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1. Full Text Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
by Maeder, Morgan L and Stefanidakis, Michael and Wilson, Christopher J and Baral, Reshica and Barrera, Luis Alberto and Bounoutas, George S and Bumcrot, David and Chao, Hoson and Ciulla, Dawn M and DaSilva, Jennifer A and Dass, Abhishek and Dhanapal, Vidya and Fennell, Tim J and Friedland, Ari E and Giannoukos, Georgia and Gloskowski, Sebastian W and Glucksmann, Alexandra and Gotta, Gregory M and Jayaram, Hariharan and Haskett, Scott J and Hopkins, Bei and Horng, Joy E and Joshi, Shivangi and Marco, Eugenio and Mepani, Rina and Reyon, Deepak and Ta, Terence and Tabbaa, Diana G and Samuelsson, Steven J and Shen, Shen and Skor, Maxwell N and Stetkiewicz, Pam and Wang, Tongyao and Yudkoff, Clifford and Myer, Vic E and Albright, Charles F and Jiang, Haiyan
Nature medicine, ISSN 1078-8956, 02/2019, Volume 25, Issue 2, pp. 229 - 233
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Retinal degeneration | Care and treatment | Genetic aspects | Research | Gene mutations | Staphylococcus aureus | Explants | CRISPR | Blindness | Retina | Genomes | Dystrophy | Nuclease | Mutation | Gene expression | Genetic modification | Index Medicus
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2. Full Text Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
by Bothmer, Anne and Phadke, Tanushree and Barrera, Luis A and Margulies, Carrie M and Lee, Christina S and Buquicchio, Frank and Moss, Sean and Abdulkerim, Hayat S and Selleck, William and Jayaram, Hariharan and Myer, Vic E and Cotta-Ramusino, Cecilia
Nature communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 13905 - 13905
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Index Medicus
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3. Full Text Structure of a prokaryotic virtual proton pump at 3.2 Å resolution
by Fang, Yiling and Jayaram, Hariharan and Shane, Tania and Kolmakova-Partensky, Ludmila and Wu, Fang and Williams, Carole and Xiong, Yong and Miller, Christopher and Argonne National Lab. (ANL), Argonne, IL (United States)
Nature (London), ISSN 0028-0836, 08/2009, Volume 460, Issue 7258, pp. 1040 - 1043
Fundamental and applied biological sciences. Psychology | Proteins | Binding and carrier proteins | Analytical, structural and metabolic biochemistry | Morphology, structure, chemical composition | Microbiology | Biological and medical sciences | Bacteriology | Amino Acid Sequence | Multigene Family | Amino Acid Transport Systems - chemistry | Antiporters - chemistry | Bacterial Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Antiporters - metabolism | Crystallography, X-Ray | Escherichia coli Proteins - metabolism | Escherichia coli - chemistry | Amino Acid Transport Systems - metabolism | Salmonella typhi - chemistry | Protein Conformation | Structural Homology, Protein | Escherichia coli Proteins - chemistry | Usage | Carrier proteins | Physiological aspects | Ion channels | Genetic aspects | Research | Structure | Enzyme-linked immunosorbent assay | Monoclonal antibodies | Mutation | E coli | Crystals | Index Medicus | MEMBRANE PROTEINS | BACTERIA | PHYSIOLOGY | ESCHERICHIA COLI | NITRIC OXIDE | RESOLUTION | CRYSTAL STRUCTURE | MATERIALS SCIENCE | DECARBOXYLATION | PROTONS | CATIONS | INSULIN | GENETICS | AMINO ACIDS | BIOCHEMISTRY | CYTOPLASM | SYNTHESIS | ARGININE | PROTEINS | FREE ENERGY
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4. Full Text Response to "unexpected mutations after CRISPR-Cas9 editing in vivo"
by Wilson, Christopher J and Fennell, Tim and Bothmer, Anne and Maeder, Morgan L and Reyon, Deepak and Cotta-Ramusino, Cecilia and Fernandez, Cecilia A and Marco, Eugenio and Barrera, Luis A and Jayaram, Hariharan and Albright, Charles F and Cox, Gerald F and Church, George M and Myer, Vic E
Nature methods, ISSN 1548-7091, 04/2018, Volume 15, Issue 4, pp. 236 - 237
Mutation | Gene Editing | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Usage | Gene mutations | Nucleotide sequence | Restriction enzymes, DNA | Causes of | Physiological aspects | Genetic engineering | Genetic aspects | Health aspects | Methods | Immune system | CRISPR | Index Medicus
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5. Full Text UDiTaS™, A genome editing detection method for indels and genome rearrangements
by Giannoukos, Georgia and Ciulla, Dawn M and Marco, Eugenio and Abdulkerim, Hayat S and Barrera, Luis A and Bothmer, Anne and Dhanapal, Vidya and Gloskowski, Sebastian W and Jayaram, Hariharan and Maeder, Morgan L and Skor, Maxwell N and Wang, Tongyao and Myer, Vic E and Wilson, Christopher J
BMC genomics, ISSN 1471-2164, 03/2018, Volume 19, Issue 1, pp. 212 - 212
CRISPR/CAS9 | NGS | Translocation detection | Next generation sequencing | Gene editing | UDiTaS | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Index Medicus
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6. Full Text Separate ion pathways in a Cl-/H+ exchanger
