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1. Full Text Electronic health records to facilitate clinical research
by Cowie, Martin R and Cowie, Martin R and Blomster, Juuso I and Blomster, Juuso I and Curtis, Lesley H and Curtis, Lesley H and Duclaux, Sylvie and Duclaux, Sylvie and Ford, Ian and Ford, Ian and Fritz, Fleur and Fritz, Fleur and Goldman, Samantha and Goldman, Samantha and Janmohamed, Salim and Janmohamed, Salim and Kreuzer, Jörg and Kreuzer, Jörg and Leenay, Mark and Leenay, Mark and Michel, Alexander and Michel, Alexander and Ong, Seleen and Ong, Seleen and Pell, Jill P and Pell, Jill P and Southworth, Mary Ross and Southworth, Mary Ross and Stough, Wendy Gattis and Stough, Wendy Gattis and Thoenes, Martin and Thoenes, Martin and Zannad, Faiez and Zannad, Faiez and Zalewski, Andrew and Zalewski, Andrew
Clinical research in cardiology, ISSN 1861-0684, 1/2017, Volume 106, Issue 1, pp. 1 - 9
Clinical trials as topic | Pragmatic clinical trials as topic | Medicine & Public Health | Cardiology | Cardiovascular diseases | Electronic health records | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Comparative Effectiveness Research - methods | Data Accuracy | Data Mining - ethics | Electronic Health Records - ethics | Humans | Access to Information | Cardiovascular Diseases - therapy | Systems Integration | Comparative Effectiveness Research - ethics | Confidentiality | Cardiovascular Diseases - epidemiology | Clinical Trials as Topic - ethics | Clinical Trials as Topic - methods | Medical Record Linkage | Research Design | Cardiovascular Diseases - diagnosis | Clinical trials | Medicine, Experimental | Medical records | Medical research | Electronic records | Index Medicus | Review
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2. Full Text Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data
by Dennis, John M and Dennis, John M and Henley, William E and Henley, William E and Weedon, Michael N and Weedon, Michael N and Lonergan, Mike and Lonergan, Mike and Rodgers, Lauren R and Rodgers, Lauren R and Jones, Angus G and Jones, Angus G and Hamilton, William T and Hamilton, William T and Sattar, Naveed and Sattar, Naveed and Janmohamed, Salim and Janmohamed, Salim and Holman, Rury R and Holman, Rury R and Pearson, Ewan R and Pearson, Ewan R and Shields, Beverley M and Shields, Beverley M and Hattersley, Andrew T and Hattersley, Andrew T and MASTERMIND Consortium
Diabetes care, ISSN 0149-5992, 09/2018, Volume 41, Issue 9, pp. 1844 - 1853
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Hypoglycemia - epidemiology | Metformin - therapeutic use | Hypoglycemic Agents - economics | Primary Health Care - statistics & numerical data | Humans | Middle Aged | Diabetes Mellitus, Type 2 - economics | Male | Sulfonylurea Compounds - economics | Diabetes Mellitus, Type 2 - epidemiology | Metformin - economics | Thiazolidinediones - therapeutic use | Aged, 80 and over | Adult | Female | Hypoglycemia - economics | Hypoglycemia - chemically induced | Body Mass Index | Hypoglycemic Agents - therapeutic use | Randomized Controlled Trials as Topic - statistics & numerical data | Risk Assessment | Sulfonylurea Compounds - therapeutic use | Thiazolidinediones - economics | Datasets as Topic - statistics & numerical data | Blood Glucose - drug effects | Cost-Benefit Analysis | Sex Factors | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | United Kingdom - epidemiology | Type 2 diabetes | Complications and side effects | Body mass index | Analysis | Clinical trials | Research | Hypoglycemic sulfonylureas | Sulfonylurea compounds | Thiazolidinediones | Risk factors | Edema | Therapy | Diabetes mellitus | Sex | Risk | Hypoglycemia | Males | Patients | Subgroups | Weight | Side effects | Reduction | Body mass | Sulfonylurea | Rosiglitazone | Genetics | Research design | Diabetes | Metformin | Females | Diabetes mellitus (non-insulin dependent) | Index Medicus
