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animals (10) 10
nitric oxide (10) 10
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nitrite (6) 6
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cell biology (2) 2
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dietary nitrate (2) 2
dietary supplements (2) 2
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free radicals (2) 2
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health (2) 2
human saliva (2) 2
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inflammatory-bowel-disease (2) 2
inorganic nitrate (2) 2
intragastric nitric-oxide (2) 2
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nitrates - analysis (2) 2
nitrates - blood (2) 2
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physiological aspects (2) 2
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1. Full Text Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis
by Dubuquoy, Laurent and Jansson, Emmelie Å and Deeb, Samir and Rakotobe, Sabine and Karoui, Mehdi and Colombel, Jean-Frédéric and Auwerx, Johan and Pettersson, Sven and Desreumaux, Pierre
Gastroenterology, ISSN 0016-5085, 2003, Volume 124, Issue 5, pp. 1265 - 1276
Background & Aims: The peroxisome proliferator-activated receptor γ (PPARγ) has been proposed as a key inhibitor of colitis through attenuation of nuclear... 
BACTERIAL LIPOPOLYSACCHARIDE | MESSENGER-RNAS | INFLAMMATORY-BOWEL-DISEASE | TOLL-LIKE RECEPTOR-4 | DIFFERENTIAL EXPRESSION | CROHNS-DISEASE | PPAR-GAMMA | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | INTESTINAL EPITHELIAL-CELLS | ADIPOSE-TISSUE
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2. Full Text A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
by Huang, Liyue and Olsson, Annika and Petersson, Joel and Holm, Lena and Lundberg, Jon O and Jansson, Emmelie Å and Nihlén, Carina and Stensdotter, Margareta and Weitzberg, Eddie and Govoni, Mirco and Malkey, Ronny and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinsk cellbiologi
Nature Chemical Biology, ISSN 1552-4450, 07/2008, Volume 4, Issue 7, pp. 411 - 417
Inorganic nitrite (NO2-) is emerging as a regulator of physiological functions and tissue responses to ischemia, whereas the more stable nitrate anion (NO3-)... 
ISCHEMIA-REPERFUSION INJURY | XANTHINE OXIDOREDUCTASE | HUMAN SALIVA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | CONVENTIONAL RATS | HUMANS | DIETARY NITRATE | SIGNALING MOLECULE | HYPOXIC CONDITIONS | BLOOD-PRESSURE | Xanthine Dehydrogenase - metabolism | Liver - enzymology | Nitrate Reductase - metabolism | Humans | Middle Aged | Reperfusion Injury - drug therapy | Nitrates - pharmacology | Nitrites - metabolism | Male | Nitrates - therapeutic use | Liver - drug effects | Nitrites - blood | Adult | Female | Blood Pressure - drug effects | Homeostasis - drug effects | Reperfusion Injury - metabolism | Disease Models, Animal | Nitrates - blood | Oxidation-Reduction | Reperfusion Injury - enzymology | Liver - metabolism | Rats | Organ Specificity | Animals | Homeostasis - physiology | Allopurinol - pharmacology | Mice | Nitric Oxide Synthase - metabolism | Nitrate Reductase - physiology | Nitric Oxide - metabolism | Bacteria | Biochemistry | Inhibitor drugs | Mammals | Nitric oxide | Rodents | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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3. Full Text The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash
by Govoni, Mirco and Jansson, Emmelie Å and Weitzberg, Eddie and Lundberg, Jon O
Nitric Oxide, ISSN 1089-8603, 2008, Volume 19, Issue 4, pp. 333 - 337
Recent studies surprisingly show that dietary inorganic nitrate, abundant in vegetables, can be metabolized in vivo to form nitrite and then bioactive nitric... 
