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1. Full Text High-Quality Binary Protein Interaction Map of the Yeast Interactome Network
by Haiyuan Yu and Pascal Braun and Muhammed A. Yildirim and Irma Lemmens and Kavitha Venkatesan and Julie Sahalie and Tomoko Hirozane-Kishikawa and Fana Gebreab and Na Li and Nicolas Simonis and Tong Hao and Jean-François Rual and Amélie Dricot and Alexei Vazquez and Ryan R. Murray and Christophe Simon and Leah Tardivo and Stanley Tam and Nenad Svrzikapa and Changyu Fan and Anne-Sophie de Smet and Adriana Motyl and Michael E. Hudson and Juyong Park and Xiaofeng Xin and Michael E. Cusick and Troy Moore and Charlie Boone and Michael Snyder and Frederick P. Roth and Albert-László Barabási and Jan Tavernier and David E. Hill and Marc Vidal
Science, ISSN 0036-8075, 10/2008, Volume 322, Issue 5898, pp. 104 - 110
Current yeast interactome network maps contain several hundred molecular complexes with limited and somewhat controversial representation of direct binary... 
Datasets | Yeasts | Screening tests | Drug interactions | Molecular interactions | Principal components analysis | Connectivity | Reports | Open reading frames | Grants | Protein interaction mapping | 2-HYBRID SCREENS | REGULATORY NETWORKS | ANNOTATION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | COMPLEXES | GENOMIC ANALYSIS | C-ELEGANS | SCALE | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | Signal Transduction | Saccharomyces cerevisiae - genetics | Computational Biology | Saccharomyces cerevisiae Proteins - genetics | Gene Regulatory Networks | Protein Interaction Mapping - standards | Saccharomyces cerevisiae - metabolism | Transcription Factors - metabolism | Protein Interaction Mapping - methods | Two-Hybrid System Techniques | Metabolic Networks and Pathways | Mass Spectrometry | Proteomics | Saccharomyces cerevisiae Proteins - metabolism | Protein Array Analysis | Protein Binding | Saccharomyces cerevisiae Proteins - isolation & purification | Proteome - metabolism | Physiological aspects | Genetic aspects | Research | Yeast fungi | Protein-protein interactions | Data analysis | Yeast | Cellular biology | Molecular biology | Spectrum analysis | Index Medicus
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2. Full Text Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library
by Rual, Jaen-François and Ceron, Julian and Koreth, John and Hao, Tong and Nicot, Anne-Sophie and Hirozane-Kishikawa, Tomoko and Vandenhaute, Jean and Orkin, Stuart H and Hill, David E and van den Heuvel, Sander and Vidal, Marc
Genome Research, ISSN 1088-9051, 2004, Volume 14, Issue 10 B, pp. 2162 - 2168
The recently completed Caenorhabditis elegans genome sequence allows application of high-throughput (HT) approaches for phenotypic analyses using RNA... 
DOUBLE-STRANDED-RNA | PROJECTS | GENOME-WIDE RNAI | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENOTYPES | CHROMOSOME-I | GENETIC INTERFERENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | CONSTRUCTION | GENETICS & HEREDITY | C-ELEGANS | RESOURCE | Open Reading Frames - physiology | Phenotype | Animals | Gene Library | RNA Interference | Caenorhabditis elegans - genetics | Gene Expression Regulation - genetics | Genotype | Genome | RNA, Helminth - genetics | Index Medicus | Resources
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3. Full Text A Map of the Interactome Network of the Metazoan C. elegans
by Siming Li and Christopher M. Armstrong and Nicolas Bertin and Hui Ge and Stuart Milstein and Mike Boxem and Pierre-Olivier Vidalain and Jing-Dong J. Han and Alban Chesneau and Tong Hao and Debra S. Goldberg and Ning Li and Monica Martinez and Jean-François Rual and Philippe Lamesch and Lai Xu and Muneesh Tewari and Sharyl L. Wong and Lan V. Zhang and Gabriel F. Berriz and Laurent Jacotot and Philippe Vaglio and Jérôme Reboul and Tomoko Hirozane-Kishikawa and Qianru Li and Harrison W. Gabel and Ahmed Elewa and Bridget Baumgartner and Debra J. Rose and Haiyuan Yu and Stephanie Bosak and Reynaldo Sequerra and Andrew Fraser and Susan E. Mango and William M. Saxton and Susan Strome and Sander van den Heuvel and Fabio Piano and Jean Vandenhaute and Claude Sardet and Mark Gerstein and Lynn Doucette-Stamm and Kristin C. Gunsalus and J. Wade Harper and Michael E. Cusick and Frederick P. Roth and David E. Hill and Marc Vidal
Science, ISSN 0036-8075, 1/2004, Volume 303, Issue 5657, pp. 540 - 543
To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the... 
