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humans (18) 18
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1. Full Text Translational promise of the apeline-APJ system
by Barnes, G and Japp, AG and Newby, DE
HEART, ISSN 1355-6037, 07/2010, Volume 96, Issue 13, pp. 1011 - 1016
Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key hormone in cardiovascular homoeostasis. It is expressed in a diverse... 
HEART | CARDIAC & CARDIOVASCULAR SYSTEMS | CONTRACTILITY | PLASMA APELIN | PEPTIDE LIGAND | IN-VIVO | NITRIC-OXIDE | ORPHAN RECEPTOR APJ | ANGIOTENSIN-II | ENDOGENOUS INOTROPE APELIN | BLOOD-PRESSURE
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2. Full Text The apelin-APJ system in heart failure. Pathophysiologic relevance and therapeutic potential
by Japp, Alan G and Newby, David E
Biochemical Pharmacology, ISSN 0006-2952, 05/2008, Volume 75, Issue 10, pp. 1882 - 1892
Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor, APJ. This novel peptidic signalling pathway is widely represented in... 
Heart failure | Inotrope | APJ | Apelin | heart failure | apelin | G-PROTEIN | VASCULAR SMOOTH-MUSCLE | BLOOD-PRESSURE | PEPTIDE APELIN | IMMUNOCYTOCHEMICAL LOCALIZATION | MESSENGER-RNA | inotrope | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ORPHAN RECEPTOR APJ | CARDIAC CONTRACTILITY | ENDOGENOUS INOTROPE APELIN | Intercellular Signaling Peptides and Proteins - metabolism | Heart Failure - metabolism | Animals | Receptors, G-Protein-Coupled - metabolism | Humans | Heart Failure - physiopathology
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3. Full Text The Diagnosis and Evaluation of Dilated Cardiomyopathy
by Japp, Alan G., PhD and Gulati, Ankur, MD and Cook, Stuart A., MD and Cowie, Martin R., MD and Prasad, Sanjay K., MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 25, pp. 2996 - 3010
Abstract Dilated cardiomyopathy (DCM) is best understood as the final common response of myocardium to diverse genetic and environmental insults. A rigorous... 
Cardiovascular | Internal Medicine | imaging | remodeling | implantable cardioverter-defibrillator | RANDOMIZED CONTROLLED-TRIALS | CHRONIC HEART-FAILURE | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOVASCULAR MAGNETIC-RESONANCE | CARDIAC-RESYNCHRONIZATION THERAPY | COLLEGE-OF-CARDIOLOGY | EUROPEAN-SOCIETY | FUNCTIONAL MITRAL REGURGITATION | NONISCHEMIC CARDIOMYOPATHY | MYOCARDIAL FIBROSIS | CARDIOLOGY WORKING GROUP | Cardiomyopathy, Dilated - diagnosis | Phenotype | Cardiomyopathy, Dilated - etiology | Humans | Cardiomyopathy, Dilated - therapy | Heart | Analysis | Mortality | Development and progression | Diagnosis | Cardiology | Cardiomyopathy, Dilated | Cardiovascular agents | Heart failure | Heart attacks | Sarcoidosis | Cardiomyopathy | Cardiovascular disease | Viruses | Mitochondrial DNA | Inflammation | Kinases | Metabolism | Inflammatory diseases | Muscular dystrophy | Proteins | Biopsy | Human immunodeficiency virus--HIV | Coronary vessels | Tomography | Viral infections | Deoxyribonucleic acid--DNA
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4. Full Text Unlocking the Therapeutic Potential of Apelin
by Japp, Alan G and Newby, David E
Hypertension, ISSN 0194-911X, 08/2016, Volume 68, Issue 2, pp. 307 - 309
SYSTEM | PERIPHERAL VASCULAR DISEASE | INHIBITION | HEART-FAILURE
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5. Full Text Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis
by Chin, Calvin W.L., MD and Everett, Russell J., MD and Kwiecinski, Jacek, MD and Vesey, Alex T., MD, PhD and Yeung, Emily and Esson, Gavin and Jenkins, William, MD and Koo, Maria and Mirsadraee, Saeed, MD and White, Audrey C and Japp, Alan G., MD, PhD and Prasad, Sanjay K., MD and Semple, Scott, PhD and Newby, David E., MD, PhD and Dweck, Marc R., MD, PhD
JACC: Cardiovascular Imaging, ISSN 1936-878X, 2016, Volume 10, Issue 11, pp. 1320 - 1333
Abstract Objectives Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic... 
