American Journal of Hematology, ISSN 0361-8609, 03/2016, Volume 91, Issue 3, pp. 330 - 340
The field of chronic lymphocytic leukemia (CLL) has witnessed considerable change since the time clinical staging was introduced in clinical practice in 1975....
BRUTONS TYROSINE KINASE | INDEPENDENT PREDICTOR | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | B-CELL-RECEPTOR | INITIAL THERAPY | PHASE-III | RECURRENT MUTATIONS | OPEN-LABEL | KINASE INHIBITOR IBRUTINIB | HEMATOLOGY | PREVIOUSLY UNTREATED PATIENTS | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Prognosis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Molecular Targeted Therapy - methods | Chronic lymphocytic leukemia | Chemotherapy | Analysis | Immunotherapy | Monoclonal antibodies | Cytogenetics | Tumor proteins | Cancer
BRUTONS TYROSINE KINASE | INDEPENDENT PREDICTOR | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | B-CELL-RECEPTOR | INITIAL THERAPY | PHASE-III | RECURRENT MUTATIONS | OPEN-LABEL | KINASE INHIBITOR IBRUTINIB | HEMATOLOGY | PREVIOUSLY UNTREATED PATIENTS | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Prognosis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Molecular Targeted Therapy - methods | Chronic lymphocytic leukemia | Chemotherapy | Analysis | Immunotherapy | Monoclonal antibodies | Cytogenetics | Tumor proteins | Cancer
Journal Article
American Journal of Hematology, ISSN 0361-8609, 06/2019, Volume 94, Issue 6, pp. 710 - 725
Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the...
INTRINSIC IBRUTINIB RESISTANCE | NERVOUS-SYSTEM INVOLVEMENT | 15-YEAR FOLLOW-UP | BRUTON TYROSINE KINASE | PROGRESSION-FREE SURVIVAL | PLUS RITUXIMAB | NON-HODGKIN-LYMPHOMA | PHASE-II | HIGH-DOSE CYTARABINE | HEMATOLOGY | MINIMAL RESIDUAL DISEASE
INTRINSIC IBRUTINIB RESISTANCE | NERVOUS-SYSTEM INVOLVEMENT | 15-YEAR FOLLOW-UP | BRUTON TYROSINE KINASE | PROGRESSION-FREE SURVIVAL | PLUS RITUXIMAB | NON-HODGKIN-LYMPHOMA | PHASE-II | HIGH-DOSE CYTARABINE | HEMATOLOGY | MINIMAL RESIDUAL DISEASE
Journal Article
American Journal of Hematology, ISSN 0361-8609, 03/2016, Volume 91, Issue 3, pp. 330 - 340
Journal Article
Cancer, ISSN 0008-543X, 06/2017, Volume 123, Issue 12, pp. 2268 - 2273
BACKGROUND Ibrutinib is a Bruton tyrosine kinase inhibitor and is approved for the treatment of patients with chronic lymphocytic leukemia (CLL) in frontline...
ibrutinib | Richter transformation | Chronic lymphocytic leukemia (CLL) | venetoclax | CLL | EVOLUTION | THERAPY | ONCOLOGY | RESISTANCE | MUTATIONS | Pyrazoles - therapeutic use | Follow-Up Studies | Humans | Middle Aged | Male | Survival Rate | Disease Progression | Deprescriptions | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Drug-Related Side Effects and Adverse Reactions | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Chronic lymphocytic leukemia | Care and treatment | Cancer patients | Health aspects | Patient outcomes | Tyrosine | Therapy | Transformation | Chronic lymphatic leukemia | Leukemia | Medical services | Agent orange | Lymphatic leukemia | Patients | Survival | Intolerance | Salvage | Mutation | Protein-tyrosine kinase | Cancer | Ibrutinib | chronic lymphocytic leukemia
ibrutinib | Richter transformation | Chronic lymphocytic leukemia (CLL) | venetoclax | CLL | EVOLUTION | THERAPY | ONCOLOGY | RESISTANCE | MUTATIONS | Pyrazoles - therapeutic use | Follow-Up Studies | Humans | Middle Aged | Male | Survival Rate | Disease Progression | Deprescriptions | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Drug-Related Side Effects and Adverse Reactions | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Chronic lymphocytic leukemia | Care and treatment | Cancer patients | Health aspects | Patient outcomes | Tyrosine | Therapy | Transformation | Chronic lymphatic leukemia | Leukemia | Medical services | Agent orange | Lymphatic leukemia | Patients | Survival | Intolerance | Salvage | Mutation | Protein-tyrosine kinase | Cancer | Ibrutinib | chronic lymphocytic leukemia
Journal Article
American journal of hematology, ISSN 0361-8609, 10/2017, Volume 92, Issue 10, pp. 1113 - 1114
Journal Article
Oncology (Williston Park, N.Y.), ISSN 0890-9091, 12/2012, Volume 26, Issue 12, pp. 1146 - 1152
Richter's transformation, or Richter's syndrome, is an uncommon clinicopathological condition observed in about 5% to 10% of patients with chronic lymphocytic...
