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Angewandte Chemie International Edition, ISSN 1433-7851, 11/2003, Volume 42, Issue 43, pp. 5274 - 5293
Approximately 40 % of the world population live in areas with the risk of malaria. Each year, 300–500 million people suffer from acute malaria, and 0.5–2.5... 
malaria | drug design | medicinal chemistry | biological targets | Medicinal chemistry | Drug design | Biological targets | Malaria | UNCOMPLICATED FALCIPARUM-MALARIA | CRYSTAL-STRUCTURE | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ARTEMISININ DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN FARNESYLTRANSFERASE | CHLORPROGUANIL-DAPSONE | IN-VITRO ACTIVITIES | ISOPRENOID BIOSYNTHESIS | PLASMODIUM-FALCIPARUM | NONMEVALONATE PATHWAY | Ethanolamines - pharmacology | Humans | Fluorenes - pharmacology | Dapsone - therapeutic use | Plasmodium falciparum - drug effects | Flavonoids - therapeutic use | Sesquiterpenes - therapeutic use | Artemisinins - pharmacology | Malaria - epidemiology | Plasmodium falciparum - genetics | Drug Design | Flavonoids - pharmacology | Plasmodium falciparum - physiology | Aminoquinolines - pharmacology | Fosfomycin - analogs & derivatives | Fluorenes - urine | Fosfomycin - therapeutic use | Atovaquone | Global Health | Fosfomycin - pharmacology | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Antimalarials - therapeutic use | Clinical Trials as Topic | Proguanil - analogs & derivatives | Antimalarials - pharmacology | Malaria - prevention & control | Proguanil - therapeutic use | Drug Resistance - genetics | Animals | Artemisinins - therapeutic use | Ethanolamines - urine | Naphthyridines - therapeutic use | Dapsone - pharmacology | Malaria - drug therapy | Sesquiterpenes - pharmacology | Aminoquinolines - therapeutic use | Drug Combinations | Naphthyridines - pharmacology | Proguanil - pharmacology
Journal Article
Current Drug Targets, ISSN 1389-4501, 01/2007, Volume 8, Issue 1, pp. 3 - 13
Journal Article
Vogelwarte, ISSN 0049-6650, 02/2018, Volume 56, Issue 1, pp. 21 - 28
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2010, Volume 132, Issue 11, pp. 3953 - 3964
Posttranscriptional modifications of ribosomal RNA (rRNA) nucleotides are a common mechanism of modulating the ribosome's function and conferring bacterial... 
IRON-SULFUR CLUSTER | BIOTIN SYNTHASE | 4FE-4S CLUSTERS | S-ADENOSYLMETHIONINE | METHYLTRANSFERASE | PROTEIN | ESCHERICHIA-COLI | LYSINE 2,3-AMINOMUTASE REACTION | CHEMISTRY, MULTIDISCIPLINARY | CONFERS RESISTANCE | LYASE-ACTIVATING ENZYME
Journal Article
Science, ISSN 0036-8075, 9/1999, Volume 285, Issue 5433, pp. 1573 - 1576
A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of... 
Enzymes | Malaria | Terpenoids | Antimalarials | Amino acids | Apicoplasts | Reports | Parasites | Parasitemia | Dosage | Chromosomes | PARASITE TOXOPLASMA-GONDII | ERYTHROCYTES | HIGHER-PLANTS | APICOMPLEXAN PARASITES | FOSMIDOMYCIN | ISOPENTENYL DIPHOSPHATE | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | TERPENOID BIOSYNTHESIS | MEVALONATE-INDEPENDENT PATHWAY | Oxidoreductases - antagonists & inhibitors | Molecular Sequence Data | Multienzyme Complexes - metabolism | Genes, Protozoan | Organelles - drug effects | Plasmodium falciparum - drug effects | Organophosphorus Compounds - metabolism | Oxidoreductases - chemistry | Terpenes - pharmacology | Plasmodium falciparum - genetics | Cloning, Molecular | Plasmodium falciparum - metabolism | Pentosephosphates - metabolism | Aldose-Ketose Isomerases - metabolism | Fosfomycin - analogs & derivatives | Recombinant Proteins - metabolism | Amino Acid Sequence | Malaria, Falciparum - drug therapy | Aldose-Ketose Isomerases - chemistry | Recombinant Proteins - antagonists & inhibitors | Oxidoreductases - metabolism | Fosfomycin - pharmacology | Oxidoreductases - genetics | Enzyme Inhibitors - pharmacology | Multienzyme Complexes - genetics | Mevalonic Acid - metabolism | Multienzyme Complexes - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Antimalarials - pharmacology | Multienzyme Complexes - chemistry | Malaria, Falciparum - parasitology | Animals | Malaria - parasitology | Hemiterpenes | Mice | Aldose-Ketose Isomerases - genetics | Malaria - drug therapy | Aldose-Ketose Isomerases - antagonists & inhibitors | Organelles - metabolism | Plasmodium | Research | Pharmacology | Biochemistry | Drug therapy
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19334
Journal Article
Zeitschrift für Naturforschung C, ISSN 0939-5075, 09/2017, Volume 72, Issue 9, pp. 405 - 415
Cytochrome P450 monooxygenases (P450s) are ubiquitous enzymes with a broad substrate spectrum. Insect P450s are known to catalyze reactions such as the... 
biotechnology | fusion proteins | cytochrome P450 | insects | protein expression | CYTOCHROMES P450 | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MONOXIDE-BINDING PIGMENT | LIVER MICROSOMES | HOUSE-FLY | PURIFICATION | REDUCTASE | PHARMACOLOGY & PHARMACY | EXPRESSION | HEME DOMAINS | Gene expression | Observations
Journal Article
CELL REPORTS, ISSN 2211-1247, 11/2019, Volume 29, Issue 9, pp. 2862 - 2862
Intracellular accumulation of alpha-synuclein (alpha-syn) and formation of Lewy bodies are neuropathological characteristics of Parkinson's disease (PD) and... 
SYNAPTIC FAILURE | TRANSMISSION | PHOSPHORYLATION | NEURODEGENERATION | DYSFUNCTION | SUBSTANTIA-NIGRA | EXPRESSION | BRAIN | PROPAGATION | PARKINSONS-DISEASE | CELL BIOLOGY
Journal Article