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3. Full Text Randomized 52-week Phase 2 Trial of Albiglutide Versus Placebo in Adult Patients With Newly Diagnosed Type 1 Diabetes
by Pozzilli, Paolo and Bosi, Emanuele and Cirkel, Deborah and Harris, Julia and Leech, Nicola and Tinahones, Francisco J and Vantyghem, Marie-Christine and Vlasakakis, Georgios and Ziegler, Anette-Gabriele and Janmohamed, Salim
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 03/2020, Volume 105, Issue 6, pp. E2192 - E2206
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Prognosis | Blood Glucose - analysis | Follow-Up Studies | Glucagon-Like Peptide 1 - analogs & derivatives | Humans | Biomarkers - analysis | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - metabolism | Male | Diabetes Mellitus, Type 1 - drug therapy | Young Adult | Adolescent | Adult | Female | Incretins - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Beta cells | Peptides | Titration | Diabetes mellitus (insulin dependent) | Diabetes | Pharmacokinetics | Diabetes mellitus (non-insulin dependent) | Bayesian analysis | Insulin | Index Medicus | Abridged Index Medicus
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4. Full Text Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus—Rationale, design, and baseline characteristics
by Green, Jennifer B and Hernandez, Adrian F and D’Agostino, Ralph B and Granger, Chris B and Janmohamed, Salim and Jones, Nigel P and Leiter, Lawrence A and Noronha, Drusilla and Russell, Rachael and Sigmon, Kristina and Del Prato, Stefano and McMurray, John J.V
The American heart journal, ISSN 0002-8703, 09/2018, Volume 203, pp. 30 - 38
Type 2 diabetes | Medical research | Care and treatment | Chronic kidney failure | Patient outcomes | Cardiac patients | Clinical trials | Glycosylated hemoglobin | Medicine, Experimental | Glucose | Heart attack | Dextrose | Myocardial infarction | Heart | Glucagon | Drug development | Randomization | Atherosclerosis | Hemoglobin | Drug metabolism | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Glucagon-like peptide 1 | Cerebral infarction | Stroke | Enrollments | Diabetes mellitus | Coronary artery | Pancreatitis | Metabolism | Angina pectoris | Coronary artery disease | Disease control | Patients | Insulin | Arteriosclerosis | Infarction | Diabetes | Index Medicus | Abridged Index Medicus
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5. Full Text Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology
by Jackson, Neville and Atar, Dan and Borentain, Maria and Breithardt, Günter and van Eickels, Martin and Enes, Matthias and Fraass, Uwe and Friede, Tim and Hannachi, Hakima and Janmohamed, Salim and Kreuzer, Jörg and Lanay, Martin and Lautsch, Dominik and Le Floch, Chantal and Mol, Peter and Naci, Huseyin and Samani, Nilesh J and Svensson, Anders and Thorstensen, Cathrine and Tijssen, Jan and Vandzhura, Victoria and Zalewski, Anew and Kirchhof, Paulus
European heart journal, ISSN 0195-668X, 2016, Volume 37, Issue 9, pp. 747 - 754
New therapies | Health technology assessment | Cardiovascular disease burden | Cardiovascular | Clinical trials | Drug development | Personalized medicine | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Drug Approval - economics | Clinical Trials as Topic - economics | Technology Assessment, Biomedical - economics | Cardiovascular Diseases - drug therapy | Drug Discovery - economics | Europe | Humans | Precision Medicine - economics | Cost of Illness | Interprofessional Relations | Data Collection | Drug Approval - legislation & jurisprudence | Societies, Medical | Drug Industry - economics | Costs and Cost Analysis - economics | Clinical Trials as Topic - standards | Therapies, Investigational - economics | Cardiovascular Diseases - economics | Index Medicus
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6. Full Text Relative bioavailability and the effect of meal type and timing on the pharmacokinetics of migalastat in healthy volunteers
by Johnson, Franklin K and Mudd, Paul N and Janmohamed, Salim G
