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malaria (42) 42
animals (39) 39
plasmodium berghei - genetics (27) 27
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1. High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei
by Janse, Chris J and Ramesar, Jai and Waters, Andrew P
Nature Protocols, ISSN 1754-2189, 06/2006, Volume 1, Issue 1, pp. 346 - 356
This protocol describes a method of genetic transformation for the rodent malaria parasite Plasmodium berghei with a high transfection efficiency of 10(-3) -... 
BIOCHEMICAL RESEARCH METHODS | GENE-TRANSFER | Transformation, Genetic | Triazines - pharmacology | Culture Techniques | Humans | Plasmodium berghei - genetics | Pyrimethamine - pharmacology | Genetic Markers | Antimalarials - pharmacology | Animals | Transfection - methods | Plasmodium berghei - growth & development | Mice | Mutation | Drug Resistance | Plasmodium berghei - drug effects | Tetrahydrofolate Dehydrogenase - genetics
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2. Full Text Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging
by Ploemen, I.H.J and Prudencio, M and Douradinha, B.G and Ramesar, J and Fonager, J and Gemert, G.J.A. van and Luty, A.J.F and Hermsen, C.C and Sauerwein, R.W and Baptista, F.G and Mota, M.M and Waters, A.P and Que, I and Lowik, C.W.G.M and Khan, S.M and Janse, C.J and Franke-Fayard, B
PLoS One, ISSN 1932-6203, 2009, Volume 4, Issue 11, pp. e7881 - e7881
The quantitative analysis of Plasmodium development in the liver in laboratory animals in cultured cells is hampered by low parasite infection rates and the... 
HIGH-EFFICIENCY TRANSFECTION | PARASITES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DRUG DISCOVERY | BLOOD STAGES | BERGHEI | INFECTION | MICE | EXOERYTHROCYTIC STAGES | PLASMODIUM-FALCIPARUM MALARIA | Cell Line | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Humans | Mice, Inbred C57BL | Luminescence | Reverse Transcriptase Polymerase Chain Reaction | Hepatocytes - parasitology | Diagnostic Imaging - methods | Plasmodium berghei - metabolism | Animals | Malaria - pathology | Sporozoites - metabolism | Malaria - parasitology | Female | Mice | Liver - parasitology | Infection | Malaria | Parasitic diseases | Luciferase | Genetic engineering | Comparative analysis | Health aspects | Drugs | Cell culture | Flow cytometry | Bioluminescence | Primaquine | Liver | Transgenic | Infections | Vaccines | Parasites | Drug screening | Developmental stages | Rodents | Surgery | Imaging | Life cycle engineering | Quantitative analysis | Vector-borne diseases | Parasitology | Sensitivity analysis | Research & development--R&D | Real time | Studies | Polymerase chain reaction | Tafenoquine | Laboratory tests | Screening | Chemotherapy | Infectious diseases | Hepatocytes | Correlation analysis | Laboratory animals | Endocrinology | Life cycles | Research & development | R&D
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3. Full Text A novel 'Gene Insertion/Marker Out' (GIMO) method for transgene expression and gene complementation in rodent malaria parasites
by Lin, Jing-wen and Annoura, Takeshi and Sajid, Mohammed and Chevalley-Maurel, Séverine and Ramesar, Jai and Klop, Onny and Franke-Fayard, Blandine M. D and Janse, Chris J and Khan, Shahid M
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, p. e29289
Research on the biology of malaria parasites has greatly benefited from the application of reverse genetic technologies, in particular through the analysis of... 
HIGH-EFFICIENCY TRANSFECTION | IN-VITRO | PROTEIN | FALCIPARUM | BIOLOGY | SELECTABLE MARKER | MOSQUITO | BLOOD STAGES | PLASMODIUM-BERGHEI | SELECTION | GENOME | Rodentia - parasitology | Animals | Transgenes | Genetic Complementation Test | Plasmodium - genetics | Infection | Proteins | Plasmodium falciparum | Malaria | Analysis | Genetically modified organisms | Genetic research | Genetic aspects | Genetic engineering | Drug resistance | Gene expression | Methods | Flow cytometry | Genes | Transgenic | Insertion | Infections | Genomes | Biology | Negative selection | Parasites | Gene deletion | Transfection | Clonal deletion | Deletion | Complementation | Dihydrofolate reductase | Genetic modification | Vector-borne diseases | Parasitology | Mutants | Laboratory tests | Mutation | Laboratory animals
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4. Full Text Three members of the 6-cys protein family of plasmodium play a role in gamete fertility
by Dijk, M.R. van and Schaijk, B.C.L. van and Khan, S.M and Dooren, M.W. van and Ramesar, J and Kaczanowski, S and Gemert, G.J.A. van and Kroeze, H and Stunnenberg, H.G and Eling, W.M and Sauerwein, R.W and Waters, A.P and Janse, C.J
Plos Pathogens, ISSN 1553-7366, 2010, Volume 6, Issue 4, pp. 1 - 13
The process of fertilization is critically dependent on the mutual recognition of gametes and in Plasmodium, the male gamete surface protein P48/45 is vital to... 
