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1. Full Text Primary angiitis of the central nervous system (PACNS) - a rare and serious, but treatable entity
by Jacob, S
NEUROLOGY INDIA, ISSN 0028-3886, 05/2019, Volume 67, Issue 3, pp. 942 - 944
Strokes (42.2%), headaches (24.4%), seizures (17.8%), and cognitive impairment (11.1%) were the most common presenting symptoms. More than two-thirds of... 
NEUROSCIENCES | Central nervous system diseases | Care and treatment | Vasculitis | Diagnosis | Headaches | Nervous system | Inflammation | Biopsy | Medical prognosis
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2. Full Text PO142 A retrospective review of 24 cases of neurosarcoidosis
by Murley, Alexander and Hayton, Thomas and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue Suppl 1, pp. A50 - A50
BackgroundNeurosarcoidosis has a heterogeneous presentation, often with a delay in diagnosis. We aimed to clarify the clinical features, investigation results... 
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3. Full Text PO244 Case report: ‘en coup de sabre’ and cerebral vasculitis
by Simoni, Michela and Jacob, Saiju and Woolmore, John
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue Suppl 1, pp. A76 - A77
Introduction‘En coup the sabre’, a linear form of facial scleroderma, is rarely complicated by neurological symptoms. The aetiology of the underlying cerebral... 
Scleroderma
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4. Full Text 299 Immune-dysregulation in late onset myasthenia gravis
by Girija, Sadalage and Saiju, Jacob and Paul, Maddison
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 10/2018, Volume 89, Issue 10, pp. A48 - A48
IntroductionThe aim of our study was to establish if there were any clinical and immunological differences between early (EOMG) and late onset myasthenia... 
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5. Full Text Autoimmune encephalitis - The evolving spectrum: An Indian case series
by Jacob, Saiju
Neurology India, ISSN 0028-3886, 12/2015, Volume 63, Issue 5, pp. 647 - 649
  Other antibodies which are less commonly identified include those against α-amino-3-hydroxy-5-methyl-4-isoxazo lepropionic acid receptor [AMPAR] (LE with... 
ANTIBODIES | LIMBIC ENCEPHALITIS | NMDA-RECEPTOR ENCEPHALITIS | NEUROSCIENCES | Viral antibodies | Encephalitis | Care and treatment | Antibodies | Physiological aspects | Research | Risk factors | Proteins | Immunoglobulins | Potassium | Index Medicus
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6. Full Text Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection
by Scotton, William J and Karim, Abid and Jacob, Saiju and Jacob, Saiju
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1941, pp. 225 - 255
Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to... 
Paraneoplastic | Neuropsychiatric disorder | Pathogenic markers | mGluR1 | NMDAR | Glutamate receptor | Neuronal surface antibodies | Transfected cell-based assay | AMPAR | KAR | mGluR5 | Autoimmune encephalitis
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7. Full Text PO140 An unusual presentation of nmo, and mri review of 31 nmo patients
by Michael, Sophia and Mistry, Niraj and Nader, Kurdow and Chavda, Swarupsinh and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue Suppl 1, pp. A49 - A50
A 31 year old lady was admitted with worsening of right sided hemiparesis, on a background five month history of mild right upper limb weakness, and upper limb... 
Aquaporins
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8. Full Text Restless leg syndrome in patients with liver cirrhosis: Waiting for the shoe to drop
by Bose, S and Jacob, S
NEUROLOGY INDIA, ISSN 0028-3886, 05/2019, Volume 67, Issue 3, pp. 657 - 659
There have been many studies now showing a positive correlation between the prevalence of RLS in patients with cirrhosis. [...]the prevalence of RLS in the... 
NEUROSCIENCES | DISEASE | PREVALENCE | Studies | Ammonia | Restless legs syndrome | Sleep | Dopamine | Liver diseases | Population | Iron | Family medical history | Kidney diseases | Liver cirrhosis | Quality of life
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9. Full Text THUR 159 Radiological findings in two patients with autoimmune GFAP astrocytopathy
by Daniel, White and Markand, Patel and Wasim, Muhammad and Tom, Hayton and Satheesh, Ramalingam and Vijay, Sawlani and Saiju, Jacob
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 10/2018, Volume 89, Issue 10, pp. A19 - A19
BackgroundAutoimmune Glial Fibrillary Acidic Protein (GFAP) Astrocytopathy is a relatively new category of immune-mediated disease involving the central... 
Spinal cord | Cognitive ability
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10. Full Text WED 148 Imaging findings in autoimmune encephalitis: a retrospective review
by Jawad, Fazal and Nouman, Sadiq and Michael, Bowen and Wali, Muhammad Wasim and Vijay, Sawlani and Saiju, Jacob
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 10/2018, Volume 89, Issue 10, pp. A17 - A17
BackgroundNeuroimaging findings in autoimmune encephalitis may include normal MRI as well as limbic and extra-limbic involvement. Prompt recognition allows... 
Autoimmune diseases | Encephalitis
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11. Full Text IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
by Leite, Maria Isabel and Jacob, Saiju and Viegas, Stuart and Cossins, Judy and Clover, Linda and Morgan, B. Paul and Beeson, David and Willcox, Nick and Vincent, Angela
Brain, ISSN 0006-8950, 7/2008, Volume 131, Issue 7, pp. 1940 - 1952
Only around 80% of patients with generalized myasthenia gravis (MG) have serum antibodies to acetylcholine receptor [AChR; acetylcholine receptor antibody... 