Clinical pharmacology in drug development, ISSN 2160-763X, 05/2015, Volume 4, Issue 3, pp. 193 - 202
pharmacokinetics | Fabry disease | migalastat HCl | food effect | Migalastat HCl | Food effect | Pharmacokinetics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | 1-Deoxynojirimycin - pharmacokinetics | Area Under Curve | Humans | Middle Aged | Half-Life | Biological Availability | Male | Metabolic Clearance Rate | Healthy Volunteers | Pharmaceutical Solutions | Young Adult | Capsules | Fasting - blood | Dietary Fats - administration & dosage | Postprandial Period | 1-Deoxynojirimycin - administration & dosage | Drug Compounding | 1-Deoxynojirimycin - analogs & derivatives | Adult | Female | 1-Deoxynojirimycin - adverse effects | Meals | Drug Administration Schedule | Administration, Oral | Food-Drug Interactions | 1-Deoxynojirimycin - blood | Cross-Over Studies | Texas | Adolescent | Aged | Therapeutic Equivalency | Bioavailability | Index Medicus
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7. Full Text Relative bioavailability and the effect of meal type and timing on the pharmacokinetics of migalastat in healthy volunteers
: Clinical Pharmacology in Drug Development
by Johnson, Franklin K and Mudd, Paul N and Janmohamed, Salim G
Clinical pharmacology in drug development, ISSN 2160-763X, 03/2015, Volume 4, Issue 3, pp. 193 - 202
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8. Full Text Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology
by Jackson, Neville and Atar, Dan and Borentain, Maria and Breithardt, Guenter and van Eickels, Martin and Enes, Matthias and Fraass, Uwe and Friede, Tim and Hannachi, Hakima and Janmohamed, Salim and Kreuzer, Joerg and Lanay, Martin and Lautsch, Dominik and Le Floch, Chantal and Mol, Peter and Naci, Huseyin and Samani, Nilesh J and Svensson, Anders and Thorstensen, Cathrine and Tijssen, Jan and Vandzhura, Victoria and Zalewski, Anew and Kirchhof, Paulus
European heart journal, ISSN 0195-668X, 03/2016, Volume 37, Issue 9, pp. 747 - 754
C-REACTIVE PROTEIN | New therapies | Health technology assessment | Cardiovascular | Clinical trials | SUBTILISIN/KEXIN TYPE 9 | MONOCLONAL-ANTIBODY | Drug development | Personalized medicine | KEY DATA ELEMENTS | Cardiovascular disease burden | HIGH-RISK | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | DOUBLE-BLIND | ASSOCIATION TASK-FORCE | PLACEBO-CONTROLLED TRIAL | CORONARY-HEART-DISEASE
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9. Full Text New medicinal products for chronic heart failure: advances in clinical trial design and efficacy assessment
: Design of chronic heart failure clinical trials
by Cowie, Martin R and Filippatos, Gerasimos S and Alonso Garcia, Maria de los Angeles and Anker, Stefan D and Baczynska, Anna and Bloomfield, Daniel M and Borentain, Maria and Bruins Slot, Karsten and Cronin, Maureen and Doevendans, Pieter A and El-Gazayerly, Amany and Gimpelewicz, Claudio and Honarpour, Narimon and Janmohamed, Salim and Janssen, Heidi and Kim, Albert M and Lautsch, Dominik and Laws, Ian and Lefkowitz, Martin and Lopez-Sendon, Jose and Lyon, Alexander R and Malik, Fady I and McMurray, John J.V and Metra, Marco and Figueroa Perez, Santiago and Pfeffer, Marc A and Pocock, Stuart J and Ponikowski, Piotr and Prasad, Krishna and Richard-Lordereau, Isabelle and Roessig, Lothar and Rosano, Giuseppe M.C and Sherman, Warren and Stough, Wendy Gattis and Swedberg, Karl and Tyl, Benoit and Zannad, Faiez and Boulton, Caroline and De Graeff, Pieter
European journal of heart failure, ISSN 1388-9842, 06/2017, Volume 19, Issue 6, pp. 718 - 727
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10. Full Text Phase 3 study of migalastat HCl for Fabry disease: Stage 1 results
by Nicholls, Kathy and Germain, Dominique P and Feliciani, Claudio and Shankar, Suma and Ezgu, Fatih and Janmohamed, Salim G and Laing, Shiona M and Schroyer, Rosemary O and Bragat, Alex C and Sitaraman, Sheela and Boudes, Pol F