LIFE-CYCLE | TRANSMISSION-BLOCKING IMMUNITY | HIGH-EFFICIENCY TRANSFECTION | SURFACE PROTEIN | NUCLEOTIDE SUBSTITUTION | MICROBIOLOGY | TARGET ANTIGEN | MOSQUITO TRANSMISSION | AMINO-ACID SITES | VIROLOGY | DETECTING POSITIVE SELECTION | MALARIA PARASITE | PARASITOLOGY | Gene Expression | Plasmodium berghei - physiology | Molecular Sequence Data | Male | Gene Expression Profiling | Protozoan Proteins - genetics | Blotting, Western | Polymorphism, Genetic | Blotting, Northern | Animals | Protozoan Proteins - metabolism | Fertility | Base Sequence | Polymerase Chain Reaction | Female | Germ Cells - metabolism | Plasmodium falciparum | Genetic aspects | Germ cells | Research | Gene mutations | Sexual reproduction | Proteins | Medical research | Genetics | Parasites | Malaria
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5. Full Text Murine Malaria Parasite Sequestration: CD36 Is the Major Receptor, but Cerebral Pathology Is Unlinked to Sequestration
by Blandine Franke-Fayard and Chris J. Janse and Margarida Cunha-Rodrigues and Jai Ramesar and Philippe Büscher and Ivo Que and Clemens Löwik and Peter J. Voshol and Marion A. M. den Boer and Sjoerd G. van Duinen and Maria Febbraio and Maria M. Mota and Andrew P. Waters and Diane E. Griffin
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2005, Volume 102, Issue 32, pp. 11468 - 11473
Sequestration of malaria-parasite-infected erythrocytes in the microvasculature of organs is thought to be a significant cause of pathology. Cerebral malaria... 
Adipose tissues | Spleen | Biological Sciences | Schizonts | Lungs | Malaria | Infections | Mice | Parasitism | Parasites | Blood | Plasmodium | Real-time in vivo imaging | P. berghei | Imaging | Luciferase | FALCIPARUM-INFECTED ERYTHROCYTES | MULTIDISCIPLINARY SCIENCES | BERGHEI | imaging | PATHOGENESIS | real-time in vivo imaging | CYTOADHERENCE CHARACTERISTICS | PLASMODIUM-FALCIPARUM | INSULIN-RESISTANCE | ENDOTHELIAL-CELLS | FATTY-ACID | luciferase | MICE | MOLECULAR-MECHANISMS | Gene Transfer Techniques | Green Fluorescent Proteins | Malaria, Cerebral - pathology | Lung - pathology | Adipose Tissue - parasitology | Luciferases - metabolism | Lung - parasitology | Plasmodium berghei - genetics | Adipose Tissue - pathology | Malaria, Cerebral - physiopathology | Plasmodium berghei - metabolism | Animals | Protozoan Proteins - metabolism | CD36 Antigens - metabolism | Microscopy, Fluorescence - methods | Time Factors | Brain - pathology | Erythrocytes - parasitology | Brain - parasitology | Research | Erythrocytes
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6. Full Text Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite
by Jorge M. Santos and Neuza Duarte and Jessica Kehrer and Jai Ramesar and M. Cristina Avramut and Abraham J. Koster and Johannes T. Dessens and Friedrich Frischknecht and Séverine Chevalley-Maurel and Chris J. Janse and Blandine Franke-Fayard and Gunnar R. Mair
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 26, pp. 7183 - 7188
Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and... 
Crystalloid | DOZI | Malaria | Ookinete | Palmitoylation | ookinete | COMPLEX | MULTIDISCIPLINARY SCIENCES | MOSQUITO | malaria | INVASION | TRANSLATIONAL REPRESSION | crystalloid | BIOLOGY | PROTEIN PALMITOYLATION | PLASMODIUM-BERGHEI | EXPRESSION | palmitoylation | REVEALS | Acyltransferases - physiology | Animals | Oocysts - physiology | Plasmodium berghei - physiology | Organelles - physiology | Plasmodium berghei - enzymology | Female | Mice, Inbred BALB C | Malaria - transmission | Protozoan Proteins - physiology | Plasmodium berghei - pathogenicity | Medical research | Transferases | Host-parasite relationships | Medicine, Experimental | Development and progression | Cell organelles | Research | Health aspects | Biological Sciences
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7. Full Text ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model
by Cunningham, Deirdre A and Lin, Jing-Wen and Brugat, Thibaut and Jarra, William and Tumwine, Irene and Kushinga, Garikai and Ramesar, Jai and Franke-Fayard, Blandine and Langhorne, Jean
Malaria Journal, ISSN 1475-2875, 05/2017, Volume 16, Issue 1, pp. 185 - 11
Background: Parasite cytoadherence within the microvasculature of tissues and organs of infected individuals is implicated in the pathogenesis of several... 
