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Protein Engineering, Design and Selection, ISSN 1741-0126, 10/2019
Journal Article
Protein engineering, design & selection : PEDS, ISSN 1741-0126, 08/2019
Intrinsically disordered protein regions may fold upon binding to an interaction partner. It is often argued that such coupled binding and folding enables the... 
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 11/2017, Volume 42, Issue 11, p. 847
There is increasing interest in studying protein interactions and their role in cell biology using kinetics. However, there is confusion about the proper... 
Proteins | Rate constants | Cellular biology | Kinetics | Protein interaction
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1541 - 17
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their... 
HMTH1 PROTEIN | MOTIF 2 | OXIDATIVE STRESS | HUMAN MTH1 | MESSENGER-RNA | OXIDIZED FORMS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GENETIC INTERACTION | HUMAN MUTT HOMOLOG | PROTEIN HYDROLYZES | A549 Cells | Cell Line | Multigene Family | Pyrophosphatases - classification | Humans | Gene Expression Regulation, Neoplastic | Pyrophosphatases - genetics | Substrate Specificity | Gene Expression Profiling - methods | Phylogeny | Gene Regulatory Networks | Gene Expression Regulation, Enzymologic | Pyrophosphatases - metabolism | MCF-7 Cells | RNA Interference | Cell Line, Tumor | Hydrolase | Nucleotide sequence | mRNA processing | Redundancy | Homeostasis | Epistasis | Gene expression | Metabolism | Tissues | Substrates | Proteins | Cell cycle | Crystal structure | Cancer | NUDT4 protein | phylogenetic tree | NUDT21 protein | Medical and Health Sciences | Nudix hydrolase | NUDT6 protein | functional genomics | DNA content | enzyme structure | enzyme activity | NUDT8 protein | protein | upregulation | cancer cell line | protein expression | algorithm | NUDT14 protein | colorectal cancer | cancer tissue | Medicinsk bioteknologi | gene silencing | melanoma | human cell | NUDT17 protein | biochemical composition | NUDT12 protein | Medical Biotechnology | NUDT10 protein | NUDT19 protein | metabolism | gene expression | unclassified drug | NUDT5 protein | sequence alignment | Medicin och hälsovetenskap | NUDT22 protein | tissue microarray | Article | NUDT1 protein | NUDT7 protein | NUDT20 protein | NUDT16 protein | gene interaction | immunohistochemistry | human | enzyme | cell survival | human tissue | cell cycle | NUDT13 protein | breast cancer | NUDT11 protein | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | homeostasis | A-549 cell line | controlled study | cancer | cell cycle regulation
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2014, Volume 53, Issue 6, pp. 1548 - 1551
Many intrinsically disordered proteins fold upon binding to other macromolecules. The secondary structure present in the well‐ordered complex is often formed... 
secondary structure | NMR spectroscopy | proteins | ligand binding | conformational selection | ORDER | DOMAIN | MOLECULAR RECOGNITION | SLOW | TRANSITION-STATE | INDUCED FIT | CHEMISTRY, MULTIDISCIPLINARY | Protein folding | Hormones | Proteins | Binding | Molecular structure | Helical | Ligands | Recognition | Monitoring
Journal Article
Biophysical Journal, ISSN 0006-3495, 10/2014, Volume 107, Issue 8, p. 1997
  We are writing to make an important and general comment that relates to the conclusions of a paper recently published in the Biophysical Journal by Krieger... 
Proteins | Ligands | Biophysics | Kinetics
Journal Article
Journal Article
Physical Chemistry Chemical Physics, ISSN 1463-9076, 03/2014, Volume 16, Issue 14, pp. 6323 - 6331
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins are very common and instrumental for cellular signaling.... 
Proteins | Binding | Landscapes | Rate constants | Binding energy | Constants | Affinity | Folding
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 11/2017, Volume 42, Issue 11, pp. 847 - 849
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
IUBMB Life, ISSN 1521-6543, 07/2014, Volume 66, Issue 7, pp. 449 - 452
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 02/2016, Volume 36, pp. 18 - 24
Protein or protein regions that are not forming well-defined structures in their free states under native-like conditions are called intrinsically disordered... 
NATIVELY UNFOLDED PROTEINS | UNSTRUCTURED PROTEINS | MECHANISM | MOLECULAR RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATE CONSTANTS | C-MYB | TRANSITION-STATE | TRANSACTIVATION DOMAIN | SIDE-CHAIN INTERACTIONS | CONFORMATIONAL SELECTION | CELL BIOLOGY