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index medicus (32) 32
microbiology (29) 29
humans (24) 24
pseudomonas aeruginosa - genetics (24) 24
cystic fibrosis (21) 21
mutation (18) 18
pseudomonas aeruginosa (17) 17
pseudomonas infections - microbiology (17) 17
cystic fibrosis - microbiology (15) 15
bacteria (14) 14
research (14) 14
cystic-fibrosis patients (13) 13
evolution (13) 13
phenotype (11) 11
phylogeny (11) 11
pseudomonas aeruginosa - isolation & purification (11) 11
escherichia-coli (10) 10
pseudomonas aeruginosa - classification (10) 10
evolution, molecular (9) 9
gene expression regulation, bacterial (9) 9
genetic aspects (9) 9
genome, bacterial (9) 9
adaptation (8) 8
bacteriology (8) 8
gene expression (8) 8
genomics (8) 8
infection (8) 8
multidisciplinary sciences (8) 8
bacterial proteins - genetics (7) 7
infections (7) 7
antibiotic-resistance (6) 6
biological evolution (6) 6
cystic fibrosis - complications (6) 6
environment (6) 6
genetic adaptation (6) 6
genome (6) 6
molecular sequence data (6) 6
motility (6) 6
myxococcus xanthus - growth & development (6) 6
pseudomonas aeruginosa - drug effects (6) 6
pseudomonas aeruginosa - pathogenicity (6) 6
pseudomonas aeruginosa - physiology (6) 6
research article (6) 6
resistance (6) 6
sequence (6) 6
sequence analysis, dna (6) 6
analysis (5) 5
biological sciences (5) 5
child (5) 5
cystic-fibrosis (5) 5
dk/atira/pure/researchoutput/pubmedpublicationtype/d016428 (5) 5
expression (5) 5
gliding motility (5) 5
health aspects (5) 5
identification (5) 5
journal article (5) 5
lipopolysaccharide (5) 5
pseudomonas aeruginosa - metabolism (5) 5
pseudomonas infections - complications (5) 5
adaptation, physiological (4) 4
aggregation (4) 4
anti-bacterial agents - pharmacology (4) 4
antibiotics (4) 4
article (4) 4
biotechnology & applied microbiology (4) 4
c-factor (4) 4
cells (4) 4
chronic infection (4) 4
diversity (4) 4
genes (4) 4
genes, bacterial (4) 4
genotype (4) 4
mutants (4) 4
myxococcus xanthus - genetics (4) 4
physiological aspects (4) 4
proteins (4) 4
pseudomonas aeruginosa - growth & development (4) 4
signaling protein (4) 4
sporulation (4) 4
strains (4) 4
virulence factors (4) 4
airways (3) 3
antibiotic resistance (3) 3
bacterial proteins - metabolism (3) 3
base sequence (3) 3
beta-lactamase (3) 3
biofilm (3) 3
biofilm formation (3) 3
biotechnology (3) 3
chemotaxis (3) 3
differentiation (3) 3
dna sequencing (3) 3
drug resistance, bacterial (3) 3
dynamics (3) 3
ecology (3) 3
epidemiology (3) 3
evolutionary biology (3) 3
evolutionary genetics (3) 3
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1. Full Text Complete genome sequence of the myxobacterium Sorangium cellulosum
by Krug, Daniel and Bolten, Christoph J and Whitworth, David E and Rachid, Shwan and Suen, Garret and Pradella, Silke and Jelsbak, Lotte and Wenzel, Silke C and Schuster, Stephan C and Bekel, Thomas and Gerth, Klaus and Bode, Edna and Perlova, Olena and Mahmud, Taifo and McHardy, Alice C and Pühler, Alfred and Doss, Sabrina and Rosenau, Frank and Groeger, Carolin and Sasse, Florenz and Linke, Bukhard and Mormann, Sascha and Wilhelm, Susanne and Muñoz-Dorado, Jose and Kegler, Carsten and Martinez-Arias, Rosa and Konietzny, Sebastian and Welch, Roy D and Beyer, Stefan and Gross, Frank and Wittmann, Christoph and Bartels, Daniela and Merai, Michelle and Knauber, Tina and Scharfe, Maren and Bode, Helge B and Schneiker, Susanne and Gaigalat, Lars and Altmeyer, Matthias O and Frank, Bettina and Weissman, Kira J and Perez, Juana and Rückert, Christian and Müller, Rolf and Kaiser, Olaf and Kalinowski, Jörn and Kopp, Maren and Alici, Aysel and Goesmann, Alexander and Jelsbak, Lars and Raddatz, Günter and Treuner-Lange, Anke and Blöcker, Helmut and Meyer, Folker and Elnakady, Yasser A and Krause, Lutz and Vorhölter, Frank-Jörg and Choudhuri, Jomuna V and Velicer, Gregory J
Nature Biotechnology, ISSN 1087-0156, 11/2007, Volume 25, Issue 11, pp. 1281 - 1289
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We... 
