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1. Full Text Reply
by Jaffe, Glenn J., MD
Ophthalmology, ISSN 0161-6420, 2016, Volume 124, Issue 4, pp. e45 - e45
Ophthalmology
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2. Full Text Reply
by Jaffe, Glenn J., MD
Ophthalmology, ISSN 0161-6420, 2016, Volume 124, Issue 2, pp. e19 - e19
Ophthalmology
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3. Full Text Intravitreal Aflibercept for Diabetic Macular Edema
by Korobelnik, Jean-François, MD and Do, Diana V., MD and Schmidt-Erfurth, Ursula, MD and Boyer, David S., MD and Holz, Frank G., MD and Heier, Jeffrey S., MD and Midena, Edoardo, MD and Kaiser, Peter K., MD and Terasaki, Hiroko, MD and Marcus, Dennis M., MD and Nguyen, Quan D., MD and Jaffe, Glenn J., MD and Slakter, Jason S., MD and Simader, Christian, MD and Soo, Yuhwen, PhD and Schmelter, Thomas, PhD and Yancopoulos, George D., MD, PhD and Stahl, Neil, PhD and Vitti, Robert, MD and Berliner, Alyson J., MD, PhD and Zeitz, Oliver, MD and Metzig, Carola, MD and Brown, David M., MD
Ophthalmology, ISSN 0161-6420, 2014, Volume 121, Issue 11, pp. 2247 - 2254
Purpose A head-to-head comparison was performed between vascular endothelial growth factor blockade and laser for treatment of diabetic macular edema (DME).... 
Ophthalmology | OPHTHALMOLOGY | VEGF TRAP | RETINOPATHY | RANIBIZUMAB | LASER | ENDOTHELIAL GROWTH-FACTOR | Diabetic Retinopathy - drug therapy | Receptors, Vascular Endothelial Growth Factor - therapeutic use | Intravitreal Injections | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Laser Coagulation | Diabetes Mellitus, Type 1 - complications | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Diabetic Retinopathy - physiopathology | Angiogenesis Inhibitors - therapeutic use | Female | Angiogenesis Inhibitors - adverse effects | Visual Acuity - physiology | Diabetes Mellitus, Type 2 - complications | Double-Blind Method | Tomography, Optical Coherence | Diabetic Retinopathy - surgery | Macular Edema - surgery | Macular Edema - physiopathology | Macular Edema - drug therapy | Aged | Receptors, Vascular Endothelial Growth Factor - adverse effects | Medical colleges | Dropsy | Edema | Endothelial growth factors | Analysis | Diabetes | Consulting services
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4. Full Text Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration
by Martin, Daniel F., MD and Maguire, Maureen G., PhD and Fine, Stuart L., MD and Ying, Gui-shuang, PhD and Jaffe, Glenn J., MD and Grunwald, Juan E., MD and Toth, Cynthia, MD and Redford, Maryann, DDS, MPH and Ferris, Frederick L., MD and Comparison Age-related Macular
Ophthalmology, ISSN 0161-6420, 2012, Volume 119, Issue 7, pp. 1388 - 1398
Objective To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to... 
Ophthalmology | OPHTHALMOLOGY | Macular degeneration | Care and treatment | Angiogenesis inhibitors | Drug therapy | Analysis
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5. Full Text Risk of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials
by Grunwald, Juan E., MD and Daniel, Ebenezer, MBBS, MD and Huang, Jiayan, MS and Ying, Gui-shuang, PhD and Maguire, Maureen G., PhD and Toth, Cynthia A., MD and Jaffe, Glenn J., MD and Fine, Stuart L., MD and Blodi, Barbara, MD and Klein, Michael L., MD and Martin, Alison A and Hagstrom, Stephanie A., PhD and Martin, Daniel F., MD and CATT Res Grp and CATT Research Group
Ophthalmology, ISSN 0161-6420, 2014, Volume 121, Issue 1, pp. 150 - 161
Purpose To describe risk factors for geographic atrophy (GA) in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Design Cohort... 