Cardiovascular | magnetic resonance imaging | fibrosis | myocardium | aortic stenosis | hypertrophy | T1 mapping | CARDIAC & CARDIOVASCULAR SYSTEMS | CORONARY | CARDIOVASCULAR MAGNETIC-RESONANCE | T1 VALUES | VALIDATION | ADENOSINE STRESS | DISEASE | VALVE-REPLACEMENT | OPTIMIZATION | PROGNOSTIC-SIGNIFICANCE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Cardiomyopathies - diagnostic imaging | Prospective Studies | Ventricular Function, Left | Humans | Middle Aged | Heart Failure - physiopathology | Male | Cardiomyopathies - etiology | Case-Control Studies | Aortic Valve Stenosis - diagnostic imaging | Aortic Valve Stenosis - mortality | Cardiomyopathies - physiopathology | Ventricular Remodeling | Time Factors | Cardiomyopathies - mortality | Female | Heart Failure - diagnostic imaging | Heart Failure - etiology | Heart Failure - mortality | Hypertrophy, Left Ventricular - mortality | Echocardiography | Hypertrophy, Left Ventricular - etiology | Risk Factors | Aortic Valve Stenosis - physiopathology | Kaplan-Meier Estimate | Myocardium - pathology | Disease Progression | Magnetic Resonance Imaging | Aortic Valve Stenosis - complications | Biopsy | Fibrosis | Aged | Hypertrophy, Left Ventricular - physiopathology | Hypertrophy, Left Ventricular - diagnostic imaging | Usage | Magnetic resonance imaging | Aortic valve stenosis | Cardiac patients | Research | Diagnosis | Health aspects | cTnI, cardiac troponin I | ECV, extracellular volume | IQR, interquartile range | LVH, left ventricular hypertrophy | LV, left ventricular | LGE, late gadolinium enhancement | AVR, aortic valve replacement | BNP, brain natriuretic peptide | ECG, electrocardiogram | CMR, cardiac magnetic resonance | iECV, indexed extracellular volume
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6. Full Text Heart failure and healthcare informatics
by Anwar, Mohamed S and Japp, Alan G and Mills, Nicholas L
PLoS Medicine, ISSN 1549-1277, 05/2019, Volume 16, Issue 5, p. e1002806
[...]evaluation of key healthcare metrics can help to identify the areas of practice that differ most from guideline recommendations. [...]recent work has... 
MEDICINE, GENERAL & INTERNAL | PATTERNS | Heart failure | Medical research | Medical advice systems | Analysis | Medicine, Experimental | Evidence-based medicine | Medical informatics | Care and treatment | Usage | Diagnosis | Risk factors | Health care | Heart | Therapy | Enzymes | Diagnostic tests | Science | Medical diagnosis | Primary care | Scholarships & fellowships | Data collection | Population | Titration | Clinical medicine | Informatics | Heart diseases | Drug dosages | Health informatics
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7. Full Text Acute cardiovascular effects of apelin in humans: Potential role in patients with chronic heart failure
by Japp, A.G and Cruden, N.L and Barnes, G and Van Gemeren, N and Mathews, J and Adamson, J and Johnston, N.R and Denvir, M.A and Megson, I.L and Flapan, A.D and Newby, D.E
Circulation, ISSN 0009-7322, 04/2010, Volume 121, Issue 16, pp. 1818 - 1827
Background-Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study... 
Heart failure | APJ receptor, human | Apelin, AGTRL1 ligand, human | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | ENDOGENOUS PEPTIDE LIGAND | ATHEROSCLEROSIS | BLOOD-PRESSURE | apelin, AGTRL1 ligand, human | CIGARETTE-SMOKING | PLASMA-CONCENTRATIONS | IN-VIVO | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ORPHAN RECEPTOR APJ | CARDIAC CONTRACTILITY | HEMATOLOGY | Injections, Intravenous | Cardiac Output - drug effects | Humans | Middle Aged | Nitroprusside - administration & dosage | Ventricular Pressure - drug effects | Myocardial Contraction - drug effects | Male | Heart Failure - drug therapy | Acetylcholine - administration & dosage | Regional Blood Flow - drug effects | Forearm - blood supply | Female | Coronary Circulation - drug effects | Vasodilation - drug effects | Intercellular Signaling Peptides and Proteins - administration & dosage | Chronic Disease | Vasodilator Agents - administration & dosage | Plethysmography | Ligands (Biochemistry) | Physiological aspects | Development and progression | Diagnosis | Research | Biological markers
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8. Full Text Vascular Effects of Apelin In Vivo in Man
by Japp, Alan G., MRCP and Cruden, Nicholas L., PhD and Amer, David A.B and Li, Vivienne K.Y., BSc and Goudie, Ewan B., BSc and Johnston, Neil R., MSc and Sharma, Sushma, PhD and Neilson, Ilene, BSc and Webb, David J., MD, FRCP and Megson, Ian L., PhD and Flapan, Andrew D., MD, MRCP and Newby, David E., PhD, FRCP
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2008, Volume 52, Issue 11, pp. 908 - 913
Vascular Effects of Apelin In Vivo in Man Alan G. Japp, Nicholas L. Cruden, David A. B. Amer, Vivienne K. Y. Li, Ewan B. Goudie, Neil R. Johnston, Sushma... 