ICAM-1 | SMAC | CD36 | Schizont membrane-associated cytoadherence protein | Sequestration | Plasmodium chabaudi | INFECTIOUS DISEASES | FALCIPARUM-INFECTED ERYTHROCYTES | RODENT | INTERCELLULAR-ADHESION MOLECULE-1 | ANTIGENIC VARIATION | MEMBRANE PROTEIN-1 | LUNG INJURY | TROPICAL MEDICINE | MURINE MALARIA | PARASITOLOGY | CEREBRAL MALARIA | CD36 Antigens - genetics | Mice, Inbred C57BL | Protozoan Proteins - genetics | Intercellular Adhesion Molecule-1 - metabolism | Animals | Protozoan Proteins - metabolism | CD36 Antigens - metabolism | Intercellular Adhesion Molecule-1 - genetics | Plasmodium chabaudi - genetics | Plasmodium chabaudi - physiology | Malaria - parasitology | Female | Mice | Hosts | Bioluminescence | Anaemia | Liver | Genes | Erythrocytes | Transmission | Infections | Parasites | Tissues | Aquatic insects | Blood | Proteins | Molecules | Receptors | Species | Public health | Vector-borne diseases | Human diseases | Malaria | Blood cells | Organs | Imaging techniques | Weight | Endothelium | Studies | Pathology | Lungs | Circulatory system | Interactions | Symptoms | Body organs
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8. Full Text The malaria secretome: From algorithms to essential function in blood stage infection
by Van Ooij, Christiaan and Tamez, Pamela and Bhattacharjee, Souvik and Hiller, N. Luisa and Harrison, Travis and Liolios, Konstantinos and Kooij, Taco and Ramesar, Jai and Balu, Bharath and Adams, John and Waters, Andy and Janse, Chris and Haldar, Kasturi
PLoS Pathogens, ISSN 1553-7366, 06/2008, Volume 4, Issue 6, pp. e1000084 - e1000084
The malaria agent Plasmodium falciparum is predicted to export a "secretome'' of several hundred proteins to remodel the host erythrocyte. Prediction of... 
HIGH-EFFICIENCY TRANSFECTION | MICROBIOLOGY | RED-CELLS | MAURERS CLEFTS | VIROLOGY | HOST CELL INTERFACE | ERYTHROCYTES | PLASMODIUM-FALCIPARUM | HISTIDINE-RICH PROTEIN | GENE DISRUPTION | TARGETING SIGNAL | PARASITE | PARASITOLOGY | Malaria | Humans | Rodentia | Protozoan Proteins - genetics | Protein Sorting Signals | Protein Transport | Algorithms | Animals | Conserved Sequence | Plasmodium falciparum - pathogenicity | Erythrocytes - parasitology | Genomics - methods | Protozoan Proteins - secretion | Plasmodium falciparum - chemistry | Plasmodium falciparum | Usage | Bacterial proteins | Causes of | Physiological aspects | Research | Health aspects | Proteins | Parasites | Erythrocytes
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9. Full Text Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria
by Lin, Jing-Wen and Sodenkamp, Jan and Cunningham, Deirdre and Deroost, Katrien and Tshitenge, Tshibuayi Christine and McLaughlin, Sarah and Lamb, Tracey J and Spencer-Dene, Bradley and Hosking, Caroline and Ramesar, Jai and Janse, Chris J and Graham, Christine and O'Garra, Anne and Langhorne, Jean
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 41722
The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed... 
IMMUNE-RESPONSE | FALCIPARUM-INFECTED ERYTHROCYTES | PLASMODIUM-VIVAX MALARIA | CHABAUDI | MARKER | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RECEPTOR | CANCER | RESPIRATORY-DISTRESS-SYNDROME | Erythropoiesis | Immune response | Malaria | Anemia | Virulence | Genomes | Platelet aggregation | Parasites | Blood | Pathology | Cell death | Rodents | Genetic factors
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10. Full Text Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole
by Fougère, Aurélie and Jackson, Andrew P and Paraskevi Bechtsi, Dafni and Braks, Joanna A. M and Annoura, Takeshi and Fonager, Jannik and Spaccapelo, Roberta and Ramesar, Jai and Chevalley-Maurel, Séverine and Klop, Onny and van der Laan, Annelies M. A and Tanke, Hans J and Kocken, Clemens H. M and Pasini, Erica M and Khan, Shahid M and Böhme, Ulrike and van Ooij, Christiaan and Otto, Thomas D and Janse, Chris J and Franke-Fayard, Blandine
PLoS Pathogens, ISSN 1553-7366, 11/2016, Volume 12, Issue 11, p. e1005917
Many variant proteins encoded by Plasmodium-specific multigene families are exported into red blood cells (RBC). P. falciparum-specific variant proteins... 