SECONDARY METABOLITES | MYXOCOCCUS-XANTHUS | GENE-CLUSTER | PHOSPHOPEPTIDES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOSYNTHESIS | ANNOTATION | STREPTOMYCES-COELICOLOR | GLIDING MOTILITY | IDENTIFICATION | PROTEIN-KINASES | Biotechnology | Genome, Bacterial - genetics | Myxococcales - classification | Myxococcales - genetics | Base Sequence | Molecular Sequence Data | Myxococcales - metabolism | Phylogeny | Sequence Analysis, DNA
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2. Full Text Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective
by Folkesson, Anders and Jelsbak, Lars and Yang, Lei and Johansen, Helle Krogh and Ciofu, Oana and Hoiby, Niels and Molin, Soren
Nature Reviews Microbiology, ISSN 1740-1526, 12/2012, Volume 10, Issue 12, pp. 841 - 851
The airways of patients with cystic fibrosis (CF) are nearly always infected with many different microorganisms. This environment offers warm, humid and... 
RESPIRATORY-TRACT | INHALED TOBRAMYCIN | BETA-LACTAMASE | ESCHERICHIA-COLI POPULATION | STRESS-RESPONSE | MICROBIAL ECOLOGY | MICROBIOLOGY | ALGINATE SYNTHESIS | LUNG INFECTION | AMINOGLYCOSIDE-RESISTANCE | YOUNG-CHILDREN | Biological Evolution | Host-Parasite Interactions - genetics | Pseudomonas aeruginosa - genetics | Cystic Fibrosis - microbiology | Humans | Respiratory System - microbiology | Pseudomonas Infections - microbiology | Usage | Antibiotics | Causes of | Cystic fibrosis | Development and progression | Pseudomonas aeruginosa | Research | Drug therapy | Health aspects
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3. Full Text Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria
by Mette V. Larsen and Salvatore Cosentino and Simon Rasmussen and Carsten Friis and Henrik Hasman and Rasmus Lykke Marvig and Lars Jelsbak and Thomas Sicheritz-Pontén and David W. Ussery and Frank M. Aarestrup and Ole Lund
Journal of Clinical Microbiology, ISSN 0095-1137, 04/2012, Volume 50, Issue 4, pp. 1355 - 1361
OA  Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+... 
RECOMBINATION | NETWORK | GERMANY | ESCHERICHIA-COLI | MUTATION | MICROBIOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | OUTBREAK | HELICOBACTER-PYLORI | CLOSTRIDIUM-DIFFICILE | CLONES | Genes, Bacterial | Genome, Bacterial | Bacterial Typing Techniques | Bacteria - classification | Databases, Genetic | Contig Mapping | High-Throughput Nucleotide Sequencing | Multilocus Sequence Typing | Bacteria - genetics | Bacteriology
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4. Full Text Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators
by Marvig, Rasmus Lykke and Johansen, Helle Krogh and Molin, Søren and Jelsbak, Lars
PLoS Genetics, ISSN 1553-7390, 09/2013, Volume 9, Issue 9, p. e1003741
Genome sequencing of bacterial pathogens has advanced our understanding of their evolution, epidemiology, and response to antibiotic therapy. However, we still... 