Datasets | Transcriptomes | Yeasts | Drug interactions | Genes | Reports | Open reading frames | Protein interaction mapping | Pharynx | Worms | Medical schools | CAENORHABDITIS-ELEGANS | INFORMATION | MULTIDISCIPLINARY SCIENCES | COMPLEXES | GENE-EXPRESSION | PROTEIN-PROTEIN INTERACTIONS | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | EYE DEVELOPMENT | GENOME | DROSOPHILA | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Genomics | Open Reading Frames | Computational Biology | Genes, Helminth | Caenorhabditis elegans Proteins - metabolism | Two-Hybrid System Techniques | Phenotype | Animals | Protein Binding | Transcription, Genetic | Caenorhabditis elegans Proteins - genetics | Proteome - metabolism | Evolution, Molecular | Cell interaction | Protein metabolism | Genetic aspects | Chemical properties | Research | Proteins | Bacteria | Models | Microbiology | proteomics | protein-protein interactions | Index Medicus
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4. Full Text A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration
by Lim, Janghoo and Hao, Tong and Shaw, Chad and Patel, Akash J and Szabó, Gábor and Rual, Jean-François and Fisk, C. Joseph and Li, Ning and Smolyar, Alex and Hill, David E and Barabási, Albert-László and Vidal, Marc and Zoghbi, Huda Y
Cell, ISSN 0092-8674, 2006, Volume 125, Issue 4, pp. 801 - 814
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the... 
INTERACTION DATABASE | GENE | CEREBELLAR-ATAXIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | INTERACTION MAP | C-ELEGANS | MICE | TOXICITY | MEDIATES NEURODEGENERATION | DROSOPHILA | CELL BIOLOGY | Neurodegenerative Diseases - pathology | Humans | Computational Biology | Molecular Sequence Data | Neurodegenerative Diseases - genetics | Proteome | Neurodegenerative Diseases - metabolism | Nerve Tissue Proteins - genetics | Purkinje Cells - physiology | Nerve Tissue Proteins - metabolism | Two-Hybrid System Techniques | Animals | Databases, Protein | Mutation | Ataxia - genetics | Ataxia - metabolism | Purkinje Cells - pathology | Ataxia - pathology | Evolution, Molecular | Genetic research | Genetic aspects | Research | Yeast fungi | Purkinje cells | Cerebellar ataxia | Proteins | Physiological aspects | Neurosciences | Analysis | Index Medicus
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5. Full Text A Protein Complex Network of Drosophila melanogaster
by Guruharsha, K.G and Rual, Jean-François and Zhai, Bo and Mintseris, Julian and Vaidya, Pujita and Vaidya, Namita and Beekman, Chapman and Wong, Christina and Rhee, David Y and Cenaj, Odise and McKillip, Emily and Shah, Saumini and Stapleton, Mark and Wan, Kenneth H and Yu, Charles and Parsa, Bayan and Carlson, Joseph W and Chen, Xiao and Kapadia, Bhaveen and VijayRaghavan, K and Gygi, Steven P and Celniker, Susan E and Obar, Robert A and Artavanis-Tsakonas, Spyros
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 3, pp. 690 - 703
Determining the composition of protein complexes is an essential step toward understanding the cell as an integrated system. Using coaffinity purification... 
