozuma, Ken and Isshiki, Takaaki
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 17, pp. S34 - S34
  Background It has been established the effectiveness of paclitaxel-coated balloon (PCB) catheter in patients with in-stent restenosis. 
Cardiovascular | Internal Medicine | Transluminal angioplasty | Paclitaxel | Angioplasty | Stents | Heart attacks
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16. Full Text Abstract 19470: Predicted Impact of Carotid Artery Atherosclerotic Disease for Screening of Abdominal Aortic Aneurysm in Women
by Shiratori, Yoshitaka and Yokoyama, Naoyuki and Kozuma, Ken and Isshiki, Takaaki and Maruyama, Yasuyuki
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A19470 - A19470
Introduction:Screening of abdominal aortic aneurysm (AAA) for women has not been established. The aim of this study was to determine the predictive factors... 
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17. Full Text Upfront Thrombus Aspiration in Primary Coronary Intervention for Patients With ST-Segment Elevation Acute Myocardial Infarction. Report of the VAMPIRE (VAcuuM asPIration thrombus REmoval) Trial
by Ikari, Yuji and Sakurada, Masami and Kozuma, Ken and Kawano, Shigeo and Katsuki, Takaaki and Kimura, Kazuo and Suzuki, Takahiko and Yamashita, Takehiro and Takizawa, Akinori and Misumi, Kazuo and Hashimoto, Hideki and Isshiki, Takaaki and VAMPIRE Investigators
JACC: Cardiovascular Interventions, ISSN 1936-8798, 08/2008, Volume 1, Issue 4, pp. 424 - 431
Objectives: This study evaluated safety and efficacy of upfront thrombus aspiration during primary percutaneous coronary intervention (PCI) in patients with... 
coronary flow | thrombectomy | ST-segment elevation myocardial infarction | CARDIAC & CARDIOVASCULAR SYSTEMS | Coronary Circulation | Embolism - prevention & control | Prospective Studies | Humans | Japan | Thrombectomy - instrumentation | Treatment Outcome | Myocardial Infarction - diagnostic imaging | Thrombectomy - adverse effects | Equipment Design | Patient Selection | Angioplasty, Balloon, Coronary - adverse effects | Coronary Angiography | Myocardial Infarction - therapy | Suction - adverse effects | Time Factors | Thrombectomy - methods | Myocardial Infarction - physiopathology | Embolism - etiology | Suction - instrumentation | Index Medicus
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18. Full Text Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study
by Ogawa, Hisao, MD, FJCC and Isshiki, Takaaki, MD, FJCC and Kimura, Takeshi, MD, FJCC and Yokoi, Hiroyoshi, MD and Nanto, Shinsuke, MD, FJCC and Takayama, Morimasa, MD, FJCC and Kitagawa, Kazuo, MD and Nishikawa, Masakatsu, MD and Miyazaki, Shunichi, MD, FJCC and Ikeda, Yasuo, MD and Nakamura, Masato, MD, FJCC and Tanaka, Yuko, MS and Saito, Shigeru, MD, FJCC
Journal of Cardiology, ISSN 0914-5087, 2015, Volume 68, Issue 1, pp. 29 - 36
Abstract Background We examined the effects of cytochrome P450 2C19 (CYP2C19) polymorphisms on the efficacy and safety of prasugrel and clopidogrel in a post... 
Cardiovascular | Prasugrel | Clopidogrel | Platelet aggregation | Major adverse cardiovascular events | CYP2C19 | COST-EFFECTIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | GENETIC-POLYMORPHISM | GENOTYPE | REACTIVITY | ANTIPLATELET THERAPY | IMPACT | INTERVENTION | CLOPIDOGREL RESPONSIVENESS | CLINICAL-OUTCOMES | Prasugrel Hydrochloride - pharmacology | Double-Blind Method | Ticlopidine - pharmacology | Humans | Middle Aged | Cytochrome P-450 CYP2C19 - genetics | Genotype | Male | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Phenotype | Alleles | Platelet Aggregation Inhibitors - pharmacology | Female | Aged | Acute Coronary Syndrome - genetics | Aspirin - pharmacology | Hemorrhage - chemically induced | Percutaneous Coronary Intervention - adverse effects | Platelet Aggregation - genetics | Pharmacogenomic Variants - genetics | Index Medicus
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19. Coronary artery disease. Introduction
by Isshiki, Takaaki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2011, Volume 69, pp. 1 - 2
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20. Full Text Reply: Using Intravascular Ultrasound in Patients With Acute Coronary Syndrome: Characterizing Attenuated Plaque Is (Im)possible?
by Hibi, Kiyoshi and Kozuma, Ken and Kimura, Kazuo and Isshiki, Takaaki
JACC: Cardiovascular Interventions, ISSN 1936-8798, 12/2018, Volume 11, Issue 24, pp. 2545 - 2546
CARDIAC & CARDIOVASCULAR SYSTEMS
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