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Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis | Biochemistry | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2011, Volume 103, Issue 16, pp. 1236 - 1251
Background Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their... 
CANCER-CELLS | IN-VITRO | MRP1 | ATP-DEPENDENT TRANSPORT | CYCLOOXYGENASE-2 | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INCREASED SENSITIVITY | GENE-EXPRESSION | NEURONAL DIFFERENTIATION | RESISTANCE-ASSOCIATED PROTEIN | Predictive Value of Tests | Recurrence | Up-Regulation | Prognosis | Prospective Studies | Drug Resistance, Multiple | Humans | Child, Preschool | Drug Resistance, Neoplasm | Infant | Male | Young Adult | Transfection | Time Factors | Polymerase Chain Reaction | Female | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Cell Differentiation | N-Myc Proto-Oncogene Protein | Gene Expression Regulation, Neoplastic - drug effects | Odds Ratio | Child | Disease Models, Animal | Pyrazoles - pharmacology | Down-Regulation | Gene Silencing | Kaplan-Meier Estimate | Oncogene Proteins - metabolism | Proportional Hazards Models | Mice, Transgenic | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Blotting, Western | Disease-Free Survival | Animals | Neuroblastoma - drug therapy | Adolescent | Cell Line, Tumor | Mice | Neuroblastoma - metabolism | Multidrug Resistance-Associated Proteins - metabolism | Cell Movement | RNA, Small Interfering - metabolism | Antimitotic agents | Genetic aspects | Research | Neuroblastoma | Antineoplastic agents | Gene expression | Drug therapy | Health aspects | Toxins | Medical prognosis | Clinical outcomes | Childrens health | Tumors | Index Medicus
Journal Article
European Journal of Cancer, ISSN 0959-8049, 09/2017, Volume 83, pp. 132 - 141
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 06/2005, Volume 19, Issue 11, pp. 1294 - 1305
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. its three subfamilies have distinct roles:... 
Bcl-2 | MITOCHONDRIAL APOPTOSIS | MEMBRANE | apoptosis | DEVELOPMENTAL BIOLOGY | Bak | INITIATE APOPTOSIS | BH3-only | CELL-DEATH | BH3 DOMAIN | FAMILY | CYTOCHROME-C | Mcl-1 | IN-VIVO | GENETICS & HEREDITY | X-DEFICIENT MICE | ADENOVIRUS E1B 19K | Bcl-x(L) | Genetic research | DNA binding proteins | Research | Apoptosis
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2010, Volume 6, Issue 12
  Epstein-Barr virus (EBV) is associated with human malignancies, especially those affecting the B cell compartment such as Burkitt lymphoma. The virally... 
Medical research | Leukemia | Viruses | Cytotoxicity | Grants | Experiments | Proteins | Scholarships & fellowships | Lymphomas | Laboratory animals | Charitable foundations | Viral infections | Apoptosis
Journal Article
Molecular Cell, ISSN 1097-2765, 2005, Volume 17, Issue 3, pp. 393 - 403
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove... 
CYTOCHROME-C | COMPLEX | SURVIVAL FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | BIM | RELEASE | PEPTIDE | CELL-DEATH | FAMILY | MEMBER | CELL BIOLOGY | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | Genetic Complementation Test | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Carrier Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Cell Survival - physiology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | bcl-X Protein | Peptide Fragments - metabolism | Membrane Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Biosensing Techniques | Ligands | Mice | Apoptosis - physiology | Proteins - chemistry | In Vitro Techniques | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus
Journal Article