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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 11/2019, Volume 116, Issue 45, pp. 22692 - 22698
Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia, is associated with noncoding... 
VARIANTS | RIGHT ASYMMETRIC EXPRESSION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | LOCI | CTCF | epigenetics | GENOME | CHROMATIN ARCHITECTURE | atrial fibrillation | GENE | genome topology | COMMON | PITX2 | DOMAINS | Cardiac arrhythmia | CRISPR | Chromatin | Immunoprecipitation | Transcription | Arrhythmia | Maintenance | Gene deletion | Enhancers | Fibrillation | Clonal deletion | Disruption | Chromosomes | Binding sites | Conformation
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7577, pp. 245 - 248
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 1, pp. 62 - 80
Human immunodeficiency virus-1 (HIV-1) infection currently requires lifelong therapy with drugs that are used in combination to control viremia. The... 
DRUG | SUBSTITUTION PATTERNS | BMS-663068 | CHEMISTRY, MEDICINAL | CONFORMATIONAL-CHANGES | PHOSPHATE PRODRUGS | ENVELOPE GLYCOPROTEINS | ACTIVE MOIETY | BMS-626529 | HIV-1-INFECTED PATIENTS | RECEPTOR-BINDING
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1332 - 1340
During a medicinal chemistry campaign to identify inhibitors of the hepatitis C virus nonstructural protein 5B (RNA-dependent RNA polymerase), a... 
NONNUCLEOSIDE INHIBITORS | VIRUS POLYMERASE | POTENT | DEPENDENT RNA-POLYMERASE | CRYSTAL-STRUCTURE | BIOSYNTHESIS | PHOSPHOLIPIDS | PHARMACOLOGY & PHARMACY | PHOSPHATIDYLCHOLINE | RECEPTOR ANTAGONIST | DISCOVERY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2014, Volume 57, Issue 5, pp. 1855 - 1879
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 6, pp. 3485 - 3495
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 11, pp. 1423 - 1429
[Display omitted] Indole- and azaindole-based glyoxylyl amide derivatives have been described as HIV-1 attachment inhibitors (AIs) that act by blocking the... 
HIV-1 | Bicyclic | Tricyclic | Indole | Azaindole | Heteroaryl | Attachment Inhibitor | Replacement | Heterocycle | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Surveys | Quinoline | Antiviral agents | HIV (Viruses)
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 6308 - 6327
The optimization of the 4-methoxy-6-azaindole series of HIV-1 attachment inhibitors (AIs) that originated with 1 to deliver temsavir (3, BMS-626529) is... 
SUBSTITUTION PATTERNS | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | ENTRY INHIBITORS | CONFORMATIONAL-CHANGES | PHOSPHATE PRODRUGS | CENTER-DOT-O | ANTIRETROVIRAL DRUG-RESISTANCE | ANTIVIRAL ACTIVITY | RANDOMIZED CONTROLLED-TRIAL | HYDROGEN-BONDS
Journal Article