Molecular genetics and metabolism, ISSN 1096-7192, 02/2013, Volume 108, Issue 2, pp. S70 - S70
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11. Full Text Effect of darapladib treatment on endarterectomy carotid plaque lipoprotein-associated phospholipase a2 activity: A randomized, controlled trial
by Johnson, Joel L and Shi, Yi and Snipes, Rose and Janmohamed, Salim and Rolfe, Timothy E and Davis, Bill and Postle, Anthony and Macphee, Colin H
PloS one, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e89034 - e89034
1-Alkyl-2-acetylglycerophosphocholine Esterase - blood | Humans | Carotid Stenosis - drug therapy | Caspase 3 - metabolism | Caspase 8 - metabolism | Oximes - therapeutic use | Male | Dose-Response Relationship, Drug | Endarterectomy, Carotid | Plaque, Atherosclerotic - enzymology | Time Factors | Female | Benzaldehydes - therapeutic use | Plaque, Atherosclerotic - blood | Carotid Stenosis - surgery | Biomarkers - metabolism | Plaque, Atherosclerotic - surgery | Lysophosphatidylcholines - metabolism | Benzaldehydes - pharmacology | Gene Expression Regulation - drug effects | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | Oximes - pharmacology | Aged | Carotid Stenosis - enzymology | Plaque, Atherosclerotic - drug therapy | Drugs | Plasma | Heart attacks | Lipids | Cardiovascular disease | Matrix metalloproteinase | Servers | Caspase-3 | Clinical outcomes | Lysophosphatidylcholine | Randomization | Databases | Java (programming language) | Atherosclerosis | HyperText Markup Language | Metalloproteinase | Safety | Pharmacodynamics | Phospholipase A2 | Caspase | Pharmacology | Gene expression | Low density lipoprotein | Caspase-8 | Phospholipase | Coronary vessels | Biomarkers | Acute coronary syndromes | Index Medicus | Data bases
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12. Full Text Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide onmajor cardiovascular events in patients with type 2 diabetes mellitus-Rationale, design, and baseline characteristics
by Green, Jennifer B and Hernandez, Adrian F and D'Agostino, Ralph B and Granger, Chris B and Janmohamed, Salim and Jones, Nigel P and Leiter, Lawrence A and Noronha, Drusilla and Russell, Rachael and Sigmon, Kristina and Del Prato, Stefano and McMurray, John J. V
The American heart journal, ISSN 0002-8703, 09/2018, Volume 203, pp. 30 - 38
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology
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13. Full Text The pharmacological treatment of primary aldosteronism
by Janmohamed, Salim and Bouloux, Pierre-Marc G
Expert opinion on pharmacotherapy, ISSN 1465-6566, 04/2006, Volume 7, Issue 5, pp. 563 - 573
amiloride | potassium canrenoate | adrenal | aldosterone | eplerenone | primary aldosteronism | aldosterone blockade | primary hyperaldosteronism | mineralocorticoid receptor antagonist | hypertension | spironolactone | Hypertension | Amiloride | Eplerenone | Potassium canrenoate | Primary aldosteronism | Mineralocorticoid receptor antagonist | Spironolacrone | Adrenal | Aldosterone | Primary hyperaldosteronism | Aldosterone blockade | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Glucocorticoids - therapeutic use | Receptors, Mineralocorticoid - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Hyperaldosteronism - complications | Sodium Channel Blockers - pharmacology | Clinical Trials as Topic | Hyperaldosteronism - metabolism | Calcium Channel Blockers - pharmacology | Hyperaldosteronism - drug therapy | Hypertension - etiology | Mineralocorticoid Receptor Antagonists - therapeutic use | Aldosterone - metabolism | Spironolactone - pharmacology | Amiloride - therapeutic use | Mineralocorticoid Receptor Antagonists - pharmacology | Amiloride - pharmacology | Glucocorticoids - pharmacology | Hypertension - prevention & control | Sodium Channel Blockers - therapeutic use | Drug Therapy, Combination | Spironolactone - therapeutic use | Practice Guidelines as Topic | Index Medicus
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