PROLYMPHOCYTIC LEUKEMIA | CELL LYMPHOPROLIFERATIVE DISORDERS | B-CELL | ONCOLOGY | FRACTIONATED CYCLOPHOSPHAMIDE | GM-CSF | HODGKIN LYMPHOMA | LIPOSOMAL DAUNORUBICIN | FLUDARABINE | EPSTEIN-BARR-VIRUS | MUTATIONAL STATUS | Predictive Value of Tests | Genetic Predisposition to Disease | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Risk Factors | Treatment Outcome | Gene Expression Regulation, Leukemic | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Disease Progression | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - mortality | Stem Cell Transplantation | Diagnostic Imaging | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Lymphoma, Large B-Cell, Diffuse - therapy | Phenotype | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biopsy | Immunotherapy | Lymphoma, Large B-Cell, Diffuse - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Lymphoma, Large B-Cell, Diffuse - genetics
PROLYMPHOCYTIC LEUKEMIA | CELL LYMPHOPROLIFERATIVE DISORDERS | B-CELL | ONCOLOGY | FRACTIONATED CYCLOPHOSPHAMIDE | GM-CSF | HODGKIN LYMPHOMA | LIPOSOMAL DAUNORUBICIN | FLUDARABINE | EPSTEIN-BARR-VIRUS | MUTATIONAL STATUS | Predictive Value of Tests | Genetic Predisposition to Disease | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Risk Factors | Treatment Outcome | Gene Expression Regulation, Leukemic | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Disease Progression | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - mortality | Stem Cell Transplantation | Diagnostic Imaging | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Lymphoma, Large B-Cell, Diffuse - therapy | Phenotype | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biopsy | Immunotherapy | Lymphoma, Large B-Cell, Diffuse - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Lymphoma, Large B-Cell, Diffuse - genetics
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2017, Volume 23, Issue 9, pp. 2154 - 2158
Background: Ibrutinib is an active therapy with an acceptable safety profile for patients with chronic lymphocytic leukemia (CLL), including high-risk patients...
TRIAL | CLL | ONCOLOGY | INITIAL THERAPY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Pyrimidines - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Remission Induction | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Rituximab - administration & dosage | Disease-Free Survival | Pyrazoles - administration & dosage | Pyrimidines - adverse effects | Adult | Female | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Pyrazoles - adverse effects | Rituximab - adverse effects | Therapy | Chronic lymphatic leukemia | Cell survival | Risk groups | Leukemia | p53 Protein | Medical treatment | Stem cell transplantation | Rituximab | Risk | Transplantation | Lymphatic leukemia | Survival | Patients | Clonal deletion | Experimental design | Safety engineering | Deletion | Remission | Fatalities | Mutation | Cancer | deletion 17p | chronic lymphocytic leukemia | Ibrutinib | rituximab
TRIAL | CLL | ONCOLOGY | INITIAL THERAPY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Pyrimidines - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Remission Induction | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Rituximab - administration & dosage | Disease-Free Survival | Pyrazoles - administration & dosage | Pyrimidines - adverse effects | Adult | Female | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Pyrazoles - adverse effects | Rituximab - adverse effects | Therapy | Chronic lymphatic leukemia | Cell survival | Risk groups | Leukemia | p53 Protein | Medical treatment | Stem cell transplantation | Rituximab | Risk | Transplantation | Lymphatic leukemia | Survival | Patients | Clonal deletion | Experimental design | Safety engineering | Deletion | Remission | Fatalities | Mutation | Cancer | deletion 17p | chronic lymphocytic leukemia | Ibrutinib | rituximab
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 01/2014, Volume 11, Issue 1, pp. 6 - 8
A landmark study has delineated and identified the genetic pathways that drive the natural course of chronic lymphocytic leukaemia (CLL) B cells into Richter's...
Genetic aspects | Diagnosis | Gene mutations | Identification and classification | Richter's syndrome
Genetic aspects | Diagnosis | Gene mutations | Identification and classification | Richter's syndrome
Journal Article
Expert Opinion in Biological Therapy, ISSN 1471-2598, 02/2013, Volume 13, Issue 2, pp. 169 - 182
Introduction: The last decade has witnesd immense progress in the treatment of chronic lymphocytic leukemia (CLL). Chemoimmunotherapy (CIT) combining rituximab...
