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Journal of Computational Chemistry, ISSN 0192-8651, 08/2008, Volume 29, Issue 11, pp. 1859 - 1865
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 03/2014, Volume 103, Issue 3, pp. 828 - 839
Journal Article
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 06/2017, Volume 106, Issue 6, pp. 1490 - 1498
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167935
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans... 
URATE OXIDASE | CHRONIC GOUT | ACID | EVOLUTION | PEGLOTICASE | EFFICACY | PHARMACOKINETICS | MULTIDISCIPLINARY SCIENCES | RASBURICASE | POLYETHYLENE-GLYCOL | CHROMATOGRAPHY | Recombinant Proteins - therapeutic use | Urate Oxidase - therapeutic use | Humans | Gout - drug therapy | Half-Life | Rats | Substrate Specificity | Polyethylene Glycols - chemistry | Recombinant Proteins - pharmacokinetics | Recombinant Proteins - biosynthesis | Urate Oxidase - adverse effects | Papio | Urate Oxidase - immunology | Animals | Recombinant Proteins - immunology | T-Lymphocytes - metabolism | Swine | Dogs | Escherichia coli - metabolism | Calorimetry, Differential Scanning | T-Lymphocytes - immunology | Kinetics | Hydrogen-Ion Concentration | Enzymes | Care and treatment | Physiological aspects | Inflammation | Research | Uric acid | Health aspects | Haplotypes | Urate oxidase | Gout | Biochemistry | pH effects | Thermal stability | Proteins | Infusion | Pain | Anaphylaxis | Enzymatic activity | E coli | Polyethylene glycol | Liabilities | Primates | Lead | Rheumatism | Oxidation | Protein engineering | Kidneys | Crystallization | Crystals | Solubility | Radioactive half-life | Injection | Joint diseases | Patients | Properties (attributes) | Acids | Immunogenicity | Histocompatibility antigen HLA | Binding sites | Pharmaceuticals
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2012, Volume 101, Issue 9, pp. 3078 - 3090
The preformulation of a trivalent recombinant protein-based vaccine candidate for protection against is described both in the presence and in the absence of... 
protein formulation | formulation | fluorescence spectroscopy | vaccines | vaccine adjuvants | preformulation | Fluorescence spectroscopy | Vaccine adjuvants | Vaccines | Protein formulation | Formulation | Preformulation | CHEMISTRY, MEDICINAL | STABILITY | ANTIGENS | ADSORPTION | CHEMISTRY, MULTIDISCIPLINARY | HYDRATION | PNEUMOCOCCAL CONJUGATE VACCINE | IMMUNIZATION | PHARMACOLOGY & PHARMACY | Temperature | Adhesins, Bacterial - chemistry | Bacterial Proteins - chemistry | Phosphates - chemistry | Spectroscopy, Fourier Transform Infrared | Streptococcus pneumoniae - immunology | Trehalose - chemistry | Aluminum Compounds - chemistry | Excipients - chemistry | Adjuvants, Immunologic - chemistry | Aluminum Hydroxide - chemistry | Light | Protein Denaturation | Bacterial Proteins - immunology | Scattering, Radiation | Protein Stability | Circular Dichroism | Vaccines, Synthetic - chemistry | Phosphates - immunology | Sucrose - chemistry | Sorbitol - chemistry | Spectrometry, Fluorescence | Technology, Pharmaceutical - methods | Lipoproteins - chemistry | Aluminum Compounds - immunology | Chemistry, Pharmaceutical | Pneumococcal Vaccines - chemistry | Adsorption | Aluminum Hydroxide - immunology | Pneumococcal Vaccines - immunology | Protein Conformation | Protein-Serine-Threonine Kinases - chemistry | Hydrogen-Ion Concentration | Proteins | Phosphates | Antigens | Pneumonia | Bacterial pneumonia | Fluorescence | Universities and colleges | Pharmacists | Streptococcus pneumoniae
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 04/2012, Volume 8, Issue 4, pp. 453 - 464
Influenza is a prevalent, highly contagious and sometimes fatal respiratory disease. Vaccination provides an effective approach to control the disease, but... 
influenza | recombinant hemagglutinin | plant-derived | vaccine | formulation development | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Formulation development | Plant-derived | Recombinant hemagglutinin | Vaccine | Influenza | STABILIZERS | VIRUS | A H1N1 | IMMUNOLOGY | ADSORPTION | HYDRATION | ALUMINUM SALT ADJUVANTS | MEMBRANE-FUSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEINS | Influenza A Virus, H1N1 Subtype - immunology | Influenza Vaccines - administration & dosage | Temperature | Adjuvants, Immunologic - administration & dosage | Vaccines, Subunit - genetics | Plant Viruses - genetics | Aluminum Hydroxide - administration & dosage | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Excipients - chemistry | Protein Stability | Spectrum Analysis | Influenza A Virus, H1N1 Subtype - genetics | Vaccines, Synthetic - chemistry | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Vaccines, Subunit - chemistry | Vaccines, Synthetic - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Vaccines, Subunit - immunology | Chemistry, Pharmaceutical | Animals | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Recombinant Proteins - immunology | Tobacco - genetics | Vaccines, Subunit - administration & dosage | Influenza Vaccines - chemistry | Mice | Vaccines, Synthetic - administration & dosage | Genetic Vectors | Hydrogen-Ion Concentration
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2013, Volume 9, Issue 11, pp. 2362 - 2370
Journal Article
01/2012, ISBN 9781267905321
The objective of this project is to explore of the use of the empirical phase diagram approach in the formulation development of several forms of vaccines that... 
Pharmacy sciences | Immunology
Dissertation
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