by Accardi, Alessio and Walden, Michael and Nguitragool, Wang and Jayaram, Hariharan and Williams, Carole and Miller, Christopher
The Journal of general physiology, ISSN 0022-1295, 12/2005, Volume 126, Issue 6, pp. 563 - 570
Life Sciences & Biomedicine | Physiology | Science & Technology | Amino Acid Sequence | Chloride Channels - chemistry | Proton Pumps - chemistry | Molecular Sequence Data | Crystallography | Proton Pumps - metabolism | Chloride Channels - metabolism | Escherichia coli - genetics | Chlorides - metabolism | Protein Conformation | Ion Transport | Mutation | Hydrogen-Ion Concentration | Proteins | Protons | Ions | Membranes | Biochemistry | Index Medicus
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7. Full Text Development of methyl isoxazoleazepines as inhibitors of BET
by Hewitt, Michael C and Leblanc, Yves and Gehling, Victor S and Vaswani, Rishi G and Côté, Alexandre and Nasveschuk, Christopher G and Taylor, Alexander M and Harmange, Jean-Christophe and Audia, James E and Pardo, Eneida and Cummings, Rich and Joshi, Shivangi and Sandy, Peter and Mertz, Jennifer A and Sims, Robert J and Bergeron, Louise and Bryant, Barbara M and Bellon, Steve and Poy, Florence and Jayaran, Hariharan and Tang, Yong and Albrecht, Brian K
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 05/2015, Volume 25, Issue 9, pp. 1842 - 1848
Isoxazoles | Unbound clearance | Bromodomains | MYC | BET inhibitors | Humans | Azepines - chemical synthesis | Models, Molecular | Transcription Factors - antagonists & inhibitors | Structure-Activity Relationship | Oxazoles - chemistry | Azepines - pharmacology | Dose-Response Relationship, Drug | Oxazoles - chemical synthesis | Azepines - chemistry | Nuclear Proteins - antagonists & inhibitors | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Structure | Oxazoles - pharmacology | RNA-Binding Proteins - antagonists & inhibitors | Index Medicus
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8. Full Text Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
by Albrecht, Brian K and Gehling, Victor S and Hewitt, Michael C and Vaswani, Rishi G and Côté, Alexandre and Leblanc, Yves and Nasveschuk, Christopher G and Bellon, Steve and Bergeron, Louise and Campbell, Robert and Cantone, Nico and Cooper, Michael R and Cummings, Richard T and Jayaram, Hariharan and Joshi, Shivangi and Mertz, Jennifer A and Neiss, Adrianne and Normant, Emmanuel and O’Meara, Michael and Pardo, Eneida and Poy, Florence and Sandy, Peter and Supko, Jeffrey and Sims, Robert J and Harmange, Jean-Christophe and Taylor, Alexander M and Audia, James E
Journal of medicinal chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1330 - 1339
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Transcription Factors - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Antineoplastic Agents - therapeutic use | Azepines - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Genes, myc - drug effects | Rats | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Clinical Trials as Topic | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | Azepines - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Nuclear Proteins - antagonists & inhibitors | Dogs | Cell Line, Tumor | Azepines - pharmacokinetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Leukemia, Myeloid, Acute - genetics | Index Medicus
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9. Full Text X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation
by Hariharan Jayaram and Hui Fan and Brian R. Bowman and Amy Ooi and Jyothi Jayaram and Ellen W. Collisson and Julien Lescar and B. V. Venkataram Prasad
Journal of Virology, ISSN 0022-538X, 07/2006, Volume 80, Issue 13, pp. 6612 - 6620
Life Sciences & Biomedicine | Science & Technology | Virology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Microbiology | Nucleocapsid - chemistry | Protein Structure, Tertiary | Protein Structure, Secondary | Humans | Crystallography, X-Ray | Nucleocapsid Proteins - chemistry | Structure-Activity Relationship | Virus Assembly | Animals | Coronavirus Infections - metabolism | RNA, Viral - chemistry | Coronavirus - chemistry | Coronavirus - metabolism | Nucleocapsid Proteins - metabolism | Nucleocapsid - metabolism | Protein Binding | RNA, Viral - metabolism | Dimerization | Index Medicus | Structure and Assembly
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10. Full Text Cryoelectron Microscopy Structures of Rotavirus NSP2-NSP5 and NSP2-RNA Complexes: Implications for Genome Replication
by Xiaofang Jiang and Hariharan Jayaram and Mukesh Kumar and Steven J. Ludtke and Mary K. Estes and B. V. Venkataram Prasad
Journal of Virology, ISSN 0022-538X, 11/2006, Volume 80, Issue 21, pp. 10829 - 10835