Fc receptors | Chronic lymphatic leukemia | Cyclophosphamide | Conferences | Clinical trials | Monoclonal antibodies | fludarabine | Oncology | rituximab
Fc receptors | Chronic lymphatic leukemia | Cyclophosphamide | Conferences | Clinical trials | Monoclonal antibodies | fludarabine | Oncology | rituximab
Journal Article
American Journal of Hematology, ISSN 0361-8609, 10/2017, Volume 92, Issue 10, pp. 1113 - 1114
HEMATOLOGY | PATIENT | LEUKEMIA | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Male | Epstein-Barr Virus Infections - drug therapy | Herpesvirus 4, Human | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Epstein-Barr Virus Infections - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging | Epstein-Barr Virus Infections - diagnostic imaging | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Epstein-Barr Virus Infections - metabolism
Journal Article
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 9, pp. 1668 - 1668
Journal Article
International Journal of Hematology, ISSN 0925-5710, 07/2013, Volume 98, Issue 1, pp. 3 - 3
Byline: Preetesh Jain (1), Francisco Vega-Vazquez (1), Stefan Faderl (1) Author Affiliation: (1) MD Anderson Cancer Center, University of Texas, Houston, TX,...
HEMATOLOGY | Leukemia, Myeloid, Acute - pathology | Humans | Leukemia, Myeloid, Acute - metabolism | Bone Marrow Cells - pathology | Male | Nuclear Proteins - metabolism | Leukemia, Myeloid, Acute - blood | Tandem Repeat Sequences | fms-Like Tyrosine Kinase 3 - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Cell Nucleus Shape | Cell Shape | Aged | Mutation | Nuclear Proteins - genetics | Leukemia, Myeloid, Acute - genetics
HEMATOLOGY | Leukemia, Myeloid, Acute - pathology | Humans | Leukemia, Myeloid, Acute - metabolism | Bone Marrow Cells - pathology | Male | Nuclear Proteins - metabolism | Leukemia, Myeloid, Acute - blood | Tandem Repeat Sequences | fms-Like Tyrosine Kinase 3 - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Cell Nucleus Shape | Cell Shape | Aged | Mutation | Nuclear Proteins - genetics | Leukemia, Myeloid, Acute - genetics
Journal Article
Blood, ISSN 0006-4971, 03/2015, Volume 125, Issue 13, pp. 2062 - 2067
Ibrutinib is a Bruton tyrosine kinase inhibitor approved for the treatment of patients with relapsed refractory chronic lymphocytic leukemia (RR-CLL). We...
HEMATOLOGY | LYMPHOMA | BRUTONS TYROSINE KINASE | Clinical Trials as Topic - mortality | Pyrazoles - therapeutic use | Prognosis | Humans | Middle Aged | Antineoplastic Agents - therapeutic use | Cell Transformation, Neoplastic - chemically induced | Withholding Treatment - statistics & numerical data | Disease Progression | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Retrospective Studies | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Clinical Trials and Observations
HEMATOLOGY | LYMPHOMA | BRUTONS TYROSINE KINASE | Clinical Trials as Topic - mortality | Pyrazoles - therapeutic use | Prognosis | Humans | Middle Aged | Antineoplastic Agents - therapeutic use | Cell Transformation, Neoplastic - chemically induced | Withholding Treatment - statistics & numerical data | Disease Progression | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Retrospective Studies | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Clinical Trials and Observations
Journal Article
American Journal of Hematology, ISSN 0361-8609, 09/2013, Volume 88, Issue 9, pp. 798 - 802
Various subsets of DLBCL are distinguished based on molecular and immunohistochemical features. CD5 expressing DLBCL (CD5+ DLBCL) is increasingly recognized as...
