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Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 533 - 534
BIOCHEMISTRY Formaldehyde, a DNA-damaging agent formed in cells, has now been shown to support metabolic processes that involve molecular units containing a... 
GLYCINE | SERINE | PATHWAY | MULTIDISCIPLINARY SCIENCES | CANCER | TUMORS | ONE-CARBON METABOLISM | Toxins, Biological | Biochemistry | Metabolism | Humans | Biological research | Physiological aspects | Toxins | Research | Biology, Experimental | Enzymes | CRISPR | Vitamin B | Amino acids | Aldehydes | Carbon | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 04/2017, Volume 42, Issue 4, p. 274
Metabolomics generates a profile of small molecules that are derived from cellular metabolism and can directly reflect the outcome of complex networks of... 
Metabolomics | Separation | Data acquisition | Mass spectroscopy | Liquid chromatography | Biochemistry | Metabolism | Utilities | Reviews | Cellular communication | Water analysis | Physiology | Mass spectrometry | Expansion
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5442 - 5442
Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and serine synthesis are required in... 
FLUX ANALYSIS | TARGET | NETWORK | PATHWAY | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | INHIBITORS | DEHYDROGENASE | Pentose phosphate | Toxicity | Serine | Biosynthesis | Phosphoglycerate dehydrogenase | Carboxylic acids | Metabolism | Carbon | Mass balance | Alterations | Pentose | Pentose phosphate pathway | Disruption | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 809 - 15
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which... 
GLUTAMINE DEPRIVATION | DIAGNOSIS | INHIBITION | MICRORNA 135 | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | GROWTH | MUTANT P53 | HYPOXIA | EXPRESSION | PROGRESSION | Adenocarcinoma | Tricarboxylic acid cycle | Deprivation | Reactive oxygen species | p53 Protein | MiRNA | Metabolism | Ribonucleic acids | Bioaccumulation | Pancreatic cancer | Glycolysis | Nutrients | Phosphofructokinase | Tumors | Cancer | Adaptation | Glutamine | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2018, Volume 28, Issue 5, pp. 669 - 670
Studies have shown that tumors commonly exhibit normal or enhanced respiration in addition to glycolytic metabolism. In this issue, report a reduction in... 
METABOLISM | CANCER | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY | Tumors
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2018, Volume 33, Issue 3, pp. 337 - 339
Altered glucose metabolism is common in cancer. In this issue of , Morita et al. report new mouse models that express specific isoforms of pyruvate kinase to... 
CELLS | ISOFORM | ONCOLOGY | PKM2 | CELL BIOLOGY | Animals | Protein Isoforms | Glycolysis | Mice | Glucose | Neoplasms | Pyruvate Kinase | Physiological aspects | Glucose metabolism | Analysis | Dextrose | Cancer | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2019, Volume 35, Issue 3, pp. 339 - 341
Altered metabolism is a common feature of new and recurring malignancy. In this issue of , Reina-Campos and colleagues report upregulation of the serine,... 
ONCOLOGY | METHYLATION | CELL BIOLOGY | Physiological aspects | Medical colleges | Disease susceptibility | Glycine | Prostate cancer | Serine
Journal Article
CELL, ISSN 0092-8674, 11/2017, Volume 171, Issue 4, pp. 736 - 737
Nearly 3% of the human population carries bi-allelicloss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Vitamin B 12 | Succinates | Gene Knockout Techniques | Humans | Vitamins
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2016, Volume 12, Issue 8, pp. 577 - 578
  Glucose metabolism has long been thought to operate with exquisite specificity and near-optimal efficiency. New findings show, however, that two glycolytic... 
Glycolysis | Cell Proliferation | Metabolism | Humans | Carbohydrate Metabolism | Enzymes | Biochemistry | Glucose | Index Medicus
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 03/2016, Volume 41, Issue 3, p. 211
  Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is... 