ANTIGENIC VARIATION | PHOSPHATIDYLCHOLINE TRANSFER PROTEIN | FALCIPARUM STEVOR PROTEINS | RODENT MALARIA PARASITE | MICROBIOLOGY | INFECTED ERYTHROCYTES | SEQUESTRATION | PATHOGENESIS | VIROLOGY | GENE | CYTOADHERENCE | SURFACE-ANTIGENS | PARASITOLOGY | Multigene Family | Humans | Liver | Phylogeny | Protein Transport | Plasmodium falciparum | Animals | Protozoan Proteins - metabolism | Fluorescent Antibody Technique | Hepatocytes - virology | Malaria, Falciparum - metabolism | Mice | Organisms, Genetically Modified | Erythrocytes - parasitology | Malaria, Falciparum - virology | Disease Models, Animal | Vacuoles - virology | Plasmodium | Genetic aspects | Health aspects | Blood proteins | Proteins | Parasitology | Infectious diseases | Malaria | Laboratories | Erythrocytes | Colleges & universities | Biology | Parasites | Blood | Exports
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11. Full Text Rapid generation of marker-free P. falciparum fluorescent reporter lines using modified CRISPR/Cas9 constructs and selection protocol
by Mogollon, Catherin Marin and Van Pul, Fiona J. A and Imai, Takashi and Ramesar, Jai and Chevalley-Maurel, Seâverine and De Roo, Guido M and Veld, Sabrina A.J and Kroeze, Hans and Franke-Fayard, Blandine M.D and Janse, Chris J and Khan, Shahid M
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0168362
The CRISPR/Cas9 system is a powerful genome editing technique employed in a wide variety of organisms including recently the human malaria parasite, P.... 
LIVER-STAGE | GAMETOCYTES | PLASMODIUM-FALCIPARUM | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | EXPRESSES GFP | NEGATIVE SELECTION | MALARIA PARASITE | BLOOD STAGES | TARGETED GENE DELETION | LUCIFERASE | Malaria, Falciparum - drug therapy | Malaria, Falciparum - genetics | Genome, Protozoan | Humans | Drug Resistance - drug effects | Gene Editing | Heterocyclic Compounds, 4 or More Rings - pharmacology | Antimalarials - pharmacology | Drug Resistance - genetics | Isoquinolines - pharmacology | Plasmodium falciparum - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | Mutation | Plasmodium falciparum | Genotype | Genetic engineering | Genetic aspects | Properties | Innovations | Vector-borne diseases | CRISPR | Flow cytometry | Malaria | Genes | Erythrocytes | Transgenic | Fluorescence | Genomes | Hsp70 protein | Parasites | Blood | Promoters | Proteins | Cytometry | Transfection | Plasmids | Calcium-binding protein | Glyceraldehyde-3-phosphate dehydrogenase | Kinetics | Transgenes | Calmodulin | Growth kinetics
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12. Full Text Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites
by Fonager, Jannik and Franke-Fayard, Blandine M.D and Adams, John H and Ramesar, Jai and Klop, Onny and Khan, Shahid M and Janse, Chris J and Waters, Andrew P
BMC Genomics, ISSN 1471-2164, 03/2011, Volume 12, Issue 1, pp. 155 - 155
Background: The genome of a number of species of malaria parasites ( Plasmodium spp.) has been sequenced in the hope of identifying new drug and vaccine... 
HIGH-EFFICIENCY TRANSFECTION | COMPARATIVE GENOMICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | SLEEPING-BEAUTY | BLOOD STAGES | T-DNA | INSERTIONAL MUTAGENESIS | MAMMALIAN-CELLS | ASYMMETRIC INTERLACED PCR | MEDIATED MUTAGENESIS | FUNCTIONAL GENOMICS | RNA, Protozoan - genetics | Promoter Regions, Genetic | Transfection | Plasmids | Plasmodium berghei - genetics | Transposases - genetics | Genes, Protozoan | Gene Expression Profiling | Mutagenesis, Insertional | Genomics - methods | Sequence Analysis, DNA | DNA Transposable Elements | Plasmodium | Usage | Malaria | Mutagenesis | Causes of | Physiological aspects | Genetic aspects | Research | Methods | Proteins | Genomics | Genetics | Parasites | Mutation
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