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Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 539 - 550
In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns... 
MEDICINE, RESEARCH & EXPERIMENTAL | DANGER SIGNALS | STERILE INFLAMMATION | CHROMATIN PROTEIN HMGB1 | IN-VIVO | SEPTIC SHOCK | MOBILITY GROUP BOX-1 | RECEPTOR | DEFICIENT MICE | CELL-DEATH | TRANSGENIC MICE | Acetaminophen - adverse effects | Inflammation - chemically induced | Leukocyte Elastase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Tumor Necrosis Factor-alpha - genetics | Analgesics, Non-Narcotic - pharmacology | Hepatocytes - pathology | Hepatocytes - metabolism | Neutrophil Infiltration | fas Receptor - metabolism | Necrosis - pathology | HMGB1 Protein - genetics | Shock, Septic - metabolism | Inflammation - metabolism | Acetaminophen - pharmacology | Analgesics, Non-Narcotic - adverse effects | HMGB1 Protein - metabolism | fas Receptor - genetics | Chemical and Drug Induced Liver Injury - pathology | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Neutrophils - pathology | Shock, Septic - genetics | Shock, Septic - pathology | Lipopolysaccharides - toxicity | Macrophages - pathology | Shock, Septic - chemically induced | Leukocyte Elastase - genetics | Necrosis - metabolism | Chemical and Drug Induced Liver Injury - genetics | Mice, Knockout | Necrosis - chemically induced | Macrophages - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Inflammation - genetics | Mice | Necrosis - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Physiological aspects | Causes of | Inflammation | Genetic aspects | Cell death | Necrosis | Chromosomal proteins | Mass spectrometry | Analysis | Proteins | Studies | Rodents | Mortality | Gangrene | Homeostasis | Mitochondrial DNA | Laboratory animals | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Proteomics - Clinical Applications, ISSN 1862-8346, 2009, Volume 3, Issue 6, pp. 720 - 729
Flucloxacillin is a synthetic penicillin used in the treatment of Staphylococcal infections. Adverse reactions to the drug are believed to arise through... 
Allergens | Plasma | Protein adducts | Target for drugs | DICLOXACILLIN | HUMAN PLASMA | HUMAN SERUM-ALBUMIN | PROTEIN PK(A) VALUES | BIOCHEMICAL RESEARCH METHODS | BIOAVAILABILITY | PHARMACOKINETICS | RATIONALIZATION | CLOXACILLIN | BINDING | PENICILLIN
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 6, pp. 2118 - 2132
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2011, Volume 187, Issue 1, pp. 200 - 211
A mechanistic understanding of the relationship between the chemistry of drug Ag formation and immune function is lacking. Thus, mass spectrometric methods... 
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2015, Volume 283, Issue 3, pp. 168 - 177
Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is... 
Biomarkers | Inflammation | Bile acids | HMGB1 | Primary human hepatocytes | Obstructive cholestasis | RAT HEPATOCYTES | ACETAMINOPHEN HEPATOTOXICITY | INDUCED LIVER-INJURY | CELL-DEATH | DUCT-LIGATED MICE | RECEPTOR TGR5 | URSODEOXYCHOLIC ACID | ONCOTIC NECROSIS | PRIMARY BILIARY-CIRRHOSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Bile Acids and Salts - blood | Species Specificity | Bile Acids and Salts - toxicity | Humans | Mice, Inbred C57BL | Cells, Cultured | Hepatocytes - pathology | Biomarkers - blood | Hepatocytes - metabolism | Jaundice, Obstructive - pathology | Necrosis | Dose-Response Relationship, Drug | Animals | Cholestasis, Extrahepatic - blood | Jaundice, Obstructive - blood | Glycochenodeoxycholic Acid - toxicity | Acetylation | Primary Cell Culture | Keratin-18 - blood | Cholestasis, Extrahepatic - pathology | HMGB1 Protein - blood | Hepatocytes - drug effects | Keratin | Care and treatment | Jaundice, Obstructive | Analysis | Cholestasis | Deoxycholic acid | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | GLYCINE | PATIENTS | INJURIES | RODENTS | BILIARY TRACT | TOXICITY | LEVELS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | POLYPEPTIDES | NECROSIS | CHOLIC ACID | INFLAMMATION | LIVER | LIVER CELLS | AMINOTRANSFERASES | BILE | bile acids | primary human hepatocytes | inflammation | biomarkers | obstructive cholestasis | apoptosis
Journal Article