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e-4031 (5) 5
effective refractory period (5) 5
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Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 12/2017, Volume 121, Issue 6, pp. 465 - 470
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 03/2019, Volume 139, Issue 3, pp. 180 - 185
We analyzed how the enhancement of net sarcoplasmic reticulum (SR) Ca uptake may affect cardiac electrophysiological properties in vivo by using caldaret which... 
Reverse-mode Na+/Ca2+ exchanger | Caldaret | Sarco/endoplasmic reticulum Ca2+-ATPase | Ryanodine receptor | DRUG | TERFENADINE | TORSADES-DE-POINTES | PROFILES | SENSITIVITY | RATS | MCC-135 | SARCOPLASMIC-RETICULUM | VENTRICULAR-MUSCLES | PHARMACOLOGY & PHARMACY | ELEVATION MYOCARDIAL-INFARCTION
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 06/2018, Volume 137, Issue 2, pp. 237 - 240
We analyzed torsadogenic and pharmacokinetic profile of E-4031 using chronic atrioventricular block dogs. E-4031 in intravenous doses of 0.03, 0.1 and... 
Torsade de pointes | E-4031 | CiPA | DRUG | TORSADES-DE-POINTES | D-SOTALOL | SAFETY | PHARMACOLOGY & PHARMACY | MODEL | ANTIARRHYTHMIC AGENT | Dose-response relationship (Biochemistry) | Drug metabolism | Models | Patient outcomes | Cardiovascular agents
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 281 - 284
A beverage made of red wine vinegar and grape juice (Yamanashi-no-megumi(TM)) was developed as a supplemental fluid containing polyphenols, which has been... 
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 06/2016, Volume 131, Issue 2, pp. 150 - 153
Since astemizole in an oral dose of 50 mg/kg/day was recently reported to exert anti-cancer effect in mice, we evaluated its proarrhythmic potential using the... 
Re-profiling | Torsade de pointes | Astemizole | TORSADES-DE-POINTES | PHARMACOLOGY & PHARMACY | QT INTERVAL PROLONGATION | POTASSIUM CHANNEL | Atrioventricular Block | Animals | Antineoplastic Agents - adverse effects | Dogs | Torsades de Pointes - chemically induced | Female | Male | Astemizole - adverse effects | Disease Models, Animal
Journal Article
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 04/2018, Volume 136, Issue 4, pp. 234 - 241
Effects of moxifloxacin on QTc as well as proarrhythmic surrogate markers including J-T c, T -T and short-term variability (STV) of repolarization were... 
Thorough QT study | Moxifloxacin | J-Tpeak | Exposure-response modeling | ICH E14 | J-T | Electrocardiography | Usage | Dosage and administration | Electrocardiogram
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 281 - 284
A beverage made of red wine vinegar and grape juice (Yamanashi-no-megumi™) was developed as a supplemental fluid containing polyphenols, which has been... 
constipation | red wine | phosphodiesterase | colonic motility | vinegar | Colonic motility | Red wine | Vinegar | Constipation | Phosphodiesterase | PHOSPHODIESTERASE INHIBITORS | SMOOTH-MUSCLE | IN-VIVO | PHARMACOLOGY & PHARMACY | GRAPE JUICE | Beverages - adverse effects | Constipation - prevention & control | Colon - enzymology | Vitis - chemistry | Colon - physiology | Colon - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Male | Acetic Acid - chemistry | Muscle, Smooth - drug effects | Vitis - adverse effects | Wine - adverse effects | Colon - physiopathology | Female | Muscle, Smooth - physiology | Cholinergic Agonists - pharmacology | Guinea Pigs | Phosphoric Diester Hydrolases - metabolism | Fruit and Vegetable Juices - adverse effects | Enzyme Inhibitors - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Constipation - physiopathology | Rats, Sprague-Dawley | Acetic Acid - adverse effects | Wine - analysis | Animals | Constipation - enzymology | Muscle Contraction - drug effects | Fruit and Vegetable Juices - analysis | Muscle, Smooth - physiopathology | Polyphenols - adverse effects | Nitric Oxide Synthase - metabolism | Muscle Relaxation - drug effects | Polyphenols - therapeutic use | In Vitro Techniques | Polyphenols - administration & dosage | Muscle, Smooth - enzymology | Wine | Arginine | Carbachol | Guinea pigs | Nitric oxide | Rodents | Animal tissues | Polyphenols | Pharmacology | Colon
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 09/2019, Volume 141, Issue 1, pp. 86 - 89
Information is still limited whether β-blockade may augment or attenuate the onset of torsade de pointes in patients with I inhibitor-induced labile... 
Torsade de pointes | IKr inhibitor | β-blockade
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 8, pp. 1370 - 1373
Intravenous tetramethylpyrazine has been widely used in China as a complementary and/or alternative medicine to treat patients with ischemic heart disease. We... 
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2009, Volume 28, Issue 23, pp. 3717 - 3729
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 08/2017, Volume 134, Issue 4, pp. 239 - 246
Journal Article