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Nature Reviews Drug Discovery, ISSN 1474-1776, 12/2012, Volume 11, Issue 12, pp. 909 - 922
In vitro pharmacological profiling is increasingly being used earlier in the drug discovery process to identify undesirable off-target activity profiles that... 
TARGET | CHANNEL | ELECTROPHYSIOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CARDIAC-ARRHYTHMIA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RECEPTOR ANTAGONIST | BLOOD-PRESSURE | DISCOVERY | PDE4 INHIBITORS | PREDICTION | Risk Assessment | Drug Discovery | Drug Industry | Drug-Related Side Effects and Adverse Reactions | Drugs | Adverse and side effects | Pharmacology | Research
Journal Article
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2010, Volume 62, Issue 2, pp. e11 - e12
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2017, Volume 174, Issue 14, pp. 2302 - 2317
Background and Purpose Neuroinflammation is initiated by a variety of stimuli including infections, sepsis, neurodegenerative diseases or traumatic brain... 
SYSTEMIC INFLAMMATION | MICROGLIAL ACTIVATION | LEUKOCYTE RECRUITMENT | CONCISE GUIDE | OXIDASE | PHARMACOLOGY | IN-VIVO | VAP-1/SSAO | PHARMACOLOGY & PHARMACY | BRAIN | MORPHOLOGY | Inflammation - chemically induced | Rats, Long-Evans | Cell Adhesion Molecules - antagonists & inhibitors | Rats | Male | Lipopolysaccharides - antagonists & inhibitors | Allyl Compounds - pharmacology | Sulfonamides - pharmacology | Cell Adhesion Molecules - metabolism | Amine Oxidase (Copper-Containing) - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Allyl Compounds - administration & dosage | Inflammation - metabolism | Animals | Amine Oxidase (Copper-Containing) - antagonists & inhibitors | Inflammation - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Lipopolysaccharides - pharmacology | Sulfonamides - administration & dosage | Oxidases | Brain | Nervous system diseases | Amines | Neurons | Analysis | Inflammation | Mitogens | Injuries | Animal models | Traumatic brain injury | Substantia nigra | Oxidase | Inflammatory response | Western blotting | Lipopolysaccharides | Recruitment | Head injuries | Extravasation | Rodents | Neostriatum | Inhibition | Semicarbazide | Semicarbazide-sensitive amine oxidase | Neurodegenerative diseases | Neutrophils | Leukocytes (neutrophilic) | Adhesion | Microglia | Neurological diseases | Sepsis | Immunofluorescence | Research Papers | Research Paper
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2017, Volume 174, Issue 14, pp. 2302 - 2317
Journal Article
European Respiratory Journal, ISSN 0903-1936, 09/2016, Volume 48, Issue suppl 60, p. PA4035
Journal Article
International Journal of Hematology, ISSN 0925-5710, 10/2019
Journal Article
eLife, ISSN 2050-084X, 07/2018, Volume 7
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 16, pp. 26066 - 26078
Journal Article
Respiratory Research, ISSN 1465-9921, 03/2015, Volume 16, Issue 1, p. 42
Background and purpose: The persistent influx of neutrophils into the lung and subsequent tissue damage are characteristics of COPD, cystic fibrosis and acute... 