2-COMPONENT REGULATORY SYSTEM | RATES | BACTERIA | MUTANTS | GENETIC ADAPTATION | CYSTIC-FIBROSIS PATIENTS | ESCHERICHIA-COLI | GENETICS & HEREDITY | RESISTANCE | MISMATCH REPAIR | HUMAN HOST ENVIRONMENT | Pseudomonas aeruginosa - isolation & purification | Cystic Fibrosis - microbiology | Humans | Cystic Fibrosis - pathology | Mutation Rate | Drug Resistance, Microbial - genetics | Phylogeny | Phenotype | Pseudomonas aeruginosa - genetics | Pseudomonas aeruginosa - pathogenicity | Cystic Fibrosis - genetics | Mutation | Genome | Evolution, Molecular | Host-bacteria relationships | Gene mutations | Genetic research | Pseudomonas aeruginosa | Genetic aspects | Nucleotide sequencing | Research | DNA sequencing | Cystic fibrosis | Evolution | Infections | Bacteriology
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5. Full Text Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
by Wang, Mingxun and Carver, Jeremy J and Phelan, Vanessa V and Sanchez, Laura M and Garg, Neha and Peng, Yao and Nguyen, Don Duy and Watrous, Jeramie and Kapono, Clifford A and Luzzatto-Knaan, Tal and Porto, Carla and Bouslimani, Amina and Melnik, Alexey V and Meehan, Michael J and Liu, Wei-Ting and Crüsemann, Max and Boudreau, Paul D and Esquenazi, Eduardo and Sandoval-Calderón, Mario and Kersten, Roland D and Pace, Laura A and Quinn, Robert A and Duncan, Katherine R and Hsu, Cheng-Chih and Floros, Dimitrios J and Gavilan, Ronnie G and Kleigrewe, Karin and Northen, Trent and Dutton, Rachel J and Parrot, Delphine and Carlson, Erin E and Aigle, Bertrand and Michelsen, Charlotte F and Jelsbak, Lars and Sohlenkamp, Christian and Pevzner, Pavel and Edlund, Anna and McLean, Jeffrey and Piel, Jörn and Murphy, Brian T and Gerwick, Lena and Liaw, Chih-Chuang and Yang, Yu-Liang and Humpf, Hans-Ulrich and Maansson, Maria and Keyzers, Robert A and Sims, Amy C and Johnson, Andrew R and Sidebottom, Ashley M and Sedio, Brian E and Klitgaard, Andreas and Larson, Charles B and Boya, Cristopher A.P and Torres-Mendoza, Daniel and Gonzalez, David J and Silva, Denise B and Marques, Lucas M and Demarque, Daniel P and Pociute, Egle and O'Neill, Ellis C and Briand, Enora and Helfrich, Eric J. N and Granatosky, Eve A and Glukhov, Evgenia and Ryffel, Florian and Houson, Hailey and Mohimani, Hosein and Kharbush, Jenan J and Zeng, Yi and Vorholt, Julia A and Kurita, Kenji L and Charusanti, Pep and McPhail, Kerry L and Nielsen, Kristian Fog and Vuong, Lisa and Elfeki, Maryam and Traxler, Matthew F and Engene, Niclas and Koyama, Nobuhiro and Vining, Oliver B and Baric, Ralph and Silva, Ricardo R and Mascuch, Samantha J and Tomasi, Sophie and Jenkins, Stefan and Macherla, Venkat and Hoffman, Thomas and Agarwal, Vinayak and Williams, Philip G and Dai, Jingqui and Neupane, Ram and Gurr, Joshua and Rodríguez, Andrés M. C and Lamsa, Anne and Zhang, Chen and Dorrestein, Kathleen and Duggan, Brendan M and Almaliti, Jehad and Allard, Pierre-Marie and Phapale, Prasad and ...
Nature Biotechnology, ISSN 1087-0156, 09/2016, Volume 34, Issue 8, pp. 828 - 837
The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not... 
METABOLOMICS | GENE-CLUSTER | DEREPLICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REPOSITORY | IDENTIFICATION | EXTRACTS | GENOME | DISCOVERY | RESOURCE | Mass Spectrometry - statistics & numerical data | Biological Products - chemistry | Biological Products - classification | Information Storage and Retrieval - methods | Databases, Chemical | Internationality | Database Management Systems | Information Dissemination - methods | Data Curation - methods | Electronic data processing | Natural products | Chemical research | Molecular dynamics | Research | Chemical properties | Mass spectrometry | Methods | Biotechnology | Life Sciences | Ecology, environment
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6. Full Text Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts
by Søren Damkiær and Lei Yang and Søren Molin and Lars Jelsbak
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 19, pp. 7766 - 7771
The genetic basis of bacterial adaptation to a natural environment has been investigated in a highly successful Pseudomonas aeruginosa lineage (DK2) that... 