Hypertension | Nitrate | Nitric oxide | Vegetarian | Nitric oxide synthase-independent | Oral bacteria | Nitrite | Antibacterial mouthwash | Vasodilation | OXIDE PRODUCTION | vasodilation | BIOCHEMISTRY & MOLECULAR BIOLOGY | oral bacteria | BLOOD-PRESSURE | CELL BIOLOGY | HUMAN SALIVA | REDUCTION | IN-VIVO | vegetarian | GENERATION | HEALTH | ISCHEMIA-REPERFUSION | STOMACH | INORGANIC NITRATE | Nitrates - blood | Bacteria - metabolism | Mouth - drug effects | Humans | Middle Aged | Bacteria - drug effects | Nitrites - metabolism | Chlorhexidine - pharmacology | Saliva - chemistry | Nitrates - administration & dosage | Cross-Over Studies | Young Adult | Mouthwashes - pharmacology | Nitrates - metabolism | Analysis of Variance | Chlorhexidine - analogs & derivatives | Mouth - microbiology | Nitrites - blood | Adult | Anti-Bacterial Agents - pharmacology | Nitrites - analysis | Nitric Oxide - metabolism | Nitrates - analysis | Antibacterial agents | Nitrites | Vasodilators | Dietary supplements
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4. Full Text Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis
by Dubuquoy, Laurent and Jansson, Emmelie A and Deeb, Samir and Rakotobe, Sabine and Karoui, Mehdi and Colombel, Jean-Frédéric and Auwerx, Johan and Pettersson, Sven and Desreumaux, Pierre
Gastroenterology, ISSN 0016-5085, 05/2003, Volume 124, Issue 5, p. 1265
The peroxisome proliferator-activated receptor gamma (PPAR gamma) has been proposed as a key inhibitor of colitis through attenuation of nuclear factor kappa B... 
Colon - cytology | Intestinal Mucosa - physiopathology | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Humans | RNA, Messenger - analysis | Intestinal Mucosa - cytology | Epithelial Cells - physiology | Toll-Like Receptors | Gene Expression - physiology | Colon - physiopathology | Female | Epithelial Cells - cytology | Enterobacteriaceae | Caco-2 Cells | Drosophila Proteins | Promoter Regions, Genetic | Receptors, Cell Surface - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Intestinal Mucosa - microbiology | Transcription Factors - genetics | Mice, Inbred C3H | Animals | Mice | Mutation | Colitis, Ulcerative - physiopathology
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5. Full Text Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shutting of PPAR-γ and ReIA
by Kelly, Denise and Campbell, Jamie I and King, Timothy P and Grant, George and Jansson, Emmelie A and Coutts, Alistair G.P and Pettersson, Sven and Conway, Shaun
Nature Immunology, ISSN 1529-2908, 01/2004, Volume 5, Issue 1, pp. 104 - 112
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6. Full Text Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash
by Petersson, Joel and Carlström, Mattias and Schreiber, Olof and Phillipson, Mia and Christoffersson, Gustaf and Jägare, Annika and Roos, Stefan and Jansson, Emmelie Å and Persson, A. Erik G and Lundberg, Jon O and Holm, Lena and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinsk cellbiologi and Integrativ Fysiologi
Free Radical Biology and Medicine, ISSN 0891-5849, 04/2009, Volume 46, Issue 8, pp. 1068 - 1075
Recently, it has been suggested that the supposedly inert nitrite anion is reduced in vivo to form bioactive nitric oxide with physiological and therapeutic... 
Blood Pressure | Gastric Mucosal Damage | Nitrate | Cardiovascular | Endothelial Dysfunction | Atherosclerosis | Nitrite | Nitric Oxide | Gastric Mucus | DASH | INTRAGASTRIC NITRIC-OXIDE | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | SALIVA | REDUCTION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GENERATION | VASODILATION | ISCHEMIA-REPERFUSION | HYPERTENSION | Atherosclcrosis | Administration, Oral | Nitrites - metabolism | Rats | Feeding Behavior | Male | Gastric Mucosa - metabolism | Nitric Oxide - analysis | Rats, Sprague-Dawley | Nitrates - administration & dosage | Nitrates - metabolism | Animals | Anti-Infective Agents, Local - administration & dosage | Diet | Blood Pressure - drug effects | Chlorhexidine - administration & dosage | Mouthwashes - administration & dosage | Gastric Mucosa - chemistry | Cytoprotection | Blood pressure | Diet therapy | Nitrites | Nitric oxide | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICINE | MEDICIN
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7. Full Text Nitrated oleic acid up-regulates PPARγ and attenuates experimental inflammatory bowel disease
by Borniquel, Sara and Jansson, Emmelie Å and Cole, Marsha P and Freeman, Bruce A and Lundberg, Jon O
Free Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 48, Issue 4, pp. 499 - 505
Nitric oxide and its metabolites undergo nitration reactions with unsaturated fatty acids during oxidative inflammatory conditions, forming electrophilic... 