Life Sciences & Biomedicine | Science & Technology | Virology | RNA-Binding Proteins - genetics | Multiprotein Complexes | Rotavirus - physiology | Rotavirus - genetics | Rotavirus - chemistry | Viral Nonstructural Proteins - chemistry | RNA, Viral - genetics | X-Ray Diffraction | Protein Structure, Quaternary | Nucleic Acid Conformation | Viral Nonstructural Proteins - ultrastructure | Binding Sites | Genome, Viral | Recombinant Proteins - ultrastructure | RNA-Binding Proteins - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Recombinant Proteins - genetics | Virus Assembly | Macromolecular Substances | Cryoelectron Microscopy | RNA-Binding Proteins - ultrastructure | RNA, Viral - chemistry | Image Processing, Computer-Assisted | Virus Replication | Rotavirus - ultrastructure | Protein Conformation | RNA, Viral - ultrastructure | Index Medicus | Structure and Assembly
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11. Full Text Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
by Crawford, Terry D and Tsui, Vickie and Flynn, E. Megan and Wang, Shumei and Taylor, Alexander M and Côté, Alexandre and Audia, James E and Beresini, Maureen H and Burdick, Daniel J and Cummings, Richard and Dakin, Les A and Duplessis, Martin and Good, Andrew C and Hewitt, Michael C and Huang, Hon-Ren and Jayaram, Hariharan and Kiefer, James R and Jiang, Ying and Murray, Jeremy and Nasveschuk, Christopher G and Pardo, Eneida and Poy, Florence and Romero, F. Anthony and Tang, Yong and Wang, Jian and Xu, Zhaowu and Zawadzke, Laura E and Zhu, Xiaoyu and Albrecht, Brian K and Magnuson, Steven R and Bellon, Steve and Cochran, Andrea G and Argonne National Lab. (ANL), Argonne, IL (United States)
Journal of medicinal chemistry, ISSN 0022-2623, 06/2016, Volume 59, Issue 11, pp. 5391 - 5402
TATA-Binding Protein Associated Factors - metabolism | Humans | Molecular Conformation | Structure-Activity Relationship | Fluorometry | Transcription Factor TFIID - metabolism | Pyridones - chemical synthesis | Dose-Response Relationship, Drug | Transcription Factor TFIID - antagonists & inhibitors | Histone Acetyltransferases - metabolism | Water - chemistry | Fluorescence Resonance Energy Transfer | Binding Sites - drug effects | TATA-Binding Protein Associated Factors - antagonists & inhibitors | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - metabolism | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Histone Acetyltransferases - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Pyrroles - chemistry | Ligands | Pyridones - chemistry | Pyridones - pharmacology | Index Medicus | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | BASIC BIOLOGICAL SCIENCES | substituents | molecules | peptides and proteins | water | mixtures
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12. Full Text Structure of a Slow CLC Cl−/H+ Antiporter from a Cyanobacterium
by Jayaram, Hariharan and Robertson, Janice L and Wu, Fang and Williams, Carole and Miller, Christopher
Biochemistry (Easton), ISSN 0006-2960, 02/2011, Volume 50, Issue 5, pp. 788 - 794
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Antiporters - chemistry | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Chloride Channels - genetics | Synechocystis - chemistry | Synechocystis - enzymology | Chlorides - metabolism | Antiporters - genetics | Synechocystis - genetics | Hydrogen - metabolism | Amino Acid Sequence | Escherichia coli - enzymology | Chloride Channels - chemistry | Protein Structure, Secondary | Bacterial Proteins - genetics | Antiporters - metabolism | Escherichia coli Proteins - metabolism | Escherichia coli - chemistry | Chloride Channels - metabolism | Sequence Alignment | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Kinetics | Mutation | Escherichia coli Proteins - chemistry | Index Medicus
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13. Full Text Activation of autophagic programmed cell death and innate immune gene expression reveals immuno-competence of integumental epithelium in Bombyx mori infected by a dipteran parasitoid
by Pradeep, Appukuttan Nair R and Pradeep, Appukuttan Nair R and Anitha, Jayaram and Anitha, Jayaram and Awasthi, Arvind K and Awasthi, Arvind K and Babu, Mohd A and Babu, Mohd A and Geetha, Murthy N and Geetha, Murthy N and Arun, Hariharan K and Arun, Hariharan K and Chandrashekhar, Sagar and Chandrashekhar, Sagar and Rao, Guruprasad C and Rao, Guruprasad C and Vijayaprakash, Nanjappa B and Vijayaprakash, Nanjappa B
Cell and tissue research, ISSN 0302-766X, 5/2013, Volume 352, Issue 2, pp. 371 - 385
Human Genetics | Biomedicine | PPO2 expression | Proteomics | Host–parasite interaction | Molecular Medicine | Bombyx mori (Insecta) | Apoptosis | Toll pathway activation | Host-parasite interaction | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Bombyx - immunology | Signal Transduction | Male | Diptera - genetics | Gene Expression Profiling | Bombyx - genetics | Diptera - metabolism | Diptera - immunology | Bombyx - metabolism | Animals | Bombyx - parasitology | Cell Death - physiology | Female | Apoptosis - physiology | Host-Parasite Interactions | Oxidases | Infection | Genes | Physiological aspects | Calpain | Biochemistry | Epithelium | Gene expression | Health aspects | Butterflies & moths | Parasitic diseases | Autophagy | Immune system | Index Medicus
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