Phenotypes | Biological evolution | Genes | Alleles | Evolution | Pseudomonas aeruginosa | Cystic fibrosis | Infections | Genetic mutation | Biological adaptation | Chronic infection | Epistasis | Gene expression | Microbial evolution | Evolution of regulatory networks | epistasis | PERSPECTIVE | MECHANISM | CONVERSION | MULTIDISCIPLINARY SCIENCES | ENVIRONMENT | microbial evolution | chronic infection | CYSTIC-FIBROSIS PATIENTS | PROBE LEVEL | evolution of regulatory networks | ESCHERICHIA-COLI POPULATION | INFECTION | MUCOID PSEUDOMONAS-AERUGINOSA | MUTATIONS | gene expression | Genome, Bacterial | Cystic Fibrosis - microbiology | Humans | Bacterial Proteins - genetics | Gene Expression Profiling | Phylogeny | Gene Regulatory Networks | Pseudomonas Infections - microbiology | Point Mutation | Phenotype | Pseudomonas aeruginosa - genetics | Time Factors | Epistasis, Genetic | RNA Polymerase Sigma 54 - genetics | Trans-Activators - genetics | Gene Expression Regulation, Bacterial | Sigma Factor - genetics | Evolution, Molecular | Host-parasite relationships | Physiological aspects | Evolutionary genetics | Genetic aspects | Research | Health aspects | Biological Sciences
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7. Full Text Application of RNA-seq and bioimaging methods to study microbe–microbe interactions and their effects on biofilm formation and gene expression
by Amador, Cristina Isabel and Sternberg, Claus and Jelsbak, Lars
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1734, pp. 131 - 158
Complex interactions between pathogenic bacteria, the microbiota, and the host can modify pathogen physiology and behavior. We describe two different... 
RNA sequencing | Bacterial physiology | Biofilms | Microbe–microbe interactions | Bacterial pathogens | Interspecies interactions | Sequence Analysis, RNA - methods | Genome, Bacterial | Flow Cytometry | Genetic Engineering | Biomarkers | Molecular Imaging | Gene Expression Regulation, Bacterial | Genomics - methods | Microbial Interactions
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8. Full Text Evolutionary dynamics of bacteria in a human host environment
by Lei Yang and Lars Jelsbak and Rasmus Lykke Marvig and Søren Damkiær and Christopher T. Workman and Martin Holm Rau and Susse Kirkelund Hansen and Anders Folkesson and Helle Krogh Johansen and Oana Ciofu and Niels Høiby and Morten O. A. Sommer and Søren Molin and Richard E. Lenski
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 18, pp. 7481 - 7486
Laboratory evolution experiments have led to important findings relating organism adaptation and genomic evolution. However, continuous monitoring of long-term... 
Phenotypes | Genomics | Evolution | Pseudomonas aeruginosa | Cystic fibrosis | Evolutionary genetics | Genomes | Infections | Genetic mutation | Biological adaptation | Natural population | Chronic infection | Genome sequences | Transcriptomics | Microbial evolution | genome sequences | natural population | HYPERMUTABLE PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | microbial evolution | LUNG INFECTIONS | GENOME | OPEN SOFTWARE | BIOFILM COMMUNITIES | chronic infection | GENETIC ADAPTATION | CYSTIC-FIBROSIS PATIENTS | SEQUENCE | transcriptomics | DIVERSITY | Genetic Drift | Oligonucleotide Array Sequence Analysis | Cystic Fibrosis - microbiology | Adaptation, Biological - genetics | Humans | Selection, Genetic | Molecular Sequence Data | DNA Primers - genetics | Gene Expression Profiling | Phylogeny | Sequence Analysis, DNA | Biological Evolution | Genetic Variation | Genome, Bacterial - genetics | Phenotype | Pseudomonas aeruginosa - genetics | Base Sequence | Polymorphism, Single Nucleotide - genetics | Genetic Pleiotropy - genetics | Bacteria | Research | Population genetics | Natural history | Biological Sciences
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9. Full Text Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
by Bartell, Jennifer A and Blazier, Anna S and Yen, Phillip and Thøgersen, Juliane C and Jelsbak, Lars and Goldberg, Joanna B and Papin, Jason A
Nature Communications, ISSN 2041-1723, 03/2017, Volume 8, Issue 1, p. 14631
Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with less potential for resistance than targets in... 