YEAST | ORGANIZATION | EVOLUTION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERACTION MAP | COMPREHENSIVE ANALYSIS | RESOURCE | SUBUNIT | INTERACTOME | CELL BIOLOGY | Drosophila melanogaster - metabolism | Animals | Proteomics | Drosophila Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Drosophila Proteins - metabolism | SNARE Proteins - metabolism | Protein Interaction Mapping | Proteins | Mass spectrometry | Drosophila | Analysis | Genes | Index Medicus | interactome | protein complex map | proteome
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6. Full Text An experimentally derived confidence score for binary protein-protein interactions
by Hill, David E and Cusick, Michael E and Pawson, Tony and Rual, Jean-François and Braun, Pascal and Dreze, Matija and Vidal, Marc and Roncari, Luba and Vandenhaute, Jean and Roth, Frederick P and Lemmens, Irma and Tasan, Murat and Wrana, Jeffrey L and Murray, Ryan R and de Smet, Anne-Sophie and Tavernier, Jan and Barrios-Rodiles, Miriam and Sahalie, Julie M and Yu, Haiyuan and Venkatesan, Kavitha
Nature Methods, ISSN 1548-7091, 01/2009, Volume 6, Issue 1, pp. 91 - 97
Information on protein-protein interactions is of central importance for many areas of biomedical research. At present no method exists to systematically and... 
INTERACTION NETWORK | INTERACTION DATABASE | 2-HYBRID | BIOCHEMICAL RESEARCH METHODS | UPDATE | SACCHAROMYCES-CEREVISIAE | MAMMALIAN-CELLS | MAP | PREDICTION | Protein Interaction Mapping - methods | Animals | Proteins - metabolism | Humans | Sensitivity and Specificity | Protein Binding | Proteins - analysis | Protein microarrays | Evaluation | Usage | Mass spectrometry | Analysis | Protein-protein interactions | Biomedical research | Research methodology | Standards | Proteomics | Quality control | Index Medicus
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7. Full Text RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition
by Wang, Jinling and Robida-Stubbs, Stacey and Tullet, Jennifer M. A and Rual, Jean-François and Vidal, Marc and Keith Blackwell, T
PLoS Genetics, ISSN 1553-7390, 08/2010, Volume 6, Issue 8, p. e1001048
Caenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative stress resistance and promotes longevity under reduced... 
LIFE-SPAN EXTENSION | OXIDATIVE-STRESS | CAENORHABDITIS-ELEGANS | FACTOR SKN-1 | COP9 SIGNALOSOME | GENETICS & HEREDITY | GENE-EXPRESSION | C-ELEGANS | MECHANISMS | DIETARY RESTRICTION | MOLECULAR-BASIS | Protein Biosynthesis | Caenorhabditis elegans - genetics | Gene Expression Regulation | Stress, Physiological | Caenorhabditis elegans Proteins - metabolism | Longevity | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Caenorhabditis elegans - physiology | Animals | RNA Interference | Transcription, Genetic | Caenorhabditis elegans Proteins - genetics | Oxidative stress | Caenorhabditis elegans | Transcription factors | Physiological aspects | Genetic aspects | Research | Index Medicus | Proteins | Studies | Protein synthesis | Cloning | Aging | Genetics | Genomes | Diabetes | Stress response | Experiments | Worms
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8. Full Text Association of Dishevelled with the Clathrin AP-2 Adaptor Is Required for Frizzled Endocytosis and Planar Cell Polarity Signaling
by Yu, Anan and Rual, Jean-François and Tamai, Keiko and Harada, Yuko and Vidal, Marc and He, Xi and Kirchhausen, Tomas
Developmental Cell, ISSN 1534-5807, 01/2007, Volume 12, Issue 1, pp. 129 - 141
Upon activation by Wnt, the Frizzled receptor is internalized in a process that requires the recruitment of Dishevelled. We describe a novel interaction... 