Ophthalmology | CATT | AREA | BEVACIZUMAB | SUSCEPTIBILITY | DISEASE | AMD | OPHTHALMOLOGY | RANIBIZUMAB | PROGRESSION | Follow-Up Studies | Geographic Atrophy - diagnosis | Humans | Middle Aged | Geographic Atrophy - drug therapy | Male | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Genotyping Techniques | Bevacizumab | Incidence | Ranibizumab | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Female | Visual Acuity - physiology | Fluorescein Angiography | Geographic Atrophy - epidemiology | Wet Macular Degeneration - epidemiology | Antibodies, Monoclonal, Humanized - therapeutic use | Risk Factors | Proportional Hazards Models | Wet Macular Degeneration - diagnosis | Wet Macular Degeneration - drug therapy | Aged | Cohort Studies | Macular degeneration | Clinical trials | Physiological aspects | Comparative analysis | Drug therapy | Risk factors | Biomedical engineering | Medical research | Medicine, Experimental
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6. Full Text Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration
by Holz, Frank G., MD, FEBO and Sadda, SriniVas R., MD and Staurenghi, Giovanni, MD, FARVO and Lindner, Moritz, MD and Bird, Alan C., MD, FARVO and Blodi, Barbara A., MD and Bottoni, Ferdinando, MD, FEBO and Chakravarthy, Usha, MBBS, PhD and Chew, Emily Y., MD, FARVO and Csaky, Karl, MD, PhD and Curcio, Christine A., PhD, FARVO and Danis, Ron, MD and Fleckenstein, Monika, MD and Freund, K. Bailey, MD and Grunwald, Juan, MD and Guymer, Robyn, MBBS, PhD and Hoyng, Carel B., MD, PhD and Jaffe, Glenn J., MD, FARVO and Liakopoulos, Sandra, MD and Monés, Jordi M., MD, PhD and Oishi, Akio, MD, PhD and Pauleikhoff, Daniel, MD and Rosenfeld, Philip J., MD, PhD and Sarraf, David, MD and Spaide, Richard F., MD and Tadayoni, Ramin, MD, PhD and Tufail, Adnan, MD, FRCOphth and Wolf, Sebastian, MD, PhD and Schmitz-Valckenberg, Steffen, MD, FEBO and CAM Grp
Ophthalmology, ISSN 0161-6420, 2016, Volume 124, Issue 4, pp. 464 - 478
Purpose To summarize the results of 2 consensus meetings (Classification of Atrophy Meeting [CAM]) on conventional and advanced imaging modalities used to... 
Ophthalmology | RETICULAR PSEUDODRUSEN | OPTICAL COHERENCE TOMOGRAPHY | QUANTITATIVE FUNDUS AUTOFLUORESCENCE | GEOGRAPHIC ATROPHY PROGRESSION | GROWTH-FACTOR THERAPY | SCANNING LASER OPHTHALMOSCOPY | OPHTHALMOLOGY | SUBRETINAL DRUSENOID DEPOSITS | INDOCYANINE GREEN ANGIOGRAPHY | CHOROIDAL NEOVASCULARIZATION | RETINAL-PIGMENT EPITHELIUM | Macular degeneration | Clinical trials | Physiological aspects | Medicine, Experimental | Medical research
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7. Full Text Efficacy of Intravitreal Ocriplasmin for Treatment of Vitreomacular Adhesion
by Haller, Julia A., MD and Stalmans, Peter, MD, PhD and Benz, Matthew S., MD and Gandorfer, Arnd, MD and Pakola, Stephen J., MD and Girach, Aniz, MD and Kampik, Anselm, MD and Jaffe, Glenn J., MD and Toth, Cynthia A., MD and MIVI-TRUST Study Grp
Ophthalmology, ISSN 0161-6420, 2015, Volume 122, Issue 1, pp. 117 - 122
Purpose To evaluate the efficacy of a single intravitreal injection of ocriplasmin 125 μg across relevant subpopulations of patients with symptomatic... 