SURVIVAL | BIOMARKERS | TRANSFORMATION | MICROARRAY | RITUXIMAB | GENE-EXPRESSION | DISTINCT SUBGROUPS | COMPARATIVE GENOMIC HYBRIDIZATION | IDENTIFICATION | HEMATOLOGY | CHEMOTHERAPY | L-Lactate Dehydrogenase - metabolism | CD5 Antigens - genetics | Gene Expression | Lymphoma, Large B-Cell, Diffuse - drug therapy | Age Factors | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Rituximab | Treatment Outcome | Antineoplastic Agents - therapeutic use | CD5 Antigens - metabolism | Lymphoma, Large B-Cell, Diffuse - mortality | B-Lymphocytes - drug effects | L-Lactate Dehydrogenase - genetics | Sex Factors | Survival Analysis | Aged | B-Lymphocytes - pathology | Neoplasm Staging | Lymphoma, Large B-Cell, Diffuse - genetics | B-Lymphocytes - metabolism | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Chemotherapy | Lymphomas | Cancer
SURVIVAL | BIOMARKERS | TRANSFORMATION | MICROARRAY | RITUXIMAB | GENE-EXPRESSION | DISTINCT SUBGROUPS | COMPARATIVE GENOMIC HYBRIDIZATION | IDENTIFICATION | HEMATOLOGY | CHEMOTHERAPY | L-Lactate Dehydrogenase - metabolism | CD5 Antigens - genetics | Gene Expression | Lymphoma, Large B-Cell, Diffuse - drug therapy | Age Factors | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Rituximab | Treatment Outcome | Antineoplastic Agents - therapeutic use | CD5 Antigens - metabolism | Lymphoma, Large B-Cell, Diffuse - mortality | B-Lymphocytes - drug effects | L-Lactate Dehydrogenase - genetics | Sex Factors | Survival Analysis | Aged | B-Lymphocytes - pathology | Neoplasm Staging | Lymphoma, Large B-Cell, Diffuse - genetics | B-Lymphocytes - metabolism | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Chemotherapy | Lymphomas | Cancer
Journal Article
American Journal of Hematology, ISSN 0361-8609, 12/2018, Volume 93, Issue 12, pp. 1568 - 1569
Journal Article
Current Treatment Options in Oncology, ISSN 1527-2729, 6/2013, Volume 14, Issue 2, pp. 127 - 143
Discovery of targeted BCR-ABL protein tyrosine kinase inhibitors (TKI) in the therapy of patients with chronic myeloid leukemia (CML) is perhaps the most...
Nilotinib | Dasatinib | Imatinib | Medicine & Public Health | BCR-ABL tyrosine kinase | Oncology | Chronic myeloid leukemia | Omacetaxine | Ponatinib | Bosutinib | Tyrosine kinase inhibitors | CHRONIC MYELOGENOUS LEUKEMIA | BCR-ABL MUTATIONS | 2-YEAR FOLLOW-UP | HIGH-DOSE IMATINIB | SMALL-MOLECULE INHIBITOR | CANCER STEM-CELLS | 400 MG | FRONT-LINE TREATMENT | ONCOLOGY | DIAGNOSED CHRONIC-PHASE | Protein Kinase Inhibitors - therapeutic use | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Drug Resistance, Neoplasm | Clinical Trials as Topic | Protein-Tyrosine Kinases - antagonists & inhibitors | Randomized Controlled Trials as Topic | Comparative analysis | Drug resistance | Patient compliance | Stem cells
Nilotinib | Dasatinib | Imatinib | Medicine & Public Health | BCR-ABL tyrosine kinase | Oncology | Chronic myeloid leukemia | Omacetaxine | Ponatinib | Bosutinib | Tyrosine kinase inhibitors | CHRONIC MYELOGENOUS LEUKEMIA | BCR-ABL MUTATIONS | 2-YEAR FOLLOW-UP | HIGH-DOSE IMATINIB | SMALL-MOLECULE INHIBITOR | CANCER STEM-CELLS | 400 MG | FRONT-LINE TREATMENT | ONCOLOGY | DIAGNOSED CHRONIC-PHASE | Protein Kinase Inhibitors - therapeutic use | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Drug Resistance, Neoplasm | Clinical Trials as Topic | Protein-Tyrosine Kinases - antagonists & inhibitors | Randomized Controlled Trials as Topic | Comparative analysis | Drug resistance | Patient compliance | Stem cells
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 01/2014, Volume 11, Issue 1, pp. 6 - 8
A landmark study has delineated and identified the genetic pathways that drive the natural course of chronic lymphocytic leukaemia (CLL) B cells into Richter's...
CHRONIC LYMPHOCYTIC-LEUKEMIA | RISK | IMPACT | MUTATIONS | ONCOLOGY | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Antineoplastic Agents - therapeutic use | Receptors, Antigen, B-Cell - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Signal Transduction - drug effects | Cell Transformation, Neoplastic - genetics | Pre-B Cell Receptors - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Cell Transformation, Neoplastic - pathology | Lymphoma, Large B-Cell, Diffuse - genetics
CHRONIC LYMPHOCYTIC-LEUKEMIA | RISK | IMPACT | MUTATIONS | ONCOLOGY | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Antineoplastic Agents - therapeutic use | Receptors, Antigen, B-Cell - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Signal Transduction - drug effects | Cell Transformation, Neoplastic - genetics | Pre-B Cell Receptors - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Cell Transformation, Neoplastic - pathology | Lymphoma, Large B-Cell, Diffuse - genetics
Journal Article