LUNG | TARGETING VIRULENCE | MULTIDISCIPLINARY SCIENCES | QUANTITATIVE PREDICTION | RESISTANCE | CONSTRAINT-BASED MODELS | INHIBITORS | COBRA TOOLBOX | GENOME | CELLULAR-METABOLISM | STRAIN PA14 | Genes, Bacterial | Reproducibility of Results | Pseudomonas aeruginosa - growth & development | Small Molecule Libraries - metabolism | Biomass | Mutation - genetics | Genes, Essential | Oligopeptides - biosynthesis | Metabolic Networks and Pathways | Pseudomonas aeruginosa - genetics | Pseudomonas aeruginosa - pathogenicity | Virulence - genetics | Culture Media | Models, Biological | Pseudomonas aeruginosa - metabolism | Virulence Factors - biosynthesis
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10. Full Text The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
by Jochumsen, Nicholas and Marvig, Rasmus L and Damkiær, Søren and Jensen, Rune Lyngklip and Paulander, Wilhelm and Molin, Søren and Jelsbak, Lars and Folkesson, Anders
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, p. 13002
Colistin is an antimicrobial peptide that has become the only remaining alternative for the treatment of multidrug-resistant Gram-negative bacterial... 
2-COMPONENT REGULATORY SYSTEM | MUTANTS | BENEFICIAL MUTATIONS | CYSTIC-FIBROSIS PATIENTS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | ADAPTIVE RESISTANCE | ADAPTATION | ANTIBIOTIC-RESISTANCE | POLYMYXIN RESISTANCE | CATIONIC PEPTIDES | Colistin - chemistry | Peptides - chemistry | Antimicrobial Cationic Peptides - chemistry | Cystic Fibrosis - microbiology | Drug Resistance, Bacterial | Phenotype | Genome, Fungal | Pseudomonas aeruginosa - genetics | DNA Mutational Analysis | Epistasis, Genetic | Pseudomonas aeruginosa - metabolism | Alleles | Escherichia coli - metabolism | Polymorphism, Single Nucleotide | Mutation | Evolution, Molecular | Regulators | Phenotypes | Peptides | Transcription | Colistin | Cystic fibrosis | Epistasis | Genomes | Drug resistance | Antiinfectives and antibacterials | Gene sequencing | Pathways | Fibrosis | Antimicrobial peptides | Evolution | Pseudomonas aeruginosa
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11. Full Text Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
by Hansen, Susse Kirkelund and Rau, Martin Holm and Johansen, Helle Krogh and Ciofu, Oana and Jelsbak, Lars and Yang, Lei and Folkesson, Anders and Jarmer, Hanne Østergaard and Aanæs, Kasper and Von Buchwald, Christian and Høiby, Niels and Molin, Søren
ISME Journal, ISSN 1751-7362, 01/2012, Volume 6, Issue 1, pp. 31 - 45
The opportunistic pathogen Pseudomonas aeruginosa is a frequent colonizer of the airways of patients suffering from cystic fibrosis (CF). Depending on early... 
adaptive evolution | chronic infection | cystic fibrosis | protected environment | SMALL-COLONY VARIANTS | CONVERSION | ENVIRONMENT | PHENOTYPE | GENETIC ADAPTATION | LASR MUTANTS | DISEASE | ECOLOGY | AIRWAYS | YOUNG-CHILDREN | BIOFILM FORMATION | Lung - microbiology | Pseudomonas aeruginosa - isolation & purification | Cystic Fibrosis - microbiology | Humans | Pseudomonas Infections - complications | Paranasal Sinuses - microbiology | Cystic Fibrosis - complications | Pseudomonas Infections - microbiology | Pseudomonas Infections - genetics | Biological Evolution | Respiratory Tract Infections - microbiology | Pseudomonas aeruginosa - genetics | Cystic Fibrosis - genetics | Adolescent | Respiratory Tract Infections - complications | Mutation | Child | Chronic Disease | Original
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