Ophthalmology | TRACTION | TRIAL | VITRECTOMY | PHARMACOLOGICAL VITREOLYSIS | POSTERIOR VITREOUS DETACHMENT | MICROPLASMIN | OPHTHALMOLOGY | Consulting services | Analysis
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8. Full Text Baseline Predictors for One-Year Visual Outcomes with Ranibizumab or Bevacizumab for Neovascular Age-related Macular Degeneration
by Ying, Gui-shuang, PhD and Huang, Jiayan, MS and Maguire, Maureen G., PhD and Jaffe, Glenn J., MD and Grunwald, Juan E., MD and Toth, Cynthia, MD and Daniel, Ebenezer, MBBS, MS, MPH and Klein, Michael, MD and Pieramici, Dante, MD and Wells, John, MD and Martin, Daniel F., MD and Comparison Age-Related Macular and Comparison of Age-related Macular Degeneration Treatments Trials Research Group
Ophthalmology, ISSN 0161-6420, 2013, Volume 120, Issue 1, pp. 122 - 129
Objective To determine the baseline predictors of visual acuity (VA) outcomes 1 year after treatment with ranibizumab or bevacizumab for neovascular... 
Ophthalmology | OPHTHALMOLOGY | HEMORRHAGE | SUBGROUP ANALYSIS | Antibodies, Monoclonal, Humanized - therapeutic use | Intravitreal Injections | Tomography, Optical Coherence | Humans | Middle Aged | Male | Treatment Outcome | Wet Macular Degeneration - physiopathology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Bevacizumab | Wet Macular Degeneration - drug therapy | Time Factors | Ranibizumab | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Female | Aged | Visual Acuity - physiology | Cohort Studies | Fluorescein Angiography | Macular degeneration | Physiological aspects | Medical colleges | Angiogenesis inhibitors | Consulting services
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9. Full Text Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study)
by Schmitz-Valckenberg, Steffen, MD and Sahel, José-Alain, MD and Danis, Ronald, MD and Fleckenstein, Monika, MD and Jaffe, Glenn J., MD and Wolf, Sebastian, MD and Pruente, Christian, MD and Holz, Frank G., MD
Ophthalmology, ISSN 0161-6420, 2016, Volume 123, Issue 2, pp. 361 - 368
Purpose The Geographic Atrophy Progression (GAP) study was designed to assess the rate of geographic atrophy (GA) progression and to identify prognostic... 
Ophthalmology | EYE | OPHTHALMOLOGY | VISUAL-ACUITY | TRIALS | ENLARGEMENT | FUNDUS AUTOFLUORESCENCE PATTERNS | Optical Imaging | Retinal Pigment Epithelium - pathology | Prospective Studies | Geographic Atrophy - diagnosis | Humans | Macular Degeneration - complications | Female | Male | Aged | Visual Acuity - physiology | Disease Progression | Fluorescein Angiography | Macular degeneration | Physiological aspects | Fluorescence | Analysis | Index Medicus
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10. Full Text Dual Antagonism of PDGF and VEGF in Neovascular Age-Related Macular Degeneration
by Jaffe, Glenn J., MD and Ciulla, Thomas A., MD, MBA and Ciardella, Antonio P., MD and Devin, Francois, MD and Dugel, Pravin U., MD and Eandi, Chiara M., MD and Masonson, Harvey, MD and Monés, Jordi, MD, PhD and Pearlman, Joel A., MD, PhD and Quaranta-El Maftouhi, Maddalena, MD and Ricci, Federico, MD and Westby, Keith, MBA and Patel, Samir C., MD
Ophthalmology, ISSN 0161-6420, 2016, Volume 124, Issue 2, pp. 224 - 234
Purpose To assess the safety and efficacy of E10030 (Fovista; Ophthotech, New York, NY), a platelet-derived growth factor (PDGF) antagonist, administered in... 