Cardiovascular | Internal Medicine | endothelium | APJ receptor | apelin | vasodilator | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | MECHANISM | HUMAN FOREARM | NITRIC-OXIDE | RECEPTOR | APJ | LIGAND | Blood Pressure | Heart Rate | Vasomotor System - physiology | Humans | Forearm - blood supply | Adult | Male | Vasodilation - physiology | Regional Blood Flow | Protein Isoforms - physiology | Apelin | Intercellular Signaling Peptides and Proteins - physiology | Aspirin | Dilatation | Analysis | Nitric oxide | Blood vessels | Sodium nitroferricyanide | Cyanides | College administrators | Endothelium | Studies | Heart rate | Variance analysis | Rodents | Veins & arteries
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9. Full Text A 49-year-old with chest pain and collapse
by Moss, Alastair J and Lim, Kelvin HH and Japp, Alan G
Heart, ISSN 1355-6037, 06/2017, Volume 103, Issue 12, pp. 968 - 968
Clinical introductionA 49-year-old man presented to the emergency department following sudden onset chest pain with collapse. He was refurbishing his home when... 
Coronary artery disease | Cardiac computer tomographic (CT) imaging | RUPTURE | WALL | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | Aneurysm, False - complications | Humans | Middle Aged | Male | Angina Pectoris - etiology | Shock - etiology | Computed Tomography Angiography | Heart Ventricles | Shock - diagnostic imaging | Aneurysm, False - diagnostic imaging | Heart Diseases - therapy | Aneurysm, False - therapy | Angina Pectoris - diagnostic imaging | Heart Diseases - complications | Heart Diseases - diagnostic imaging | Pain | Heart attacks | Medical prognosis | Mortality | Catheters | Blood clots | Image Challenge | 1506
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10. Full Text Sustained cardiovascular actions of apj agonism during renin-angiotensin system activation and in patients with heart failure
by Barnes, Gareth D and Alam, Shirjel and Carter, Gordon and Pedersen, Christian M and Lee, Kristina M and Hubbard, Thomas J and Veitch, Scott and Jeong, Herim and White, Audrey and Cruden, Nicholas L and Huson, Les and Japp, Alan G and Newby, David E
Circulation: Heart Failure, ISSN 1941-3289, 05/2013, Volume 6, Issue 3, pp. 482 - 491
Background-To assess cardiovascular actions of APJ agonism during prolonged (Pyr(1)) apelin-13 infusion and reninangiotensin system activation. Methods and... 
Heart failure | Human | Vasodilatation | APJ | Apelin | ENDOGENOUS LIGAND | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | apelin | CONTRACTILITY | FOREARM | ENDOTHELIAL FUNCTION | VASCULAR SMOOTH-MUSCLE | BLOOD-PRESSURE | vasodilatation | PEPTIDE APELIN | VASOPRESSIN | ORPHAN RECEPTOR APJ | HYPERTENSION | human | Angiotensin II - administration & dosage | Humans | Middle Aged | Heart Failure - physiopathology | Cardiography, Impedance | Male | Renin-Angiotensin System - physiology | Cardiovascular System - drug effects | Receptors, G-Protein-Coupled - agonists | Heart Failure - drug therapy | Intercellular Signaling Peptides and Proteins - physiology | Cross-Over Studies | Intercellular Signaling Peptides and Proteins - metabolism | Sodium - urine | Intercellular Signaling Peptides and Proteins - pharmacology | Apelin Receptors | Forearm - blood supply | Vascular Resistance - drug effects | Female | Aged | Blood Pressure - drug effects | Hemodynamics | Plethysmography
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11. Full Text Notable case The hazards of brussels sprouts consumption at Christmas
by Pettit, SJ and Japp, AG and Gardner, RS
MEDICAL JOURNAL OF AUSTRALIA, ISSN 0025-729X, 12/2012, Volume 197, Issue 11-12, pp. 661 - 662
MEDICINE, GENERAL & INTERNAL | WARFARIN RESISTANCE
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12. Full Text Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure A Cardiovascular Magnetic Resonance Study
by Gulati, A and Japp, AG and Raza, S and Halliday, BP and Jones, DA and Newsome, S and Ismail, NA and Morarji, K and Khwaja, J and Spath, N and Shakespeare, C and Kalra, PR and Lloyd, G and Mathur, A and Cleland, JGF and Cowie, MR and Assomull, RG and Pennell, DJ and Ismail, TF and Prasad, SK
CIRCULATION-CARDIOVASCULAR IMAGING, ISSN 1941-9651, 09/2018, Volume 11, Issue 9
BACKGROUND: Myocardial fibrosis, identified by late gadolinium enhancement cardiovascular magnetic resonance, predicts outcomes in chronic heart failure (HF).... 
