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1995, ISBN 0935702369, xvi, 232
Book
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5245 - 10
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 03/2019, Volume 431, Issue 5, pp. 1038 - 1047
Single-copy loss-of-function mutations in the progranulin gene ( ) underlie the neurodegenerative disease frontotemporal lobar degeneration, while homozygous... 
progranulin | neurodegeneration | maturation | cathepsin D | propeptide | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | POLYMORPHISM | PROCATHEPSIN-D | CANCER | DEFICIENCY | LYSOSOMAL-ENZYME | GROWTH | ACTIVATION PEPTIDE | EXPRESSION | Cathepsins | Enzymes | Nervous system diseases | Hydrogen-ion concentration | Analysis
Journal Article
Cancer research, ISSN 0008-5472, 08/2019, Volume 79, Issue 16, pp. 4283 - 4292
KIT is a type-3 receptor tyrosine kinase that is frequently mutated at exon 11 or 17 in a variety of cancers. First-generation KIT tyrosine kinase inhibitors... 
ONCOLOGY | TYROSINE KINASE | COMPLEX REVEALS | PROTEIN-KINASE INHIBITOR | C-KIT | STI-571 INHIBITION | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | PHASE-I | IMATINIB MESYLATE
Journal Article
Biophysical Journal, ISSN 0006-3495, 04/2019, Volume 116, Issue 8, pp. 1432 - 1445
Human immunodeficiency virus-1 viral infectivity factor (Vif) is an intrinsically disordered protein responsible for the ubiquitination of the APOBEC3 (A3)... 
CBF-BETA | MOLECULAR-DYNAMICS | APOBEC3F | BIOPHYSICS | MECHANISM | RESTRICTION FACTORS | IDENTIFICATION | BINDING | INSIGHTS | Ubiquitin | Antiviral agents | Ligases | Crystals | Therapeutics | Molecular dynamics | Nuclear magnetic resonance spectroscopy | Structure | HIV (Viruses) | Homeopathy | Materia medica and therapeutics | Protein binding
Journal Article
Biochemistry, ISSN 0006-2960, 02/2019, Volume 58, Issue 6, pp. 848 - 857
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to... 
LIPOXYGENASE | SITE | COMPLEX | PRODUCTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | POSITIONAL SPECIFICITY | HYDROPEROXIDE GLUTATHIONE-PEROXIDASE | HUMAN 15-LIPOXYGENASE | PRIMARY DETERMINANT | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 05/2019, Volume 294, Issue 22, pp. 8779 - 8790
Journal Article
Molecular Informatics, ISSN 1868-1743, 03/2019, Volume 38, Issue 3, pp. e1800089 - n/a
Journal Article
Biochemistry, ISSN 0006-2960, 06/2019, Volume 58, Issue 23, pp. 2670 - 2674
Progranulin (PGRN) is an evolutionarily conserved glycoprotein associated with several disease states, including neurodegeneration, cancer, and autoimmune... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | FAMILY
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 512, Issue 2, pp. 208 - 212
Protein kinase CK2 has emerged as an attractive cancer therapeutic target. Previous studies have highlighted the challenge of optimizing CK2 ATP-competitive... 
Structure-based inhibitor design | Linear 2-propenone scaffold | Protein kinase CK2 | Anti-cancer activity | DESIGN | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-KINASE CK2 | COUMARIN | DERIVATIVES | BINDING | Prevention | Antimitotic agents | Benzoic acid | Care and treatment | Hydrogen | Drug discovery | Drug therapy | Antineoplastic agents | Organic acids | Cancer
Journal Article
Journal Article