Ophthalmology | VISUAL-ACUITY | CELLS | INTRAVITREAL RANIBIZUMAB | ANGIOGENESIS | DAILY CLINICAL-PRACTICE | GROWTH-FACTOR THERAPY | TREATMENTS TRIALS | OPHTHALMOLOGY | PERICYTE COVERAGE | MECHANISMS | CHOROIDAL NEOVASCULARIZATION | Macular degeneration | Medical colleges | Management science | Platelet-derived growth factor | Analysis | Physiological aspects | Vascular endothelial growth factor | Consulting services | Endothelium
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11. Full Text A Phase 1 Study of Intravitreous E10030 in Combination with Ranibizumab in Neovascular Age-Related Macular Degeneration
by Jaffe, Glenn J., MD and Eliott, Dean, MD and Wells, John A., MD and Prenner, Jonathan L., MD and Papp, Andras, MD and Patel, Samir, MD
Ophthalmology, ISSN 0161-6420, 2016, Volume 123, Issue 1, pp. 78 - 85
Purpose To assess the safety and tolerability of E10030 (Fovista; Ophthotech, New York, NY), a platelet-derived growth factor (PDGF) antagonist, when... 
Ophthalmology | CELLS | THERAPY | VERTEPORFIN | ANGIOGENESIS | INJECTION | VEGF | OPHTHALMOLOGY | PDGF-B | CHOROIDAL THICKNESS | TUMOR VASCULATURE | PERICYTE | Retinal Neovascularization - diagnosis | Aptamers, Nucleotide - pharmacology | Prospective Studies | Intravitreal Injections | Humans | Middle Aged | Male | Treatment Outcome | Aptamers, Nucleotide - administration & dosage | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Visual Acuity | Macular Degeneration - diagnosis | Macular Degeneration - drug therapy | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Aged, 80 and over | Female | Ranibizumab - administration & dosage | Aged | Retinal Neovascularization - drug therapy | Drug Therapy, Combination | Fundus Oculi | Platelet-Derived Growth Factor - antagonists & inhibitors | Fluorescein Angiography | Macular degeneration | Physiological aspects | Platelet-derived growth factor | Vascular endothelial growth factor | Analysis | Index Medicus
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12. Full Text Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials
by Daniel, Ebenezer, MBBS, PhD and Toth, Cynthia A., MD and Grunwald, Juan E., MD and Jaffe, Glenn J., MD and Martin, Daniel F., MD and Fine, Stuart L., MD and Huang, Jiayan, MS and Ying, Gui-shuang, MD, PhD and Hagstrom, Stephanie A., PhD and Winter, Katrina, BS and Maguire, Maureen G., PhD and Comparison of Age-related Macular and Comparison of Age-related Macular Degeneration Treatments Trials Research Group
Ophthalmology, ISSN 0161-6420, 2014, Volume 121, Issue 3, pp. 656 - 666
Objective To describe risk factors for scar in eyes treated with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). Design... 
Ophthalmology | GLAUCOMA FILTRATION SURGERY | SUBRETINAL HEMORRHAGE | PHOTODYNAMIC THERAPY | VISUAL FUNCTION | BEVACIZUMAB | OPHTHALMOLOGY | RETINAL ANGIOMATOUS PROLIFERATION | NATURAL-HISTORY | CHOROIDAL NEOVASCULARIZATION | RANIBIZUMAB | ENDOTHELIAL GROWTH-FACTOR | Prospective Studies | Cicatrix - etiology | Intravitreal Injections | Humans | Middle Aged | Male | Cicatrix - diagnosis | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Wet Macular Degeneration - genetics | Bevacizumab | Incidence | Ranibizumab | Angiogenesis Inhibitors - therapeutic use | Female | Postoperative Complications | Visual Acuity - physiology | Fluorescein Angiography | Antibodies, Monoclonal, Humanized - therapeutic use | Tomography, Optical Coherence | Risk Factors | Genotype | Wet Macular Degeneration - diagnosis | Wet Macular Degeneration - drug therapy | Fibrosis | Retina - pathology | Cohort Studies | Macular degeneration | Clinical trials | Physiological aspects | Comparative analysis | Drug therapy | Risk factors
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