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antimalarials - chemistry (1) 1
antimalarials - metabolism (1) 1
antimalarials - pharmacology (1) 1
chemistry, medicinal (1) 1
drug evaluation, preclinical (1) 1
inhibition (1) 1
isocoumarins - chemistry (1) 1
isocoumarins - metabolism (1) 1
isocoumarins - pharmacology (1) 1
lysine-trna ligase - chemistry (1) 1
lysine-trna ligase - metabolism (1) 1
mefloquine (1) 1
metabolite (1) 1
models, molecular (1) 1
plasmodium falciparum - drug effects (1) 1
plasmodium falciparum - enzymology (1) 1
protein conformation (1) 1
provides (1) 1
stereoisomerism (1) 1
structural basis (1) 1
transfer-rna synthetase (1) 1
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1. Full Text Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
by Das, Pronay and Babbar, Palak and Malhotra, Nipun and Sharma, Manmohan and Jachak, Goraknath R and Gonnade, Rajesh G and Shanmugam, Dhanasekaran and Harlos, Karl and Yogavel, Manickam and Sharma, Amit and Reddy, D. Srinivasa
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 13, pp. 5664 - 5678
The dependence of drug potency on diastereomeric configurations is a key facet. Using a novel general divergent synthetic route for a three-chiral center... 
CHEMISTRY, MEDICINAL | INHIBITION | TRANSFER-RNA SYNTHETASE | STRUCTURAL BASIS | MEFLOQUINE | PROVIDES | METABOLITE | Plasmodium falciparum - enzymology | Antimalarials - metabolism | Stereoisomerism | Models, Molecular | Plasmodium falciparum - drug effects | Antimalarials - pharmacology | Isocoumarins - pharmacology | Antimalarials - chemistry | Lysine-tRNA Ligase - metabolism | Protein Conformation | Lysine-tRNA Ligase - chemistry | Drug Evaluation, Preclinical | Isocoumarins - metabolism | Isocoumarins - chemistry
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