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Journal of Clinical Investigation, ISSN 0021-9738, 02/2018, Volume 128, Issue 2, pp. 734 - 745
The underlying cellular mechanisms of catatonia, an executive "psychomotor" syndrome that is observed across neuropsychiatric diseases, have remained obscure.... 
Schizophrenia | Catatonia | Diagnosis | Health aspects | Myelin proteins | Executive function | Mental disorders | Myelin | Genes | Inflammation | Substantia alba | Microglia | Autism | Neurodegeneration | Rodents | Oligodendrocytes | Trends | Psychiatry | Age | Animal cognition
Journal Article
Glia, ISSN 0894-1491, 05/2018, Volume 66, Issue 5, pp. 920 - 933
Human mesial temporal lobe epilepsy (MTLE) features subregion‐specific hippocampal neurodegeneration and reactive astrogliosis, including up‐regulation of the... 
stereology | astroglia | digital pathology | hippocampal sclerosis | GFAP | HUMAN BRAIN | TEMPORAL-LOBE EPILEPSY | SCLEROSIS | INTERNATIONAL CONSENSUS CLASSIFICATION | GLIAL-CELLS | NEUROSCIENCES | FIBRILLARY ACIDIC PROTEIN | SEIZURE-LIKE EVENTS | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | DENTATE GYRUS | Immunohistochemistry | Epilepsy, Temporal Lobe - enzymology | Neurons - pathology | Humans | Astrocytes - pathology | Cerebral Cortex - pathology | Drug Resistant Epilepsy - enzymology | Male | Epilepsy, Temporal Lobe - surgery | Gliosis - enzymology | Astrocytes - enzymology | Glial Fibrillary Acidic Protein - metabolism | Gliosis - pathology | Adult | Female | Epilepsy, Temporal Lobe - pathology | Glutamate-Ammonia Ligase - metabolism | Cerebral Cortex - enzymology | Neurodegenerative Diseases - pathology | White Matter - enzymology | Drug Resistant Epilepsy - pathology | White Matter - pathology | Cell Death - physiology | Neurons - enzymology | Drug Resistant Epilepsy - surgery | Neurodegenerative Diseases - enzymology | Brain | Neurons | Ligases | Glutamine | Neuroimaging | Temporal lobe | Image processing | Astrocytes | Glial fibrillary acidic protein | Epilepsy | Cortex | Substantia alba | Neuronal-glial interactions | Image analysis | Digital imaging | Gliosis | Neurodegeneration | Surgery | Stratum radiatum | Stereology | Degeneration | Glutamate-ammonia ligase | Hippocampus | Cortex (temporal)
Journal Article
Glia, ISSN 0894-1491, 07/2017, Volume 65, Issue 7, pp. 1176 - 1185
Microglia as principle innate immune cells of the central nervous system (CNS) are the first line of defense against invading pathogens. They are capable of... 
monocytes | inflammation | Rs‐LPS | cytokines | chemokines | TRIF | MyD88 | neutrophils | Rs-LPS | CELLS | ACTIVATION | RECOGNITION | ENDOTOXIN | RHODOBACTER-SPHAEROIDES | NEUROSCIENCES | DIPHOSPHORYL-LIPID-A | RHODOPSEUDOMONAS-SPHAEROIDES | NONTOXIC LIPOPOLYSACCHARIDE | CD14 | INNATE IMMUNITY | Adaptor Proteins, Vesicular Transport - genetics | Myelin Sheath - drug effects | Adaptor Proteins, Vesicular Transport - metabolism | Lipopolysaccharide Receptors - metabolism | Dose-Response Relationship, Drug | Up-Regulation - physiology | Toll-Like Receptor 4 - antagonists & inhibitors | Animals, Newborn | Macrophages - physiology | Brain - cytology | Phagocytosis - drug effects | Cytokines - metabolism | Microglia - drug effects | Myelin Sheath - pathology | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Phagocytosis - physiology | Toll-Like Receptor 4 - genetics | Mice, Transgenic | Toll-Like Receptor 4 - metabolism | Up-Regulation - drug effects | Animals | Lipopolysaccharides - pharmacology | Corpus Striatum - drug effects | Lipopolysaccharide Receptors - genetics | Macrophages - drug effects | Mice | Myeloid Differentiation Factor 88 - metabolism | Photosynthesis | Septic shock | Mitogens | Brain | Central nervous system | CD14 antigen | Lipopolysaccharides | Recruitment | Proteins | Phagocytes | Receptors | Rodents | Toll-like receptors | Bacteria | Immune system | Pathogens | Immune response | Cytokines | TLR4 protein | Microglia | Major histocompatibility complex | Functional morphology | MyD88 protein | Sepsis | Infiltration | Chemokines
Journal Article
Glia, ISSN 0894-1491, 04/2016, Volume 64, Issue 4, pp. 635 - 649
Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll-like receptor (TLR) 4 recognizes bacterial... 