Survival analysis | Cell growth | Glucose | Metabolism | Cells | Cancer
Journal Article
Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 12, pp. 3587 - 3601.e4
Most cancer cells exhibit metabolic flexibility, enabling them to withstand fluctuations in intratumoral concentrations of glucose (and other nutrients) and... 
NADPH | ERR | MPC1 | glutaminase | nuclear receptor | breast cancer | pyruvate carrier | pentose phosphate pathway | oxidative stress | mitochondrial metabolism | COMPLEX I | TCA CYCLE | PGC1-ALPHA | RESISTANCE | TUMOR-CELLS | HYPOXIA | OXIDATIVE-METABOLISM | LACTATE METABOLISM | EXPRESSION | CHEMOTHERAPY | CELL BIOLOGY
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2019, Volume 20, Issue 9, pp. 1186 - 1195
Macrophages are activated during microbial infection to coordinate inflammatory responses and host defense. Here we find that in macrophages activated by... 
Glycerin | Usage | Immunotherapy | Glycerol | DNA binding proteins | Research | Macrophages | Phosphates | Glycerol-3-phosphate dehydrogenase | Oxidative metabolism | Genes | Inflammatory response | Exposure | Inflammation | Glucose | Metabolism | Lipopolysaccharides | Mitochondria | Glucose dehydrogenase | Immunosuppression | Cell activation | Microorganisms | Shutdowns | Histones | Coenzyme A | Oxidation | Glycerols | Acetylation | Index Medicus
Journal Article
Nature Communications, 08/2019, Volume 10, Issue 1, pp. 1 - 12
The tumor milieu consists of numerous cell types each existing in a different environment. However, a characterization of metabolic heterogeneity at... 
Discordance | Melanoma | Metabolism | Heterogeneity | Landscapes | Mitochondria | Algorithms | Stromal cells | Computer applications | Glycolysis | Head and neck | Hypoxia | Tumors
Journal Article
EBioMedicine, ISSN 2352-3964, 05/2017, Volume 19, Issue C, pp. 4 - 5
Journal Article
Analytical Chemistry, ISSN 0003-2700, 02/2014, Volume 86, Issue 4, pp. 2175 - 2184
Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1278 - 1283
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute... 
Antioxidants | Oxidative stress | Medical research | Cellular metabolism | REPORTS | Erythrocytes | Cell lines | Antibodies | Oxidation | Cell membranes | Hemoglobins | CELLS | OXIDATIVE STRESS | PROTEIN | METABOLISM | MULTIDISCIPLINARY SCIENCES | ROS | TUMOR-SUPPRESSOR | ISOFORM | CANCER | Enzyme Activators - pharmacology | Neoplasm Transplantation | Protein Subunits | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Pyruvate Kinase - chemistry | Diamide - pharmacology | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Mutant Proteins - antagonists & inhibitors | Cell Line | Oxidation-Reduction | Pyruvate Kinase - metabolism | Cell Survival | Mutant Proteins - genetics | Mutant Proteins - metabolism | Cysteine - chemistry | Pyruvate Kinase - antagonists & inhibitors | Animals | Mice, Nude | Mutant Proteins - chemistry | Acetylcysteine - pharmacology | Cell Line, Tumor | Glucose - metabolism | Mice | Neoplasms, Experimental - metabolism | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Amino Acid Substitution | Reactive oxygen species | Enzyme inhibitors | Pyruvate kinase | Lung cancer | Cancer cells | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Enzymes | Biochemistry | Cellular biology | Kinases | Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6116, pp. 222 - 226
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 11/2014, Volume 10, Issue 11
  Fluxes are the central trait of metabolism and Kinetic Flux Profiling (KFP) is an effective method of measuring them. To generalize its applicability, we... 
Parameter estimation | Metabolites | Time series | Data processing | Glucose | Metabolism | Enzyme kinetics | Experiments | Isotopes | Methods
Journal Article
Cancer & metabolism, ISSN 2049-3002, 2017, Volume 5, Issue 1, pp. 8 - 8
Journal Article
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