Experimental colitis | Nitrated fatty acids | Free radicals | Nitric oxide | PPARγ | PROTECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | FATTY-ACIDS | PPAR gamma | THERAPY | LIGANDS | ENDOCRINOLOGY & METABOLISM | ACTIVATED-RECEPTOR-GAMMA | NITRIC-OXIDE | HUMAN BLOOD | ROSIGLITAZONE | DERIVATIVES
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8. Full Text Dietary nitrate increases gastric mucosal blood flow and mucosal defense
by Petersson, Joel and Phillipson, Mia and Jansson, Emmelie Å and Patzak, Andreas and Lundberg, Jon O and Holm, Lena and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinsk cellbiologi
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 03/2007, Volume 292, Issue 3, pp. G718 - G724
Salivary nitrate from dietary or endogenous sources is reduced to nitrite by oral bacteria. In the acidic stomach, nitrite is further reduced to bioactive... 
Rats | Laser-Doppler flowmetry | Endothelial nitric oxide synthase deficient | chromium-labeled EDTA clearance | Gastric mucus | Nitrite | PHYSIOLOGY | INTRAGASTRIC NITRIC-OXIDE | ACID | RAT | PERMEABILITY | PROTECTION | BICARBONATE | laser-Doppler flowmetry | endothelial nitric oxide synthase deficient | gastric mucus | nitrite | IN-VIVO | LASER-DOPPLER | rats | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | THICKNESS | Diclofenac - pharmacology | Nitrates - pharmacology | Nitrites - metabolism | Male | Mucus - drug effects | Stomach - metabolism | Nitrites - administration & dosage | Vascular Resistance - physiology | Regional Blood Flow - drug effects | Gastric Mucosa - drug effects | Vascular Resistance - drug effects | Mucus - metabolism | Blood Pressure - drug effects | Stomach - drug effects | Gastric Mucosa - blood supply | Taurocholic Acid - pharmacology | Permeability - drug effects | Administration, Oral | Mice, Inbred C57BL | Nitric Oxide Synthase Type III | Nitrites - pharmacology | Rats, Sprague-Dawley | Nitrates - administration & dosage | Mice, Knockout | Animals | Taurocholic Acid - administration & dosage | Nitric Oxide Synthase Type II - genetics | Gastric Mucosa - physiology | Mice | Mucus - chemistry | Diclofenac - administration & dosage | Nitric Oxide - metabolism | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICINE | Nitric Oxide/metabolism | Mice; Inbred C57BL | Nitric Oxide Synthase Type II/genetics | Gastric Mucosa/blood supply/drug effects/physiology | Diclofenac/administration & dosage/pharmacology | Regional Blood Flow/drug effects | Rats; Sprague-Dawley | Administration; Oral | Taurocholic Acid/administration & dosage/pharmacology | Mice; Knockout | Mucus/chemistry/drug effects/metabolism | Nitrites/administration & dosage/metabolism/pharmacology | Permeability/drug effects | Blood Pressure/drug effects | MEDICIN | Stomach/drug effects/metabolism | Vascular Resistance/drug effects/physiology | Nitrates/administration & dosage/pharmacology
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9. Full Text The Wnt/β-Catenin Signaling Pathway Targets PPARγ Activity in Colon Cancer Cells
by Emmelie Å. Jansson and Alexandra Are and Gediminas Greicius and I-Chun Kuo and Denise Kelly and Velmurugesan Arulampalam and Sven Pettersson and Tak Wah Mak
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2005, Volume 102, Issue 5, pp. 1460 - 1465
Control of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/β-catenin signaling. The nuclear receptor peroxisome... 
T lymphocytes | Biological Sciences | Transfection | HEK293 cells | Genetic vectors | Epithelial cells | Cell nucleus | Cell lines | Colorectal cancer | Antibodies | Reporter genes | T cell transcription factor 4 | Wnt signaling | APC | Nuclear receptors | mice | Colon epithelium | ANDROGEN RECEPTOR | MULTIPLE INTESTINAL NEOPLASIA | TRANSCRIPTIONAL ACTIVITY | colon epithelium | ACTIVATED RECEPTOR-GAMMA | MULTIDISCIPLINARY SCIENCES | BETA-CATENIN | IDENTIFICATION | nuclear receptors | APC(Min) mice | GENE | EXPRESSION | ABERRANT CRYPT FOCI | APCMin mice
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10. Full Text Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate
by Jansson, Emmelie Å and Petersson, Joel and Reinders, Claudia and Sobko, Tanja and Björne, Håkan and Phillipson, Mia and Weitzberg, Eddie and Holm, Lena and Lundberg, Jon O and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinsk cellbiologi
Free Radical Biology and Medicine, ISSN 0891-5849, 2007, Volume 42, Issue 4, pp. 510 - 518
Nitrate is abundant in our diet with particularly high levels in many vegetables. Ingested nitrate is concentrated in saliva and reduced to nitrite by bacteria... 