Complement activation | Myasthenia gravis | AChR antibodies | IgG subclasses | Seronegative MG | seronegative MG | AUTOANTIBODIES | myasthenia gravis | NEUROSCIENCES | CLINICAL NEUROLOGY | complement activation | THYMUS | ACHR | INHIBITION | PLASMA | DISEASE | TYROSINE KINASE MUSK | MUTATIONS | CELL-LINE | Cell Line | Autoantibodies - metabolism | Binding Sites, Antibody - immunology | Immunoglobulin G - blood | Autoantibodies - blood | Humans | Receptor Protein-Tyrosine Kinases - immunology | False Negative Reactions | Complement Activation - immunology | Immunoglobulin M - metabolism | Microscopy, Fluorescence - methods | Immunoglobulin G - immunology | Thymus Gland - pathology | Adult | Fetus - immunology | Receptors, Cholinergic - immunology | Thymus Gland - immunology | Myasthenia Gravis - immunology | Antigen-Antibody Reactions - immunology | Immunoglobulin G - metabolism | Myasthenia Gravis - pathology | Index Medicus | Abridged Index Medicus | Original
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12. Full Text KEEP YOUR HEAD DOWN AND SHAKE
by Sadalage, Girija and Yousaf, Muhammad and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2016, Volume 87, Issue 12, pp. e1 - e1
IntroductionCamptocormia is due to weakness of neck extensors or increased tone of neck flexors. Spinal myoclonus is a frequent occurrence in different... 
SURGERY | PSYCHIATRY | CLINICAL NEUROLOGY
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13. Full Text USE OF PLASMA EXCHANGE FOR NEUROLOGICAL INDICATIONS
by Sadalage, Girija and Yoganayagam, Nicola and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2016, Volume 87, Issue 12, pp. e1 - e1
BackgroundSeveral neurological conditions are amenable to immunomodulatory therapy. Plasma exchange has been shown to be beneficial in a variety of... 
SURGERY | PSYCHIATRY | CLINICAL NEUROLOGY
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14. Full Text PO205 A prospective clinical and immunological study of late onset myasthenia gravis
by Sadalage, Girija and Jacob, Saiju and Hilton-Jones, David and Buckley, Camilla and Vincent, Angela and Maddison, Paul
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue Suppl 1, pp. A65 - A66
IntroductionEpidemiological studies conducted in several countries have shown that the incidence of myasthenia gravis in the older population (>50 years) is... 
Health risk assessment | Immunology
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15. Full Text RITUXIMAB USE IN A PATIENT WITH ANTI-RI POSITIVE OPSOCLONUS MYOCLONUS SYNDROME
by Sadalage, Girija and Bowen, John and Nightingale, Simon and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2016, Volume 87, Issue 12, pp. e1 - e1
Opsoclonus Myoclonus syndrome (OMS) is described as a classical paraneoplastic syndrome having an incidence of 1 in 10 million per year, and can often be... 
SURGERY | PSYCHIATRY | CLINICAL NEUROLOGY
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16. Full Text MANAGEMENT OF MYASTHENIA GRAVIS COMPARED TO NATIONAL GUIDELINES
by Perera, Pulukkuttiralalage Senali and Tiet, May Yung and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2016, Volume 87, Issue 12, pp. e1 - e1
BackgroundMyasthenia Gravis (MG) is an autoimmune disorder presenting with fatigable muscle weakness leading to potential respiratory distress. Clinical... 
SURGERY | PSYCHIATRY | CLINICAL NEUROLOGY
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17. Full Text WHAT INFLUENCES FALSE POSITIVE ACHR ANTIBODY RESULTS?
by Sadalage, Girija and Torane, Pravin and Karim, Abid and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2016, Volume 87, Issue 12, pp. e1 - e1
Acetylcholine receptor antibodies are seen in nearly 85% of patients with generalised myasthenia gravis (MG). Two main assays are used to detect the... 
SURGERY | PSYCHIATRY | CLINICAL NEUROLOGY
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18. Full Text 1712 ‘Less contented as a person’: preliminary data from the lgi1-qol study
by Binks, Sophie NM and Jacob, Saiju and Maddison, Paul and Coebergh, Jan and Isabel Leite, M and Irani, Sarosh R
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue Suppl 1, pp. A7 - A7
ObjectiveTo describe the long-term cognitive, neuropsychiatric and quality of life (QOL) outcomes in LGI1-antibody encephalitis.Methods42 patients, forming the... 
Localization | Encephalitis
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19. Full Text PO021 Adem triggered by toxic effect of synthetic cannabinoid, black mamba
by Samra, Kiran and Boon, Ian and Packer, Gregory and Abbas, Ahmed and Pucci, Mark and Reddy-Kolanu, Vinay and Ramalingam, Satheesh and Jacob, Saiju
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 12/2017, Volume 88, Issue Suppl 1, pp. A18 - A18
Acute disseminated encephalomyelitis (ADEM) is a multifocal demyelinating disease triggered by infection, vaccination or, as in this case, an exogenous toxin.... 
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20. Full Text Slowly progressive distal muscle weakness: neuropathy or myopathy?
by Nahari, Yafit and Abbas, Ahmed and Curtis, Elizabeth and Jacob, Saiju
BMJ Case Reports, 04/2019, Volume 12, Issue 4
Nonaka myopathy is an autosomal recessive and slowly progressive distal myopathy. It is part of a rare group of myopathies predominantly affecting the distal... 
Case studies | Immunoglobulins | Electromyography | Diabetes | Family medical history | Mutation | Peripheral neuropathy | Kinases
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