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FEBS Letters, ISSN 0014-5793, 06/2019
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
FEBS Letters, ISSN 0014-5793, 07/2019, Volume 593, Issue 14, pp. 1863 - 1873
Serine hydroxymethyltransferase ( SHMT ) is the major source of 1‐carbon units required for nucleotide synthesis. Humans have cytosolic ( SHMT 1) and... 
one carbon metabolism | cancer | antifolates | serine hydroxymethyltransferase | TARGET | GLYCINE | CELLS | COMPLEX | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | BIOPHYSICS | SUBSTRATE | ENZYMES | Index Medicus
Journal Article
Biochemistry, ISSN 0006-2960, 02/2019, Volume 58, Issue 7, pp. 887 - 899
Arabidopsis thaliana NUDT1 (AtNUDT1) belongs to the Nudix family of proteins, which have a diverse range of substrates, including oxidized nucleotides such as... 
HUMAN MTH1 | ENZYME | MECHANISM | SIGNIFICANT TARGET | DNA | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUDIX HYDROLASES | 8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE PYROPHOSPHOHYDROLASE | MUTT PROTEIN | FAMILY
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2010, Volume 132, Issue 14, pp. 5096 - 5104
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2017, Volume 27, Issue 16, pp. 3897 - 3904
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 11, pp. 8054 - 8060
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 20, pp. 10888 - 10904
Abstract Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides... 
IN-VITRO | REPAIR | PROTEIN | STRUCTURE VALIDATION | MECHANISM | MGMT | DNA | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALKYLATION DAMAGE | TEMOZOLOMIDE | Index Medicus | Nucleic Acid Enzymes
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 256 - 263
The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available against acute myelogenous leukemia (AML). Together with... 
MEDICINE, RESEARCH & EXPERIMENTAL | CYTOSINE-ARABINOSIDE | CELLS | ARA-C SENSITIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | CELL BIOLOGY | IN-VITRO | DNA | CHRONIC LYMPHOCYTIC-LEUKEMIA | MUTATIONS | EXPRESSION | Cytarabine - pharmacology | Prognosis | Apoptosis - drug effects | Cytarabine - therapeutic use | Humans | Leukemia, Myeloid, Acute - metabolism | SAM Domain and HD Domain-Containing Protein 1 | Child, Preschool | Infant | Male | Viral Regulatory and Accessory Proteins - pharmacology | Molecular Targeted Therapy | Monomeric GTP-Binding Proteins - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Child | Disease Models, Animal | Arabinofuranosylcytosine Triphosphate - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Animals | Monomeric GTP-Binding Proteins - metabolism | Adolescent | Aged | Mice | In Vitro Techniques | Cellular proteins | Molecular targeted therapy | Care and treatment | Cytarabine | Patient outcomes | Drug interactions | Innovations | Development and progression | Genetic aspects | Blood diseases | Health aspects | Biomarkers | Cytotoxicity | Chemotherapy | Gene expression | Leukemia | Index Medicus | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Hematology | Hematologi | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article