Ulcer | Nitrate | Nitrite | Saliva | NSAIDs | Nitric oxide | nitric oxide | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUCOSAL PROTECTION | HUMANS | nitrate | MUC5AC | saliva | nitrite | NITRIC-OXIDE PRODUCTION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | ulcer | GENERATION | MUCUS | THICKNESS | INORGANIC NITRATE | Stomach Ulcer - chemically induced | Mucin-6 | Diclofenac - adverse effects | Rats | Male | DNA Primers | Gastric Mucosa - metabolism | Rats, Sprague-Dawley | Nitrates - administration & dosage | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Diet | Base Sequence | Nitric Oxide - metabolism | Mucins - genetics | Stomach Ulcer - prevention & control | Physiological aspects | Ulcers | Nonsteroidal anti-inflammatory drugs | Medical and Health Sciences | Medicin och hälsovetenskap | Rats; Sprague-Dawley | Diclofenac/adverse effects | MEDICINE | Nitric Oxide/metabolism | Nitrates/administration & dosage | Stomach Ulcer/chemically induced/prevention & control | MEDICIN | Anti-Inflammatory Agents; Non-Steroidal/adverse effects | Mucins/genetics | Gastric Mucosa/metabolism
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11. Full Text Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
by Coutts, Alistair G P and Kelly, Denise and King, Timothy P and Conway, Shaun and Campbell, Jamie I and Jansson, Emmelie A and Pettersson, Sven and Grant, George
Nature Immunology, ISSN 1529-2908, 01/2004, Volume 5, Issue 1, pp. 104 - 112
The human gut microflora is important in regulating host inflammatory responses and in maintaining immune homeostasis. The cellular and molecular bases of... 
ACTIVATED RECEPTOR-GAMMA | INHIBITION | ACETYLATION | IMMUNE-RESPONSES | GENE-EXPRESSION | ALPHA | IMMUNOLOGY | NF-KAPPA-B | MAMMALIAN-CELLS | INTESTINAL EPITHELIAL-CELLS | BOWEL-DISEASE | Caco-2 Cells | NF-kappa B - antagonists & inhibitors | RNA Interference - immunology | Cytokines - metabolism | Bacteroides - immunology | Humans | NF-kappa B - immunology | Salmonella Infections - immunology | Gastrointestinal Tract - microbiology | Rats | Transcription Factor RelA | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Salmonella enteritidis - immunology | Gastrointestinal Tract - immunology | Receptors, Cytoplasmic and Nuclear - immunology | Animals | Salmonella Infections - microbiology | Electrophoretic Mobility Shift Assay | HeLa Cells | Transcription Factors - immunology | Microscopy, Fluorescence | Cytokines - immunology | NF-B protein | peroxisome proliferator-activated receptor-g | RelA protein | Crm-1 protein | PPAR-g protein
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12. Full Text Cardioprotective effects of vegetables: Is nitrate the answer?
by Lundberg, Jon O and Feelisch, Martin and Björne, Håkan and Jansson, Emmelie Å and Weitzberg, Eddie
Nitric Oxide, ISSN 1089-8603, 2006, Volume 15, Issue 4, pp. 359 - 362
A diet rich in fruits and vegetables is associated with a lower risk of certain forms of cancer and cardiovascular disease, but the mechanisms behind this... 
Hypertension | Nitrite | Cardiovascular | Nitrate reductase | Gastric cancer | Nitric oxide | nitric oxide | gastric cancer | BIOCHEMISTRY & MOLECULAR BIOLOGY | nitrate reductase | DIETARY NITRATE | SIGNALING MOLECULE | cardiovascular | CORONARY HEART-DISEASE | CELL BIOLOGY | nitrite | NITRIC-OXIDE PRODUCTION | REDUCTION | FRUIT | IN-VIVO | HEALTH | ISCHEMIA-REPERFUSION | hypertension | BLOOD | Nitrates - metabolism | Nitric Oxide - biosynthesis | Nitrates - physiology | Vegetables | Humans | Nitrites - metabolism | Cardiotonic Agents - pharmacology | Prevention | Nitrites | Analysis | Physiological aspects | Cancer
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13. Full Text Generation of NO by probiotic bacteria in the gastrointestinal tract
by Sobko, Tanja and Huang, Liyue and Midtvedt, Tore and Norin, Elisabeth and Gustafsson, Lars E and Norman, Mikael and Jansson, Emmelie Å and Lundberg, Jon O
Free Radical Biology and Medicine, ISSN 0891-5849, 2006, Volume 41, Issue 6, pp. 985 - 991
Probiotic bacteria elicit a number of beneficial effects in the gut but the mechanisms for these health promoting effects are not entirely understood. Recent... 