CELLBIO | SIGNALING | MU-2 SUBUNIT | APPENDAGE DOMAIN | WINGLESS | XENOPUS EMBRYOS | BINDING-SITE | DEVELOPMENTAL BIOLOGY | BETA-CATENIN | SORTING SIGNALS | VERTEBRATE GASTRULATION | DROSOPHILA EMBRYOS | CONVERGENT-EXTENSION | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Wnt Proteins - pharmacology | Embryo, Nonmammalian - cytology | Adaptor Protein Complex mu Subunits - metabolism | Humans | Molecular Sequence Data | Phosphoproteins - metabolism | Embryo, Nonmammalian - drug effects | Xenopus - embryology | Phosphoproteins - chemistry | Adaptor Protein Complex 2 - metabolism | Cattle | Protein Binding - drug effects | Cell Polarity - drug effects | Dishevelled Proteins | Protein Structure, Tertiary | Amino Acid Sequence | Endocytosis - drug effects | Frizzled Receptors - metabolism | Clathrin - metabolism | Amino Acid Motifs | Endocytosis - physiology | Protein Interaction Mapping | Two-Hybrid System Techniques | Animals | Signal Transduction - drug effects | Mice | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus
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9. Full Text An empirical framework for binary interactome mapping
by Gebreab, Fana and Vinayagam, Arunachalam and Murray, Ryan R and Rau, Kirstin and Timm, Jan and Boone, Charles and Braun, Pascal and Lalowski, Maciej and Szeto, David and Yu, Haiyuan and Zenkner, Martina and Tavernier, Jan and Heinzmann, Kathrin and Wanker, Erich E and Simonis, Nicolas and Vazquez, Alexei and Xin, Xiaofeng and Hao, Tong and Borick, Heather and Klitgord, Niels and Lin, Chenwei and Lemmens, Irma and Barabási, Albert-László and Venkatesan, Kavitha and Stelzl, Ulrich and Hill, David E and Cusick, Michael E and Simon, Christophe and Hirozane-Kishikawa, Tomoko and Dann, Elizabeth and Cevik, Sebiha and Sahalie, Julie M and Roth, Frederick P and Dricot, Amélie and Smolyar, Alex and Vidal, Marc and Yildirim, Muhammed A and Rual, Jean-François and de Smet, Anne-Sophie and Goh, Kwang-Il
Nature Methods, ISSN 1548-7091, 01/2009, Volume 6, Issue 1, pp. 83 - 90
Several attempts have been made to systematically map protein-protein interaction, or 'interactome', networks. However, it remains difficult to assess the... 
INTERACTION NETWORK | YEAST | BIOCHEMICAL RESEARCH METHODS | PROTEIN-PROTEIN INTERACTIONS | MOLECULAR INTERACTION DATABASE | MAP | PROTEOMICS | RESOURCE | Proteins - genetics | Protein Interaction Mapping - methods | Proteins - metabolism | Databases, Protein | Humans | Sensitivity and Specificity | Protein Binding | Proteins - analysis | Usage | Mass spectrometry | Analysis | Protein-protein interactions | Data analysis | Binary system | Research methodology | Proteomics | Quality control | Index Medicus
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10. Full Text SH3 interactome conserves general function over specific form
by Xin, Xiaofeng and Gfeller, David and Cheng, Jackie and Tonikian, Raffi and Sun, Lin and Guo, Ailan and Lopez, Lianet and Pavlenco, Alevtina and Akintobi, Adenrele and Zhang, Yingnan and Rual, Jean‐François and Currell, Bridget and Seshagiri, Somasekar and Hao, Tong and Yang, Xinping and Shen, Yun A and Salehi‐Ashtiani, Kourosh and Li, Jingjing and Cheng, Aaron T and Bouamalay, Dryden and Lugari, Adrien and Hill, David E and Grimes, Mark L and Drubin, David G and Grant, Barth D and Vidal, Marc and Boone, Charles and Sidhu, Sachdev S and Bader, Gary D
Molecular Systems Biology, ISSN 1744-4292, 07/2013, Volume 9, Issue 1, pp. 1DUMMY - n/a
Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. We surveyed the... 
SH3 domains | yeast two‐hybrid | phage display | network evolution | protein interaction conservation | yeast two-hybrid | INTERACTION DATABASE | PEPTIDE RECOGNITION MODULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAENORHABDITIS-ELEGANS | EVOLUTION | SEMANTIC SIMILARITY MEASURES | REGULATORY NETWORKS | PROTEIN-PROTEIN INTERACTIONS | C-ELEGANS | INTERACTION NETWORKS | DOMAINS | Amino Acid Sequence | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Saccharomyces cerevisiae - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | src Homology Domains - genetics | Saccharomyces cerevisiae Proteins - genetics | Protein Interaction Mapping | Saccharomyces cerevisiae - metabolism | Two-Hybrid System Techniques | Animals | Saccharomyces cerevisiae Proteins - metabolism | Conserved Sequence | Endocytosis - genetics | Structural Homology, Protein | Caenorhabditis elegans Proteins - genetics | Evolution, Molecular | Index Medicus
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