VENTRICULAR EJECTION FRACTION | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | IDIOPATHIC DILATED CARDIOMYOPATHY | DIASTOLIC FUNCTION | AMERICAN-COLLEGE | LATE GADOLINIUM ENHANCEMENT | death, sudden, cardiac | CARDIAC RESYNCHRONIZATION THERAPY | survival rate | ASSOCIATION TASK-FORCE | fibrosis | IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PRIMARY PREVENTION | gadolinium | FOCUSED UPDATE | Heart failure | Treatment outcome | Care and treatment | Usage | Medical examination | Magnetic resonance imaging | Cardiac patients | Analysis | Health risk assessment
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13. Full Text Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis
by Kwiecinski, Jacek and Chin, Calvin W L and Everett, Russell J and White, Audrey C and Semple, Scott and Yeung, Emily and Jenkins, William J and Shah, Anoop S V and Koo, Maria and Mirsadraee, Saeed and Lang, Chim C and Mills, Nicholas and Prasad, Sanjay K and Jansen, Maurits A and Japp, Alan G and Newby, David E and Dweck, Marc R
European Heart Journal - Cardiovascular Imaging, ISSN 2047-2404, 03/2018, Volume 19, Issue 3, pp. 347 - 356
Abstract Aims Asymmetric wall thickening has been described in patients with aortic stenosis. However, it remains poorly characterized and its prognostic... 
magnetic resonance | aortic stenosis | troponin | hypertrophy | asymmetric wall thickening | echocardiography | WALL | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | MARKER | CARDIOMYOPATHY | VALVE | RECOMMENDATIONS | SEPTAL HYPERTROPHY | STRESS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Confidence Intervals | Prognosis | Prospective Studies | Humans | Middle Aged | Echocardiography - methods | Gadolinium | Male | Reference Values | Case-Control Studies | Aortic Valve Stenosis - diagnostic imaging | Aortic Valve Stenosis - mortality | Cardiomegaly - mortality | Female | Aortic Valve Stenosis - surgery | Severity of Illness Index | Risk Assessment | Aortic Valve Stenosis - physiopathology | Cardiomegaly - diagnostic imaging | Proportional Hazards Models | Adaptation, Physiological - physiology | Cardiomegaly - physiopathology | Myocardium - pathology | Survival Rate | Treatment Outcome | Magnetic Resonance Imaging, Cine - methods | Aged | Transcatheter Aortic Valve Replacement - methods | Original
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14. Full Text Echocardiographic Quantification of Left Ventricular Systolic Function
by Japp, Alan G., PhD, MRCP and Moir, Stuart, MBBS, PhD and Mottram, Philip M., MBBS, PhD
Heart, Lung and Circulation, ISSN 1443-9506, 2015, Volume 24, Issue 6, pp. 532 - 535
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | STRAIN | EJECTION FRACTION | HEART-FAILURE | Predictive Value of Tests | Risk Assessment | Humans | Middle Aged | Stroke Volume - physiology | Male | Echocardiography, Doppler, Color - methods | Disease Progression | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Systole - physiology | Adult | Ventricular Function, Left - physiology | Early Diagnosis
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15. Full Text Use of implantable cardioverter defibrillators in patients with left ventricular assist devices
by Pettit, Stephen J and Petrie, Mark C and Connelly, Derek T and Japp, Alan G and Payne, John R and Haj‐Yahia, Saleem and Gardner, Roy S
European Journal of Heart Failure, ISSN 1388-9842, 07/2012, Volume 14, Issue 7, pp. 696 - 702
Patients with left ventricular assist devices (LVADs) are at high risk of sustained ventricular arrhythmias, but these may be remarkably well tolerated and the... 