Allergy | Nitrate | Nitrite | Colitis | Newborn infants | Lactobacilli | NITRATE REDUCTION | colitis | CIRCULATION | FLORA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMANS | RATS | allergy | lactobacilli | nitrate | nitrite | NITRIC-OXIDE PRODUCTION | ENDOCRINOLOGY & METABOLISM | ISCHEMIA-REPERFUSION | newborn infants | BLOOD | Nitric Oxide - biosynthesis | Rats, Wistar | Humans | Intestine, Small - microbiology | Rats | Male | Stomach - metabolism | Cecum - microbiology | Colon - metabolism | Animals | Cecum - metabolism | Delivery, Obstetric | Female | Lactobacillus rhamnosus - metabolism | Colon - microbiology | Intestine, Small - metabolism | Stomach - microbiology | Infant, Newborn | Probiotics - metabolism | Nitrites | Nitric oxide | Dietary supplements
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14. Full Text Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash
by Petersson, Joel and Carlström, Mattias and Schreiber, Olof and Phillipson, Mia and Christoffersson, Gustaf and Jägare, Annika and Roos, Stefan and Jansson, Emmelie Å and Persson, A Erik G and Lundberg, Jon O and Holm, Lena and Sveriges lantbruksuniversitet
Free Radical Biology And Medicine, ISSN 1873-4596, 2009, Volume 46, Issue 8, p. 1068
Recently, it has been suggested that the supposedly inert nitrite anion is reduced in vivo to form bioactive nitric oxide with physiological and therapeutic... 
Livsmedelsvetenskap | Food Science
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15. Full Text Nitrated oleic acid up-regulates PPAR[gamma] and attenuates experimental inflammatory bowel disease
by Borniquel, Sara and Jansson, Emmelie A and Cole, Marsha P and Freeman, Bruce A and Lundberg, Jon O
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2010, Volume 48, Issue 4, p. 499
Nitric oxide and its metabolites undergo nitration reactions with unsaturated fatty acids during oxidative inflammatory conditions, forming electrophilic... 
Dextran | Mesalamine | Nitration | Metabolites | Oleic acid | Gastrointestinal diseases | Nitric oxide | Colitis | Sulfates
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16. Full Text Rectal nitric oxide and fecal calprotectin in inflammatory bowel disease
by Reinders, Claudia I and Jonkers, Daisy and Jansson, Emmelie Å and Stockbrügger, Reinhold W and Stobberingh, Ellen E and Hellström, Per M and Lundberg, Jon O
Scandinavian Journal of Gastroenterology, ISSN 0036-5521, 2007, Volume 42, Issue 10, pp. 1151 - 1157
Objective. The assessment of intestinal inflammation in patients with inflammatory bowel disease (IBD) remains a difficult challenge. Both rectal nitric oxide... 
Bowel inflammation | nitric oxide | Crohn's disease | colitis | Colitis | Nitric oxide | PROTEIN | CROHNS-DISEASE | NITRATE | MARKER | ULCERATIVE-COLITIS | LYMPHOCYTIC COLITIS | INTESTINAL INFLAMMATION | bowel inflammation | COLORECTAL-CANCER | SYNTHASE ACTIVITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Netherlands | Feces - chemistry | Leukocyte L1 Antigen Complex - analysis | Humans | Biomarkers - analysis | Crohn Disease - diagnosis | Inflammatory Bowel Diseases - diagnosis | Reference Values | Nitrites - analysis | Nitric Oxide - analysis | Nitrates - analysis
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17. The Wnt/beta-catenin signaling pathway targets PPAR gamma activity in colon cancer cells
by Emmelie A Jansson and Alexandra Are and Gediminas Greicius and I-Chun Kuo
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2005, Volume 102, Issue 5, p. 1460
  Control of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/{beta}-catenin signaling. The nuclear receptor peroxisom