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aging (17) 17
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Journal Article
NATURE MEDICINE, ISSN 1078-8956, 01/2016, Volume 22, Issue 1, pp. 78 - 78
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2004, Volume 114, Issue 9, pp. 1299 - 1307
The Ink4a/Arflocus encodes 2 tumor suppressor molecules, p16(INK4a) and Arf, which are principal mediators of cellular senescence. To study the links between... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | P16(INK4A) EXPRESSION | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | TELOMERASE ACTIVITY | TUMOR-SUPPRESSOR | SIRT1 DEACETYLASE | CELLULAR SENESCENCE
Journal Article
Nature, ISSN 0028-0836, 08/2007, Volume 448, Issue 7155, pp. 807 - 810
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 4, p. dju057
Journal Article
Cell, ISSN 0092-8674, 01/2013, Volume 152, Issue 1-2, pp. 340 - 351
Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16 ), which faithfully reports... 
Journal Article
Blood, ISSN 0006-4971, 03/2011, Volume 117, Issue 12, pp. 3257 - 3267
Abstract Previous authors have suggested that tumor suppressor expression promotes aging while preventing cancer, but direct experimental support for this... 
Plenary Paper
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2007, Volume 1, Issue 1, pp. 9 - 11
The “rate-of-living theory” is an ancient explanation of longevity which holds that aging occurs due to the exhaustion of some finite substance—breaths,... 
Stem Cells - cytology | Cellular Senescence | Cell Division | Humans
Journal Article
Aging Cell, ISSN 1474-9718, 10/2012, Volume 11, Issue 5, pp. 916 - 918
Summary The p16INK4a tumor suppressor gene is a mediator of cellular senescence and has been suggested to be a biomarker of ‘molecular’ age in several tissues... 
immunosenescence | p16 | CDKN2a | human | T cell | INK4/ARF | Human | Immunosenescence | P16 | ARF | INK4 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Highly active antiretroviral therapy | Antiviral agents | Medical colleges | Care and treatment |