ventricular fibrillation | implantable cardioverter defibrillator | left ventricular assist device | ventricular tachycardia | Left ventricular assist device | Ventricular tachycardia | Implantable cardioverter defibrillator | Ventricular fibrillation | ARRHYTHMIAS | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | RISK | CIRCULATORY SUPPORT | SHOCKS | THERAPY | PRIMARY PREVENTION | Stroke Volume | Tachycardia, Ventricular - therapy | Risk Assessment - methods | Ventricular Fibrillation - pathology | Defibrillators, Implantable - adverse effects | Ventricular Function, Left | Humans | Tachycardia, Ventricular - pathology | Heart-Assist Devices - adverse effects | Ventricular Fibrillation - therapy
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16. Full Text Effect of PSI‐697, a Novel P‐Selectin Inhibitor, on Platelet–Monocyte Aggregate Formation in Humans
by Japp, Alan G and Chelliah, Raj and Tattersall, Laura and Lang, Ninian N and Meng, Xu and Weisel, Kathleen and Katz, Arie and Burt, David and Fox, Keith A. A and Feuerstein, Giora Z and Connolly, Thomas M and Newby, David E
Journal of the American Heart Association, ISSN 2047-9980, 02/2013, Volume 2, Issue 1, pp. e006007 - n/a
Background Platelet activation is central to the pathogenesis of acute coronary syndromes. Surface expression of P‐selectin on activated platelets induces... 
P‐selectin | platelets | thrombosis | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | VENOUS THROMBOSIS | THROMBIN-STIMULATED PLATELETS | SMALL-MOLECULE INHIBITOR | GLYCOPROTEIN LIGAND-1 | DIABETES-MELLITUS | INFLAMMATION | IN-VIVO | BINDING | P-selectin | TISSUE FACTOR | Selenoprotein P - blood | Double-Blind Method | Smoking - blood | Administration, Oral | Humans | Monocytes - metabolism | Scotland | Platelet Adhesiveness - drug effects | Cross-Over Studies | Monocytes - drug effects | Flow Cytometry | Time Factors | Blood Platelets - metabolism | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Selenoprotein P - antagonists & inhibitors | Blood Platelets - drug effects | Hydroxyquinolines - administration & dosage
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17. Das deutsche Künstlerdrama
: von der Aufklärung bis zur Gegenwart
by Japp, Uwe
2004, ISBN 3110181533, xii, 290
History and criticism | German drama
Book
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18. Full Text Translational promise of the apelin–APJ system
by Barnes, Gareth and Japp, Alan G and Newby, David E
Heart, ISSN 1355-6037, 07/2010, Volume 96, Issue 13, pp. 1011 - 1016
Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key hormone in cardiovascular homoeostasis. It is expressed in a diverse... 
Cardiovascular Diseases - etiology | Cardiovascular Diseases - physiopathology | Cardiovascular Diseases - metabolism | Humans | Translational Medical Research | Renin-Angiotensin System - physiology | Adipokines | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Carrier Proteins - metabolism | Ligands | Mice | Apelin | Receptors, G-Protein-Coupled - physiology | Heart failure | Care and treatment | Ligands (Biochemistry) | Physiological aspects | Homeostasis | Research | Renin-angiotensin system | Phosphorylation | Disease | Amino acids | Cardiomyocytes | Glucose | Metabolism | Insulin | Endothelium | Nitric oxide | Rodents | Insulin resistance | Blood pressure | Physiology | Diabetes | Veins & arteries
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19. Full Text Standardised recording of sediments in the excavation of the Sabaean town of Sirwah, Yemen
by Pietsch, Dana and Schenk, Karin and Japp, Sarah and Schnelle, Mike
Journal of Archaeological Science, ISSN 0305-4403, 05/2013, Volume 40, Issue 5, pp. 2430 - 2445
The application of sediment description in excavations helps to interpret sedimentary archives on archaeological sites. Although there are a few standardised... 
Stratigraphy | Sabaean culture | Site-formation history | Anthropogenic deposits | Soil manual | SOILS | AGRICULTURE | ARCHAEOLOGICAL SITE | ARABIA | HOLOCENE | MARIB | ARCHAEOLOGY | GEOSCIENCES, MULTIDISCIPLINARY | OASIS | RAMLAT AS-SABATAYN | HIGHLANDS | ANTHROPOLOGY | CLIMATE | Archaeology | Radiocarbon dating | Analysis | Excavations (Archaeology) | Sediments (Geology) | Archaeological dating
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