monocytes | damage | CELLS | RECRUITMENT | ACTIVATION | MACROPHAGES | chemokines | RECEPTOR 4 | LPS | I INTERFERON | inflammation | LIPOPOLYSACCHARIDE | cytokines | neutrophils | Toll-like receptor | BRAIN | Toll‐like receptor | Monocytes | Cytokines | Neutrophils | Inflammation | Damage | Chemokines | NEUROSCIENCES | Escherichia coli | Adaptor Proteins, Vesicular Transport - genetics | Brain Injuries - complications | Male | Brain Ischemia - immunology | Adaptor Proteins, Vesicular Transport - metabolism | Lipopolysaccharide Receptors - metabolism | Stroke - pathology | Microglia - immunology | Brain Injuries - immunology | Toll-Like Receptor 4 - agonists | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages - immunology | Stroke - immunology | Disease Models, Animal | Infarction, Middle Cerebral Artery | Lipopolysaccharides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Toll-Like Receptor 4 - genetics | Escherichia coli Infections - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Animals | Escherichia coli Infections - pathology | Interferon-beta - metabolism | Brain Ischemia - pathology | Brain - pathology | Lipopolysaccharide Receptors - genetics | Feedback, Physiological - physiology | Brain - immunology | Brain Injuries - pathology | Neuroimmunomodulation | Escherichia coli Infections - complications | Bacterial infections | Biological response modifiers | Health aspects | Interferon beta | Rodents | Infections
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e104064
Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and... 
RESPIRATORY-INFECTION | RESPONSES | PROTECTIVE IMMUNITY | IL-12 PRODUCTION | INHIBITION | MOLECULE | INTERLEUKIN-10 PRODUCTION | MULTIDISCIPLINARY SCIENCES | BINDING | PERTUSSIS TOXIN | 3RD SIGNAL | CD8-Positive T-Lymphocytes - cytology | Dendritic Cells - immunology | Humans | Mice, Inbred C57BL | Solubility | Cell Adhesion - drug effects | Antigens, CD - metabolism | Cell Movement - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | Adenylate Cyclase Toxin - pharmacology | CD8-Positive T-Lymphocytes - drug effects | Dendritic Cells - drug effects | Cell Proliferation - drug effects | Dendritic Cells - cytology | Cell Death - drug effects | Toll-Like Receptors - metabolism | CD8-Positive T-Lymphocytes - immunology | Bordetella pertussis - chemistry | Enzymes | Whooping-cough | Dendritic cells | T cells | Peptides | Leukocyte migration | CD8 antigen | Virulence | Biochemistry | Vaccines | Cytosol | Proteins | Adenylate cyclase | Cell activation | Cell adhesion | CD25 antigen | Foxp3 protein | Pathogens | Antigens | Cytokines | Immunoregulation | Cyclic AMP | Interleukin 17 | Adhesives | γ-Interferon | Interleukin 10 | Cell migration | Lymph | Cell proliferation | CCL19 protein | Laboratories | Lymphocytes T | Infections | Activation | Lymph nodes | Homing | Phagocytes | Immunology | Lymphocytes | CCL21 protein | Cell cycle | Toll-like receptors | Immune system | CD11b antigen | Immune response | Cough | CD4 antigen | Whooping cough | Drainage | Signaling | Molecular biology | Chemokines
Journal Article
Journal Article
Glia, ISSN 0894-1491, 06/2015, Volume 63, Issue 6, pp. 1083 - 1099
The putative protein tyrosine kinase (PTK) inhibitor tyrphostin AG126 has proven beneficial in various models of inflammatory disease. Yet molecular targets... 
BTK | signaling | TLR | inflammation | microglia | multiple sclerosis | Signaling | Multiple sclerosis | Inflammation | Microglia | MULTIPLE-SCLEROSIS LESIONS | KAPPA-B ACTIVATION | MICROGLIAL ACTIVATION | INTRACELLULAR CALCIUM | TARGETING BTK | NEUROSCIENCES | SIGNAL-TRANSDUCTION | BRUTONS TYROSINE KINASE | BRAIN MACROPHAGES | CENTRAL-NERVOUS-SYSTEM | CELL DEPLETION | Spleen - physiopathology | Protein-Tyrosine Kinases - metabolism | Spleen - drug effects | Protein Kinase Inhibitors - chemistry | Th17 Cells - drug effects | Microglia - physiology | Neuroprotective Agents - pharmacology | Female | Tyrphostins - chemistry | Th17 Cells - pathology | Nitriles - metabolism | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Immunologic Factors - chemistry | Th17 Cells - physiology | Encephalomyelitis, Autoimmune, Experimental - pathology | Neuroprotective Agents - chemistry | Cytokines - metabolism | Microglia - drug effects | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Spleen - cytology | Tyrphostins - pharmacology | Hydrolysis | Animals | Signal Transduction - drug effects | Nitriles - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - metabolism | Immunologic Factors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Kinases | Medical research | Immune system
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 07/2019, Volume 33, Issue 7, pp. 8634 - 8647
Reduced expression of 2'-3 '-cyclic nucleotide 3 '-phosphodiesterase (Cnp) in humans and mice causes white matter inflammation and catatonic signs. These... 
catatonic signs | hurdle test | phagocytosis | ACTIVATION | SIGNS | CSF1R inhibitor PLX5622 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELINOGENESIS | MOUSE | RECEPTOR | SCHIZOPHRENIA | CELL BIOLOGY | ROLES | BIOLOGY | WHITE-MATTER HYPERINTENSITIES | CELL | executive function
Journal Article