Adhesion molecules | VAP-1/SSAO | Lung inflammation | Neutrophils | COPD | INDUCED ASTHMA | RECRUITMENT | VASCULAR ADHESION PROTEIN-1 | AIRWAY INFLAMMATION | SENSITIVE AMINE OXIDASE | CXCR2 ANTAGONIST | INDUCED LUNG INFLAMMATION | RESPIRATORY SYSTEM | IN-VIVO | INFECTION | CYSTIC-FIBROSIS | Respiratory Tract Infections - enzymology | Cell Adhesion Molecules - antagonists & inhibitors | Rhinovirus - pathogenicity | Cecum - microbiology | Picornaviridae Infections - virology | Lipopolysaccharides | Lung - enzymology | Cecum - surgery | Bronchoconstriction - drug effects | Asthma - immunology | Pneumonia - immunology | Respiratory Tract Infections - etiology | Asthma - virology | Neutrophil Infiltration - drug effects | Disease Models, Animal | Klebsiella Infections - enzymology | Asthma - physiopathology | Anti-Inflammatory Agents - pharmacology | Pneumonia - enzymology | Asthma - enzymology | Allylamine - analogs & derivatives | Enzyme Inhibitors - pharmacology | Lung - physiopathology | Cell Adhesion Molecules - metabolism | Picornaviridae Infections - enzymology | Lung - drug effects | Respiratory Tract Infections - immunology | Picornaviridae Infections - physiopathology | Mice, Inbred BALB C | Endothelial Cells - enzymology | Leukocyte Rolling - drug effects | Rats, Wistar | Benzamides - pharmacokinetics | Picornaviridae Infections - drug therapy | Dose-Response Relationship, Drug | Ligation | Amine Oxidase (Copper-Containing) - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Allylamine - pharmacology | Anti-Inflammatory Agents - pharmacokinetics | Benzamides - pharmacology | Klebsiella Infections - drug therapy | Picornaviridae Infections - immunology | Pneumonia - etiology | Mice, Inbred C57BL | Punctures | Respiratory Tract Infections - drug therapy | Klebsiella Infections - microbiology | Asthma - drug therapy | Amine Oxidase (Copper-Containing) - metabolism | Endothelial Cells - immunology | Animals | Pneumonia - drug therapy | Klebsiella Infections - immunology | Klebsiella pneumoniae - pathogenicity | Allylamine - pharmacokinetics | Lung - immunology | Endothelial Cells - drug effects | Health aspects | Analysis | Endothelium | VAP-1 | SSAO | Research
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2013, Volume 347, Issue 2, pp. 365 - 374
Semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), is a member of the copper-dependent amine oxidase family that... 
VASCULAR ADHESION PROTEIN-1 | DEAMINATION | INFLAMMATION | VAP-1 INHIBITORS | PHARMACOLOGY & PHARMACY | DIABETIC MACULAR EDEMA | HUMAN UMBILICAL ARTERY | SERUM | SENSITIVE AMINE OXIDASE | THIAZOLE DERIVATIVES | BINDING | Small Molecule Libraries - pharmacology | Species Specificity | Dermatitis - immunology | Humans | Allyl Compounds - chemistry | Cell Adhesion Molecules - antagonists & inhibitors | Dermatitis - enzymology | Dose-Response Relationship, Drug | Microsomes - drug effects | Amine Oxidase (Copper-Containing) - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Anti-Inflammatory Agents - therapeutic use | Pneumonia - immunology | Anti-Inflammatory Agents - pharmacokinetics | Molecular Structure | Disease Models, Animal | Rabbits | Allyl Compounds - pharmacokinetics | Sulfonamides - chemistry | Anti-Inflammatory Agents - pharmacology | Pneumonia - enzymology | Enzyme Inhibitors - pharmacology | Small Molecule Libraries - therapeutic use | Rats | Microsomes - enzymology | Allyl Compounds - pharmacology | Allyl Compounds - therapeutic use | Sulfonamides - pharmacology | Enzyme Inhibitors - therapeutic use | Sulfonamides - pharmacokinetics | Small Molecule Libraries - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Pneumonia - drug therapy | Sulfonamides - therapeutic use | Models, Biological | Dogs | Adipose Tissue - enzymology | Mice | In Vitro Techniques | Small Molecule Libraries - pharmacokinetics | Adipose Tissue - drug effects | Dermatitis - drug therapy
Journal Article
QJM: An International Journal of Medicine, ISSN 1460-2393, 09/2016
Journal Article
Progress in Neurobiology, ISSN 0301-0082, 1995, Volume 46, Issue 4, pp. 423 - 462
The inhibitory neurotransmitter GABA acts in the mammalian brain through two different receptor classes: GABA and GABA receptors. GABA receptors differ... 
Baclofen - pharmacology | Receptors, GABA-B - drug effects | Animals | Potassium Channels - physiology | Central Nervous System - drug effects | Receptors, GABA-B - physiology | Autoreceptors - drug effects
Journal Article